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The map label for this gene is purM

Identifier: 148243170

GI number: 148243170

Start: 1791088

End: 1792122

Strand: Direct

Name: purM

Synonym: SynRCC307_2071

Alternate gene names: 148243170

Gene position: 1791088-1792122 (Clockwise)

Preceding gene: 148243167

Following gene: 148243171

Centisome position: 80.5

GC content: 64.83

Gene sequence:

>1035_bases
ATGGATTACAAGAGCGCCGGCGTTGACGTCGAAGCCGGACGCCATTTCGTTGAACGCATCCGCACCAGCGTGGAGGCCAC
CCACCGCCCAGAAGTCCTCGGAGGATTGGGCGGCTTTGGCGGGCTTTGCCGCTTGCCAGCCGGACTTGAAAAGCCCCTGC
TTGTGGCTGGCACCGATGGCGTGGGCACCAAGCTCGAACTCGCCCAGGAGTGCGGCCGGCACCACGGGGTGGGCATCGAT
CTGGTGGCGATGTGCGCCAACGACGTGATCACCTGCGGCGCTGAGCCGCTGTTCTTTCTCGACTACATCGCCACCGGCAA
GCTCAGCCCGGCCGCCATGGCCGAAGTGGTGGAAGGAATCGCCAGTGGCTGCAGCCAAAGCGGCTGCAGCCTGCTGGGGG
GCGAAACCGCCGAAATGCCTGGCTTCTACCCAGCCGGTCGCTACGACCTGGCGGGCTTCTGCGTGGCCGTTGTCGATGAG
CCGCGGCTGATCGACGGTCAAACCATTCAGGCCGGTGATCAGCTGCTGGCCATCGCCAGCAGCGGCGTGCACAGCAATGG
CTTCAGCCTGGTGCGGCGCATCTTGGAAGCCAATCAAGTCCCACTGGAAACCAGCCAAGCGGCCCTGGGCGGCCGCAGCG
CGGCAGAAGCCCTGCTGGAGCCAACCCTGCTGTATGCACCACTGGTGAAGGCCCTGCTGCAGAGCCCAGAGCTGGAGCTG
CGGGGCATGGCCCACATCACTGGCGGAGGATTGCCTGAAAACCTGCCGCGGCCCCTTCCCCAAGGACTCGCCGCTCAGAT
CGATCCAGGCAGCTGGCAGAGGCCCGCACTGTTCCACTGGCTTCAGGAGCTGGGATCGGTGCCTGAGCGCGATCTCTGGC
ACACCTTCAACCTGGGGATTGGCTACGTGTTGGTGCTCCCTGAAAGCAGCTGCCAGCAGGCGCTTGAGGTGGTGCACAAC
AGTGGCTTTACAGGCTGGATATGCGGCGAAATCGTTGTTGGGCAGGGGGTTCTCGGCCTGCCGGCAGGGGCCTAA

Upstream 100 bases:

>100_bases
AATGGCGCCCCTCTGATCAGCAACAGCAATCCCCCCGATCAGCCAGCCTTATCGGACAGGCCTTGCGCGACGATGGGATC
AACGGCAGCAGCCTGAGGAG

Downstream 100 bases:

>100_bases
AGCAGGCTGCAGCTCGACAAGGCTGGCAAGATGGTCGGCAAAGAGAAAAAACAGTCGTCTTTGTTACGTGCCTTTTAACG
AGTCCAATCGCTTAACCCGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MDYKSAGVDVEAGRHFVERIRTSVEATHRPEVLGGLGGFGGLCRLPAGLEKPLLVAGTDGVGTKLELAQECGRHHGVGID
LVAMCANDVITCGAEPLFFLDYIATGKLSPAAMAEVVEGIASGCSQSGCSLLGGETAEMPGFYPAGRYDLAGFCVAVVDE
PRLIDGQTIQAGDQLLAIASSGVHSNGFSLVRRILEANQVPLETSQAALGGRSAAEALLEPTLLYAPLVKALLQSPELEL
RGMAHITGGGLPENLPRPLPQGLAAQIDPGSWQRPALFHWLQELGSVPERDLWHTFNLGIGYVLVLPESSCQQALEVVHN
SGFTGWICGEIVVGQGVLGLPAGA

Sequences:

>Translated_344_residues
MDYKSAGVDVEAGRHFVERIRTSVEATHRPEVLGGLGGFGGLCRLPAGLEKPLLVAGTDGVGTKLELAQECGRHHGVGID
LVAMCANDVITCGAEPLFFLDYIATGKLSPAAMAEVVEGIASGCSQSGCSLLGGETAEMPGFYPAGRYDLAGFCVAVVDE
PRLIDGQTIQAGDQLLAIASSGVHSNGFSLVRRILEANQVPLETSQAALGGRSAAEALLEPTLLYAPLVKALLQSPELEL
RGMAHITGGGLPENLPRPLPQGLAAQIDPGSWQRPALFHWLQELGSVPERDLWHTFNLGIGYVLVLPESSCQQALEVVHN
SGFTGWICGEIVVGQGVLGLPAGA
>Mature_344_residues
MDYKSAGVDVEAGRHFVERIRTSVEATHRPEVLGGLGGFGGLCRLPAGLEKPLLVAGTDGVGTKLELAQECGRHHGVGID
LVAMCANDVITCGAEPLFFLDYIATGKLSPAAMAEVVEGIASGCSQSGCSLLGGETAEMPGFYPAGRYDLAGFCVAVVDE
PRLIDGQTIQAGDQLLAIASSGVHSNGFSLVRRILEANQVPLETSQAALGGRSAAEALLEPTLLYAPLVKALLQSPELEL
RGMAHITGGGLPENLPRPLPQGLAAQIDPGSWQRPALFHWLQELGSVPERDLWHTFNLGIGYVLVLPESSCQQALEVVHN
SGFTGWICGEIVVGQGVLGLPAGA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=335, Percent_Identity=45.0746268656716, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI209869995, Length=335, Percent_Identity=45.0746268656716, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI209869993, Length=335, Percent_Identity=45.0746268656716, Blast_Score=288, Evalue=4e-78,
Organism=Escherichia coli, GI1788845, Length=331, Percent_Identity=51.3595166163142, Blast_Score=343, Evalue=8e-96,
Organism=Caenorhabditis elegans, GI17567511, Length=319, Percent_Identity=41.0658307210031, Blast_Score=217, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6321203, Length=337, Percent_Identity=46.5875370919881, Blast_Score=285, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24582400, Length=278, Percent_Identity=40.2877697841727, Blast_Score=204, Evalue=6e-53,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SYNR3 (A5GVR5)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001228327.1
- ProteinModelPortal:   A5GVR5
- SMR:   A5GVR5
- STRING:   A5GVR5
- GeneID:   5157709
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_2071
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35947; Mature: 35947

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKSAGVDVEAGRHFVERIRTSVEATHRPEVLGGLGGFGGLCRLPAGLEKPLLVAGTDG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHCCCCCCCCEEEECCCC
VGTKLELAQECGRHHGVGIDLVAMCANDVITCGAEPLFFLDYIATGKLSPAAMAEVVEGI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
ASGCSQSGCSLLGGETAEMPGFYPAGRYDLAGFCVAVVDEPRLIDGQTIQAGDQLLAIAS
HHCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHEEEEEECCCCEECCCEECCCCCEEEECC
SGVHSNGFSLVRRILEANQVPLETSQAALGGRSAAEALLEPTLLYAPLVKALLQSPELEL
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
RGMAHITGGGLPENLPRPLPQGLAAQIDPGSWQRPALFHWLQELGSVPERDLWHTFNLGI
CCEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCHHHHEEECCCC
GYVLVLPESSCQQALEVVHNSGFTGWICGEIVVGQGVLGLPAGA
EEEEEECCHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDYKSAGVDVEAGRHFVERIRTSVEATHRPEVLGGLGGFGGLCRLPAGLEKPLLVAGTDG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHCCCCCCCCEEEECCCC
VGTKLELAQECGRHHGVGIDLVAMCANDVITCGAEPLFFLDYIATGKLSPAAMAEVVEGI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
ASGCSQSGCSLLGGETAEMPGFYPAGRYDLAGFCVAVVDEPRLIDGQTIQAGDQLLAIAS
HHCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHEEEEEECCCCEECCCEECCCCCEEEECC
SGVHSNGFSLVRRILEANQVPLETSQAALGGRSAAEALLEPTLLYAPLVKALLQSPELEL
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
RGMAHITGGGLPENLPRPLPQGLAAQIDPGSWQRPALFHWLQELGSVPERDLWHTFNLGI
CCEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCHHHHEEECCCC
GYVLVLPESSCQQALEVVHNSGFTGWICGEIVVGQGVLGLPAGA
EEEEEECCHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA