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The map label for this gene is thrC [H]

Identifier: 148260782

GI number: 148260782

Start: 1969591

End: 1970994

Strand: Reverse

Name: thrC [H]

Synonym: Acry_1787

Alternate gene names: 148260782

Gene position: 1970994-1969591 (Counterclockwise)

Preceding gene: 148260783

Following gene: 148260781

Centisome position: 58.15

GC content: 70.58

Gene sequence:

>1404_bases
ATGCGCTACGTCTCCACCCGCGGTGCGGCCCCGTCCCGTGAATTCGACGATGTCCTGCTGGCCGGGCTGGCCGAGGATGG
CGGGCTGTTCGTGCCCGAGACCTGGCCGGTCTTCTCGCCGGCGGAATGGCGCGCGCTGCGCGGCCTGCCCTATGCCGAGC
TCGCCGCCCGCGTCATGGCCCCGTTCATGACCGGCGGCGCCATCGGCTTCGACGATCTGCAAGCCATCACCCGCGCGTCC
TATCGCGGGTTCGACCATGCGGCGGTCGTCCCGCTGGTCCAGCTCGAACCCTCGCTCTTCGTGCTGGAACTGTTCCACGG
CCCGACCCTCGCCTTCAAGGATCTCGCCCTCCAGGTCGCCGGCCGCCTGTTCGACCATGTCCTGTCCGCCCGCGACGAGC
GGGTGACGATCGTGGGCGCCACCTCGGGCGATACCGGCTCCGCCGCGATCGAGGCCTGCCGCGACCGCCTGCGGGTCGAC
ATCGCCATCCTCCACCCCGAAGGCCGCACCTCCGAGGTCCAGCGCCGGCAGATGACCACGGTCAAGGCCCGCAACGTCCT
CAACATCGCCCTCTCCGGCACGTTCGACGACTGCCAGGACCTGGTGAAGGCGATGTTCGCCGATGCGCCCTTCCGCACCG
AGCTGCGCCTGTCGGCGGTCAACTCGATCAACTGGGCGCGCATCGCCGGCCAGATCCCCTATTTCGCCGCCGCCGCCCTC
GCCCTCGGCGCGCCGGACCGCCCGGTCGCCGTCGCGGTGCCGACCGGCAATTTCGGCAACATCCTCGCCGCCTGGGCGGC
GCGGCAGATGGGCCTGCCGATCGAGCGCTTCATCGTCGGCAGCAACGCGAACGACATCCTCGCCCGCTTCCTCGCCGCCA
ACGACATGCGCACCGCCGGCGTGGTCGAAACCGTCTCCCCCTCGATGGACATCCAGGTCAGCTCGAATTTCGAGCGCCTC
CTGTTCGAGGCGCTGGGCAGGGATGCGCCGGAGACCGCCCACACCATGGTCGATTTCCGCGCCAGCGGCACGATGAAGGT
CTCCCGCGAGGTCTGGCAGTCGGTCCGGCGCGACTTCGCCGGCCTCGCCCTCGACGATGCGGCGACCCTTGCCGAAATCG
CCCGCATCCGCGCCGAGTCAGGCTACATCGCCGACCCGCATACCGCGATCGGCATCGCCGCCGCCCGCGCCGCCGCCCCG
GTCGGCGTGCCGGTCATCGCCGCGGCGACCGCGCATCCCGCCAAGTTCCCGGCGGCGATGCATCGCGCGATCGGCATTCG
CCCGGGGCTGCCGCCGCGGCTCGACGACCTATATGACCGTCAGGAACATTTCGTACGCGCGGGCAACAGCCTCGGCGAGG
TCGAGACCCTGGTCCGCCATTTCGCGCACAGGAACGATGCATGA

Upstream 100 bases:

>100_bases
GCGCCCAGGACGACGGCGAGACGATCGCCAACGCCTGATCCGCAGCGGCGCCGCCGCGCGCGGCGCCGCCCGCTGACGCC
TTTCCAGGAACGACCTGCCG

Downstream 100 bases:

>100_bases
GTGACACAGTGCAGGTGACGAAACTCGACTCCGGCCTGACCATCCTGACCGAACGGATGGACCGGGTGGAGACCGTCTCC
TTCGGCGCCTATGCCGGCGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MRYVSTRGAAPSREFDDVLLAGLAEDGGLFVPETWPVFSPAEWRALRGLPYAELAARVMAPFMTGGAIGFDDLQAITRAS
YRGFDHAAVVPLVQLEPSLFVLELFHGPTLAFKDLALQVAGRLFDHVLSARDERVTIVGATSGDTGSAAIEACRDRLRVD
IAILHPEGRTSEVQRRQMTTVKARNVLNIALSGTFDDCQDLVKAMFADAPFRTELRLSAVNSINWARIAGQIPYFAAAAL
ALGAPDRPVAVAVPTGNFGNILAAWAARQMGLPIERFIVGSNANDILARFLAANDMRTAGVVETVSPSMDIQVSSNFERL
LFEALGRDAPETAHTMVDFRASGTMKVSREVWQSVRRDFAGLALDDAATLAEIARIRAESGYIADPHTAIGIAAARAAAP
VGVPVIAAATAHPAKFPAAMHRAIGIRPGLPPRLDDLYDRQEHFVRAGNSLGEVETLVRHFAHRNDA

Sequences:

>Translated_467_residues
MRYVSTRGAAPSREFDDVLLAGLAEDGGLFVPETWPVFSPAEWRALRGLPYAELAARVMAPFMTGGAIGFDDLQAITRAS
YRGFDHAAVVPLVQLEPSLFVLELFHGPTLAFKDLALQVAGRLFDHVLSARDERVTIVGATSGDTGSAAIEACRDRLRVD
IAILHPEGRTSEVQRRQMTTVKARNVLNIALSGTFDDCQDLVKAMFADAPFRTELRLSAVNSINWARIAGQIPYFAAAAL
ALGAPDRPVAVAVPTGNFGNILAAWAARQMGLPIERFIVGSNANDILARFLAANDMRTAGVVETVSPSMDIQVSSNFERL
LFEALGRDAPETAHTMVDFRASGTMKVSREVWQSVRRDFAGLALDDAATLAEIARIRAESGYIADPHTAIGIAAARAAAP
VGVPVIAAATAHPAKFPAAMHRAIGIRPGLPPRLDDLYDRQEHFVRAGNSLGEVETLVRHFAHRNDA
>Mature_467_residues
MRYVSTRGAAPSREFDDVLLAGLAEDGGLFVPETWPVFSPAEWRALRGLPYAELAARVMAPFMTGGAIGFDDLQAITRAS
YRGFDHAAVVPLVQLEPSLFVLELFHGPTLAFKDLALQVAGRLFDHVLSARDERVTIVGATSGDTGSAAIEACRDRLRVD
IAILHPEGRTSEVQRRQMTTVKARNVLNIALSGTFDDCQDLVKAMFADAPFRTELRLSAVNSINWARIAGQIPYFAAAAL
ALGAPDRPVAVAVPTGNFGNILAAWAARQMGLPIERFIVGSNANDILARFLAANDMRTAGVVETVSPSMDIQVSSNFERL
LFEALGRDAPETAHTMVDFRASGTMKVSREVWQSVRRDFAGLALDDAATLAEIARIRAESGYIADPHTAIGIAAARAAAP
VGVPVIAAATAHPAKFPAAMHRAIGIRPGLPPRLDDLYDRQEHFVRAGNSLGEVETLVRHFAHRNDA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=453, Percent_Identity=34.2163355408389, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI149193323, Length=450, Percent_Identity=34.2222222222222, Blast_Score=246, Evalue=4e-65,
Organism=Escherichia coli, GI1786185, Length=435, Percent_Identity=32.183908045977, Blast_Score=205, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=39.6929824561403, Blast_Score=315, Evalue=1e-86,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50308; Mature: 50308

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYVSTRGAAPSREFDDVLLAGLAEDGGLFVPETWPVFSPAEWRALRGLPYAELAARVMA
CCCCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHH
PFMTGGAIGFDDLQAITRASYRGFDHAAVVPLVQLEPSLFVLELFHGPTLAFKDLALQVA
HHHCCCCCCHHHHHHHHHHHHCCCCCHHHCEEEEECCCEEEEEECCCCCHHHHHHHHHHH
GRLFDHVLSARDERVTIVGATSGDTGSAAIEACRDRLRVDIAILHPEGRTSEVQRRQMTT
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHH
VKARNVLNIALSGTFDDCQDLVKAMFADAPFRTELRLSAVNSINWARIAGQIPYFAAAAL
HHHCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEHHHHCCCCHHHHHCCCHHHHHHHH
ALGAPDRPVAVAVPTGNFGNILAAWAARQMGLPIERFIVGSNANDILARFLAANDMRTAG
HCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHHHHHCCCCCCC
VVETVSPSMDIQVSSNFERLLFEALGRDAPETAHTMVDFRASGTMKVSREVWQSVRRDFA
CCEECCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHC
GLALDDAATLAEIARIRAESGYIADPHTAIGIAAARAAAPVGVPVIAAATAHPAKFPAAM
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHH
HRAIGIRPGLPPRLDDLYDRQEHFVRAGNSLGEVETLVRHFAHRNDA
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRYVSTRGAAPSREFDDVLLAGLAEDGGLFVPETWPVFSPAEWRALRGLPYAELAARVMA
CCCCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHH
PFMTGGAIGFDDLQAITRASYRGFDHAAVVPLVQLEPSLFVLELFHGPTLAFKDLALQVA
HHHCCCCCCHHHHHHHHHHHHCCCCCHHHCEEEEECCCEEEEEECCCCCHHHHHHHHHHH
GRLFDHVLSARDERVTIVGATSGDTGSAAIEACRDRLRVDIAILHPEGRTSEVQRRQMTT
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHH
VKARNVLNIALSGTFDDCQDLVKAMFADAPFRTELRLSAVNSINWARIAGQIPYFAAAAL
HHHCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEHHHHCCCCHHHHHCCCHHHHHHHH
ALGAPDRPVAVAVPTGNFGNILAAWAARQMGLPIERFIVGSNANDILARFLAANDMRTAG
HCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHHHHHCCCCCCC
VVETVSPSMDIQVSSNFERLLFEALGRDAPETAHTMVDFRASGTMKVSREVWQSVRRDFA
CCEECCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHC
GLALDDAATLAEIARIRAESGYIADPHTAIGIAAARAAAPVGVPVIAAATAHPAKFPAAM
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHH
HRAIGIRPGLPPRLDDLYDRQEHFVRAGNSLGEVETLVRHFAHRNDA
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]