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The map label for this gene is hemA [H]

Identifier: 148259065

GI number: 148259065

Start: 43357

End: 44583

Strand: Reverse

Name: hemA [H]

Synonym: Acry_0044

Alternate gene names: 148259065

Gene position: 44583-43357 (Counterclockwise)

Preceding gene: 148259066

Following gene: 148259064

Centisome position: 1.32

GC content: 64.87

Gene sequence:

>1227_bases
ATGAATCGCGACCATCCGTTCATCGCCCAATGCGACAAGGCCCTGGCCGATATCCGCGCCGCCGGCCGCTACCGCCGCTT
CGTGGCGCTGGAAAAGCTGGCCGATCGTTTCCCCTATTACAAGGTGACGATGGAAGGCCGCACCCAGGACATTCTGGTGT
GGTCCTCAAACGATTATCTGGCCATGGGCACCGACCCCGAGGTGATCGAAGCCTCGATCGAGGCCGCGCGCACCATGGGC
GCCGGCGCCGGCGGCACGCGCAACATCGCCGGCTCCTCCCCCATCCACGTCGCGCTCGAGGCCGAACTCGCCGCCCTGCA
CGGCAAGGATGCGGCCCTGCTGTTCACCTCCGGCTATGTCTCGAACCAGGCGACTCTGACCGCGATCCTCAACTCGATGC
CCGGCTGGCACGTGTTTTCCGACGCGCAGAACCACAATTCGATGATCGTCGGCATCAAGGGCGGCAAGGCGGCGACGGTG
CATGTCTTCGCCCATAACGACCTCGCCGATCTCGAAGCCCGTCTTGCGGCGGCGCCGGCGGATGCGCCGAAGATGATCGC
CTTCGAGAGCGTCTATTCGATGGACGGCGACATCGCCCCGATCGGCGCGATCTGCGACCTCGCCGACAAGTATAACGCCA
TCACCTATCTCGACGAGGTTCACGCCGTCGGCATGTATGGGCCGCACGGTGCCGGCGTCTCCGAGCGCGACGGCGTTGCC
CATCGGCTCACCATCATCGAGGGCACGCTGGCCAAGGCCTATGGCTGCCACGGCGGCTACATCGCCGGCGATGCCAGCGT
GATCGACTATATCCGCTCGGTTGCGGCCGGCTTCATCTTCACCACCGCCCTGCCCCCGCCCACCGTCGCGGCGGCGCTTG
CCTCGATCCGCCGGCTGAAGGTCGACCAGGCGCGGCGCGATACGCTGTTCGAACGGGCAAATCTGCTGAAATCGAAATTC
GACCAGGCCAGACTGCCGCGCCTGCCGACAGAGAGCCACATCGTCCCGCTGATGATCGGCAACGCGACACGGGCAACCGA
AGTCTCGATGCGGCTGATCCGCGAATTCGGCATGTACGCAACTCCGATCAACTACCCGACGGTACCGGCTGGCACCGAAC
GGCTACGTTTCACACCGGGCCCCAAACATACGGAAGCGATGATGGACCAGCTCGTCGCCGCCTTGCGTCATATTCTTTCC
GGCGAAACCGGAACGGTGGCGGCCTGA

Upstream 100 bases:

>100_bases
TTGAACTTATGTCCTTGACGAGCGATGCCGCTTTCCCCGCAATAGTCAACGTTCGGGCACGGCCACGTCGCCGGCTCCGA
GAGACTACGAGGAGCATCGT

Downstream 100 bases:

>100_bases
CCCGGTCTTGCAGCCAGCGACGAGCCTCGCTATAGCCTCGCGCAGCGCCGACATAGCTCAGCGGTAGAGCAACTGATTCG
TAATCAGTAGGTCCCCAGTT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MNRDHPFIAQCDKALADIRAAGRYRRFVALEKLADRFPYYKVTMEGRTQDILVWSSNDYLAMGTDPEVIEASIEAARTMG
AGAGGTRNIAGSSPIHVALEAELAALHGKDAALLFTSGYVSNQATLTAILNSMPGWHVFSDAQNHNSMIVGIKGGKAATV
HVFAHNDLADLEARLAAAPADAPKMIAFESVYSMDGDIAPIGAICDLADKYNAITYLDEVHAVGMYGPHGAGVSERDGVA
HRLTIIEGTLAKAYGCHGGYIAGDASVIDYIRSVAAGFIFTTALPPPTVAAALASIRRLKVDQARRDTLFERANLLKSKF
DQARLPRLPTESHIVPLMIGNATRATEVSMRLIREFGMYATPINYPTVPAGTERLRFTPGPKHTEAMMDQLVAALRHILS
GETGTVAA

Sequences:

