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The map label for this gene is pncB [H]

Identifier: 148358480

GI number: 148358480

Start: 372353

End: 373756

Strand: Direct

Name: pncB [H]

Synonym: LPC_0346

Alternate gene names: 148358480

Gene position: 372353-373756 (Clockwise)

Preceding gene: 148358479

Following gene: 148358481

Centisome position: 10.41

GC content: 40.95

Gene sequence:

>1404_bases
ATGATAAACATCACAGGAACCTACACTGATCAATATCAATTGGCTATGGCTCAAGTGTATTTTTTAAAAGGGCATCATGA
GCGCATAGCGACATTCGATTATTTTTTTCGTGCTCTTCCTTTTAAAGGAGGCTATGCGATTTTTGCGGGTTTGGAGGATT
TACTGGATGTTCTCGAACAACTTCGCTTTGAACAACAAGACATCGAGTTTTTACAACATCAGAACATGCATCCTGATTTT
ATTGACTATTTGCAACAGTTTAAGTTCACTGGAGCAGTGTATGCGTCGCGCGAGGGAGATGTTGTATTTCCTACGCGGCC
AGTGGTTATTATCGAAGCCAATTTGATTGAAGCACAAATCATAGAAACGTTATTATTAAATATTCTTAATTTTCAGACGC
TTATTGCGACAAAAGCCAGACGCATCAGGCAGGTTGCGGGGGAGCGGATTTTAATTGATTTTGGACTAAGGAGAGCACAG
GGCGCTGGAGGGTATTTTGCAAGCCGTGCAGCCATAGTCGGTGGCTTTGATTCGACAAGCAATGTCAGAGCCGGGCGTGA
TTATTCAATTCCTGTATCGGGTACTATGGCTCATTCCTTTATCCAAAGTTACGATAGTGAGATACAAGCTTTTTCTGATT
ATGCTGAAGCTTGGCCGGAGAATTGCTTCTTGCTAGTAGATACTTATAATACGTTGCAAAGTGGTGTTCCTAATGCAATC
AAAATAGCTAAGGAAATGGAGAAGAGAGGACATAGGCTCAAAGGCATTCGCCTGGATAGTGGCGATTTGGCATGGTTATC
CAAGAGGGCTCGCCACATGTTAGACGAGGCCGGTTTAAACTATGTGGCTATTACAGTTTCCAATCAACTCGATGAGTATG
TCATCAAGAATTTGTTAGAGCAGGATGCGCCTATTGATGCTTTTGGTGTGGGGACCAATCTCGCGATTGGTGCCCCGGAT
GCGGCTCTTGATGGGGTTTATAAATTAGCATTTATAAATGGTCAACCTAGCATTAAATTATCAGATACCCCTGCAAAGAT
CACTATTCCTTATCAAAAGCAAGTCTACAGGGTGTTCGAAAGAGATGGGACGTATCGCGGCGCGGATGTTGTCTGTCTCA
AAACGGAAAAAAAAATTGATATGATGCATCATCCTTTTGAAATTCTAAAATCGCTTTCGATAAAGCACTATAAAAAAGAA
GCATTACTGCATAAAGTGATGGAAAACGGCAAACGGTTACTGCCTAAAAAATCACTTAGAGAAATAGTCAGATTTAGCCA
GCAATGTTTTGATCGATTGCCTTTGGAATACAAGCGTTTTATTAATCCTCATATCTATAAAGTGGGTTTAAGTACCGAGC
TTAAAATGAAGAGAGATCAACTGATAGCTGAACACTCAAGATAA

Upstream 100 bases:

>100_bases
TCAAGAGTAAACGGAACTAGGCCAGTTGTTGTCCATATTAAATTTTTAACTTATACCGTGCATGGTCAAAATAAAAGCAA
TATAATCGACAAGGATATAC

Downstream 100 bases:

>100_bases
TTTTATGAAGACTTTAATCATCCTCGATGTTCAAAATGATTTCATGCCAGGCGGCTCACTGGGGGTACCGAATGGTGATG
CGATTGTTCCCGTTATTAAC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MINITGTYTDQYQLAMAQVYFLKGHHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQLRFEQQDIEFLQHQNMHPDF
IDYLQQFKFTGAVYASREGDVVFPTRPVVIIEANLIEAQIIETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQ
GAGGYFASRAAIVGGFDSTSNVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCFLLVDTYNTLQSGVPNAI
KIAKEMEKRGHRLKGIRLDSGDLAWLSKRARHMLDEAGLNYVAITVSNQLDEYVIKNLLEQDAPIDAFGVGTNLAIGAPD
AALDGVYKLAFINGQPSIKLSDTPAKITIPYQKQVYRVFERDGTYRGADVVCLKTEKKIDMMHHPFEILKSLSIKHYKKE
ALLHKVMENGKRLLPKKSLREIVRFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLIAEHSR

Sequences:

>Translated_467_residues
MINITGTYTDQYQLAMAQVYFLKGHHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQLRFEQQDIEFLQHQNMHPDF
IDYLQQFKFTGAVYASREGDVVFPTRPVVIIEANLIEAQIIETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQ
GAGGYFASRAAIVGGFDSTSNVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCFLLVDTYNTLQSGVPNAI
KIAKEMEKRGHRLKGIRLDSGDLAWLSKRARHMLDEAGLNYVAITVSNQLDEYVIKNLLEQDAPIDAFGVGTNLAIGAPD
AALDGVYKLAFINGQPSIKLSDTPAKITIPYQKQVYRVFERDGTYRGADVVCLKTEKKIDMMHHPFEILKSLSIKHYKKE
ALLHKVMENGKRLLPKKSLREIVRFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLIAEHSR
>Mature_467_residues
MINITGTYTDQYQLAMAQVYFLKGHHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQLRFEQQDIEFLQHQNMHPDF
IDYLQQFKFTGAVYASREGDVVFPTRPVVIIEANLIEAQIIETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQ
GAGGYFASRAAIVGGFDSTSNVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCFLLVDTYNTLQSGVPNAI
KIAKEMEKRGHRLKGIRLDSGDLAWLSKRARHMLDEAGLNYVAITVSNQLDEYVIKNLLEQDAPIDAFGVGTNLAIGAPD
AALDGVYKLAFINGQPSIKLSDTPAKITIPYQKQVYRVFERDGTYRGADVVCLKTEKKIDMMHHPFEILKSLSIKHYKKE
ALLHKVMENGKRLLPKKSLREIVRFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLIAEHSR

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=521, Percent_Identity=32.0537428023033, Blast_Score=254, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71997952, Length=514, Percent_Identity=36.3813229571984, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI71997947, Length=514, Percent_Identity=36.3813229571984, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI71997955, Length=204, Percent_Identity=47.0588235294118, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24581587, Length=510, Percent_Identity=35.8823529411765, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 53176; Mature: 53176

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINITGTYTDQYQLAMAQVYFLKGHHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQ
CEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LRFEQQDIEFLQHQNMHPDFIDYLQQFKFTGAVYASREGDVVFPTRPVVIIEANLIEAQI
HHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCEEECCCCEEEEECCHHHHHH
IETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQGAGGYFASRAAIVGGFDSTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHCCCCCCHHHHCCEEEECCCCCC
NVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCFLLVDTYNTLQSGVPNAI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHCCCHHH
KIAKEMEKRGHRLKGIRLDSGDLAWLSKRARHMLDEAGLNYVAITVSNQLDEYVIKNLLE
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
QDAPIDAFGVGTNLAIGAPDAALDGVYKLAFINGQPSIKLSDTPAKITIPYQKQVYRVFE
CCCCCCEECCCCCEEECCCCHHHCCEEEEEEECCCCCEEECCCCCEEEECHHHHHHHHHH
RDGTYRGADVVCLKTEKKIDMMHHPFEILKSLSIKHYKKEALLHKVMENGKRLLPKKSLR
HCCCCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHH
EIVRFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLIAEHSR
HHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MINITGTYTDQYQLAMAQVYFLKGHHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQ
CEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LRFEQQDIEFLQHQNMHPDFIDYLQQFKFTGAVYASREGDVVFPTRPVVIIEANLIEAQI
HHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCEEECCCCEEEEECCHHHHHH
IETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQGAGGYFASRAAIVGGFDSTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHCCCCCCHHHHCCEEEECCCCCC
NVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCFLLVDTYNTLQSGVPNAI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHCCCHHH
KIAKEMEKRGHRLKGIRLDSGDLAWLSKRARHMLDEAGLNYVAITVSNQLDEYVIKNLLE
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
QDAPIDAFGVGTNLAIGAPDAALDGVYKLAFINGQPSIKLSDTPAKITIPYQKQVYRVFE
CCCCCCEECCCCCEEECCCCHHHCCEEEEEEECCCCCEEECCCCCEEEECHHHHHHHHHH
RDGTYRGADVVCLKTEKKIDMMHHPFEILKSLSIKHYKKEALLHKVMENGKRLLPKKSLR
HCCCCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHH
EIVRFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLIAEHSR
HHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]