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The map label for this gene is xdhB [H]

Identifier: 148260159

GI number: 148260159

Start: 1286956

End: 1288512

Strand: Reverse

Name: xdhB [H]

Synonym: Acry_1155

Alternate gene names: 148260159

Gene position: 1288512-1286956 (Counterclockwise)

Preceding gene: 148260160

Following gene: 148260158

Centisome position: 38.02

GC content: 70.52

Gene sequence:

>1557_bases
ATGACACAACAGAAAATTCGCTTTCATTTCCGTGGCGGGATCGTCGCGGTCGGCGACCTGCCGATCACGACCACGGTTCT
CGACTGGCTGCGGGAGAGCGCGGGGCAATGCGGCACCAAGGAAGGCTGCGCCGAGGGTGATTGCGGGGCCTGCACGGTCA
TCGTCGCCGAACTGGCGGAGGCCGCGCCGCCTGCCGGCGCCGTCCGCGTCGGCGGGCTCGATCTGCGGCCGGTCAATGCG
TGCATCCGTTTCCTGCCGACGCTGCATGGCAAGGCGCTGCTGACGGTGGAGGATCTGCGTCCTCTGGCCGGCGGCGCGCT
GCATCCGGTGCAGCAGGCGCTGGTCGACTGCCACGCCTCTCAATGCGGCTTCTGCACGCCGGGTTTCGCGATGTCGCTCC
TCGCGCTGTATCTCGATCATCAGGGAGCCACGCCGCCGAACCGGCAGGCCATCGCCGACCGGCTGGCCGGCAACCTCTGC
CGCTGCACCGGCTATCGGCCGATCCTCGATGCCGCCGAGCGGATGTTCACGCTTCCTCCGGTCGCGTTCGACGCGGCGCC
GGTGGAAGCCTCCCTGCGCAGGATCGCGGCGGAAACGCCGCCGGCGTTCAGTTACGAGGCGGCCGATCCCGCCCTCGCGG
CGGACGGCGTCCCCCGGTTAAACCGCTTTCACGCGCCGCGCACCGCCGAACGCCTGGCCGCGCTCTGCGCTGAAAAACCC
GCGGCGCGCATCCTGGGCGGCGCCACCGATATCGGCCTGTGGGTGAACAAGCAGTTCCGCGACGTGGGCGATCTGATTTC
GGTCAACGACGTCGCCGAACTGCGCGCGATCGAGGCGACGCCGGAGGGGCTGACCATCGGCGCCGCCGTACCGCTCGAGG
ATGCCTGGAACGCGCTCGCCGCCCTGGTGCCGGAATGTCGTGAAATGGCGCTGCGCTTTGCCGGGCCGCCGGTGCGCCAC
GCCGGCACGATGGGCGGCAACGTCGCCAATGGTTCGCCGATCGGCGATGCGCCGCCGGTGCTCATGGCGCTTGGCGCGAC
ACTGGTCCTGCAACAAGGCGGGACGATCCGGCGTCTGCCGATCGACGCATTCTATCTCGATTACATGAAAACCGCCCGCG
CACCTGGCGAGTTCCTGCGCGCGATCGAGATTCCCCGTCCCGATCCGGCGACGCGGTTCCGCGCCTACAAGATCTCGAAG
CGCCATGACTGCGACATCTCGACCCTCAGCCTCGGCGCGGCGGTCACGCTGCGGGACGGCGCCGTGCGGGACGTCCGCCT
CGCATTCGGCGGCATGGCCGCGACCGTGCGCCGCGCCGCGGCGGCGGAAGCCGCGCTGCGCGGCCAGCCCTGGAACGAGG
CGACGATCGCGGCGGCGATGAACGCCCTCGGGGCCGATTTCACGCCCCTGACCGATTTGCGGGCGAGTGCCGGCTACCGG
ATGCGCGTGGCGCGCAACCTGCTGCGGCGGCTCCATCTCGAACTGACGGCGTCCGCGGCTGGACCGGCGCTGCGCACGCG
CGCCGTCCCGTCCGGCATGATGGCAGGTGCCGCATGA

Upstream 100 bases:

>100_bases
TCATAAGCGCGCGCTTATATGTGTCATTTAAACTGCGACCCGCCCGTGCGATGGATTAGTCTGTTTCGTCGGAGTTGAAA
CGGGACGGGCCGCAAGGACC

Downstream 100 bases:

>100_bases
ACGAGCAGAGCCGTCCTGGGTCAGCCACATCCCGTGCCACGAAGCCCGGCGTTGCCGGTTTCGCGGCGGGTGTCACGGTT
GCCTGGTCGGAAGCGGACGA

Product: molybdopterin dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MTQQKIRFHFRGGIVAVGDLPITTTVLDWLRESAGQCGTKEGCAEGDCGACTVIVAELAEAAPPAGAVRVGGLDLRPVNA
CIRFLPTLHGKALLTVEDLRPLAGGALHPVQQALVDCHASQCGFCTPGFAMSLLALYLDHQGATPPNRQAIADRLAGNLC
RCTGYRPILDAAERMFTLPPVAFDAAPVEASLRRIAAETPPAFSYEAADPALAADGVPRLNRFHAPRTAERLAALCAEKP
AARILGGATDIGLWVNKQFRDVGDLISVNDVAELRAIEATPEGLTIGAAVPLEDAWNALAALVPECREMALRFAGPPVRH
AGTMGGNVANGSPIGDAPPVLMALGATLVLQQGGTIRRLPIDAFYLDYMKTARAPGEFLRAIEIPRPDPATRFRAYKISK
RHDCDISTLSLGAAVTLRDGAVRDVRLAFGGMAATVRRAAAAEAALRGQPWNEATIAAAMNALGADFTPLTDLRASAGYR
MRVARNLLRRLHLELTASAAGPALRTRAVPSGMMAGAA

Sequences:

>Translated_518_residues
MTQQKIRFHFRGGIVAVGDLPITTTVLDWLRESAGQCGTKEGCAEGDCGACTVIVAELAEAAPPAGAVRVGGLDLRPVNA
CIRFLPTLHGKALLTVEDLRPLAGGALHPVQQALVDCHASQCGFCTPGFAMSLLALYLDHQGATPPNRQAIADRLAGNLC
RCTGYRPILDAAERMFTLPPVAFDAAPVEASLRRIAAETPPAFSYEAADPALAADGVPRLNRFHAPRTAERLAALCAEKP
AARILGGATDIGLWVNKQFRDVGDLISVNDVAELRAIEATPEGLTIGAAVPLEDAWNALAALVPECREMALRFAGPPVRH
AGTMGGNVANGSPIGDAPPVLMALGATLVLQQGGTIRRLPIDAFYLDYMKTARAPGEFLRAIEIPRPDPATRFRAYKISK
RHDCDISTLSLGAAVTLRDGAVRDVRLAFGGMAATVRRAAAAEAALRGQPWNEATIAAAMNALGADFTPLTDLRASAGYR
MRVARNLLRRLHLELTASAAGPALRTRAVPSGMMAGAA
>Mature_517_residues
TQQKIRFHFRGGIVAVGDLPITTTVLDWLRESAGQCGTKEGCAEGDCGACTVIVAELAEAAPPAGAVRVGGLDLRPVNAC
IRFLPTLHGKALLTVEDLRPLAGGALHPVQQALVDCHASQCGFCTPGFAMSLLALYLDHQGATPPNRQAIADRLAGNLCR
CTGYRPILDAAERMFTLPPVAFDAAPVEASLRRIAAETPPAFSYEAADPALAADGVPRLNRFHAPRTAERLAALCAEKPA
ARILGGATDIGLWVNKQFRDVGDLISVNDVAELRAIEATPEGLTIGAAVPLEDAWNALAALVPECREMALRFAGPPVRHA
GTMGGNVANGSPIGDAPPVLMALGATLVLQQGGTIRRLPIDAFYLDYMKTARAPGEFLRAIEIPRPDPATRFRAYKISKR
HDCDISTLSLGAAVTLRDGAVRDVRLAFGGMAATVRRAAAAEAALRGQPWNEATIAAAMNALGADFTPLTDLRASAGYRM
RVARNLLRRLHLELTASAAGPALRTRAVPSGMMAGAA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=493, Percent_Identity=32.0486815415822, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI71773480, Length=476, Percent_Identity=26.4705882352941, Blast_Score=144, Evalue=3e-34,
Organism=Escherichia coli, GI1789231, Length=285, Percent_Identity=28.0701754385965, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786480, Length=162, Percent_Identity=33.9506172839506, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789232, Length=143, Percent_Identity=37.7622377622378, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540638, Length=551, Percent_Identity=27.9491833030853, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17539860, Length=394, Percent_Identity=26.6497461928934, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32566215, Length=405, Percent_Identity=25.9259259259259, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17737937, Length=540, Percent_Identity=30, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24647197, Length=534, Percent_Identity=28.4644194756554, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24647201, Length=531, Percent_Identity=26.5536723163842, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24647193, Length=538, Percent_Identity=27.1375464684015, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24647195, Length=338, Percent_Identity=31.0650887573964, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24647199, Length=507, Percent_Identity=26.0355029585799, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 54540; Mature: 54408

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQKIRFHFRGGIVAVGDLPITTTVLDWLRESAGQCGTKEGCAEGDCGACTVIVAELAE
CCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
AAPPAGAVRVGGLDLRPVNACIRFLPTLHGKALLTVEDLRPLAGGALHPVQQALVDCHAS
HCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEHHHCCHHCCCCHHHHHHHHHHHCCC
QCGFCTPGFAMSLLALYLDHQGATPPNRQAIADRLAGNLCRCTGYRPILDAAERMFTLPP
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCCCC
VAFDAAPVEASLRRIAAETPPAFSYEAADPALAADGVPRLNRFHAPRTAERLAALCAEKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHCCCCHHHHHHHHHHHCCC
AARILGGATDIGLWVNKQFRDVGDLISVNDVAELRAIEATPEGLTIGAAVPLEDAWNALA
HHHHHCCCCHHHHEECHHHHHHHHHCCCCHHHHHHEEECCCCCEEEEECCCHHHHHHHHH
ALVPECREMALRFAGPPVRHAGTMGGNVANGSPIGDAPPVLMALGATLVLQQGGTIRRLP
HHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCEEECC
IDAFYLDYMKTARAPGEFLRAIEIPRPDPATRFRAYKISKRHDCDISTLSLGAAVTLRDG
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHEEEEECCCCCCCCCEEEECCEEEEECCC
AVRDVRLAFGGMAATVRRAAAAEAALRGQPWNEATIAAAMNALGADFTPLTDLRASAGYR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCHH
MRVARNLLRRLHLELTASAAGPALRTRAVPSGMMAGAA
HHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHCCCC
>Mature Secondary Structure 
TQQKIRFHFRGGIVAVGDLPITTTVLDWLRESAGQCGTKEGCAEGDCGACTVIVAELAE
CCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
AAPPAGAVRVGGLDLRPVNACIRFLPTLHGKALLTVEDLRPLAGGALHPVQQALVDCHAS
HCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEHHHCCHHCCCCHHHHHHHHHHHCCC
QCGFCTPGFAMSLLALYLDHQGATPPNRQAIADRLAGNLCRCTGYRPILDAAERMFTLPP
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCCCC
VAFDAAPVEASLRRIAAETPPAFSYEAADPALAADGVPRLNRFHAPRTAERLAALCAEKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHCCCCHHHHHHHHHHHCCC
AARILGGATDIGLWVNKQFRDVGDLISVNDVAELRAIEATPEGLTIGAAVPLEDAWNALA
HHHHHCCCCHHHHEECHHHHHHHHHCCCCHHHHHHEEECCCCCEEEEECCCHHHHHHHHH
ALVPECREMALRFAGPPVRHAGTMGGNVANGSPIGDAPPVLMALGATLVLQQGGTIRRLP
HHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCEEECC
IDAFYLDYMKTARAPGEFLRAIEIPRPDPATRFRAYKISKRHDCDISTLSLGAAVTLRDG
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHEEEEECCCCCCCCCEEEECCEEEEECCC
AVRDVRLAFGGMAATVRRAAAAEAALRGQPWNEATIAAAMNALGADFTPLTDLRASAGYR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCHH
MRVARNLLRRLHLELTASAAGPALRTRAVPSGMMAGAA
HHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]