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The map label for this gene is sthA [H]

Identifier: 148241725

GI number: 148241725

Start: 561996

End: 564230

Strand: Direct

Name: sthA [H]

Synonym: SynRCC307_0626

Alternate gene names: 148241725

Gene position: 561996-564230 (Clockwise)

Preceding gene: 148241723

Following gene: 148241729

Centisome position: 25.26

GC content: 58.03

Gene sequence:

>2235_bases
ATGGCGCAAATCATTTTTTTAATGGCCGGCCTTCAATCAGTCCTTCAAAAAGTGATTCAAAAGGCCCAGCGTGTTGTTCA
ACAATCTTCTGGTAAAAGTAATTCGAATAATGCTCAAAGTCAGCGAGAATTGAATCGTCCGCATCAACAACGCGGAGCCA
ATCCAAAGCCGGCCAATGAACCCCAGCGCTTGGATGCGGTCACCGGGTTAAACCAAGCCAATTCAGAACATCAACCCGAA
TTGGTTGCGCTGCGTAACGCTGCCCGCTCGCTGTTGAAGATGCCAGTGGCGTTCATTGGCTTCATTGAAGACAACACCCA
GCGCTTGCTTACGGTGACGGTGGCGCCGCAAGGCGAGCAGGCCTGTGATCCGCTGGATTTCAAGGAGATGCTCACCCCCA
GGGAGTGCTCGATTTGTCAGTACACAATCATGGAATCGGATCATTTGGTGATTCCTGATCTCAAGGAGTTTCTTGAGCAT
GGCGATGGGGCGAGTTACCCGGCTGAATTTCTCGAGCAGGCCAAACAAGTGGGCGGCTATCCCATCCCCTGGCCCGATGG
AGCGGGCGGCATCACGCTGAAGCCGGCGCATTTTTATGCCGGCGCCACGATTCGCACCTCCAAAGGCATGCATGTCGGCA
CCTTTTGTGTGGTGGATGTGGTGCCGCGCCCAGATTTCGGTGTTCGCGAGATTGATGTTCTTGAAAATCTGGCGGCCCAA
GCCGCGGATTATCTGGAAGAGCGCGCTCTGCTGCGCCGGCCGGCCAACTTTCAGCTGCTGCAGCAGCTCTCGAGTGGTGA
TGACGCCGCATCTGAAACCGCGTCATGGGATGCGGTGGTGATCGGTGGAGGGCCCGCCGGACTGACGGCGGCCTGCCGCT
TGTCATTTCAAGGGCTCAAGGTGGCGTTGGTGGAGCCCAAAGAGAGTTTTGGTTCGCCTACCGGCGTGAGCAGCAAGGTG
CTGCGGGAAGTGGCGATGGACCACGGTGCTGGGACCTCATGGGATGACGTGTTGTCGATCCGGCAGCTAATTGCTCAAAA
CGATGCCAAGCGGGTGGCGTTGCAATTGCAGCGTTATGGCGTCACGCACTTCAAAGGCACTGGCGAAATCAGCGGTTGCA
ACGGCGATGGCATCACCACGGTTGTCGTTCGTGATAGCACCACTGGTGTCAGTGAGCTGTTGGCCCGCAAGGTGGTGGTT
TCCACCGGCTCTAAAGCCCGGCGTCTGGGGGGTATTCCCTTTGAGCAACCTGGCTTTTATGACTCCGATTCGATCGGCTC
ACTGCGCAGCAAACCCAGCAGCCTGTTTGTCCAAGGCACTGGAATCATTGCCTTGGAGTACGCCACGATCTTTGCCGAGA
TGGGCGTTCAGGTGAGCGTTGCAGCGCGTGGCAAGCGCGATGACCTCTTGCCGATGCTTGATGGCTCGATGCGTGATGCC
TTGCTGAGTGATCTGGAAGCCAAAGGGGTTGAGATCCTTTACCAGGCCTGCGTTAAGGGGTGGCGCGCTGATGAGGTGGG
CCCGCTCGTGGAACTGGAGCTGTCAAGCGGCATCAGTGAGCGCCGCTTCTCGGCGGTGCTCTCGGCGGTGGGGCGGGTAC
CCACAACACAAGATCTCGGCATGGAGGTTTTGCTTGAGGCCGACGATGTCAGCAAACTCAAAAAGCTCCCGCTGCTGGAG
AACCAGCAATTGGAGACCAATGCGGGATCGGTCTATGTGATTGGCGATGTCTCCGGTAGCGGGCTGGCGTGTAAAGCCGT
GATGCAGGCCCAGGGCTTGGTGGATCACGTGCTGCCCTCGCTGGTGCTGAAGAGCAAACAGCCCGCCCAGAGCAATCCGA
GCCATGCCAGCCCCTCGATCATCTGGGCGATCCCGGAGTTGGCGTTTGTGGGCAGCTCCCAAAGCGAAGCCATCAACACC
TACAGCGAAGCCGAGGTGTTCTCGGTGTTGGCGCCTTTTGCTGACACCATTCGCGGCCGGCTGAAGGCTTTGCCGGCCTC
CTATTTCCTCAAGCTGGTGTGCCTGCGCCAAGACGGCCGCATCTTGGGGGTGCATGTCTACGGGGAAGGCGCCTCTGAGC
TCATCCACCTGGGGGCGTCATTGGTTGCCGATGGCAACACGGTCTTTGACCTGCAATACAAATCCTTTCCGGCCGTCACC
TTGCATGAGGTGTACCGCAATGCCGCGATGCTGGCGATCGATACGCTCTCAGGCTTGGCGCAGAAAACCGGGTAG

Upstream 100 bases:

>100_bases
AGTGATCTGAGCTCTTCAGCTGGCATGGCGGCGGCGGGCAGGCGTGTTGCGGTTCAAGCGGATGGGACGGGCCTTTGCAA
GCTGATCCGCTTCCTGCACA

Downstream 100 bases:

>100_bases
CTGCGGCGAGCGCACGCGGATCAACTGGCTTGCCCCATCGTCAACAGCCTCGAGCGGCAAGCTTGGTCCGCGCCAACTGC
CGCCACTTGGCACTTCAACC

Product: putative soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MAQIIFLMAGLQSVLQKVIQKAQRVVQQSSGKSNSNNAQSQRELNRPHQQRGANPKPANEPQRLDAVTGLNQANSEHQPE
LVALRNAARSLLKMPVAFIGFIEDNTQRLLTVTVAPQGEQACDPLDFKEMLTPRECSICQYTIMESDHLVIPDLKEFLEH
GDGASYPAEFLEQAKQVGGYPIPWPDGAGGITLKPAHFYAGATIRTSKGMHVGTFCVVDVVPRPDFGVREIDVLENLAAQ
AADYLEERALLRRPANFQLLQQLSSGDDAASETASWDAVVIGGGPAGLTAACRLSFQGLKVALVEPKESFGSPTGVSSKV
LREVAMDHGAGTSWDDVLSIRQLIAQNDAKRVALQLQRYGVTHFKGTGEISGCNGDGITTVVVRDSTTGVSELLARKVVV
STGSKARRLGGIPFEQPGFYDSDSIGSLRSKPSSLFVQGTGIIALEYATIFAEMGVQVSVAARGKRDDLLPMLDGSMRDA
LLSDLEAKGVEILYQACVKGWRADEVGPLVELELSSGISERRFSAVLSAVGRVPTTQDLGMEVLLEADDVSKLKKLPLLE
NQQLETNAGSVYVIGDVSGSGLACKAVMQAQGLVDHVLPSLVLKSKQPAQSNPSHASPSIIWAIPELAFVGSSQSEAINT
YSEAEVFSVLAPFADTIRGRLKALPASYFLKLVCLRQDGRILGVHVYGEGASELIHLGASLVADGNTVFDLQYKSFPAVT
LHEVYRNAAMLAIDTLSGLAQKTG

Sequences:

