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The map label for this gene is hflC [H]

Identifier: 148284996

GI number: 148284996

Start: 1768873

End: 1769739

Strand: Direct

Name: hflC [H]

Synonym: OTBS_1836

Alternate gene names: 148284996

Gene position: 1768873-1769739 (Clockwise)

Preceding gene: 148284995

Following gene: 148284997

Centisome position: 83.16

GC content: 31.83

Gene sequence:

>867_bases
ATGACGATAAAAAAAGTGTACTTAACAATTGTTATAGCTACTGTAGTAGTACTAGCGATATTTAATTCTGTGTTTCAGGT
TATGCAGCATCAGTATGCAGTAGTTTTTCAATTTGGAGAAGCAATAAAAATTATTTCGGAGCCAGGGTTAAGGTTTAAGA
TACCATTTGTTCAAAATGTATTGTATTTTGATAAAAGGTTAGTTTCTGTTGAAGTATCAGCTAAAGAATTAACAGCGGCA
GATGGTAAGAGAGTAATTGTTAATGCATTTGCTAAATTTAAGATTATTGACCCTATTACTTTTTTTAAAACAGTGTATAA
TCATAATGGAGTAAAAGTTAGATTAAATAAAACTATTGAGTCTGCAATGCGAAAAGTTATTGGGCGAGCTACTTTTATTA
CTTTGTTGTCTAAGCAAAGATCAGAAATCATGTCTGATATTTATGATTTAGTAAATAAAGAGGGTAAATCATTTGGAGTA
GATGTAATTGACGTAAGGATTTCAAGAACTGATCTACCAAAGGAGAATAGTGCTGCAATTTATCAGAGAATGCAAACAGA
GAGAGAAAAAGAAGCTAAGCAGATTAGAGCTGAAGGAAAGGAGGAGGCTGTGAGAATAATATCAAGGGCTGATAAAGAAT
GCGATATTATTTTAGCAGAAGCATATAAGCAGGCCAAGATATTGGAAGGGGAGGGAGATGCTGAGGCTTCTCATATATAC
AATAGTGTATATAGTCAAGATCCAGAGTTTTATCGGTTTTACCAATCATTATTAACTTATTCTAAAGTGCTAAGAAAGGA
TGATACTTCTTTTGTATTATCTCCTAATAGTGGCTTGTTTAAGTTTTTGAATTTAAGTAATAATTAA

Upstream 100 bases:

>100_bases
TATTACAAGGTAGTAAAAAAATTATTATAAGCGATGAGAGTAAATTATTGCCTCATATGGGTATATCGCTTAAATAAATA
TAAGTAGTAAGGTTTAAATC

Downstream 100 bases:

>100_bases
TATTAAAGGTTAAGTTTATGAAAAAGGCATTTTGTTTACATTTAATAGTATTTGCATTACAAGGTATAAGTAATGTTCAT
TCTAAATCGCTACTAAATCA

Product: putative membrane protease, stomatin/prohibitin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTIKKVYLTIVIATVVVLAIFNSVFQVMQHQYAVVFQFGEAIKIISEPGLRFKIPFVQNVLYFDKRLVSVEVSAKELTAA
DGKRVIVNAFAKFKIIDPITFFKTVYNHNGVKVRLNKTIESAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGV
DVIDVRISRTDLPKENSAAIYQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIY
NSVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSGLFKFLNLSNN

Sequences:

>Translated_288_residues
MTIKKVYLTIVIATVVVLAIFNSVFQVMQHQYAVVFQFGEAIKIISEPGLRFKIPFVQNVLYFDKRLVSVEVSAKELTAA
DGKRVIVNAFAKFKIIDPITFFKTVYNHNGVKVRLNKTIESAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGV
DVIDVRISRTDLPKENSAAIYQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIY
NSVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSGLFKFLNLSNN
>Mature_287_residues
TIKKVYLTIVIATVVVLAIFNSVFQVMQHQYAVVFQFGEAIKIISEPGLRFKIPFVQNVLYFDKRLVSVEVSAKELTAAD
GKRVIVNAFAKFKIIDPITFFKTVYNHNGVKVRLNKTIESAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGVD
VIDVRISRTDLPKENSAAIYQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIYN
SVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSGLFKFLNLSNN

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=314, Percent_Identity=29.6178343949045, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786697, Length=225, Percent_Identity=24, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17569493, Length=183, Percent_Identity=29.5081967213115, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193209764, Length=183, Percent_Identity=29.5081967213115, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI32564147, Length=225, Percent_Identity=25.3333333333333, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 32853; Mature: 32722

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKKVYLTIVIATVVVLAIFNSVFQVMQHQYAVVFQFGEAIKIISEPGLRFKIPFVQNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHH
LYFDKRLVSVEVSAKELTAADGKRVIVNAFAKFKIIDPITFFKTVYNHNGVKVRLNKTIE
HHHHHHHEEEEECHHHHHHCCCCEEEEEHHHHHEEECHHHHHHHHHCCCCEEEEEHHHHH
SAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGVDVIDVRISRTDLPKENSAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCHHHH
YQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCHHHHHHH
NSVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSGLFKFLNLSNN
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCC
>Mature Secondary Structure 
TIKKVYLTIVIATVVVLAIFNSVFQVMQHQYAVVFQFGEAIKIISEPGLRFKIPFVQNV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHH
LYFDKRLVSVEVSAKELTAADGKRVIVNAFAKFKIIDPITFFKTVYNHNGVKVRLNKTIE
HHHHHHHEEEEECHHHHHHCCCCEEEEEHHHHHEEECHHHHHHHHHCCCCEEEEEHHHHH
SAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGVDVIDVRISRTDLPKENSAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCHHHH
YQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCHHHHHHH
NSVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSGLFKFLNLSNN
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]