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The map label for this gene is trpE [H]

Identifier: 148260237

GI number: 148260237

Start: 1373400

End: 1374914

Strand: Reverse

Name: trpE [H]

Synonym: Acry_1234

Alternate gene names: 148260237

Gene position: 1374914-1373400 (Counterclockwise)

Preceding gene: 148260238

Following gene: 148260236

Centisome position: 40.57

GC content: 72.28

Gene sequence:

>1515_bases
ATGACACCCGAGACCGACCAGCACGCCCGTTTCCGCGCCGCCTACGATGCCGGGCGGGGCGCGCTGGCCTGGCGACTGCT
CGCCGCCGACCTGATCACGCCGGTCGCCGCCTTCCTCAAGCTCGCGCACGGCACGGCGCATTCCTTCCTGCTCGAGAGCG
TCGAGGGCGGGGCGGCGCGCGGGCGCTATTCGGTGATCGGCTTCGCGCCGGACCTGATCTGGCGGTGCGACCGCGGCCAG
GTGAGCGTGAACCGCGACCCGGCGGCGGACGCGGAAGGCTACGCGGCCGATCCGCGCCCGGCCTTCGAGAGCCTGCGCGA
CCTGATCGCGGCGACGCGGCTCGACCTGCCGGACCACCTGCCGCCGATGACCGGCGGGCTGGTCGGCTATCTCGGCTATG
ACATGGTGCGGCTGATGGAGGAGCTGCCGGCGGTGAAGCCGGACGTGCTCGGGATTCCCGACGCCGTGCTGATGCGGCCG
GGGGTGTTCGCGATTTTCGATTCGGTGCGCGACGAGATCACGCTGGCCGCACCGGTCTGGCCGCGCGCGGGGGTTTCGGC
GGCGGAGGCCTGGAGCCTCGCGACCGGGCGGATCGAGGCGGCGATGGCGGCGCTCGACCGGCCGACGCCGGCGCTGCCGG
GCCATGCCGCGCCGGCCGGGCCGGCGACCTCGAACATGAGCGAGGACGAGTTCCGCGCGATGGTGCTGCGGGGCAAGGAC
TACATCGCTGCCGGCGACGTGTTCCAGGTGGTGGCGAGCCAGCGCTTCGAGCAGGAATTCACGCTCCCGCCCTTCGCGCT
GTATCGCTCGCTGCGGCGGATCAACCCGGCGCCGTTCCTGTTCTTCCTCGATTTCGGCGCCTATCAGGCGGTCGGCTCCA
GCCCGGAGATCCTGGTGCGGCTGCGCGACGGCACGGTGACGATCCGCCCGCTGGCCGGCACGCGCCGGCGCGGGGCGACG
CGCGCCGAGGACGAGGCGCTGGAGACCGAGCTGCTGGAGGACCCGAAGGAGCGCGCCGAGCACCTGATGCTGCTCGACCT
CGCGCGCAACGATGTCGGCCGCGTCGCCGAGATCGGCTCGGTCAACGTGACCGAGAGCTTCGTGATCGAGCGGTTCTCGC
ACGTGATGCACATCTCCTCGAATGTCGAGGGCCGCATCCGGCCGGAGGCGGACGCGCTGGACGCGCTGATCGCCGGCTTC
CCGGCGGGCACGCTCTCGGGCGCGCCGAAGGTGCGGGCGATGGAGATCATCGAGGAGTTCGAGCCCAGCCGGCGCGGGCT
CTATGGCGGGTGCATCGGCTATTTCGCCGCCAACGGCACGATGGATACCTGCATCGCGCTGCGCACCGCGCTGATCAGGG
ACGGGCGGCTCTATGTCCAGGCCGGGGTCGGCATCGTCGCCGATTCCGACCCCGATGCCGAGCTCGCCGAGAGCCACGCC
AAGGCGCGCGCGCTGTTCCGCGCCGCCGAGGATGCCGGCCAGTACGTCACCCCCAACGAGGCGCCGGCCCGATGA

Upstream 100 bases:

>100_bases
GAAGACGTGCTGCAGACCTATGCCGCGGCGCTGCGCCAGCGCGACCATGTGAAGATCAACACGAAGCTGCTGAACCAGAT
CAGCAATTGAGGCCAGCGAG

Downstream 100 bases:

>100_bases
TCCTGCTGATCGACAACTACGACAGTTTCACCTTCAACCTCGTCCAGTTCTTCGGCGATCTCGGGGCGGAATGCGCGGTG
CACCGCAACGACCGGATCAG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTPETDQHARFRAAYDAGRGALAWRLLAADLITPVAAFLKLAHGTAHSFLLESVEGGAARGRYSVIGFAPDLIWRCDRGQ
VSVNRDPAADAEGYAADPRPAFESLRDLIAATRLDLPDHLPPMTGGLVGYLGYDMVRLMEELPAVKPDVLGIPDAVLMRP
GVFAIFDSVRDEITLAAPVWPRAGVSAAEAWSLATGRIEAAMAALDRPTPALPGHAAPAGPATSNMSEDEFRAMVLRGKD
YIAAGDVFQVVASQRFEQEFTLPPFALYRSLRRINPAPFLFFLDFGAYQAVGSSPEILVRLRDGTVTIRPLAGTRRRGAT
RAEDEALETELLEDPKERAEHLMLLDLARNDVGRVAEIGSVNVTESFVIERFSHVMHISSNVEGRIRPEADALDALIAGF
PAGTLSGAPKVRAMEIIEEFEPSRRGLYGGCIGYFAANGTMDTCIALRTALIRDGRLYVQAGVGIVADSDPDAELAESHA
KARALFRAAEDAGQYVTPNEAPAR

Sequences:

>Translated_504_residues
MTPETDQHARFRAAYDAGRGALAWRLLAADLITPVAAFLKLAHGTAHSFLLESVEGGAARGRYSVIGFAPDLIWRCDRGQ
VSVNRDPAADAEGYAADPRPAFESLRDLIAATRLDLPDHLPPMTGGLVGYLGYDMVRLMEELPAVKPDVLGIPDAVLMRP
GVFAIFDSVRDEITLAAPVWPRAGVSAAEAWSLATGRIEAAMAALDRPTPALPGHAAPAGPATSNMSEDEFRAMVLRGKD
YIAAGDVFQVVASQRFEQEFTLPPFALYRSLRRINPAPFLFFLDFGAYQAVGSSPEILVRLRDGTVTIRPLAGTRRRGAT
RAEDEALETELLEDPKERAEHLMLLDLARNDVGRVAEIGSVNVTESFVIERFSHVMHISSNVEGRIRPEADALDALIAGF
PAGTLSGAPKVRAMEIIEEFEPSRRGLYGGCIGYFAANGTMDTCIALRTALIRDGRLYVQAGVGIVADSDPDAELAESHA
KARALFRAAEDAGQYVTPNEAPAR
>Mature_503_residues
TPETDQHARFRAAYDAGRGALAWRLLAADLITPVAAFLKLAHGTAHSFLLESVEGGAARGRYSVIGFAPDLIWRCDRGQV
SVNRDPAADAEGYAADPRPAFESLRDLIAATRLDLPDHLPPMTGGLVGYLGYDMVRLMEELPAVKPDVLGIPDAVLMRPG
VFAIFDSVRDEITLAAPVWPRAGVSAAEAWSLATGRIEAAMAALDRPTPALPGHAAPAGPATSNMSEDEFRAMVLRGKDY
IAAGDVFQVVASQRFEQEFTLPPFALYRSLRRINPAPFLFFLDFGAYQAVGSSPEILVRLRDGTVTIRPLAGTRRRGATR
AEDEALETELLEDPKERAEHLMLLDLARNDVGRVAEIGSVNVTESFVIERFSHVMHISSNVEGRIRPEADALDALIAGFP
AGTLSGAPKVRAMEIIEEFEPSRRGLYGGCIGYFAANGTMDTCIALRTALIRDGRLYVQAGVGIVADSDPDAELAESHAK
ARALFRAAEDAGQYVTPNEAPAR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=372, Percent_Identity=39.247311827957, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI1788114, Length=372, Percent_Identity=34.4086021505376, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786809, Length=264, Percent_Identity=28.4090909090909, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87082077, Length=249, Percent_Identity=28.9156626506024, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=466, Percent_Identity=38.412017167382, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6324361, Length=278, Percent_Identity=25.8992805755396, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54374; Mature: 54243

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPETDQHARFRAAYDAGRGALAWRLLAADLITPVAAFLKLAHGTAHSFLLESVEGGAAR
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GRYSVIGFAPDLIWRCDRGQVSVNRDPAADAEGYAADPRPAFESLRDLIAATRLDLPDHL
CCEEEEEECHHHHEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
PPMTGGLVGYLGYDMVRLMEELPAVKPDVLGIPDAVLMRPGVFAIFDSVRDEITLAAPVW
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCEEEECCCC
PRAGVSAAEAWSLATGRIEAAMAALDRPTPALPGHAAPAGPATSNMSEDEFRAMVLRGKD
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEECCC
YIAAGDVFQVVASQRFEQEFTLPPFALYRSLRRINPAPFLFFLDFGAYQAVGSSPEILVR
CEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCEEEEE
LRDGTVTIRPLAGTRRRGATRAEDEALETELLEDPKERAEHLMLLDLARNDVGRVAEIGS
EECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHEEHHHHHHCCHHHHHHCCC
VNVTESFVIERFSHVMHISSNVEGRIRPEADALDALIAGFPAGTLSGAPKVRAMEIIEEF
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
EPSRRGLYGGCIGYFAANGTMDTCIALRTALIRDGRLYVQAGVGIVADSDPDAELAESHA
CHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCEEEECCCCCHHHHHHHH
KARALFRAAEDAGQYVTPNEAPAR
HHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TPETDQHARFRAAYDAGRGALAWRLLAADLITPVAAFLKLAHGTAHSFLLESVEGGAAR
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GRYSVIGFAPDLIWRCDRGQVSVNRDPAADAEGYAADPRPAFESLRDLIAATRLDLPDHL
CCEEEEEECHHHHEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
PPMTGGLVGYLGYDMVRLMEELPAVKPDVLGIPDAVLMRPGVFAIFDSVRDEITLAAPVW
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCEEEECCCC
PRAGVSAAEAWSLATGRIEAAMAALDRPTPALPGHAAPAGPATSNMSEDEFRAMVLRGKD
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEECCC
YIAAGDVFQVVASQRFEQEFTLPPFALYRSLRRINPAPFLFFLDFGAYQAVGSSPEILVR
CEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCEEEEE
LRDGTVTIRPLAGTRRRGATRAEDEALETELLEDPKERAEHLMLLDLARNDVGRVAEIGS
EECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHEEHHHHHHCCHHHHHHCCC
VNVTESFVIERFSHVMHISSNVEGRIRPEADALDALIAGFPAGTLSGAPKVRAMEIIEEF
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
EPSRRGLYGGCIGYFAANGTMDTCIALRTALIRDGRLYVQAGVGIVADSDPDAELAESHA
CHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCEEEECCCCCHHHHHHHH
KARALFRAAEDAGQYVTPNEAPAR
HHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA