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The map label for this gene is yngJ [H]

Identifier: 148259272

GI number: 148259272

Start: 288738

End: 289856

Strand: Reverse

Name: yngJ [H]

Synonym: Acry_0252

Alternate gene names: 148259272

Gene position: 289856-288738 (Counterclockwise)

Preceding gene: 148259273

Following gene: 148259268

Centisome position: 8.55

GC content: 68.01

Gene sequence:

>1119_bases
ATGGATTTCGATTTTACCGAAGAACAGCGCCTGCTGCGCGACAGTGTCGGCAAGCTTTTTGCCAGCCGCTATGCCGATTT
CGAAAAGCGCAAGGCCTATGCGAAACTTCCCGAAGGATTCGACCGCGCGGTCTGGGCCGAATACGCCGAGGCCGGGCTGC
TCGCCCTGCCCTTCGACGAGGCGCAGGGCGGCTTCGGCGGCGGGCCGGTCGAGACCATGATCGTCATGGAGGAGATCGGC
AAGGCGCTGGCCCTCGAACCCTATCTCGCCGCGATCGTCTTCGCCGGCGCCGTCCTGCGCCACGGCTCAAGCGCGGCCGT
GAGGGACGAGGTGATTCCCGCACTTGCCGCCGGCGAGACGATCGTCGCCGTCGCCCATACCGAGCGCAGTTCCCGCCACG
ACCTCGAAGACGTGACCACCACCGCGAAGCGCGACGGCGATCATTTCATCCTCGAAGGCGAGAAGTCGGTGGTCCTCGGC
GGCGATACGGCGGACTGGCTGATCGTCAGCGCCCGCCTTGCCGGCAGCCGGCGCGATCGCGACGGGATCGGCCTGTTCCT
GGTCGATGCGAAGGCCGAAGGCGTCTCCCGCCGCGGCTATCCGATGCAGGACCTGCTGCGCGGCGCGGAAATCTCGCTCG
CCAGCGTGCGGGTTCCGGCCGCGCGGCAGATCGGCGATCTCGCGGTGCTGGAGCGCGCGCGCGACGAGACGATCGCCGCC
CTCTGCGCCGAGGCGGTGGGCGCGATGGAGGCCCTGGTCGGCCTGACCGTCGACTACATGAAGCAGCGCAAGCAGTTCGG
GGTGGCGATTTCCGTCTTCCAGGCGCTGCAGCACCGCGCGGTGGACATGTATGTGGCGCTGGAACAGGCGCGCAGCCTCG
CCATCTTCGCCGCCCTCTCGGTCGCCGACGACGATGCCGAAGCGCGCGGCAAGGCGATGGCGCTGGCCAAGGCCGGGGTG
GGCAAGGCGCTGCACTTCGTCGGCCAGCAGGCGATCCAGCTGCATGGCGGCATCGCGATGACGATGGAATACAAGGCCGG
CCACTATTTCAAGCGGCTGACCATGATCGACACGATGTTCGGCAACGCCGACCACCATCGCCGCCGGCTCGCCGCCTGA

Upstream 100 bases:

>100_bases
ACCTACTTCAACTGGCGGAAGATCTCGATCTACGGCGGCTCGAACGAGATCCAGCGCAACATCATCGCCAAGGCGATCCT
GGGGTTCTGAGGACAAGACA

Downstream 100 bases:

>100_bases
CGTTCTGAACCGGCGCCGGGCCAACCCGGCGCCGGTGTTCAGCCGTCGAGGCCGAGGGCGCGCAACCGCGCGGCCTCCTC
GTCCCAGCCCGGGCGTTCCT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MDFDFTEEQRLLRDSVGKLFASRYADFEKRKAYAKLPEGFDRAVWAEYAEAGLLALPFDEAQGGFGGGPVETMIVMEEIG
KALALEPYLAAIVFAGAVLRHGSSAAVRDEVIPALAAGETIVAVAHTERSSRHDLEDVTTTAKRDGDHFILEGEKSVVLG
GDTADWLIVSARLAGSRRDRDGIGLFLVDAKAEGVSRRGYPMQDLLRGAEISLASVRVPAARQIGDLAVLERARDETIAA
LCAEAVGAMEALVGLTVDYMKQRKQFGVAISVFQALQHRAVDMYVALEQARSLAIFAALSVADDDAEARGKAMALAKAGV
GKALHFVGQQAIQLHGGIAMTMEYKAGHYFKRLTMIDTMFGNADHHRRRLAA

Sequences:

>Translated_372_residues
MDFDFTEEQRLLRDSVGKLFASRYADFEKRKAYAKLPEGFDRAVWAEYAEAGLLALPFDEAQGGFGGGPVETMIVMEEIG
KALALEPYLAAIVFAGAVLRHGSSAAVRDEVIPALAAGETIVAVAHTERSSRHDLEDVTTTAKRDGDHFILEGEKSVVLG
GDTADWLIVSARLAGSRRDRDGIGLFLVDAKAEGVSRRGYPMQDLLRGAEISLASVRVPAARQIGDLAVLERARDETIAA
LCAEAVGAMEALVGLTVDYMKQRKQFGVAISVFQALQHRAVDMYVALEQARSLAIFAALSVADDDAEARGKAMALAKAGV
GKALHFVGQQAIQLHGGIAMTMEYKAGHYFKRLTMIDTMFGNADHHRRRLAA
>Mature_372_residues
MDFDFTEEQRLLRDSVGKLFASRYADFEKRKAYAKLPEGFDRAVWAEYAEAGLLALPFDEAQGGFGGGPVETMIVMEEIG
KALALEPYLAAIVFAGAVLRHGSSAAVRDEVIPALAAGETIVAVAHTERSSRHDLEDVTTTAKRDGDHFILEGEKSVVLG
GDTADWLIVSARLAGSRRDRDGIGLFLVDAKAEGVSRRGYPMQDLLRGAEISLASVRVPAARQIGDLAVLERARDETIAA
LCAEAVGAMEALVGLTVDYMKQRKQFGVAISVFQALQHRAVDMYVALEQARSLAIFAALSVADDDAEARGKAMALAKAGV
GKALHFVGQQAIQLHGGIAMTMEYKAGHYFKRLTMIDTMFGNADHHRRRLAA

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=362, Percent_Identity=28.4530386740331, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226958412, Length=379, Percent_Identity=26.6490765171504, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI226958414, Length=364, Percent_Identity=26.6483516483516, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4557233, Length=330, Percent_Identity=25.7575757575758, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI7656849, Length=356, Percent_Identity=23.876404494382, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501859, Length=363, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI187960098, Length=372, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4557231, Length=372, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI76496475, Length=386, Percent_Identity=24.3523316062176, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4557235, Length=386, Percent_Identity=24.3523316062176, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4503943, Length=386, Percent_Identity=24.3523316062176, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87081958, Length=362, Percent_Identity=25.414364640884, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17538396, Length=382, Percent_Identity=28.0104712041885, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17569725, Length=373, Percent_Identity=25.7372654155496, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17508101, Length=327, Percent_Identity=26.605504587156, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17506239, Length=342, Percent_Identity=25.1461988304094, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17533517, Length=362, Percent_Identity=21.5469613259669, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17534899, Length=303, Percent_Identity=25.4125412541254, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17570075, Length=361, Percent_Identity=24.9307479224377, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71982178, Length=226, Percent_Identity=30.5309734513274, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71985184, Length=344, Percent_Identity=25.5813953488372, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=24.7104247104247, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551932, Length=351, Percent_Identity=23.6467236467236, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=28.3819628647215, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=26.0053619302949, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24666513, Length=364, Percent_Identity=24.4505494505494, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646207, Length=327, Percent_Identity=26.9113149847095, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24660351, Length=233, Percent_Identity=25.3218884120172, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 40193; Mature: 40193

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDFTEEQRLLRDSVGKLFASRYADFEKRKAYAKLPEGFDRAVWAEYAEAGLLALPFDE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCHH
AQGGFGGGPVETMIVMEEIGKALALEPYLAAIVFAGAVLRHGSSAAVRDEVIPALAAGET
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCE
IVAVAHTERSSRHDLEDVTTTAKRDGDHFILEGEKSVVLGGDTADWLIVSARLAGSRRDR
EEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCEEEEHHHCCCCCCC
DGIGLFLVDAKAEGVSRRGYPMQDLLRGAEISLASVRVPAARQIGDLAVLERARDETIAA
CCCEEEEEECCCCCCCCCCCCHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
LCAEAVGAMEALVGLTVDYMKQRKQFGVAISVFQALQHRAVDMYVALEQARSLAIFAALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHEEE
VADDDAEARGKAMALAKAGVGKALHFVGQQAIQLHGGIAMTMEYKAGHYFKRLTMIDTMF
CCCCCHHHCCHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHH
GNADHHRRRLAA
CCCHHHHHHCCC
>Mature Secondary Structure
MDFDFTEEQRLLRDSVGKLFASRYADFEKRKAYAKLPEGFDRAVWAEYAEAGLLALPFDE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCHH
AQGGFGGGPVETMIVMEEIGKALALEPYLAAIVFAGAVLRHGSSAAVRDEVIPALAAGET
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCE
IVAVAHTERSSRHDLEDVTTTAKRDGDHFILEGEKSVVLGGDTADWLIVSARLAGSRRDR
EEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCEEEEHHHCCCCCCC
DGIGLFLVDAKAEGVSRRGYPMQDLLRGAEISLASVRVPAARQIGDLAVLERARDETIAA
CCCEEEEEECCCCCCCCCCCCHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
LCAEAVGAMEALVGLTVDYMKQRKQFGVAISVFQALQHRAVDMYVALEQARSLAIFAALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHEEE
VADDDAEARGKAMALAKAGVGKALHFVGQQAIQLHGGIAMTMEYKAGHYFKRLTMIDTMF
CCCCCHHHCCHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHH
GNADHHRRRLAA
CCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]