>Translated_744_residues
MAQIIFLMAGLQSVLQKVIQKAQRVVQQSSGKSNSNNAQSQRELNRPHQQRGANPKPANEPQRLDAVTGLNQANSEHQPE
LVALRNAARSLLKMPVAFIGFIEDNTQRLLTVTVAPQGEQACDPLDFKEMLTPRECSICQYTIMESDHLVIPDLKEFLEH
GDGASYPAEFLEQAKQVGGYPIPWPDGAGGITLKPAHFYAGATIRTSKGMHVGTFCVVDVVPRPDFGVREIDVLENLAAQ
AADYLEERALLRRPANFQLLQQLSSGDDAASETASWDAVVIGGGPAGLTAACRLSFQGLKVALVEPKESFGSPTGVSSKV
LREVAMDHGAGTSWDDVLSIRQLIAQNDAKRVALQLQRYGVTHFKGTGEISGCNGDGITTVVVRDSTTGVSELLARKVVV
STGSKARRLGGIPFEQPGFYDSDSIGSLRSKPSSLFVQGTGIIALEYATIFAEMGVQVSVAARGKRDDLLPMLDGSMRDA
LLSDLEAKGVEILYQACVKGWRADEVGPLVELELSSGISERRFSAVLSAVGRVPTTQDLGMEVLLEADDVSKLKKLPLLE
NQQLETNAGSVYVIGDVSGSGLACKAVMQAQGLVDHVLPSLVLKSKQPAQSNPSHASPSIIWAIPELAFVGSSQSEAINT
YSEAEVFSVLAPFADTIRGRLKALPASYFLKLVCLRQDGRILGVHVYGEGASELIHLGASLVADGNTVFDLQYKSFPAVT
LHEVYRNAAMLAIDTLSGLAQKTG
>Mature_743_residues
AQIIFLMAGLQSVLQKVIQKAQRVVQQSSGKSNSNNAQSQRELNRPHQQRGANPKPANEPQRLDAVTGLNQANSEHQPEL
VALRNAARSLLKMPVAFIGFIEDNTQRLLTVTVAPQGEQACDPLDFKEMLTPRECSICQYTIMESDHLVIPDLKEFLEHG
DGASYPAEFLEQAKQVGGYPIPWPDGAGGITLKPAHFYAGATIRTSKGMHVGTFCVVDVVPRPDFGVREIDVLENLAAQA
ADYLEERALLRRPANFQLLQQLSSGDDAASETASWDAVVIGGGPAGLTAACRLSFQGLKVALVEPKESFGSPTGVSSKVL
REVAMDHGAGTSWDDVLSIRQLIAQNDAKRVALQLQRYGVTHFKGTGEISGCNGDGITTVVVRDSTTGVSELLARKVVVS
TGSKARRLGGIPFEQPGFYDSDSIGSLRSKPSSLFVQGTGIIALEYATIFAEMGVQVSVAARGKRDDLLPMLDGSMRDAL
LSDLEAKGVEILYQACVKGWRADEVGPLVELELSSGISERRFSAVLSAVGRVPTTQDLGMEVLLEADDVSKLKKLPLLEN
QQLETNAGSVYVIGDVSGSGLACKAVMQAQGLVDHVLPSLVLKSKQPAQSNPSHASPSIIWAIPELAFVGSSQSEAINTY
SEAEVFSVLAPFADTIRGRLKALPASYFLKLVCLRQDGRILGVHVYGEGASELIHLGASLVADGNTVFDLQYKSFPAVTL
HEVYRNAAMLAIDTLSGLAQKTG

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=486, Percent_Identity=25.7201646090535, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI50301238, Length=480, Percent_Identity=25, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI148277071, Length=381, Percent_Identity=25.1968503937008, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI33519430, Length=381, Percent_Identity=25.1968503937008, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI33519428, Length=381, Percent_Identity=25.1968503937008, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI33519426, Length=381, Percent_Identity=25.1968503937008, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI148277065, Length=381, Percent_Identity=25.1968503937008, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI291045266, Length=403, Percent_Identity=25.5583126550869, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI87082354, Length=495, Percent_Identity=29.4949494949495, Blast_Score=141, Evalue=2e-34,
Organism=Escherichia coli, GI1786307, Length=472, Percent_Identity=26.6949152542373, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87081717, Length=425, Percent_Identity=24.2352941176471, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=23.3256351039261, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=491, Percent_Identity=25.050916496945, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=24.7379454926625, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6325240, Length=517, Percent_Identity=25.3384912959381, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21358499, Length=489, Percent_Identity=25.7668711656442, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 79757; Mature: 79626

