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The map label for this gene is hbdA [H]

Identifier: 148259166

GI number: 148259166

Start: 166351

End: 167226

Strand: Reverse

Name: hbdA [H]

Synonym: Acry_0146

Alternate gene names: 148259166

Gene position: 167226-166351 (Counterclockwise)

Preceding gene: 148259167

Following gene: 148259157

Centisome position: 4.93

GC content: 66.1

Gene sequence:

>876_bases
ATGGAGATCAGGACTCTCGGCGTGCTCGGCGCGGGCGCGATGGGCAACGGCATCGCGCATGTCGCCGCCCTGTCCGGGCT
CGATGTCGTGCTCGTCGACACCGCGCAGGCGGTGCTGGAGAAGAGCATGGCGACCATGCGGAAGAACCTCGAGCGCCAGG
TGCAGAAGGGCACGATCGACGCGGCGGCCGAGGCAGCCGCCCTCGCCCGCGTCTCGCCCATGACCACGCATGACGCTTTT
GCGAAATGCGACATGGTGATCGAGGCGGTGCCGGAGCGCGAGGAGATCAAGCGCGCGGTCTATGCCCAGGTGATCCCGCA
TCTCGCGCCGCACGCGATCCTCGCCTCGAACACCTCGTCGATTTCGATCACGAAGCTCGGCCGGGCGTCGGGGATCGCGG
AGCGGTTCGTCGGCATGCATTTCTTCAACCCGGTGCCGATGATGAAGCTTGTCGAGGTGATAAGCGGGCTGGAGACGGCG
GATGCGACGGTTGCCGCGGTCGAAGACCTGGCAAAGCGGATGGGCAAGATCACCATCGCAGCACAGGACATGCCGGGCTT
CATCGTCAATCGCATCCTGGTGCCGATGCTCAACGAGGCGATCTTCGCGCTGCACGAGGGGATCGGCGACGTGGTCTCGA
TCGACAACGGCATGAAGCTCGGTGCCGGGCATCCGATGGGGCCGCTGACGCTGTGCGATCTGGTCGGGCTCGATGTCGCG
CTGGAAGTGATGCGCGTGCTGCATGCCGGGCTCGGCGAGGACAAGTATCGCCCCTGCCCGCTGCTGGTGAACTATGTCGA
GGCCGGCTGGCTTGGCCGCAAGACCGGGCGCGGCTTCTACGACTATTCCACCAACCCGCCGACGCCGACGCGCTGA

Upstream 100 bases:

>100_bases
AGAAGGAGCTCGGCTGAGCCCTGCGGGCTTGAGCGACATCAAGGCGCCGGGCGGCCATAAAGGCTAGCCCGGCCTGTGTT
TCAGGCGGAAGGAAAAGTAG

Downstream 100 bases:

>100_bases
GGCTTGACTTTCAAGGGAAGACCCGGCGCCGCCCGGTGCCGGGTTTTTTGCGCTTACGGGGCGCGGCTTCAGGATTTCCA
CTGGCTGAGCACCACGCTGG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MEIRTLGVLGAGAMGNGIAHVAALSGLDVVLVDTAQAVLEKSMATMRKNLERQVQKGTIDAAAEAAALARVSPMTTHDAF
AKCDMVIEAVPEREEIKRAVYAQVIPHLAPHAILASNTSSISITKLGRASGIAERFVGMHFFNPVPMMKLVEVISGLETA
DATVAAVEDLAKRMGKITIAAQDMPGFIVNRILVPMLNEAIFALHEGIGDVVSIDNGMKLGAGHPMGPLTLCDLVGLDVA
LEVMRVLHAGLGEDKYRPCPLLVNYVEAGWLGRKTGRGFYDYSTNPPTPTR

Sequences:

>Translated_291_residues
MEIRTLGVLGAGAMGNGIAHVAALSGLDVVLVDTAQAVLEKSMATMRKNLERQVQKGTIDAAAEAAALARVSPMTTHDAF
AKCDMVIEAVPEREEIKRAVYAQVIPHLAPHAILASNTSSISITKLGRASGIAERFVGMHFFNPVPMMKLVEVISGLETA
DATVAAVEDLAKRMGKITIAAQDMPGFIVNRILVPMLNEAIFALHEGIGDVVSIDNGMKLGAGHPMGPLTLCDLVGLDVA
LEVMRVLHAGLGEDKYRPCPLLVNYVEAGWLGRKTGRGFYDYSTNPPTPTR
>Mature_291_residues
MEIRTLGVLGAGAMGNGIAHVAALSGLDVVLVDTAQAVLEKSMATMRKNLERQVQKGTIDAAAEAAALARVSPMTTHDAF
AKCDMVIEAVPEREEIKRAVYAQVIPHLAPHAILASNTSSISITKLGRASGIAERFVGMHFFNPVPMMKLVEVISGLETA
DATVAAVEDLAKRMGKITIAAQDMPGFIVNRILVPMLNEAIFALHEGIGDVVSIDNGMKLGAGHPMGPLTLCDLVGLDVA
LEVMRVLHAGLGEDKYRPCPLLVNYVEAGWLGRKTGRGFYDYSTNPPTPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=40.418118466899, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=38.6885245901639, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=36.3957597173145, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=30.6896551724138, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=30.6896551724138, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI115430219, Length=220, Percent_Identity=27.7272727272727, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=40.9893992932862, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1790281, Length=269, Percent_Identity=36.8029739776952, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788682, Length=261, Percent_Identity=37.1647509578544, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=43.2525951557093, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=39.8601398601399, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=36.7697594501718, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=35.3356890459364, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=35.6890459363958, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=35.6890459363958, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=35.6890459363958, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=283, Percent_Identity=27.208480565371, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71985930, Length=283, Percent_Identity=23.321554770318, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=37.9432624113475, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=37.9432624113475, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=37.9432624113475, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI45549573, Length=237, Percent_Identity=25.7383966244726, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20129993, Length=231, Percent_Identity=25.1082251082251, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30978; Mature: 30978

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRTLGVLGAGAMGNGIAHVAALSGLDVVLVDTAQAVLEKSMATMRKNLERQVQKGTID
CCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AAAEAAALARVSPMTTHDAFAKCDMVIEAVPEREEIKRAVYAQVIPHLAPHAILASNTSS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCE
ISITKLGRASGIAERFVGMHFFNPVPMMKLVEVISGLETADATVAAVEDLAKRMGKITIA
EEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEE
AQDMPGFIVNRILVPMLNEAIFALHEGIGDVVSIDNGMKLGAGHPMGPLTLCDLVGLDVA
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEECCCCCCCHHHHHHHHHHHHH
LEVMRVLHAGLGEDKYRPCPLLVNYVEAGWLGRKTGRGFYDYSTNPPTPTR
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEIRTLGVLGAGAMGNGIAHVAALSGLDVVLVDTAQAVLEKSMATMRKNLERQVQKGTID
CCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AAAEAAALARVSPMTTHDAFAKCDMVIEAVPEREEIKRAVYAQVIPHLAPHAILASNTSS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCE
ISITKLGRASGIAERFVGMHFFNPVPMMKLVEVISGLETADATVAAVEDLAKRMGKITIA
EEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEE
AQDMPGFIVNRILVPMLNEAIFALHEGIGDVVSIDNGMKLGAGHPMGPLTLCDLVGLDVA
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEECCCCCCCHHHHHHHHHHHHH
LEVMRVLHAGLGEDKYRPCPLLVNYVEAGWLGRKTGRGFYDYSTNPPTPTR
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]