>Translated_408_residues
MNRDHPFIAQCDKALADIRAAGRYRRFVALEKLADRFPYYKVTMEGRTQDILVWSSNDYLAMGTDPEVIEASIEAARTMG
AGAGGTRNIAGSSPIHVALEAELAALHGKDAALLFTSGYVSNQATLTAILNSMPGWHVFSDAQNHNSMIVGIKGGKAATV
HVFAHNDLADLEARLAAAPADAPKMIAFESVYSMDGDIAPIGAICDLADKYNAITYLDEVHAVGMYGPHGAGVSERDGVA
HRLTIIEGTLAKAYGCHGGYIAGDASVIDYIRSVAAGFIFTTALPPPTVAAALASIRRLKVDQARRDTLFERANLLKSKF
DQARLPRLPTESHIVPLMIGNATRATEVSMRLIREFGMYATPINYPTVPAGTERLRFTPGPKHTEAMMDQLVAALRHILS
GETGTVAA
>Mature_408_residues
MNRDHPFIAQCDKALADIRAAGRYRRFVALEKLADRFPYYKVTMEGRTQDILVWSSNDYLAMGTDPEVIEASIEAARTMG
AGAGGTRNIAGSSPIHVALEAELAALHGKDAALLFTSGYVSNQATLTAILNSMPGWHVFSDAQNHNSMIVGIKGGKAATV
HVFAHNDLADLEARLAAAPADAPKMIAFESVYSMDGDIAPIGAICDLADKYNAITYLDEVHAVGMYGPHGAGVSERDGVA
HRLTIIEGTLAKAYGCHGGYIAGDASVIDYIRSVAAGFIFTTALPPPTVAAALASIRRLKVDQARRDTLFERANLLKSKF
DQARLPRLPTESHIVPLMIGNATRATEVSMRLIREFGMYATPINYPTVPAGTERLRFTPGPKHTEAMMDQLVAALRHILS
GETGTVAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=376, Percent_Identity=46.5425531914894, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI83977440, Length=376, Percent_Identity=46.5425531914894, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI83977444, Length=376, Percent_Identity=46.5425531914894, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI4502025, Length=389, Percent_Identity=44.987146529563, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI40316939, Length=389, Percent_Identity=44.987146529563, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI7657118, Length=385, Percent_Identity=33.5064935064935, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI284448556, Length=352, Percent_Identity=34.9431818181818, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI119220554, Length=393, Percent_Identity=26.7175572519084, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4758668, Length=373, Percent_Identity=28.1501340482574, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI5454084, Length=260, Percent_Identity=27.3076923076923, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI1790046, Length=351, Percent_Identity=33.6182336182336, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1786993, Length=346, Percent_Identity=33.5260115606936, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=386, Percent_Identity=31.8652849740933, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32566772, Length=403, Percent_Identity=30.272952853598, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=348, Percent_Identity=26.7241379310345, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=348, Percent_Identity=26.7241379310345, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982617, Length=283, Percent_Identity=24.0282685512367, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=283, Percent_Identity=24.0282685512367, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=411, Percent_Identity=45.2554744525547, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6320267, Length=396, Percent_Identity=26.7676767676768, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=288, Percent_Identity=24.6527777777778, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17137420, Length=379, Percent_Identity=46.7018469656992, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24662918, Length=386, Percent_Identity=35.4922279792746, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI17136286, Length=399, Percent_Identity=28.0701754385965, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24653280, Length=286, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653276, Length=286, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653278, Length=286, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 43777; Mature: 43777

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRDHPFIAQCDKALADIRAAGRYRRFVALEKLADRFPYYKVTMEGRTQDILVWSSNDYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCEE
AMGTDPEVIEASIEAARTMGAGAGGTRNIAGSSPIHVALEAELAALHGKDAALLFTSGYV
EECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEHHHCCCCEEEEEECCCC
SNQATLTAILNSMPGWHVFSDAQNHNSMIVGIKGGKAATVHVFAHNDLADLEARLAAAPA
CCCHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCEEEEEEEECCCHHHHHHHHHCCCC
DAPKMIAFESVYSMDGDIAPIGAICDLADKYNAITYLDEVHAVGMYGPHGAGVSERDGVA
CCCHHEEHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCE
HRLTIIEGTLAKAYGCHGGYIAGDASVIDYIRSVAAGFIFTTALPPPTVAAALASIRRLK
EEEEEEECHHHHHHCCCCCEECCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHH
VDQARRDTLFERANLLKSKFDQARLPRLPTESHIVPLMIGNATRATEVSMRLIREFGMYA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEE
TPINYPTVPAGTERLRFTPGPKHTEAMMDQLVAALRHILSGETGTVAA
CCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNRDHPFIAQCDKALADIRAAGRYRRFVALEKLADRFPYYKVTMEGRTQDILVWSSNDYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCEE
AMGTDPEVIEASIEAARTMGAGAGGTRNIAGSSPIHVALEAELAALHGKDAALLFTSGYV
EECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEHHHCCCCEEEEEECCCC
SNQATLTAILNSMPGWHVFSDAQNHNSMIVGIKGGKAATVHVFAHNDLADLEARLAAAPA
CCCHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCEEEEEEEECCCHHHHHHHHHCCCC
DAPKMIAFESVYSMDGDIAPIGAICDLADKYNAITYLDEVHAVGMYGPHGAGVSERDGVA
CCCHHEEHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCE
HRLTIIEGTLAKAYGCHGGYIAGDASVIDYIRSVAAGFIFTTALPPPTVAAALASIRRLK
EEEEEEECHHHHHHCCCCCEECCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHH
VDQARRDTLFERANLLKSKFDQARLPRLPTESHIVPLMIGNATRATEVSMRLIREFGMYA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEE
TPINYPTVPAGTERLRFTPGPKHTEAMMDQLVAALRHILSGETGTVAA
CCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]