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The map label for this gene is gltA [H]

Identifier: 148243375

GI number: 148243375

Start: 1978555

End: 1979724

Strand: Direct

Name: gltA [H]

Synonym: SynRCC307_2276

Alternate gene names: 148243375

Gene position: 1978555-1979724 (Clockwise)

Preceding gene: 148243374

Following gene: 148243376

Centisome position: 88.93

GC content: 63.33

Gene sequence:

>1170_bases
ATGAGCGAGGCTCCCACCGGTTTTCGCCCTGGATTGGAGGGGGTTCCTGCCACCCAGTCGGCGATCAGCAACATCGATGG
TCAGCAAGGAATCCTCAGCTACCGCGGCTACCGCATTGAGGATCTAGCCGCCCACAGCACCTTCCTGGAAACGGCCTATC
TGCTGATTTGGGGAGAACTGCCCAGTGCAGAGGCGCTCCGCGAGTTCCAGCACGACGTGCAGATGCACCGGCGGGTGAGT
TTCCGCATCCGCGACATGCTCAAGTGCTTCCCCTCGGGGGGGCACCCCATGGATGCCCTGCAATCCAGTGCCGCATCGCT
GGGGCTCTTCTATTCCAACCGCGCCCTCGACGACGAGAACTACATCCGCGGCGCCGTGATGCGCGTGCTGGCCAAGATCC
CGACGATGCTTGCGGCGTTCCACATGATTCGCCGCGGACAGGACCCCATCCAGCCACGGGATGACCTGCCCTACGCCTCC
AATTTCCTCTACATGCTCACCGAGCGGGAGCCAGACCCACTGGCGGCCCGGATCTTTGATGCCTGCCTGGTGCTCCATGC
CGAGCACACCCTCAACGCCAGCACCTTCAGCGCCCGGGTCACCGCGAGCACCCTCACCGACCCCTACGCCGTGGTGGCAT
CAGCCGTGGGCACCTTGGCCGGTCCCTTGCATGGCGGAGCCAACGAGGATGTGCTGCTGATGCTCGAGGAGATCGGCAGC
GAAGAGCGAGTCGAGGCCTACCTCGATCAAGCCATCGCTTCGAAGAGCAAGATCATGGGCTTCGGCCACCGGGAATACAA
GGTCAAAGACCCCCGCGCCACGATCCTGCAGGGGTTAGCCGAAACCCTGTTCAGCCGCTTTGGCCACGACCGCATGTACG
ACGTGGCGCGCCGACTGGAGAGCCTGGCTGCCGAAAAGCTCGGCCCCAAGGGGATCTACCCCAATGTGGATTTCTATTCC
GGGCTGGTCTATCGCAAGCTCGGCATCCCCACCGACCTGTTCACGCCAGTCTTTGCACTCTCCAGGGCCGCCGGCTGGCT
GGCCCACTGGAAAGAGCAGCTGGGTGCCAACCGGATCTACAGGCCAACGCAGATCTATACGGGCCTCGAAACCCGCAGCT
GGCTTCCTACTGAGCAGAGAAGCGGGCACAATGGCGAGCCGACTGGGTAG

Upstream 100 bases:

>100_bases
CAGCTGAAGCTGCTACTCAGCCCCAAAGTGCTGCTGGAGGGCAAAAAGTGACTGAAGCTCGCCGCGTAGCCTCGATCTGG
TGTGCAATACCGGCAAAGCG

Downstream 100 bases:

>100_bases
GTTGCCTGCAACGGTCTGCGCTGATGAGCACCGCGTTCACCCTCGATTTAGAAACTGGCTTCCGGGGCCTGCTGGAAGCT
GGCGGCGTTAGCCCTGGGCT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSEAPTGFRPGLEGVPATQSAISNIDGQQGILSYRGYRIEDLAAHSTFLETAYLLIWGELPSAEALREFQHDVQMHRRVS
FRIRDMLKCFPSGGHPMDALQSSAASLGLFYSNRALDDENYIRGAVMRVLAKIPTMLAAFHMIRRGQDPIQPRDDLPYAS
NFLYMLTEREPDPLAARIFDACLVLHAEHTLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVLLMLEEIGS
EERVEAYLDQAIASKSKIMGFGHREYKVKDPRATILQGLAETLFSRFGHDRMYDVARRLESLAAEKLGPKGIYPNVDFYS
GLVYRKLGIPTDLFTPVFALSRAAGWLAHWKEQLGANRIYRPTQIYTGLETRSWLPTEQRSGHNGEPTG

Sequences:

>Translated_389_residues
MSEAPTGFRPGLEGVPATQSAISNIDGQQGILSYRGYRIEDLAAHSTFLETAYLLIWGELPSAEALREFQHDVQMHRRVS
FRIRDMLKCFPSGGHPMDALQSSAASLGLFYSNRALDDENYIRGAVMRVLAKIPTMLAAFHMIRRGQDPIQPRDDLPYAS
NFLYMLTEREPDPLAARIFDACLVLHAEHTLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVLLMLEEIGS
EERVEAYLDQAIASKSKIMGFGHREYKVKDPRATILQGLAETLFSRFGHDRMYDVARRLESLAAEKLGPKGIYPNVDFYS
GLVYRKLGIPTDLFTPVFALSRAAGWLAHWKEQLGANRIYRPTQIYTGLETRSWLPTEQRSGHNGEPTG
>Mature_388_residues
SEAPTGFRPGLEGVPATQSAISNIDGQQGILSYRGYRIEDLAAHSTFLETAYLLIWGELPSAEALREFQHDVQMHRRVSF
RIRDMLKCFPSGGHPMDALQSSAASLGLFYSNRALDDENYIRGAVMRVLAKIPTMLAAFHMIRRGQDPIQPRDDLPYASN
FLYMLTEREPDPLAARIFDACLVLHAEHTLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVLLMLEEIGSE
ERVEAYLDQAIASKSKIMGFGHREYKVKDPRATILQGLAETLFSRFGHDRMYDVARRLESLAAEKLGPKGIYPNVDFYSG
LVYRKLGIPTDLFTPVFALSRAAGWLAHWKEQLGANRIYRPTQIYTGLETRSWLPTEQRSGHNGEPTG

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=385, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1786939, Length=380, Percent_Identity=39.4736842105263, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=34.5945945945946, Blast_Score=234, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17555174, Length=388, Percent_Identity=27.319587628866, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=372, Percent_Identity=26.8817204301075, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=425, Percent_Identity=24.7058823529412, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324328, Length=365, Percent_Identity=24.1095890410959, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24640124, Length=394, Percent_Identity=26.3959390862944, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640126, Length=394, Percent_Identity=26.3959390862944, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356863, Length=392, Percent_Identity=27.0408163265306, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 43193; Mature: 43061

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAPTGFRPGLEGVPATQSAISNIDGQQGILSYRGYRIEDLAAHSTFLETAYLLIWGEL
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHEEECCC
PSAEALREFQHDVQMHRRVSFRIRDMLKCFPSGGHPMDALQSSAASLGLFYSNRALDDEN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
YIRGAVMRVLAKIPTMLAAFHMIRRGQDPIQPRDDLPYASNFLYMLTEREPDPLAARIFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
ACLVLHAEHTLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVLLMLEEIGS
HHHHHHHHHHCCCHHHHHEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
EERVEAYLDQAIASKSKIMGFGHREYKVKDPRATILQGLAETLFSRFGHDRMYDVARRLE
HHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SLAAEKLGPKGIYPNVDFYSGLVYRKLGIPTDLFTPVFALSRAAGWLAHWKEQLGANRIY
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPTQIYTGLETRSWLPTEQRSGHNGEPTG
CCHHHHCCCCCCCCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
SEAPTGFRPGLEGVPATQSAISNIDGQQGILSYRGYRIEDLAAHSTFLETAYLLIWGEL
CCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHEEECCC
PSAEALREFQHDVQMHRRVSFRIRDMLKCFPSGGHPMDALQSSAASLGLFYSNRALDDEN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
YIRGAVMRVLAKIPTMLAAFHMIRRGQDPIQPRDDLPYASNFLYMLTEREPDPLAARIFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
ACLVLHAEHTLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVLLMLEEIGS
HHHHHHHHHHCCCHHHHHEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
EERVEAYLDQAIASKSKIMGFGHREYKVKDPRATILQGLAETLFSRFGHDRMYDVARRLE
HHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SLAAEKLGPKGIYPNVDFYSGLVYRKLGIPTDLFTPVFALSRAAGWLAHWKEQLGANRIY
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPTQIYTGLETRSWLPTEQRSGHNGEPTG
CCHHHHCCCCCCCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]