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The map label for this gene is nrdF [H]

Identifier: 148259750

GI number: 148259750

Start: 825168

End: 826184

Strand: Reverse

Name: nrdF [H]

Synonym: Acry_0738

Alternate gene names: 148259750

Gene position: 826184-825168 (Counterclockwise)

Preceding gene: 148259751

Following gene: 148259749

Centisome position: 24.38

GC content: 60.87

Gene sequence:

>1017_bases
ATGTCCGTCACCACCGCCGATACCGCCGCGCCCATCCCGGTCGAAACCCCCGCGCATTTCGACCTGCTCACGGAAAACCC
GGTCTACAAGCCGTTCCGCTACCCCTGGGCCTACGAGGCATGGCTGACCCAGCAGCGCGTCCACTGGCTGCCGGAGGAAG
TTCCCCTCGCGGACGACGTGAAGGACTGGCACCGCAACCTCACCCCCGGCGAGCGCAACCTGCTCACCCAGATCTTCCGC
TTCTTCACCCAGGCGGATGTCGAGGTGAACAACTGCTACATGAAGCACTACAGCCAGGTGTTCAAACCGACGGAAGTGCT
GATGATGCTGTCGGCCTTCTCGAACATCGAGACGATCCACATCGCCGCCTATTCGCACCTGCTCGACACGATCGGCATGC
CGGAAGTCGAATACTCGGCCTTCCTCAAATACAAGGAGATGAAGGACAAGTATGACTACATGCAGGAATTCAGCGTCGAC
TCGAAGCACGAGATCGCCAAGACGCTGGCCGCTTTCGGCGCCTTCACCGAAGGGCTGCAGCTCTTCGCCTCCTTCGCGAT
CCTGCTGAACTTCCCGCGCTTCAACAAGATGAAGGGGATGGGCCAGATCGTCTCCTGGTCGGTGCGCGACGAGAGCCTGC
ACTGCAACTCGGTGATCAAGCTGTTCCGTACCTTCGTCGCCGAGAACCCGGAAATCTGGACCGAGGAACTGCGGCGCGAG
ATCTATCTCTGCTGCGCCACCATCGTCGATCACGAGGATGCCTTCATCGACCTCGCCTTCGAGTTCGGCGCCGTCGAGGG
GCTGACCGCCGAAGAGGTGAAGCGCTACATCCGCTATATCGCGGATCGCCGTCTGCTCCAGCTCGGACTCAACCCGCTCT
TCCATGTCGACAAGAATCCGCTTCCCTGGCTCGACGAGATGCTCAACGCCGTCGAGCACACGAACTTCTTCGAGAACCGC
GCGACCGAATACAGCAAGGCCTCGACGGCCGGCTCCTGGGACGAGGCATGGTCATGA

Upstream 100 bases:

>100_bases
GCTGGTTGCCGCCGCCGCAAGCACGACCAATTACGAGGAATGCCTGGCCTGCCAGTAGTCCGGCCGCCGCATTCCCACGT
CTTTCCGAGGATCTGCCTGA

Downstream 100 bases:

>100_bases
TGAAATCGTGTTCGGGACATTCGGACAAACAGACGGGCCGAACCGGAACACTCGCCCCCTGACATGAAAAATCTCCCGGT
GAGGCATGTCCTCACCGGGT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSVTTADTAAPIPVETPAHFDLLTENPVYKPFRYPWAYEAWLTQQRVHWLPEEVPLADDVKDWHRNLTPGERNLLTQIFR
FFTQADVEVNNCYMKHYSQVFKPTEVLMMLSAFSNIETIHIAAYSHLLDTIGMPEVEYSAFLKYKEMKDKYDYMQEFSVD
SKHEIAKTLAAFGAFTEGLQLFASFAILLNFPRFNKMKGMGQIVSWSVRDESLHCNSVIKLFRTFVAENPEIWTEELRRE
IYLCCATIVDHEDAFIDLAFEFGAVEGLTAEEVKRYIRYIADRRLLQLGLNPLFHVDKNPLPWLDEMLNAVEHTNFFENR
ATEYSKASTAGSWDEAWS

Sequences:

>Translated_338_residues
MSVTTADTAAPIPVETPAHFDLLTENPVYKPFRYPWAYEAWLTQQRVHWLPEEVPLADDVKDWHRNLTPGERNLLTQIFR
FFTQADVEVNNCYMKHYSQVFKPTEVLMMLSAFSNIETIHIAAYSHLLDTIGMPEVEYSAFLKYKEMKDKYDYMQEFSVD
SKHEIAKTLAAFGAFTEGLQLFASFAILLNFPRFNKMKGMGQIVSWSVRDESLHCNSVIKLFRTFVAENPEIWTEELRRE
IYLCCATIVDHEDAFIDLAFEFGAVEGLTAEEVKRYIRYIADRRLLQLGLNPLFHVDKNPLPWLDEMLNAVEHTNFFENR
ATEYSKASTAGSWDEAWS
>Mature_337_residues
SVTTADTAAPIPVETPAHFDLLTENPVYKPFRYPWAYEAWLTQQRVHWLPEEVPLADDVKDWHRNLTPGERNLLTQIFRF
FTQADVEVNNCYMKHYSQVFKPTEVLMMLSAFSNIETIHIAAYSHLLDTIGMPEVEYSAFLKYKEMKDKYDYMQEFSVDS
KHEIAKTLAAFGAFTEGLQLFASFAILLNFPRFNKMKGMGQIVSWSVRDESLHCNSVIKLFRTFVAENPEIWTEELRREI
YLCCATIVDHEDAFIDLAFEFGAVEGLTAEEVKRYIRYIADRRLLQLGLNPLFHVDKNPLPWLDEMLNAVEHTNFFENRA
TEYSKASTAGSWDEAWS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI4557845, Length=318, Percent_Identity=29.874213836478, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI260064013, Length=321, Percent_Identity=29.9065420560748, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI42544136, Length=300, Percent_Identity=29.6666666666667, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI289177074, Length=300, Percent_Identity=29.6666666666667, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI289177076, Length=279, Percent_Identity=29.7491039426523, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789031, Length=307, Percent_Identity=23.7785016286645, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788567, Length=292, Percent_Identity=23.2876712328767, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551968, Length=282, Percent_Identity=27.6595744680851, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322434, Length=317, Percent_Identity=25.8675078864353, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18079279, Length=323, Percent_Identity=28.1733746130031, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 39303; Mature: 39172

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTTADTAAPIPVETPAHFDLLTENPVYKPFRYPWAYEAWLTQQRVHWLPEEVPLADDV
CCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCH
KDWHRNLTPGERNLLTQIFRFFTQADVEVNNCYMKHYSQVFKPTEVLMMLSAFSNIETIH
HHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEH
IAAYSHLLDTIGMPEVEYSAFLKYKEMKDKYDYMQEFSVDSKHEIAKTLAAFGAFTEGLQ
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LFASFAILLNFPRFNKMKGMGQIVSWSVRDESLHCNSVIKLFRTFVAENPEIWTEELRRE
HHHHHHHHHCCCCHHHHCCCCHHHEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
IYLCCATIVDHEDAFIDLAFEFGAVEGLTAEEVKRYIRYIADRRLLQLGLNPLFHVDKNP
HHHHHHHHHCCCCHHEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCC
LPWLDEMLNAVEHTNFFENRATEYSKASTAGSWDEAWS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
>Mature Secondary Structure 
SVTTADTAAPIPVETPAHFDLLTENPVYKPFRYPWAYEAWLTQQRVHWLPEEVPLADDV
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCH
KDWHRNLTPGERNLLTQIFRFFTQADVEVNNCYMKHYSQVFKPTEVLMMLSAFSNIETIH
HHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEH
IAAYSHLLDTIGMPEVEYSAFLKYKEMKDKYDYMQEFSVDSKHEIAKTLAAFGAFTEGLQ
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LFASFAILLNFPRFNKMKGMGQIVSWSVRDESLHCNSVIKLFRTFVAENPEIWTEELRRE
HHHHHHHHHCCCCHHHHCCCCHHHEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
IYLCCATIVDHEDAFIDLAFEFGAVEGLTAEEVKRYIRYIADRRLLQLGLNPLFHVDKNP
HHHHHHHHHCCCCHHEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCC
LPWLDEMLNAVEHTNFFENRATEYSKASTAGSWDEAWS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]