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The map label for this gene is xdhA [H]

Identifier: 148260158

GI number: 148260158

Start: 1284521

End: 1286959

Strand: Reverse

Name: xdhA [H]

Synonym: Acry_1154

Alternate gene names: 148260158

Gene position: 1286959-1284521 (Counterclockwise)

Preceding gene: 148260159

Following gene: 148260157

Centisome position: 37.97

GC content: 68.84

Gene sequence:

>2439_bases
ATGAACGAGCAGAGCCGTCCTGGGTCAGCCACATCCCGTGCCACGAAGCCCGGCGTTGCCGGTTTCGCGGCGGGTGTCAC
GGTTGCCTGGTCGGAAGCGGACGAGGCGGCGCTGGCCGCCGGCAGCCGCGTCGGTGTGGGTGTCCCGCACGAATCAGCGC
ATCTGCACGTTTCCGGCGCCGCGGCGTATGTCGACGATGTGCCGGAACGGGCGGGAACCCTGCACGCCGCGCTCGGCCTC
TCTCCGGTCGCGGCGGGAACGCTGCTCGGCATCGACACGGCGCTTCTGCGCGCGCAGCCCGGCGTCGTCGATGTCATCAT
CGCGTCCGACATTCCCGGCGCGAACGAATGCGGCCCCGTCGTGCATGACGATCCGATCCTCGCCGAGGGCGCCGTGCGCT
ATCTTGGCCAGCCGGTCTTCATCGTCGTCGCCACCACGCGCGATCTCGCGCGCCGGGCCGCGGCGAAGGCGCGCGACGCC
GTGCGGGTCGAGCCGGCGGAGCCGGTCCTCGATCCCCGTGCCGCCCATGAGGCGGGCCGCCACCTGCGCGCGCCGATGGA
ACTCGTCCGCGAGTCGGAGCCGGGCGCCTGCCGCCGGGCCATCGCGGCGGCGCCGCACCGGCTCGCCGGGCGGTTCAGCC
TCGGCGGCCAGGAGCAATTCTATCTCGAAGGCCAGATCACCTATGCGATCCCGACCGAGAATGACGGGATGCACGTGCTG
TGCTCGACGCAGCACCCGAGCGAGATGCAGCATCTCGTCGCCCATGCGCTCGGCTGGCGCAGCCATCAGGTGCTGGTCGA
ATGCCGGCGCATGGGCGGCGGGTTCGGCGGCAAGGAATCGCAGTCGGGGCTGTTCGCCTGCGCGGCCTCGATCGCCGCTT
CACGGCTCGGCCGGCCGGTGAAGCTGCGCCTCGACCGCGACGATGATTTCCTGATCACCGGCCGCCGCCACGGATTCGAA
TACGATTATGAGGTCGGCTTCGACGACAACGGCCGGATCGCGGGTCTCGTGATCACCATGATCGCCAATGCCGGCCACTC
GACCGACCTGTCGATGGCCGTGCTCACCCGCGCGCTCTGCCATGCGGACAATGCCTATTTCCTGCCCGAAATCGCGCTGA
CCGGCCATCTCGCCCGGACCGACACGCAGAGCAACACCGCCTTCCGCGGCTTCGGCGGCCCGCAGGGCGCGCTGGTCACC
GAGATCATCCTCGACTCGATCGCCCGCCGCCTCGGCCGCGACGCGCTCGAGATCCGGTGCGCGAATTTCTACGGTCGCGG
CGCGCGCGACGTCACGCCATACGGACAGACGGTCGAAGACAACGTGATTGCCGAGATCGTGGAACAGCTCGTCCGGAGCG
GCGCCTATCACGAGCGCCGCGCCGCGGTCGCGGCCTTCAACGCGACCAGTCCGGTGCTGAAGAAGGGGCTTGCGCTGACG
CCGGTGAAATTCGGCATTTCCTTCAACGTGCCGCATCTGAACCAGGCCGGCGCGCTGGTGCATGTCTATGCCGACGGCAG
CGCGCTGGTGAATCACGGCGGCACCGAGATGGGGCAGGGGCTCAACACCAAGGTCGCGCAGGTCGTCGCGGATGCGCTGG
GGATCGGCTTCGACCAGGTGCGCTGCACGGCGACGGACACGTCGAAGGTCGCGAACACCTCCGCCACCGCCGCCTCCACC
GGGGCGGATCTGAACGGCATGGCGGCGCTCGACGCGGCGCTCGCGATCCGCGGGCGGCTCGCCGCGTTCGCCGCGGAGCG
TTTTGAAACCGGAATCGAAAGCATCTGCTTTTCAAATGGTCTCGTGCGGATCGGCGGCACATCGATCAGCTTCGCCGATC
TCGTCCGCATGGCCTACGAAGCGCGCGTGCAACTCTGGAGCGACGGCTTCTACGCCACGCCGAAGATCAACTGGTCGCCA
CAGACGATGCGTGGCCGGCCGTTCTACTATTTCGCGTACGGTGCCGCGGTATCCGAGGTCGTGATCGACACGCTGAGCGG
CGAATTCACGGCACTGCGCACCGACATTCTGCACGATGCCGGGCGGTCGCTGAACCCCGCCATCGATATCGGCCAGATCG
AGGGCGGCTTCGTGCAGAGCATGGGCTGGCTGACATCGGAAGAACTGGTCTGGCATCCGAAGACCGGCATGCTGCTGACC
CATGCGCCAAGCACCTACAAGATCCCCACCGCGAACGACGTGCCGGCGGTGCTGAACACGACCCTGTTCGACAGCCCCAA
CCGGGAACCGAGCATCCACCGTTCGAAGGCGGTCGGCGAACCGCCGATGCTGCTGGCCTTCTCGGTGCTGCTCGCGATCC
GCGACGCGATCTCGGCCGCCGGCGGCCACCGCGTCGATCCGCCGCTGCGCGCACCGGCGACGCCGGAGGCGATCCTCGAC
GCGCTCGATGTCGTCCGCGCCGGCGGTGACGCACCGTGA

Upstream 100 bases:

>100_bases
GCAACCTGCTGCGGCGGCTCCATCTCGAACTGACGGCGTCCGCGGCTGGACCGGCGCTGCGCACGCGCGCCGTCCCGTCC
GGCATGATGGCAGGTGCCGC

Downstream 100 bases:

>100_bases
GTGCGGTTGTACAACCTCCACGCGGCGTGATCGTCGAGCTGCGGCGCGTTCGTGGCTCGGCGCCCCGCGAGCAGGGCACG
CGCATGATGGTGACGGCGCA

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 812; Mature: 812

Protein sequence:

>812_residues
MNEQSRPGSATSRATKPGVAGFAAGVTVAWSEADEAALAAGSRVGVGVPHESAHLHVSGAAAYVDDVPERAGTLHAALGL
SPVAAGTLLGIDTALLRAQPGVVDVIIASDIPGANECGPVVHDDPILAEGAVRYLGQPVFIVVATTRDLARRAAAKARDA
VRVEPAEPVLDPRAAHEAGRHLRAPMELVRESEPGACRRAIAAAPHRLAGRFSLGGQEQFYLEGQITYAIPTENDGMHVL
CSTQHPSEMQHLVAHALGWRSHQVLVECRRMGGGFGGKESQSGLFACAASIAASRLGRPVKLRLDRDDDFLITGRRHGFE
YDYEVGFDDNGRIAGLVITMIANAGHSTDLSMAVLTRALCHADNAYFLPEIALTGHLARTDTQSNTAFRGFGGPQGALVT
EIILDSIARRLGRDALEIRCANFYGRGARDVTPYGQTVEDNVIAEIVEQLVRSGAYHERRAAVAAFNATSPVLKKGLALT
PVKFGISFNVPHLNQAGALVHVYADGSALVNHGGTEMGQGLNTKVAQVVADALGIGFDQVRCTATDTSKVANTSATAAST
GADLNGMAALDAALAIRGRLAAFAAERFETGIESICFSNGLVRIGGTSISFADLVRMAYEARVQLWSDGFYATPKINWSP
QTMRGRPFYYFAYGAAVSEVVIDTLSGEFTALRTDILHDAGRSLNPAIDIGQIEGGFVQSMGWLTSEELVWHPKTGMLLT
HAPSTYKIPTANDVPAVLNTTLFDSPNREPSIHRSKAVGEPPMLLAFSVLLAIRDAISAAGGHRVDPPLRAPATPEAILD
ALDVVRAGGDAP

Sequences:

>Translated_812_residues
MNEQSRPGSATSRATKPGVAGFAAGVTVAWSEADEAALAAGSRVGVGVPHESAHLHVSGAAAYVDDVPERAGTLHAALGL
SPVAAGTLLGIDTALLRAQPGVVDVIIASDIPGANECGPVVHDDPILAEGAVRYLGQPVFIVVATTRDLARRAAAKARDA
VRVEPAEPVLDPRAAHEAGRHLRAPMELVRESEPGACRRAIAAAPHRLAGRFSLGGQEQFYLEGQITYAIPTENDGMHVL
CSTQHPSEMQHLVAHALGWRSHQVLVECRRMGGGFGGKESQSGLFACAASIAASRLGRPVKLRLDRDDDFLITGRRHGFE
YDYEVGFDDNGRIAGLVITMIANAGHSTDLSMAVLTRALCHADNAYFLPEIALTGHLARTDTQSNTAFRGFGGPQGALVT
EIILDSIARRLGRDALEIRCANFYGRGARDVTPYGQTVEDNVIAEIVEQLVRSGAYHERRAAVAAFNATSPVLKKGLALT
PVKFGISFNVPHLNQAGALVHVYADGSALVNHGGTEMGQGLNTKVAQVVADALGIGFDQVRCTATDTSKVANTSATAAST
GADLNGMAALDAALAIRGRLAAFAAERFETGIESICFSNGLVRIGGTSISFADLVRMAYEARVQLWSDGFYATPKINWSP
QTMRGRPFYYFAYGAAVSEVVIDTLSGEFTALRTDILHDAGRSLNPAIDIGQIEGGFVQSMGWLTSEELVWHPKTGMLLT
HAPSTYKIPTANDVPAVLNTTLFDSPNREPSIHRSKAVGEPPMLLAFSVLLAIRDAISAAGGHRVDPPLRAPATPEAILD
ALDVVRAGGDAP
>Mature_812_residues
MNEQSRPGSATSRATKPGVAGFAAGVTVAWSEADEAALAAGSRVGVGVPHESAHLHVSGAAAYVDDVPERAGTLHAALGL
SPVAAGTLLGIDTALLRAQPGVVDVIIASDIPGANECGPVVHDDPILAEGAVRYLGQPVFIVVATTRDLARRAAAKARDA
VRVEPAEPVLDPRAAHEAGRHLRAPMELVRESEPGACRRAIAAAPHRLAGRFSLGGQEQFYLEGQITYAIPTENDGMHVL
CSTQHPSEMQHLVAHALGWRSHQVLVECRRMGGGFGGKESQSGLFACAASIAASRLGRPVKLRLDRDDDFLITGRRHGFE
YDYEVGFDDNGRIAGLVITMIANAGHSTDLSMAVLTRALCHADNAYFLPEIALTGHLARTDTQSNTAFRGFGGPQGALVT
EIILDSIARRLGRDALEIRCANFYGRGARDVTPYGQTVEDNVIAEIVEQLVRSGAYHERRAAVAAFNATSPVLKKGLALT
PVKFGISFNVPHLNQAGALVHVYADGSALVNHGGTEMGQGLNTKVAQVVADALGIGFDQVRCTATDTSKVANTSATAAST
GADLNGMAALDAALAIRGRLAAFAAERFETGIESICFSNGLVRIGGTSISFADLVRMAYEARVQLWSDGFYATPKINWSP
QTMRGRPFYYFAYGAAVSEVVIDTLSGEFTALRTDILHDAGRSLNPAIDIGQIEGGFVQSMGWLTSEELVWHPKTGMLLT
HAPSTYKIPTANDVPAVLNTTLFDSPNREPSIHRSKAVGEPPMLLAFSVLLAIRDAISAAGGHRVDPPLRAPATPEAILD
ALDVVRAGGDAP

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=768, Percent_Identity=42.1875, Blast_Score=559, Evalue=1e-159,
Organism=Homo sapiens, GI71773480, Length=761, Percent_Identity=37.0565045992116, Blast_Score=444, Evalue=1e-124,
Organism=Escherichia coli, GI1789230, Length=776, Percent_Identity=27.8350515463918, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789246, Length=771, Percent_Identity=25.810635538262, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1786478, Length=775, Percent_Identity=25.1612903225806, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17540638, Length=767, Percent_Identity=40.026075619296, Blast_Score=513, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI32566215, Length=752, Percent_Identity=31.1170212765957, Blast_Score=333, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17539860, Length=723, Percent_Identity=31.5352697095436, Blast_Score=315, Evalue=7e-86,
Organism=Drosophila melanogaster, GI17737937, Length=756, Percent_Identity=41.7989417989418, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24647199, Length=777, Percent_Identity=32.8185328185328, Blast_Score=345, Evalue=6e-95,
Organism=Drosophila melanogaster, GI24647193, Length=772, Percent_Identity=31.3471502590674, Blast_Score=334, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24647201, Length=780, Percent_Identity=30.8974358974359, Blast_Score=298, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24647195, Length=774, Percent_Identity=29.9741602067183, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24647197, Length=774, Percent_Identity=29.9741602067183, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 85753; Mature: 85753

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQSRPGSATSRATKPGVAGFAAGVTVAWSEADEAALAAGSRVGVGVPHESAHLHVSGA
CCCCCCCCCCCCCCCCCCCCHHHCCEEEEECCCCHHHHHCCCCCCCCCCCCCCEEEEECC
AAYVDDVPERAGTLHAALGLSPVAAGTLLGIDTALLRAQPGVVDVIIASDIPGANECGPV
HHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
VHDDPILAEGAVRYLGQPVFIVVATTRDLARRAAAKARDAVRVEPAEPVLDPRAAHEAGR
CCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHH
HLRAPMELVRESEPGACRRAIAAAPHRLAGRFSLGGQEQFYLEGQITYAIPTENDGMHVL
HHHHHHHHHHCCCCCHHHHHHHHCCHHHCCCCCCCCCEEEEEEEEEEEEECCCCCCEEEE
CSTQHPSEMQHLVAHALGWRSHQVLVECRRMGGGFGGKESQSGLFACAASIAASRLGRPV
ECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
KLRLDRDDDFLITGRRHGFEYDYEVGFDDNGRIAGLVITMIANAGHSTDLSMAVLTRALC
EEEECCCCCEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
HADNAYFLPEIALTGHLARTDTQSNTAFRGFGGPQGALVTEIILDSIARRLGRDALEIRC
HCCCCEECCHHHHCCCEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
ANFYGRGARDVTPYGQTVEDNVIAEIVEQLVRSGAYHERRAAVAAFNATSPVLKKGLALT
EHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHEEEECCCCHHHHCCCEEC
PVKFGISFNVPHLNQAGALVHVYADGSALVNHGGTEMGQGLNTKVAQVVADALGIGFDQV
EEEECEEECCCCCCCCCCEEEEEECCCEEECCCCHHHCCCCCHHHHHHHHHHHCCCHHHE
RCTATDTSKVANTSATAASTGADLNGMAALDAALAIRGRLAAFAAERFETGIESICFSNG
EEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LVRIGGTSISFADLVRMAYEARVQLWSDGFYATPKINWSPQTMRGRPFYYFAYGAAVSEV
EEEECCCCCCHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCCCCCCEEEEEHHHHHHHH
VIDTLSGEFTALRTDILHDAGRSLNPAIDIGQIEGGFVQSMGWLTSEELVWHPKTGMLLT
HHHHCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHCCCCCCCEEEECCCCEEEE
HAPSTYKIPTANDVPAVLNTTLFDSPNREPSIHRSKAVGEPPMLLAFSVLLAIRDAISAA
ECCCCEECCCCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GGHRVDPPLRAPATPEAILDALDVVRAGGDAP
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNEQSRPGSATSRATKPGVAGFAAGVTVAWSEADEAALAAGSRVGVGVPHESAHLHVSGA
CCCCCCCCCCCCCCCCCCCCHHHCCEEEEECCCCHHHHHCCCCCCCCCCCCCCEEEEECC
AAYVDDVPERAGTLHAALGLSPVAAGTLLGIDTALLRAQPGVVDVIIASDIPGANECGPV
HHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
VHDDPILAEGAVRYLGQPVFIVVATTRDLARRAAAKARDAVRVEPAEPVLDPRAAHEAGR
CCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHH
HLRAPMELVRESEPGACRRAIAAAPHRLAGRFSLGGQEQFYLEGQITYAIPTENDGMHVL
HHHHHHHHHHCCCCCHHHHHHHHCCHHHCCCCCCCCCEEEEEEEEEEEEECCCCCCEEEE
CSTQHPSEMQHLVAHALGWRSHQVLVECRRMGGGFGGKESQSGLFACAASIAASRLGRPV
ECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
KLRLDRDDDFLITGRRHGFEYDYEVGFDDNGRIAGLVITMIANAGHSTDLSMAVLTRALC
EEEECCCCCEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
HADNAYFLPEIALTGHLARTDTQSNTAFRGFGGPQGALVTEIILDSIARRLGRDALEIRC
HCCCCEECCHHHHCCCEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
ANFYGRGARDVTPYGQTVEDNVIAEIVEQLVRSGAYHERRAAVAAFNATSPVLKKGLALT
EHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHEEEECCCCHHHHCCCEEC
PVKFGISFNVPHLNQAGALVHVYADGSALVNHGGTEMGQGLNTKVAQVVADALGIGFDQV
EEEECEEECCCCCCCCCCEEEEEECCCEEECCCCHHHCCCCCHHHHHHHHHHHCCCHHHE
RCTATDTSKVANTSATAASTGADLNGMAALDAALAIRGRLAAFAAERFETGIESICFSNG
EEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LVRIGGTSISFADLVRMAYEARVQLWSDGFYATPKINWSPQTMRGRPFYYFAYGAAVSEV
EEEECCCCCCHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCCCCCCEEEEEHHHHHHHH
VIDTLSGEFTALRTDILHDAGRSLNPAIDIGQIEGGFVQSMGWLTSEELVWHPKTGMLLT
HHHHCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHCCCCCCCEEEECCCCEEEE
HAPSTYKIPTANDVPAVLNTTLFDSPNREPSIHRSKAVGEPPMLLAFSVLLAIRDAISAA
ECCCCEECCCCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GGHRVDPPLRAPATPEAILDALDVVRAGGDAP
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]