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The map label for this gene is fabG [H]

Identifier: 148358414

GI number: 148358414

Start: 292325

End: 293023

Strand: Direct

Name: fabG [H]

Synonym: LPC_0280

Alternate gene names: 148358414

Gene position: 292325-293023 (Clockwise)

Preceding gene: 148358410

Following gene: 148358415

Centisome position: 8.17

GC content: 45.35

Gene sequence:

>699_bases
ATGGCGCGCTACCTGGTAATTGCTGCAAGCAGTGCTATCGGACAATCCGTGACAACCCTTTTAAAAAATCGTGGTGATAC
CGTTTTTACCACAGCACGAGATAATCATAAGATAAACCCTGATTTTCAACTGGATGCCACTCATTTTGATGCGGTTTTAG
ATGTTTTTCGCCAAACAGGACCCCTTGATGGCGTAGTCAATTGTGCGGGTTCACTACTTCTGAAAAATGCTCACAGCACC
AGTTTTGATGAATTTCAAGCTGCGATCAATGCGTCACTCACTACTTCTTTTGCTACCATTCGAGCTGCTGGCTTAACTAT
GAATCAAGGAGGTTCTGTTGTATTGATATCATCAGCCGCCGCTTTGGTAGGTCTGGCCAATCATGAAGCCATTGCGGCGG
CCAAAGCGGGTATCATTGGCTTGGCGCAATCTGCTGCAGCCACTTATGCTTCAAACAATTTAAGAGTAAATGTTGTGGCT
CCTGGAATGGTCAATAGCCCGCTGACCTCATCGTTATTAAGCAATCAGTTAGTTTTGAATGCATCAAAGGCAATGCATGC
TTTAGGGCGAATTGGTGTTCCGGAAGATATCGCCCACGCAATTGTGTTTTTGCTTAATCCGGACAACAGTTGGATCACAG
GGCAAGTGATTGCTGTTGATGGCGGGTTAAGCCGAGTTCGGCCCAAGATGAAAATTTAA

Upstream 100 bases:

>100_bases
TAACTTATCCAATGGCATGGGATGTCCGTATAATGAATATTGAAGTTTCCAAGCTAATCCATCATAGTAGGTATTTTTAT
ACTAATGCAAGAAGAATGAT

Downstream 100 bases:

>100_bases
TGAAACTATAATTTTTATGACGACACTGTGTTTTATATTAGGCGATCAACTCAATGAAACAATCGCTTCACTTGCGGCAA
TTAATAAACAGAAGGACATT

Product: 2-deoxy-D-gluconate-3-dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MARYLVIAASSAIGQSVTTLLKNRGDTVFTTARDNHKINPDFQLDATHFDAVLDVFRQTGPLDGVVNCAGSLLLKNAHST
SFDEFQAAINASLTTSFATIRAAGLTMNQGGSVVLISSAAALVGLANHEAIAAAKAGIIGLAQSAAATYASNNLRVNVVA
PGMVNSPLTSSLLSNQLVLNASKAMHALGRIGVPEDIAHAIVFLLNPDNSWITGQVIAVDGGLSRVRPKMKI

Sequences:

>Translated_232_residues
MARYLVIAASSAIGQSVTTLLKNRGDTVFTTARDNHKINPDFQLDATHFDAVLDVFRQTGPLDGVVNCAGSLLLKNAHST
SFDEFQAAINASLTTSFATIRAAGLTMNQGGSVVLISSAAALVGLANHEAIAAAKAGIIGLAQSAAATYASNNLRVNVVA
PGMVNSPLTSSLLSNQLVLNASKAMHALGRIGVPEDIAHAIVFLLNPDNSWITGQVIAVDGGLSRVRPKMKI
>Mature_231_residues
ARYLVIAASSAIGQSVTTLLKNRGDTVFTTARDNHKINPDFQLDATHFDAVLDVFRQTGPLDGVVNCAGSLLLKNAHSTS
FDEFQAAINASLTTSFATIRAAGLTMNQGGSVVLISSAAALVGLANHEAIAAAKAGIIGLAQSAAATYASNNLRVNVVAP
GMVNSPLTSSLLSNQLVLNASKAMHALGRIGVPEDIAHAIVFLLNPDNSWITGQVIAVDGGLSRVRPKMKI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=31.7991631799163, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI19923817, Length=180, Percent_Identity=33.8888888888889, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI32483357, Length=113, Percent_Identity=34.5132743362832, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4758504, Length=183, Percent_Identity=30.0546448087432, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI5031737, Length=119, Percent_Identity=33.6134453781513, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI10190704, Length=195, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI126723750, Length=113, Percent_Identity=31.858407079646, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI66933014, Length=192, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1787335, Length=240, Percent_Identity=30, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367365, Length=178, Percent_Identity=27.5280898876405, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788459, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789208, Length=172, Percent_Identity=28.4883720930233, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1786812, Length=178, Percent_Identity=30.8988764044944, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87082100, Length=175, Percent_Identity=27.4285714285714, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=25.5144032921811, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=191, Percent_Identity=32.9842931937173, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=243, Percent_Identity=28.3950617283951, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=186, Percent_Identity=27.4193548387097, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=113, Percent_Identity=31.858407079646, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=185, Percent_Identity=28.1081081081081, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=120, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=188, Percent_Identity=28.1914893617021, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=197, Percent_Identity=26.9035532994924, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=28.2258064516129, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644337, Length=178, Percent_Identity=32.5842696629214, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24643142, Length=231, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=120, Percent_Identity=30.8333333333333, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17737361, Length=185, Percent_Identity=30.8108108108108, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=181, Percent_Identity=28.7292817679558, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=27.3092369477912, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=26.6129032258064, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 24073; Mature: 23942

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYLVIAASSAIGQSVTTLLKNRGDTVFTTARDNHKINPDFQLDATHFDAVLDVFRQTG
CCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHCC
PLDGVVNCAGSLLLKNAHSTSFDEFQAAINASLTTSFATIRAAGLTMNQGGSVVLISSAA
CCCHHHHHHHHHEEECCCCCCHHHHHHHHCCHHHHHHHHEEEECEEECCCCCEEEEECCH
ALVGLANHEAIAAAKAGIIGLAQSAAATYASNNLRVNVVAPGMVNSPLTSSLLSNQLVLN
HEEECCCCHHHHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCHHEEE
ASKAMHALGRIGVPEDIAHAIVFLLNPDNSWITGQVIAVDGGLSRVRPKMKI
HHHHHHHHHCCCCCHHHHEEEEEEECCCCCEEEEEEEEEECCHHHCCCCCCC
>Mature Secondary Structure 
ARYLVIAASSAIGQSVTTLLKNRGDTVFTTARDNHKINPDFQLDATHFDAVLDVFRQTG
CEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHCC
PLDGVVNCAGSLLLKNAHSTSFDEFQAAINASLTTSFATIRAAGLTMNQGGSVVLISSAA
CCCHHHHHHHHHEEECCCCCCHHHHHHHHCCHHHHHHHHEEEECEEECCCCCEEEEECCH
ALVGLANHEAIAAAKAGIIGLAQSAAATYASNNLRVNVVAPGMVNSPLTSSLLSNQLVLN
HEEECCCCHHHHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCHHEEE
ASKAMHALGRIGVPEDIAHAIVFLLNPDNSWITGQVIAVDGGLSRVRPKMKI
HHHHHHHHHCCCCCHHHHEEEEEEECCCCCEEEEEEEEEECCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]