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The map label for this gene is napA [H]

Identifier: 148242537

GI number: 148242537

Start: 1277748

End: 1279064

Strand: Direct

Name: napA [H]

Synonym: SynRCC307_1438

Alternate gene names: 148242537

Gene position: 1277748-1279064 (Clockwise)

Preceding gene: 148242533

Following gene: 148242538

Centisome position: 57.43

GC content: 60.06

Gene sequence:

>1317_bases
ATGCCCGAGCTGAGTGCGCACAGCCTCGAAGTCACCGAGACCTTGATCAGCGGCGCCCGCTTCCTCGTGATCTTGGTCGC
AGCGCGACTCCTCGCGGAGACGATGGTGCGCTTCAAGCTGCCCACGATCCTGGGGGAATTGGTCGCTGGTCTGATCGTTG
GCATCTCCGGTTTGCACCTGGTGGTGCCACCGGAAACCCAATCAGCCTTGAGTGAAGGTTTTAGCGCCGTCTTAGGGGGA
TTAGCTCACGTACCAGGCGATGTTGTCGGCGAGCTCTATGCCGAAACATTCCCCAGCGTGGAGGCGGTCGCCAGCCTCGG
ACTGTTCTCCCTGCTCTTCCTCACCGGCCTGGAAAGTGATCTTGACGAGCTGGTCGCCGTTGGCGGCAAAGCCACCTCGG
TCGCCATTGCTGGGGTTGTTTTGCCCTTTGCAATCGGCACGGCAGGACTGATGGCGATCTTCCAGGTGGAGTTGATCCCA
GCGGTGTTCGCCGGGGCATCGATGACGGCTACAAGCATTGCGATCACAGCAAGCGTCTTTGGGGAGCTGAAGATGCTGCG
CTCATCCGAAGGCCAAATTGTTCTGGGCGCCGCAGTTCTCGATGACATCCTTGGCATCGTGATCCTGGCGGTGGTAGTCA
GCCTGGCGAGCAGCGGTGCGTTGACGATCGGTCCGATCATCTCCCTTGTCGCTGCAGCGGTGGTGTTCGTGCTGGCGGCC
ATCGCCTTGAGCCGTAGCGCTGCCCCCCTGTTCGACAAGTTGATTGAAAACCTCAAAGCCACCGGTGAAATCGTGGTGGC
GTCGTTTGTTGTGTTGGTGGTTTGCGCTTTCACCGCCACAGCCATTGGCCTGGAGGCAGCCCTTGGGGCCTTTGCTGCTG
GCCTGATCCTTAGCAAGTCCAAACACCGCCACGACATTGAGCAACAGGTCAAACCCGTGGTGGCCCTGTTCGCCACGATC
TTCTTTGTGCTCATCGGCACGAAGATGGACTTGAGCGTGGTGAACCCCTTTGATCCATCCAACCGAGAGGGATTGATCAT
TGCCGCCTTCCTCTTGGTGGTGGCCATCGCAGGCAAGGTGGCGGCCGGCTGGCTCTATGCCTCCAAAGAACCCACCAATC
GCCTGGTGGTGGGCTTGGGGATGATGCCCCGCGGCGAAGTGGGCTTGATCTTCCTGGGCTTGGGCAGCCAGGCCAAGTTG
CTGAGCCCCTCGCTGGAGGCGGCGATCTTGTTAATGGTGATCGGCACCACGTTCCTAGCCCCGCTGCTGTTGCGCTTTGT
GCTGACCAAGAACGAAACAGCGGCTGAAGCCAGCTGA

Upstream 100 bases:

>100_bases
GAGTTTGTCGCCATTCAGCAGCAGATAGAAACCAAATCTGCGGGTTCTTACTGACGGACTGATTTCGGGCCATAACCTTG
AAAGGTCAACCAATAAATCG

Downstream 100 bases:

>100_bases
GAAGCTCCATGCAACCGGTGGTGGTCCTTGGTGGGTTTCTGATCACCGATGAGGCCTACGGACCAATGGCTCAGTGGTTG
CACGGGCAGGGCGACACTGA

Product: Na+/H+ antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MPELSAHSLEVTETLISGARFLVILVAARLLAETMVRFKLPTILGELVAGLIVGISGLHLVVPPETQSALSEGFSAVLGG
LAHVPGDVVGELYAETFPSVEAVASLGLFSLLFLTGLESDLDELVAVGGKATSVAIAGVVLPFAIGTAGLMAIFQVELIP
AVFAGASMTATSIAITASVFGELKMLRSSEGQIVLGAAVLDDILGIVILAVVVSLASSGALTIGPIISLVAAAVVFVLAA
IALSRSAAPLFDKLIENLKATGEIVVASFVVLVVCAFTATAIGLEAALGAFAAGLILSKSKHRHDIEQQVKPVVALFATI
FFVLIGTKMDLSVVNPFDPSNREGLIIAAFLLVVAIAGKVAAGWLYASKEPTNRLVVGLGMMPRGEVGLIFLGLGSQAKL
LSPSLEAAILLMVIGTTFLAPLLLRFVLTKNETAAEAS

Sequences:

>Translated_438_residues
MPELSAHSLEVTETLISGARFLVILVAARLLAETMVRFKLPTILGELVAGLIVGISGLHLVVPPETQSALSEGFSAVLGG
LAHVPGDVVGELYAETFPSVEAVASLGLFSLLFLTGLESDLDELVAVGGKATSVAIAGVVLPFAIGTAGLMAIFQVELIP
AVFAGASMTATSIAITASVFGELKMLRSSEGQIVLGAAVLDDILGIVILAVVVSLASSGALTIGPIISLVAAAVVFVLAA
IALSRSAAPLFDKLIENLKATGEIVVASFVVLVVCAFTATAIGLEAALGAFAAGLILSKSKHRHDIEQQVKPVVALFATI
FFVLIGTKMDLSVVNPFDPSNREGLIIAAFLLVVAIAGKVAAGWLYASKEPTNRLVVGLGMMPRGEVGLIFLGLGSQAKL
LSPSLEAAILLMVIGTTFLAPLLLRFVLTKNETAAEAS
>Mature_437_residues
PELSAHSLEVTETLISGARFLVILVAARLLAETMVRFKLPTILGELVAGLIVGISGLHLVVPPETQSALSEGFSAVLGGL
AHVPGDVVGELYAETFPSVEAVASLGLFSLLFLTGLESDLDELVAVGGKATSVAIAGVVLPFAIGTAGLMAIFQVELIPA
VFAGASMTATSIAITASVFGELKMLRSSEGQIVLGAAVLDDILGIVILAVVVSLASSGALTIGPIISLVAAAVVFVLAAI
ALSRSAAPLFDKLIENLKATGEIVVASFVVLVVCAFTATAIGLEAALGAFAAGLILSKSKHRHDIEQQVKPVVALFATIF
FVLIGTKMDLSVVNPFDPSNREGLIIAAFLLVVAIAGKVAAGWLYASKEPTNRLVVGLGMMPRGEVGLIFLGLGSQAKLL
SPSLEAAILLMVIGTTFLAPLLLRFVLTKNETAAEAS

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=449, Percent_Identity=26.9487750556793, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322367, Length=428, Percent_Identity=21.0280373831776, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 44925; Mature: 44794

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELSAHSLEVTETLISGARFLVILVAARLLAETMVRFKLPTILGELVAGLIVGISGLHL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VVPPETQSALSEGFSAVLGGLAHVPGDVVGELYAETFPSVEAVASLGLFSLLFLTGLESD
EECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHH
LDELVAVGGKATSVAIAGVVLPFAIGTAGLMAIFQVELIPAVFAGASMTATSIAITASVF
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GELKMLRSSEGQIVLGAAVLDDILGIVILAVVVSLASSGALTIGPIISLVAAAVVFVLAA
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IALSRSAAPLFDKLIENLKATGEIVVASFVVLVVCAFTATAIGLEAALGAFAAGLILSKS
HHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KHRHDIEQQVKPVVALFATIFFVLIGTKMDLSVVNPFDPSNREGLIIAAFLLVVAIAGKV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
AAGWLYASKEPTNRLVVGLGMMPRGEVGLIFLGLGSQAKLLSPSLEAAILLMVIGTTFLA
HHHHEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHH
PLLLRFVLTKNETAAEAS
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PELSAHSLEVTETLISGARFLVILVAARLLAETMVRFKLPTILGELVAGLIVGISGLHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VVPPETQSALSEGFSAVLGGLAHVPGDVVGELYAETFPSVEAVASLGLFSLLFLTGLESD
EECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHH
LDELVAVGGKATSVAIAGVVLPFAIGTAGLMAIFQVELIPAVFAGASMTATSIAITASVF
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GELKMLRSSEGQIVLGAAVLDDILGIVILAVVVSLASSGALTIGPIISLVAAAVVFVLAA
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IALSRSAAPLFDKLIENLKATGEIVVASFVVLVVCAFTATAIGLEAALGAFAAGLILSKS
HHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KHRHDIEQQVKPVVALFATIFFVLIGTKMDLSVVNPFDPSNREGLIIAAFLLVVAIAGKV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
AAGWLYASKEPTNRLVVGLGMMPRGEVGLIFLGLGSQAKLLSPSLEAAILLMVIGTTFLA
HHHHEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHH
PLLLRFVLTKNETAAEAS
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]