Click here to switch to the map view.

The map label for this gene is ispD [H]

Identifier: 148241783

GI number: 148241783

Start: 618779

End: 619480

Strand: Direct

Name: ispD [H]

Synonym: SynRCC307_0684

Alternate gene names: 148241783

Gene position: 618779-619480 (Clockwise)

Preceding gene: 148241779

Following gene: 148241786

Centisome position: 27.81

GC content: 66.67

Gene sequence:

>702_bases
ATGGATCTGAACCGCGGACGCTTGCATCTGTTGATTGTTGCCGCCGGCAGTGGCCGGCGCATGGGGGCTGAGGGCAACAA
GTTGTTGCTGCCACTGCAGGGCAGGCCGCTGTTGGCCTGGACCTTGGAATCCGCCTTGGCCAGTGACGCCATTGCCTGGC
TGGGGGTGGTGGGCCAAGCCTGCGACCGTCAAGCGATTGAGGCGCTGCTGCAGTCGTTGCAGCCCCGCCAGCCCTGGTGC
TGGATTCAAGGGGGAGCGACGCGCCAGCAATCGGTGGCTTGCGGGTTGGCGGCGCTCCCCGCCGAAGCCGAGCACGTCTT
GATCCATGACGGGGCCCGTTGCCTGGCGGAACCTGCCCTGTTTGATCGCTGCGCCGAGGCCCTGCAGCGCAACGGCCAAG
CGCTGATTGCAGCGACCCCTGTGGTCGACACGATCAAACAGGTGGATGGGCAGGGCCGCATCGTGGCGACCCCGCCCCGC
TCTGAGCTTTGGGCGGCGCAAACGCCGCAAGGTTTCCCGGTGGCCCAGCTGCACCAAGCCCACCAACAGGCTGAGCAGGC
CGGCTGGGAGGTCACCGATGACGCGGCCCTCTTTGAGCGTCTTGGCTGGCCGGTTCAGGTGCTGGAGGCCAGCAGCGCCA
ACCTCAAGATCACCACGCCCTTGGATCTGGAACTAGCTGCGGCCCTGCTCAGAGCACGCTGA

Upstream 100 bases:

>100_bases
CCGCTGCCAACGGAAGCCGCTCGAGCTGCGCCTCCAGATCACCAGGGCTCAGGAACAGCACGCGCATCCGTCAGCCAACC
AGCGGAAGTGGTCGAATTGT

Downstream 100 bases:

>100_bases
GGCTGCCGCTGCGGCCATCGAGCCGCACGGTTCGCCCCAAAGGAAGCGCCGCATTGGGCTGACCATGGCCGAAGGGCAGT
CCCCCCACCACGGGAATGCC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MDLNRGRLHLLIVAAGSGRRMGAEGNKLLLPLQGRPLLAWTLESALASDAIAWLGVVGQACDRQAIEALLQSLQPRQPWC
WIQGGATRQQSVACGLAALPAEAEHVLIHDGARCLAEPALFDRCAEALQRNGQALIAATPVVDTIKQVDGQGRIVATPPR
SELWAAQTPQGFPVAQLHQAHQQAEQAGWEVTDDAALFERLGWPVQVLEASSANLKITTPLDLELAAALLRAR

Sequences:

>Translated_233_residues
MDLNRGRLHLLIVAAGSGRRMGAEGNKLLLPLQGRPLLAWTLESALASDAIAWLGVVGQACDRQAIEALLQSLQPRQPWC
WIQGGATRQQSVACGLAALPAEAEHVLIHDGARCLAEPALFDRCAEALQRNGQALIAATPVVDTIKQVDGQGRIVATPPR
SELWAAQTPQGFPVAQLHQAHQQAEQAGWEVTDDAALFERLGWPVQVLEASSANLKITTPLDLELAAALLRAR
>Mature_233_residues
MDLNRGRLHLLIVAAGSGRRMGAEGNKLLLPLQGRPLLAWTLESALASDAIAWLGVVGQACDRQAIEALLQSLQPRQPWC
WIQGGATRQQSVACGLAALPAEAEHVLIHDGARCLAEPALFDRCAEALQRNGQALIAATPVVDTIKQVDGQGRIVATPPR
SELWAAQTPQGFPVAQLHQAHQQAEQAGWEVTDDAALFERLGWPVQVLEASSANLKITTPLDLELAAALLRAR

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=235, Percent_Identity=25.1063829787234, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1789104, Length=223, Percent_Identity=34.0807174887892, Blast_Score=89, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 24981; Mature: 24981

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNRGRLHLLIVAAGSGRRMGAEGNKLLLPLQGRPLLAWTLESALASDAIAWLGVVGQA
CCCCCCEEEEEEEECCCCCEECCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHH
CDRQAIEALLQSLQPRQPWCWIQGGATRQQSVACGLAALPAEAEHVLIHDGARCLAEPAL
CCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHCHHH
FDRCAEALQRNGQALIAATPVVDTIKQVDGQGRIVATPPRSELWAAQTPQGFPVAQLHQA
HHHHHHHHHCCCCEEEEECHHHHHHHHCCCCCCEEECCCCHHCCCCCCCCCCCHHHHHHH
HQQAEQAGWEVTDDAALFERLGWPVQVLEASSANLKITTPLDLELAAALLRAR
HHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHHHHCC
>Mature Secondary Structure
MDLNRGRLHLLIVAAGSGRRMGAEGNKLLLPLQGRPLLAWTLESALASDAIAWLGVVGQA
CCCCCCEEEEEEEECCCCCEECCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHH
CDRQAIEALLQSLQPRQPWCWIQGGATRQQSVACGLAALPAEAEHVLIHDGARCLAEPAL
CCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHCHHH
FDRCAEALQRNGQALIAATPVVDTIKQVDGQGRIVATPPRSELWAAQTPQGFPVAQLHQA
HHHHHHHHHCCCCEEEEECHHHHHHHHCCCCCCEEECCCCHHCCCCCCCCCCCHHHHHHH
HQQAEQAGWEVTDDAALFERLGWPVQVLEASSANLKITTPLDLELAAALLRAR
HHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA