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The map label for this gene is pqqL [C]

Identifier: 148260781

GI number: 148260781

Start: 1968329

End: 1969594

Strand: Reverse

Name: pqqL [C]

Synonym: Acry_1786

Alternate gene names: 148260781

Gene position: 1969594-1968329 (Counterclockwise)

Preceding gene: 148260782

Following gene: 148260780

Centisome position: 58.11

GC content: 67.61

Gene sequence:

>1266_bases
ATGAGTGACACAGTGCAGGTGACGAAACTCGACTCCGGCCTGACCATCCTGACCGAACGGATGGACCGGGTGGAGACCGT
CTCCTTCGGCGCCTATGCCGGCGTCGGCACCCGCCACGAGACGGCGGCGGAAAACGGCGTCTCGCATTTCCTCGAACACA
TGGCCTTCAAGGGCACCGAGCGCCGGAGTGCCGCCGCCATCGCCGAGGCGATCGAGGATGTCGGCGGCCACATCAACGCC
TACACCTCGCGCGAGCAGACCGCCTATTACGTCAAGCTGCTGAAGGAGGATCTCTCCCTCGGCATCGACATCATCGGCGA
CATCCTCTGCCATTCCACCTTCGATCCGGCGGAATTCGAGCGCGAGCGCGGCGTCATCCTGCAAGAGATCGGCCAGGCGA
ACGACACGCCGGACGATATCGTGTTCGACCATTTCCAGCTCGCCGCCTATCCCGACCAGCCGATGGGCTGGCCCACCCTC
GGCACCGAGGAGATCATCCGCGCCATCGGGCCGGACGCGCTGCGCCGCTACATGAAGGCGCATTACACGCCGGAGAACCT
CGTCATCGCCGCTTCCGGCAATCTCGAACACGCCCGCGTGGTCGATCTCGTGGCGAAGCACTTCGCCGACCTGCCGGCCG
CGACGCGCGCCGAGCCGCTGCCGGCCGATTATGCCGGCGGCGAATACCGCGAGCTGCGCGATCTCGACCAGGCGCATCTC
GTCCTCGGCTTCCCCGCCGTCGGCTACGCCGATCCCGATTTCCACGCCGCGATGCTGCTCTCCACTTTGCTCGGCGGCGG
CATGTCCTCGCGCCTGTTCCAGGAAATCCGCGAGAAGCGCGGCCTCGTCTACTCGATCTACAGCTTCGCCCTGCCGGCGC
GCGATGCCGGGCTGTTCGGCATCTATGCCGGCACCGGCGAGGCCGAGGCGGCCGAACTCGTCCCCGTCACCCTCGGCGAG
CTGGCCAAGGTTCGCCAGAGCGTCTCCGAGGCCGAACTCCGCCGCGCCCGCGCCCAGGTCAAGGCCGGGCTGCTGATGTC
GCTGGAAAGCACCGGCAGCCGCTGCGAGCAGATCGCCCGCCAGTGGCAGATCTTCGGCCGCATCGTGCCGACCGCCGAAA
CCGTCGCGAAGATCGACGCCGTGACGGTGGACGACATCACCAACGTCGCCACCCGCATCTTCCGCGCCAAGCCCACCCTT
GCCGCGATCGGCCCGGTCGGCCGCGTGCCGCAGATGCCGAAAATCATCGAGAGGCTGGCGGCGTGA

Upstream 100 bases:

>100_bases
TCGACGACCTATATGACCGTCAGGAACATTTCGTACGCGCGGGCAACAGCCTCGGCGAGGTCGAGACCCTGGTCCGCCAT
TTCGCGCACAGGAACGATGC

Downstream 100 bases:

>100_bases
ACCGGCTCGACCTGCTCGACGCCCTGCTCGACGCCGCGAAGCGCGCCGGCGCGGAGTCCGCCGATGCGCTGATGGGCTCC
GGCACCTCGCTCTCCGTCGG

Product: processing peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSDTVQVTKLDSGLTILTERMDRVETVSFGAYAGVGTRHETAAENGVSHFLEHMAFKGTERRSAAAIAEAIEDVGGHINA
YTSREQTAYYVKLLKEDLSLGIDIIGDILCHSTFDPAEFERERGVILQEIGQANDTPDDIVFDHFQLAAYPDQPMGWPTL
GTEEIIRAIGPDALRRYMKAHYTPENLVIAASGNLEHARVVDLVAKHFADLPAATRAEPLPADYAGGEYRELRDLDQAHL
VLGFPAVGYADPDFHAAMLLSTLLGGGMSSRLFQEIREKRGLVYSIYSFALPARDAGLFGIYAGTGEAEAAELVPVTLGE
LAKVRQSVSEAELRRARAQVKAGLLMSLESTGSRCEQIARQWQIFGRIVPTAETVAKIDAVTVDDITNVATRIFRAKPTL
AAIGPVGRVPQMPKIIERLAA

Sequences:

>Translated_421_residues
MSDTVQVTKLDSGLTILTERMDRVETVSFGAYAGVGTRHETAAENGVSHFLEHMAFKGTERRSAAAIAEAIEDVGGHINA
YTSREQTAYYVKLLKEDLSLGIDIIGDILCHSTFDPAEFERERGVILQEIGQANDTPDDIVFDHFQLAAYPDQPMGWPTL
GTEEIIRAIGPDALRRYMKAHYTPENLVIAASGNLEHARVVDLVAKHFADLPAATRAEPLPADYAGGEYRELRDLDQAHL
VLGFPAVGYADPDFHAAMLLSTLLGGGMSSRLFQEIREKRGLVYSIYSFALPARDAGLFGIYAGTGEAEAAELVPVTLGE
LAKVRQSVSEAELRRARAQVKAGLLMSLESTGSRCEQIARQWQIFGRIVPTAETVAKIDAVTVDDITNVATRIFRAKPTL
AAIGPVGRVPQMPKIIERLAA
>Mature_420_residues
SDTVQVTKLDSGLTILTERMDRVETVSFGAYAGVGTRHETAAENGVSHFLEHMAFKGTERRSAAAIAEAIEDVGGHINAY
TSREQTAYYVKLLKEDLSLGIDIIGDILCHSTFDPAEFERERGVILQEIGQANDTPDDIVFDHFQLAAYPDQPMGWPTLG
TEEIIRAIGPDALRRYMKAHYTPENLVIAASGNLEHARVVDLVAKHFADLPAATRAEPLPADYAGGEYRELRDLDQAHLV
LGFPAVGYADPDFHAAMLLSTLLGGGMSSRLFQEIREKRGLVYSIYSFALPARDAGLFGIYAGTGEAEAAELVPVTLGEL
AKVRQSVSEAELRRARAQVKAGLLMSLESTGSRCEQIARQWQIFGRIVPTAETVAKIDAVTVDDITNVATRIFRAKPTLA
AIGPVGRVPQMPKIIERLAA

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=426, Percent_Identity=37.5586854460094, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI46593007, Length=427, Percent_Identity=31.3817330210773, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI24308013, Length=454, Percent_Identity=26.8722466960352, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI50592988, Length=421, Percent_Identity=25.8907363420428, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1787770, Length=218, Percent_Identity=26.1467889908257, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71999683, Length=418, Percent_Identity=31.5789473684211, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17553678, Length=426, Percent_Identity=27.9342723004695, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17510601, Length=453, Percent_Identity=25.3863134657837, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17569737, Length=411, Percent_Identity=24.8175182481752, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17555260, Length=415, Percent_Identity=19.5180722891566, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=434, Percent_Identity=33.4101382488479, Blast_Score=252, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6321813, Length=430, Percent_Identity=28.1395348837209, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319426, Length=424, Percent_Identity=24.5283018867925, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357875, Length=422, Percent_Identity=35.3080568720379, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24646943, Length=422, Percent_Identity=35.3080568720379, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI19921772, Length=449, Percent_Identity=27.6169265033408, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24667786, Length=190, Percent_Identity=25.2631578947368, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641429, Length=211, Percent_Identity=24.1706161137441, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 45848; Mature: 45716

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTVQVTKLDSGLTILTERMDRVETVSFGAYAGVGTRHETAAENGVSHFLEHMAFKGTE
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
RRSAAAIAEAIEDVGGHINAYTSREQTAYYVKLLKEDLSLGIDIIGDILCHSTFDPAEFE
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHH
RERGVILQEIGQANDTPDDIVFDHFQLAAYPDQPMGWPTLGTEEIIRAIGPDALRRYMKA
HHCCHHHHHHCCCCCCCHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHCHHHHHHHHHH
HYTPENLVIAASGNLEHARVVDLVAKHFADLPAATRAEPLPADYAGGEYRELRDLDQAHL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHE
VLGFPAVGYADPDFHAAMLLSTLLGGGMSSRLFQEIREKRGLVYSIYSFALPARDAGLFG
EEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCEEE
IYAGTGEAEAAELVPVTLGELAKVRQSVSEAELRRARAQVKAGLLMSLESTGSRCEQIAR
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWQIFGRIVPTAETVAKIDAVTVDDITNVATRIFRAKPTLAAIGPVGRVPQMPKIIERLA
HHHHHHHHCCCHHHHHHHHCEEHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHC
A
C
>Mature Secondary Structure 
SDTVQVTKLDSGLTILTERMDRVETVSFGAYAGVGTRHETAAENGVSHFLEHMAFKGTE
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
RRSAAAIAEAIEDVGGHINAYTSREQTAYYVKLLKEDLSLGIDIIGDILCHSTFDPAEFE
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHH
RERGVILQEIGQANDTPDDIVFDHFQLAAYPDQPMGWPTLGTEEIIRAIGPDALRRYMKA
HHCCHHHHHHCCCCCCCHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHCHHHHHHHHHH
HYTPENLVIAASGNLEHARVVDLVAKHFADLPAATRAEPLPADYAGGEYRELRDLDQAHL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHE
VLGFPAVGYADPDFHAAMLLSTLLGGGMSSRLFQEIREKRGLVYSIYSFALPARDAGLFG
EEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCEEE
IYAGTGEAEAAELVPVTLGELAKVRQSVSEAELRRARAQVKAGLLMSLESTGSRCEQIAR
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWQIFGRIVPTAETVAKIDAVTVDDITNVATRIFRAKPTLAAIGPVGRVPQMPKIIERLA
HHHHHHHHCCCHHHHHHHHCEEHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA