| Definition | Acidiphilium cryptum JF-5 chromosome, complete genome. |
|---|---|
| Accession | NC_009484 |
| Length | 3,389,227 |
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The map label for this gene is nrdA [H]
Identifier: 148259751
GI number: 148259751
Start: 826227
End: 828113
Strand: Reverse
Name: nrdA [H]
Synonym: Acry_0739
Alternate gene names: 148259751
Gene position: 828113-826227 (Counterclockwise)
Preceding gene: 148259752
Following gene: 148259750
Centisome position: 24.43
GC content: 64.07
Gene sequence:
>1887_bases ATGAACGCGATCAACCGACCCGAACCCGCATTGCTCGACACCGATGTGCAGATCCGTGGGGGTTATCAGATCAGGATCGA CCGCTCGCGCGATTCGCTGCTCACCGAATTCGGCCGCGCGACGCTGAACGACCGCTATCTGATGCCGGGCGAAAGCTATC AGGACCTGTTCGCCCGCGTCGCCTCCTATTATGGCGACGACGCCGAGCACGCCCAGCGGCTCTACGACTACATCAGCAAG CTCTGGTTCATGCCGGCGACCCCGGTGCTGTCGAACGGCGGCACCAAGCGCGGCCTGCCGATCTCCTGCTTCCTCAACGA GGCGTCGGACAGCCTGGAAGGCATCGTCGATCTCTGGAACGAGAATGTCTGGCTCGCCTCCAAGGGCGGCGGCATCGGCT CCTATTGGGGCAACCTGCGCTCGATCGGCGAGAAGGTTGGCCAGAACGGCAAGACCTCGGGCGTCGTTCCCTTCATCCGG GTGATGGACAGCCTGACGCTGGCGATCAGCCAGGGCTCGCTGCGCCGTGGTTCGGCCGCCGTCTACCTGCCGATTTCCCA TCCGGAGGTCGAGGAATTCATCGAGATCCGCCGCCCCACCGGTGGCGATCCGAACCGCAAGGCGCTCAACCTGCATCACG GCATCCTCGTCTCCGACGCGTTCATGCGCGCCGTGGAGGCGGACGAGATGTGGGCCCTCACCTCGCCCAAGGACGGCGCG CATGTCCGCTCCGTCTCCGCCCGCTCGCTCTGGATCCGCATCCTGACCGCCAGGATCGAGACCGGCGAGCCCTACATCAT CTTCGCCGACCACGTGAACAACGCGCGGCCCGAGCACCACAAGCTCGCCGGTCTCGAGGTAAAGACCTCCAATCTCTGCG CCGAGATCACCCTGCCCACCGGCCTTGATCATCACGGCCAACAGCGCACCGCCGTCTGCTGCCTGTCATCGATCAATCTC GAGACATGGCTCGAATGGCACGACAATCCGCAGTTCATCGAGGACGTGATGCGCTTCCTCGACAATGTCTTGCAGGATTT CATCGATAACGCGCCGGACTCGATGGCCCGCGCCAAATACGCCGCGATGCGCGAGCGCTCGGTCGGCCTTGGCGTGATGG GGTTCCACTCGCTGCTGCAGTCGCTCAACATTCCGTTCGAGAGCGCGATGGCGAAGGCCTGGAACATCCGCATCTTCCGG CATATCCGCGCCGGCGCCGATGCCGCCTCACGCAAGCTTGCCGAGGAACGCGGCCCCTGCCCCGACGCCGCCGAATACGG CGTGATGGAGCGCTTCTCGCACAAGATGGCGATCGCACCGACCGCCTCGATCTCGATCATCGCCGGCAATTCGAGCCCCG GCATCGAGCCGATCGCCGCCAATGTCTTCCTGCAGAAAACCCTGTCCGGCAGTTTCTCGGTGCGCAACCGCCACCTGCAG CAGCTCCTCGCCGCCAAGGGCCGCGACGATGAGGAAACCTGGTCGAACATCACCGTCAGCAAGGGCTCGGTACAGCATCT CGATTTTCTCACCGACGACGAGAAGGCCGTCTTCAAGACCGCCTTCGAACTCGACCAGCGCTGGGTGATCGAACACGCCG CCGACCGCACGCCGTATATCTGCCAGAGCCAGTCGATCAACGTTTTCCTGCCGGCAAATGTCCACAAGCGGGATCTGCAC CAGATCCATTTCCAGGCATGGAAGAAGGGCGTGAAGTCGCTCTATTACTGCCGCTCTCTCTCGATCCAGCGCGCTGACAC GGTGAGCGAGAAGGTGCAGCGCCACGAGCACGGCGACGCCGCCAACCGCACCGCGCCGGCCCCGGCACCGCTGGTTGCCG CCGCCGCAAGCACGACCAATTACGAGGAATGCCTGGCCTGCCAGTAG
Upstream 100 bases:
>100_bases AAGAGATTTTTTTGGATTAACTTGATCTAGTGGCGATTGCGCGATGCCTACCCAATATGTTGTTATGTGCTTCGCCGAAA CGACGGGAGCCCCCACTGCA
Downstream 100 bases:
>100_bases TCCGGCCGCCGCATTCCCACGTCTTTCCGAGGATCTGCCTGAATGTCCGTCACCACCGCCGATACCGCCGCGCCCATCCC GGTCGAAACCCCCGCGCATT
Product: ribonucleotide-diphosphate reductase subunit alpha
Products: NA
Alternate protein names: Ribonucleotide reductase [H]
Number of amino acids: Translated: 628; Mature: 628
Protein sequence:
>628_residues MNAINRPEPALLDTDVQIRGGYQIRIDRSRDSLLTEFGRATLNDRYLMPGESYQDLFARVASYYGDDAEHAQRLYDYISK LWFMPATPVLSNGGTKRGLPISCFLNEASDSLEGIVDLWNENVWLASKGGGIGSYWGNLRSIGEKVGQNGKTSGVVPFIR VMDSLTLAISQGSLRRGSAAVYLPISHPEVEEFIEIRRPTGGDPNRKALNLHHGILVSDAFMRAVEADEMWALTSPKDGA HVRSVSARSLWIRILTARIETGEPYIIFADHVNNARPEHHKLAGLEVKTSNLCAEITLPTGLDHHGQQRTAVCCLSSINL ETWLEWHDNPQFIEDVMRFLDNVLQDFIDNAPDSMARAKYAAMRERSVGLGVMGFHSLLQSLNIPFESAMAKAWNIRIFR HIRAGADAASRKLAEERGPCPDAAEYGVMERFSHKMAIAPTASISIIAGNSSPGIEPIAANVFLQKTLSGSFSVRNRHLQ QLLAAKGRDDEETWSNITVSKGSVQHLDFLTDDEKAVFKTAFELDQRWVIEHAADRTPYICQSQSINVFLPANVHKRDLH QIHFQAWKKGVKSLYYCRSLSIQRADTVSEKVQRHEHGDAANRTAPAPAPLVAAAASTTNYEECLACQ
Sequences:
>Translated_628_residues MNAINRPEPALLDTDVQIRGGYQIRIDRSRDSLLTEFGRATLNDRYLMPGESYQDLFARVASYYGDDAEHAQRLYDYISK LWFMPATPVLSNGGTKRGLPISCFLNEASDSLEGIVDLWNENVWLASKGGGIGSYWGNLRSIGEKVGQNGKTSGVVPFIR VMDSLTLAISQGSLRRGSAAVYLPISHPEVEEFIEIRRPTGGDPNRKALNLHHGILVSDAFMRAVEADEMWALTSPKDGA HVRSVSARSLWIRILTARIETGEPYIIFADHVNNARPEHHKLAGLEVKTSNLCAEITLPTGLDHHGQQRTAVCCLSSINL ETWLEWHDNPQFIEDVMRFLDNVLQDFIDNAPDSMARAKYAAMRERSVGLGVMGFHSLLQSLNIPFESAMAKAWNIRIFR HIRAGADAASRKLAEERGPCPDAAEYGVMERFSHKMAIAPTASISIIAGNSSPGIEPIAANVFLQKTLSGSFSVRNRHLQ QLLAAKGRDDEETWSNITVSKGSVQHLDFLTDDEKAVFKTAFELDQRWVIEHAADRTPYICQSQSINVFLPANVHKRDLH QIHFQAWKKGVKSLYYCRSLSIQRADTVSEKVQRHEHGDAANRTAPAPAPLVAAAASTTNYEECLACQ >Mature_628_residues MNAINRPEPALLDTDVQIRGGYQIRIDRSRDSLLTEFGRATLNDRYLMPGESYQDLFARVASYYGDDAEHAQRLYDYISK LWFMPATPVLSNGGTKRGLPISCFLNEASDSLEGIVDLWNENVWLASKGGGIGSYWGNLRSIGEKVGQNGKTSGVVPFIR VMDSLTLAISQGSLRRGSAAVYLPISHPEVEEFIEIRRPTGGDPNRKALNLHHGILVSDAFMRAVEADEMWALTSPKDGA HVRSVSARSLWIRILTARIETGEPYIIFADHVNNARPEHHKLAGLEVKTSNLCAEITLPTGLDHHGQQRTAVCCLSSINL ETWLEWHDNPQFIEDVMRFLDNVLQDFIDNAPDSMARAKYAAMRERSVGLGVMGFHSLLQSLNIPFESAMAKAWNIRIFR HIRAGADAASRKLAEERGPCPDAAEYGVMERFSHKMAIAPTASISIIAGNSSPGIEPIAANVFLQKTLSGSFSVRNRHLQ QLLAAKGRDDEETWSNITVSKGSVQHLDFLTDDEKAVFKTAFELDQRWVIEHAADRTPYICQSQSINVFLPANVHKRDLH QIHFQAWKKGVKSLYYCRSLSIQRADTVSEKVQRHEHGDAANRTAPAPAPLVAAAASTTNYEECLACQ
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 3 ATP-cone domains [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=672, Percent_Identity=30.0595238095238, Blast_Score=268, Evalue=1e-71, Organism=Escherichia coli, GI1789030, Length=621, Percent_Identity=25.9259259259259, Blast_Score=157, Evalue=2e-39, Organism=Escherichia coli, GI2367133, Length=441, Percent_Identity=27.2108843537415, Blast_Score=126, Evalue=5e-30, Organism=Caenorhabditis elegans, GI17555242, Length=664, Percent_Identity=31.4759036144578, Blast_Score=274, Evalue=1e-73, Organism=Saccharomyces cerevisiae, GI6320914, Length=693, Percent_Identity=31.024531024531, Blast_Score=276, Evalue=9e-75, Organism=Saccharomyces cerevisiae, GI6322123, Length=618, Percent_Identity=30.9061488673139, Blast_Score=259, Evalue=1e-69, Organism=Drosophila melanogaster, GI17352481, Length=614, Percent_Identity=31.2703583061889, Blast_Score=264, Evalue=1e-70,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005144 - InterPro: IPR013346 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 [H]
Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 69818; Mature: 69818
Theoretical pI: Translated: 6.82; Mature: 6.82
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNAINRPEPALLDTDVQIRGGYQIRIDRSRDSLLTEFGRATLNDRYLMPGESYQDLFARV CCCCCCCCCCEECCCEEEECCEEEEEECCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHH ASYYGDDAEHAQRLYDYISKLWFMPATPVLSNGGTKRGLPISCFLNEASDSLEGIVDLWN HHHCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHC ENVWLASKGGGIGSYWGNLRSIGEKVGQNGKTSGVVPFIRVMDSLTLAISQGSLRRGSAA CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCEE VYLPISHPEVEEFIEIRRPTGGDPNRKALNLHHGILVSDAFMRAVEADEMWALTSPKDGA EEEECCCCCHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCC HVRSVSARSLWIRILTARIETGEPYIIFADHVNNARPEHHKLAGLEVKTSNLCAEITLPT CEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHEECEEEECCCCEEEEECCC GLDHHGQQRTAVCCLSSINLETWLEWHDNPQFIEDVMRFLDNVLQDFIDNAPDSMARAKY CCCCCCCCHHHHHHHHHCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH AAMRERSVGLGVMGFHSLLQSLNIPFESAMAKAWNIRIFRHIRAGADAASRKLAEERGPC HHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC PDAAEYGVMERFSHKMAIAPTASISIIAGNSSPGIEPIAANVFLQKTLSGSFSVRNRHLQ CCHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH QLLAAKGRDDEETWSNITVSKGSVQHLDFLTDDEKAVFKTAFELDQRWVIEHAADRTPYI HHHHHCCCCCHHHHCCEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE CQSQSINVFLPANVHKRDLHQIHFQAWKKGVKSLYYCRSLSIQRADTVSEKVQRHEHGDA ECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC ANRTAPAPAPLVAAAASTTNYEECLACQ CCCCCCCCCCHHHHHCCCCCHHHHHCCC >Mature Secondary Structure MNAINRPEPALLDTDVQIRGGYQIRIDRSRDSLLTEFGRATLNDRYLMPGESYQDLFARV CCCCCCCCCCEECCCEEEECCEEEEEECCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHH ASYYGDDAEHAQRLYDYISKLWFMPATPVLSNGGTKRGLPISCFLNEASDSLEGIVDLWN HHHCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHC ENVWLASKGGGIGSYWGNLRSIGEKVGQNGKTSGVVPFIRVMDSLTLAISQGSLRRGSAA CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCEE VYLPISHPEVEEFIEIRRPTGGDPNRKALNLHHGILVSDAFMRAVEADEMWALTSPKDGA EEEECCCCCHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCC HVRSVSARSLWIRILTARIETGEPYIIFADHVNNARPEHHKLAGLEVKTSNLCAEITLPT CEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHEECEEEECCCCEEEEECCC GLDHHGQQRTAVCCLSSINLETWLEWHDNPQFIEDVMRFLDNVLQDFIDNAPDSMARAKY CCCCCCCCHHHHHHHHHCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH AAMRERSVGLGVMGFHSLLQSLNIPFESAMAKAWNIRIFRHIRAGADAASRKLAEERGPC HHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC PDAAEYGVMERFSHKMAIAPTASISIIAGNSSPGIEPIAANVFLQKTLSGSFSVRNRHLQ CCHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH QLLAAKGRDDEETWSNITVSKGSVQHLDFLTDDEKAVFKTAFELDQRWVIEHAADRTPYI HHHHHCCCCCHHHHCCEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE CQSQSINVFLPANVHKRDLHQIHFQAWKKGVKSLYYCRSLSIQRADTVSEKVQRHEHGDA ECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC ANRTAPAPAPLVAAAASTTNYEECLACQ CCCCCCCCCCHHHHHCCCCCHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10192388; 10684935; 10871362 [H]