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The map label for this gene is phr [H]

Identifier: 148242284

GI number: 148242284

Start: 1043393

End: 1044904

Strand: Direct

Name: phr [H]

Synonym: SynRCC307_1185

Alternate gene names: 148242284

Gene position: 1043393-1044904 (Clockwise)

Preceding gene: 148242282

Following gene: 148242286

Centisome position: 46.9

GC content: 60.58

Gene sequence:

>1512_bases
TTGTGCAGCAGGGACAAGGTGTCCAGCAGGAGTACAACCGCCGAATCTGTTTCAGAGCCAAACCAACCACTGCAAGTGGT
GTGGTTCAAGCGTGATCTGCGCACGATTGACCACGGGGCGCTGTCGCAGGCGAGCCGCTCGGGCCCCGTGCTGCCGTTGT
TCATCGTTGAGCCGATGTTCTGGGCTCAGCCCGATGCCTCAGCTCGTCAATGGGAGTTCTGCGCTGAATCCCTGGCGGAG
CTGCGCGAAGCATTGGCTGCTCTCGGTCAGCCGTTGGTGATCCGCACCGGTGAAGCCTTGGCGGTGCTGAAAGCGCTGCA
CCGCCAACGGGGTATCGCCCAACTTTGGAGCCATCAGGAAACCGGCAATGACTTCACCTATCGCCGCGACCGCTTGGTGG
CGAGATGGTGCCGTGAGCAATCGATTCGGTGGCATCAGCCCCGCAGCTTTGGTGTGATCCGTGCCATGGGCAACCGAGAT
GGTTGGGCCCCGGCTTGGGAATTGTTGATGCGCCAATCCGTTTGCGCTGATCCAGCGCCCTTGACCAGACTCGGAGGGAT
TGATCCCGGTGGGATTCCCAGCGCCGACGATCTCAAGCTTCCAAGTGATCCTTGCCCAGGTCGCCAACGGGGCGGGCGGT
CCCAGGGTGCGGCGCTGCTGGAGAGTTTTTTGCACCATCGCGGCCGCCGCTATGCCAAGGAACTCTCCAGTCCTCTGACA
GCGTTTGAGTCCTGTTCTCGCCTCTCGGCTCACCTCACCTTTGGCACGTTGTCGATGCGTGAAATCGTCCAGACCGCGCG
CCTGAACAACGGACCAAAAGCCTTCGTCGAACGCCTCCATTGGCATTGCCACTTCATCCAGAAACTGGAGAGCCAGCCGT
CGTTGGAATATCAAAATGCCCATCGCGCCTACGACGGTTTGCGCGCTGATGATCCCCAGAGGCTGGCGCTGTGGATTGAA
GGCCGCACCGGCTGGCCGTTTGTGGATGCCTGCATGCGTGCTCTACGGCACCACGGCTGGATCAATTTCCGCATGCGAGC
GATGTTGATGTCGGTGGCGAGTTATCAGCTTTGGCTGCCATGGCGGCAGAGCGGTGAAGCCCTTGCCCGTTTGTTTGTCG
ATTACGAGCCCGGAATCCATTGGAACCAATGCCAGATGCAATCGGGCACCTCGGGCATCAACACCGTTCGTATCTACAAC
CCGATCAAGCAAGGCCTTGATCACGACCCCGAAGGAGCGTTTATCCGTCAATGGCTACCGGAATTGCAGGGTGTTCCCGT
TTCTGGGATTCACACCCCATGGTTGTTGGCTCAACCACCTGAGACCTATCCGCATCCCGTGGTCGATTATGAAGCGGCCG
CGCGCCAAGCCCGTGATCAGGTCTGGGGCCTGCGAAAGGGACAGGGGTATCGCTGCGAAGCCGAGGCGATTCAACGCCGC
CATGGTTCACGCCGTCGCCGCCGGGCGCGGCCGCCTGCGGATAACGGCCAGCTCAGCTTGGAGTTGGGCTAA

Upstream 100 bases:

>100_bases
TCGTCTCGTCGACCGAGACAGGCGTGACGCATTGGTGGTCTAGGGCTGGATGGTCAAGAGGCGCAGAGTGGTTTGGCTAA
TCGCTAGAACCTTTGCCTAG

Downstream 100 bases:

>100_bases
GCGCGGTGGTGCTCAGATCAGTTCGGGGTGGGCTGGATCACCCTTGAAAGGGCCGATCAGATCCGATGTGATCCAGCCGC
CATAGAAGCCTCCCTGTTGG

Product: deoxyribodipyrimidine photolyase

Products: 2 pyrimidine residues (in DNA) [C]

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MCSRDKVSSRSTTAESVSEPNQPLQVVWFKRDLRTIDHGALSQASRSGPVLPLFIVEPMFWAQPDASARQWEFCAESLAE
LREALAALGQPLVIRTGEALAVLKALHRQRGIAQLWSHQETGNDFTYRRDRLVARWCREQSIRWHQPRSFGVIRAMGNRD
GWAPAWELLMRQSVCADPAPLTRLGGIDPGGIPSADDLKLPSDPCPGRQRGGRSQGAALLESFLHHRGRRYAKELSSPLT
AFESCSRLSAHLTFGTLSMREIVQTARLNNGPKAFVERLHWHCHFIQKLESQPSLEYQNAHRAYDGLRADDPQRLALWIE
GRTGWPFVDACMRALRHHGWINFRMRAMLMSVASYQLWLPWRQSGEALARLFVDYEPGIHWNQCQMQSGTSGINTVRIYN
PIKQGLDHDPEGAFIRQWLPELQGVPVSGIHTPWLLAQPPETYPHPVVDYEAAARQARDQVWGLRKGQGYRCEAEAIQRR
HGSRRRRRARPPADNGQLSLELG

Sequences:

>Translated_503_residues
MCSRDKVSSRSTTAESVSEPNQPLQVVWFKRDLRTIDHGALSQASRSGPVLPLFIVEPMFWAQPDASARQWEFCAESLAE
LREALAALGQPLVIRTGEALAVLKALHRQRGIAQLWSHQETGNDFTYRRDRLVARWCREQSIRWHQPRSFGVIRAMGNRD
GWAPAWELLMRQSVCADPAPLTRLGGIDPGGIPSADDLKLPSDPCPGRQRGGRSQGAALLESFLHHRGRRYAKELSSPLT
AFESCSRLSAHLTFGTLSMREIVQTARLNNGPKAFVERLHWHCHFIQKLESQPSLEYQNAHRAYDGLRADDPQRLALWIE
GRTGWPFVDACMRALRHHGWINFRMRAMLMSVASYQLWLPWRQSGEALARLFVDYEPGIHWNQCQMQSGTSGINTVRIYN
PIKQGLDHDPEGAFIRQWLPELQGVPVSGIHTPWLLAQPPETYPHPVVDYEAAARQARDQVWGLRKGQGYRCEAEAIQRR
HGSRRRRRARPPADNGQLSLELG
>Mature_503_residues
MCSRDKVSSRSTTAESVSEPNQPLQVVWFKRDLRTIDHGALSQASRSGPVLPLFIVEPMFWAQPDASARQWEFCAESLAE
LREALAALGQPLVIRTGEALAVLKALHRQRGIAQLWSHQETGNDFTYRRDRLVARWCREQSIRWHQPRSFGVIRAMGNRD
GWAPAWELLMRQSVCADPAPLTRLGGIDPGGIPSADDLKLPSDPCPGRQRGGRSQGAALLESFLHHRGRRYAKELSSPLT
AFESCSRLSAHLTFGTLSMREIVQTARLNNGPKAFVERLHWHCHFIQKLESQPSLEYQNAHRAYDGLRADDPQRLALWIE
GRTGWPFVDACMRALRHHGWINFRMRAMLMSVASYQLWLPWRQSGEALARLFVDYEPGIHWNQCQMQSGTSGINTVRIYN
PIKQGLDHDPEGAFIRQWLPELQGVPVSGIHTPWLLAQPPETYPHPVVDYEAAARQARDQVWGLRKGQGYRCEAEAIQRR
HGSRRRRRARPPADNGQLSLELG

Specific function: Has no photolyase activity [H]

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=477, Percent_Identity=23.6897274633124, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI4758072, Length=477, Percent_Identity=23.8993710691824, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI188536103, Length=429, Percent_Identity=22.6107226107226, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1786926, Length=482, Percent_Identity=29.4605809128631, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324962, Length=492, Percent_Identity=22.3577235772358, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137248, Length=502, Percent_Identity=23.5059760956175, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24585455, Length=502, Percent_Identity=23.5059760956175, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24648152, Length=510, Percent_Identity=20.5882352941176, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: 4.1.99.3 [C]

Molecular weight: Translated: 57117; Mature: 57117

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSRDKVSSRSTTAESVSEPNQPLQVVWFKRDLRTIDHGALSQASRSGPVLPLFIVEPMF
CCCCCCCCCCCCCHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEHEECCHH
WAQPDASARQWEFCAESLAELREALAALGQPLVIRTGEALAVLKALHRQRGIAQLWSHQE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCHHHHHCCCC
TGNDFTYRRDRLVARWCREQSIRWHQPRSFGVIRAMGNRDGWAPAWELLMRQSVCADPAP
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCC
LTRLGGIDPGGIPSADDLKLPSDPCPGRQRGGRSQGAALLESFLHHRGRRYAKELSSPLT
HHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFESCSRLSAHLTFGTLSMREIVQTARLNNGPKAFVERLHWHCHFIQKLESQPSLEYQNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
HRAYDGLRADDPQRLALWIEGRTGWPFVDACMRALRHHGWINFRMRAMLMSVASYQLWLP
HHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECC
WRQSGEALARLFVDYEPGIHWNQCQMQSGTSGINTVRIYNPIKQGLDHDPEGAFIRQWLP
HHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHH
ELQGVPVSGIHTPWLLAQPPETYPHPVVDYEAAARQARDQVWGLRKGQGYRCEAEAIQRR
HHCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
HGSRRRRRARPPADNGQLSLELG
HHHHHHHHCCCCCCCCEEEEEEC
>Mature Secondary Structure
MCSRDKVSSRSTTAESVSEPNQPLQVVWFKRDLRTIDHGALSQASRSGPVLPLFIVEPMF
CCCCCCCCCCCCCHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEHEECCHH
WAQPDASARQWEFCAESLAELREALAALGQPLVIRTGEALAVLKALHRQRGIAQLWSHQE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCHHHHHCCCC
TGNDFTYRRDRLVARWCREQSIRWHQPRSFGVIRAMGNRDGWAPAWELLMRQSVCADPAP
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCC
LTRLGGIDPGGIPSADDLKLPSDPCPGRQRGGRSQGAALLESFLHHRGRRYAKELSSPLT
HHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFESCSRLSAHLTFGTLSMREIVQTARLNNGPKAFVERLHWHCHFIQKLESQPSLEYQNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
HRAYDGLRADDPQRLALWIEGRTGWPFVDACMRALRHHGWINFRMRAMLMSVASYQLWLP
HHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECC
WRQSGEALARLFVDYEPGIHWNQCQMQSGTSGINTVRIYNPIKQGLDHDPEGAFIRQWLP
HHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHH
ELQGVPVSGIHTPWLLAQPPETYPHPVVDYEAAARQARDQVWGLRKGQGYRCEAEAIQRR
HHCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
HGSRRRRRARPPADNGQLSLELG
HHHHHHHHCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: ATP; FADH2; Flavin; pterin [C]

Metal ions: NA

Kcat value (1/min): 2.4 [C]

Specific activity: NA

Km value (mM): NA

Substrates: cyclobutadipyrimidine (in DNA) [C]

Specific reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) [C]

General reaction: C-C-bond cleavage [C]

Inhibitor: yeast DNA [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]