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The map label for this gene is htrA [H]

Identifier: 148284997

GI number: 148284997

Start: 1769757

End: 1771157

Strand: Direct

Name: htrA [H]

Synonym: OTBS_1837

Alternate gene names: 148284997

Gene position: 1769757-1771157 (Clockwise)

Preceding gene: 148284996

Following gene: 148284999

Centisome position: 83.2

GC content: 30.55

Gene sequence:

>1401_bases
ATGAAAAAGGCATTTTGTTTACATTTAATAGTATTTGCATTACAAGGTATAAGTAATGTTCATTCTAAATCGCTACTAAA
TCAAAAAGCTGTATTACCTCAACAAAAATCTGATATGCATATTAGTGTAAATAGTTTATCCGATATAGTTGAGCCATTAC
TATCTACAGTAGTAAGTATTTATGCTGTAGATACTAACATTGGGATTATTTTAAATAATAAGGTATCTAAGTATCAACAA
GAAGTGTTCTTAGGTTCTGGAGTTATCATTGATAGTTCTGGATATATTGTTACTAATGAAAATGTTATAGCAGGAGCTGA
AAATATAAAAGTAAAGTTGCATGATGGTTCAGAACTGATAGCAGAATTAGTTGGCAGTGACAAAAAAATTAATATAGCCT
TGTTAAAAATTAATTCTCCAGCAGAATTATCTTATGCTGATTTTGGTGACTCAAATCAGTCGAGAGTAGGAGATCAGGTT
ATTGCAATAGGAAGTCCTTTTGGTTTAAGAGGAACAGTAACAAATGGCATTATTTCTTCTAAAGGACGAGATATGGGTAA
CGGCATAGTAACTGATTTTATTCAAACTAATGCTGCTGTTCATATGGGTAGCTTTGGTGGACCGATGTTTAATCTTGAAG
GAAAAATTATTGGAATTAATTCCATTCATGTATCTTACTCAGGCATAAGTTTTGCTATTCCATCTAATACTGTACTTGAA
GCAGTTGAATGCTTAAAAAAAGGAGAAAAAATTCGTCGTGGTATGTTAAATGTTATGCTTAATGAATTAACTCCAGAATT
AAATGAGAATTTAGGACTTAAAAAAGATCAAAATGGAGTTCTAATAACTGAAGTTATAAAAGAAGGATCTGCAGCACAAT
GTGGAATTGCTCCTGGAGATGTAATTACTAAATTTCATGATAAAGAGATCAAAACAGGAAGAGATTTACAGGTAGCTGTA
TCTTCAACTATGCTTAATTCTGAAAGAGAAGTTGGACTTTTACGTAATGGTAAGTTGATGACTCTAAAATGTAAAATTAT
TGCCAACAAAGGTGAGGATAGTGAGCAACAAAGTAATGATCAAAGTCTTGTAGTTAATGGTGTAAAATTTGTTGATCTTA
CACCTGATTTAGTGAAGAAATATAATATTACTTCAGCTAATAATAATGGATTATTTGTTCTTGAAGTTTCGCCTAACTCT
TCTTGGGGAAGATATGGTTTGAAAATGGGGCTAAAACCTAGAGATATAATTTTATCAGTTAAACGTGATGATAATAAAAA
AGATATTTCTGTTAAAACACTAAGAGAAATAGTGACAAATATAAAGCATAATGAAATTTTCTTTACAGTTCAAAGGGGAG
ATAGAATGCTTTACATTGCTTTACCTAATATTAATAAGTAA

Upstream 100 bases:

>100_bases
AAGTGCTAAGAAAGGATGATACTTCTTTTGTATTATCTCCTAATAGTGGCTTGTTTAAGTTTTTGAATTTAAGTAATAAT
TAATATTAAAGGTTAAGTTT

Downstream 100 bases:

>100_bases
ATCTAATTTAAAGGCGATTTTAATTGCCTTTAAATATCAATTGTTAATTTAAGTTAAGTATTAAATTTAGAAGTAATTAG
CTTAGTATTTAGCAAAATTA

Product: periplasmic serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKKAFCLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHISVNSLSDIVEPLLSTVVSIYAVDTNIGIILNNKVSKYQQ
EVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELIAELVGSDKKINIALLKINSPAELSYADFGDSNQSRVGDQV
IAIGSPFGLRGTVTNGIISSKGRDMGNGIVTDFIQTNAAVHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGDVITKFHDKEIKTGRDLQVAV
SSTMLNSEREVGLLRNGKLMTLKCKIIANKGEDSEQQSNDQSLVVNGVKFVDLTPDLVKKYNITSANNNGLFVLEVSPNS
SWGRYGLKMGLKPRDIILSVKRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK

Sequences:

>Translated_466_residues
MKKAFCLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHISVNSLSDIVEPLLSTVVSIYAVDTNIGIILNNKVSKYQQ
EVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELIAELVGSDKKINIALLKINSPAELSYADFGDSNQSRVGDQV
IAIGSPFGLRGTVTNGIISSKGRDMGNGIVTDFIQTNAAVHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGDVITKFHDKEIKTGRDLQVAV
SSTMLNSEREVGLLRNGKLMTLKCKIIANKGEDSEQQSNDQSLVVNGVKFVDLTPDLVKKYNITSANNNGLFVLEVSPNS
SWGRYGLKMGLKPRDIILSVKRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK
>Mature_466_residues
MKKAFCLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHISVNSLSDIVEPLLSTVVSIYAVDTNIGIILNNKVSKYQQ
EVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELIAELVGSDKKINIALLKINSPAELSYADFGDSNQSRVGDQV
IAIGSPFGLRGTVTNGIISSKGRDMGNGIVTDFIQTNAAVHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGDVITKFHDKEIKTGRDLQVAV
SSTMLNSEREVGLLRNGKLMTLKCKIIANKGEDSEQQSNDQSLVVNGVKFVDLTPDLVKKYNITSANNNGLFVLEVSPNS
SWGRYGLKMGLKPRDIILSVKRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=313, Percent_Identity=31.9488817891374, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI7019477, Length=317, Percent_Identity=33.7539432176656, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI4506141, Length=290, Percent_Identity=33.7931034482759, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI24308541, Length=260, Percent_Identity=36.9230769230769, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1786356, Length=387, Percent_Identity=35.4005167958656, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1789629, Length=450, Percent_Identity=30.8888888888889, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1789630, Length=283, Percent_Identity=34.6289752650177, Blast_Score=136, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646839, Length=259, Percent_Identity=36.6795366795367, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50692; Mature: 50692

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAFCLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHISVNSLSDIVEPLLSTVVSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHEE
YAVDTNIGIILNNKVSKYQQEVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELI
EEEECCEEEEECCHHHHHHHHHHCCCCEEECCCCEEEECCCEEECCCEEEEEEECCHHHH
AELVGSDKKINIALLKINSPAELSYADFGDSNQSRVGDQVIAIGSPFGLRGTVTNGIISS
HHHHCCCCEEEEEEEEECCCCCCEECCCCCCCCHHCCCEEEEECCCCCCCEECCCCEECC
KGRDMGNGIVTDFIQTNAAVHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
CCCCCCCCHHHHHHHCCCEEEECCCCCCEEECCCEEEEEEEEEEEECCEEEECCCHHHHH
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGD
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCEEEEHHHCCCCCCCCCCCCCH
VITKFHDKEIKTGRDLQVAVSSTMLNSEREVGLLRNGKLMTLKCKIIANKGEDSEQQSND
HHHHCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEECCEEEEEEEEEEECCCCCCHHHCCC
QSLVVNGVKFVDLTPDLVKKYNITSANNNGLFVLEVSPNSSWGRYGLKMGLKPRDIILSV
CEEEEECEEEEECCHHHHHHEECCCCCCCCEEEEEECCCCCCCCCCEEECCCCHHEEEEE
KRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK
ECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCC
>Mature Secondary Structure
MKKAFCLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHISVNSLSDIVEPLLSTVVSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHEE
YAVDTNIGIILNNKVSKYQQEVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELI
EEEECCEEEEECCHHHHHHHHHHCCCCEEECCCCEEEECCCEEECCCEEEEEEECCHHHH
AELVGSDKKINIALLKINSPAELSYADFGDSNQSRVGDQVIAIGSPFGLRGTVTNGIISS
HHHHCCCCEEEEEEEEECCCCCCEECCCCCCCCHHCCCEEEEECCCCCCCEECCCCEECC
KGRDMGNGIVTDFIQTNAAVHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
CCCCCCCCHHHHHHHCCCEEEECCCCCCEEECCCEEEEEEEEEEEECCEEEECCCHHHHH
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGD
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCEEEEHHHCCCCCCCCCCCCCH
VITKFHDKEIKTGRDLQVAVSSTMLNSEREVGLLRNGKLMTLKCKIIANKGEDSEQQSND
HHHHCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEECCEEEEEEEEEEECCCCCCHHHCCC
QSLVVNGVKFVDLTPDLVKKYNITSANNNGLFVLEVSPNSSWGRYGLKMGLKPRDIILSV
CEEEEECEEEEECCHHHHHHEECCCCCCCCEEEEEECCCCCCCCCCEEECCCCHHEEEEE
KRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK
ECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893; 9274032 [H]