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQIIFLMAGLQSVLQKVIQKAQRVVQQSSGKSNSNNAQSQRELNRPHQQRGANPKPANE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCC
PQRLDAVTGLNQANSEHQPELVALRNAARSLLKMPVAFIGFIEDNTQRLLTVTVAPQGEQ
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHEEEEECCCCEEEEEEECCCCCC
ACDPLDFKEMLTPRECSICQYTIMESDHLVIPDLKEFLEHGDGASYPAEFLEQAKQVGGY
CCCCCCHHHHCCCCCCCCEEEEEECCCCEECHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
PIPWPDGAGGITLKPAHFYAGATIRTSKGMHVGTFCVVDVVPRPDFGVREIDVLENLAAQ
CCCCCCCCCCEEECCCCEECCCEEECCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHH
AADYLEERALLRRPANFQLLQQLSSGDDAASETASWDAVVIGGGPAGLTAACRLSFQGLK
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHCCCCCCEEEECCCCCCHHHHHHEEECCCE
VALVEPKESFGSPTGVSSKVLREVAMDHGAGTSWDDVLSIRQLIAQNDAKRVALQLQRYG
EEEECCHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCC
VTHFKGTGEISGCNGDGITTVVVRDSTTGVSELLARKVVVSTGSKARRLGGIPFEQPGFY
CEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
DSDSIGSLRSKPSSLFVQGTGIIALEYATIFAEMGVQVSVAARGKRDDLLPMLDGSMRDA
CCCCCCHHHCCCCEEEEECCCEEEEHHHHHHHHCCCEEEEEECCCCCCCCHHCCCHHHHH
LLSDLEAKGVEILYQACVKGWRADEVGPLVELELSSGISERRFSAVLSAVGRVPTTQDLG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHCCCCCCHHCC
MEVLLEADDVSKLKKLPLLENQQLETNAGSVYVIGDVSGSGLACKAVMQAQGLVDHVLPS
CEEEEECHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
LVLKSKQPAQSNPSHASPSIIWAIPELAFVGSSQSEAINTYSEAEVFSVLAPFADTIRGR
HHHCCCCCCCCCCCCCCCEEEEECCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKALPASYFLKLVCLRQDGRILGVHVYGEGASELIHLGASLVADGNTVFDLQYKSFPAVT
HHHCCHHHHHHHHEEECCCCEEEEEEECCCHHHHHHHCHHHEECCCEEEEEEECCCCCHH
LHEVYRNAAMLAIDTLSGLAQKTG
HHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQIIFLMAGLQSVLQKVIQKAQRVVQQSSGKSNSNNAQSQRELNRPHQQRGANPKPANE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCC
PQRLDAVTGLNQANSEHQPELVALRNAARSLLKMPVAFIGFIEDNTQRLLTVTVAPQGEQ
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHEEEEECCCCEEEEEEECCCCCC
ACDPLDFKEMLTPRECSICQYTIMESDHLVIPDLKEFLEHGDGASYPAEFLEQAKQVGGY
CCCCCCHHHHCCCCCCCCEEEEEECCCCEECHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
PIPWPDGAGGITLKPAHFYAGATIRTSKGMHVGTFCVVDVVPRPDFGVREIDVLENLAAQ
CCCCCCCCCCEEECCCCEECCCEEECCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHH
AADYLEERALLRRPANFQLLQQLSSGDDAASETASWDAVVIGGGPAGLTAACRLSFQGLK
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHCCCCCCEEEECCCCCCHHHHHHEEECCCE
VALVEPKESFGSPTGVSSKVLREVAMDHGAGTSWDDVLSIRQLIAQNDAKRVALQLQRYG
EEEECCHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCC
VTHFKGTGEISGCNGDGITTVVVRDSTTGVSELLARKVVVSTGSKARRLGGIPFEQPGFY
CEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
DSDSIGSLRSKPSSLFVQGTGIIALEYATIFAEMGVQVSVAARGKRDDLLPMLDGSMRDA
CCCCCCHHHCCCCEEEEECCCEEEEHHHHHHHHCCCEEEEEECCCCCCCCHHCCCHHHHH
LLSDLEAKGVEILYQACVKGWRADEVGPLVELELSSGISERRFSAVLSAVGRVPTTQDLG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHCCCCCCHHCC
MEVLLEADDVSKLKKLPLLENQQLETNAGSVYVIGDVSGSGLACKAVMQAQGLVDHVLPS
CEEEEECHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
LVLKSKQPAQSNPSHASPSIIWAIPELAFVGSSQSEAINTYSEAEVFSVLAPFADTIRGR
HHHCCCCCCCCCCCCCCCEEEEECCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKALPASYFLKLVCLRQDGRILGVHVYGEGASELIHLGASLVADGNTVFDLQYKSFPAVT
HHHCCHHHHHHHHEEECCCCEEEEEEECCCHHHHHHHCHHHEECCCEEEEEEECCCCCHH
LHEVYRNAAMLAIDTLSGLAQKTG
HHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA