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The map label for this gene is menA [H]

Identifier: 147675764

GI number: 147675764

Start: 2394076

End: 2394993

Strand: Reverse

Name: menA [H]

Synonym: VC0395_A2246

Alternate gene names: 147675764

Gene position: 2394993-2394076 (Counterclockwise)

Preceding gene: 147673421

Following gene: 147674928

Centisome position: 79.2

GC content: 49.67

Gene sequence:

>918_bases
ATGAATAACTCTGTGCAAATTTGGTTGGATGCCGCGCGTCCGAAAACCTTGCCTCTGGCGCTGATCTCCATTTTAACCGG
GAGTGCATTAGCCTTCTCTGCGGGAAATTTTCACTGGCTGATCGCGGTGTTAGCTCTGCTGACCGCGACTTTGCTGCAAA
TTCTGTCCAATCTTGCCAATGATTATGGCGATGCGGTGAAAGGCACCGACAACCATGCTCGTTTAGGACCGATGCGCGCC
ATTCAATCGGGGGCGGTGAGCTTAAGTGATATGAAACGCGCCATGGCGATCAATGTTATTCTGACCATGGTGTCAGGCTT
GGCATTGGTGCTGTATGCCTTTGATAACCTGCAAAATATCTTGATATTTATTGGCTTAGGCGTATTGGCGATTTTAGCGG
CGATTGCTTATACCGTCGGGAATAAACCTTATGGCTATGTCGGGCTTGGCGATCTATCGGTATTCCTATTTTTTGGCTTG
CTTGGCGTCTCCGGCAGTTTTTTCTTACACACTGGCTATATCGAATGGAGCTTGTTATTACCGTCTTTAGGCTGCGGTTT
ACTGGCGGTGGCGGTACTGAATGTCAACAATATGCGCGATATTGAAAACGATGCGCAGTGTGGCAAACGCACTGTGGCGG
TGCGCTTGGGACAAGTGCGTGCGAAGCAGTATCACTTTGCTTTGTTGTTTGGTGCCGTTGCCGCGTTTGCAGGTTACCTC
GTTTTACAAGACAAACCACTGTGGATCAGCTTGCCCTTTTTGCTCTGTTTGTCGGTGGTGACTCGTCACGGTCGAGCCGT
CTGGTTTACCGAGCAACCCGCGCAAATTGCCCCCATGATGCCCGTGGTGGTGAAAACGTCGGTGATCACCAACCTTTTGT
TTGTTGGAGTGATCATTGCCCAAACTCTGACAAGTTAA

Upstream 100 bases:

>100_bases
GCTTAATTTTTGAAGTGAAAGCCCACCCGAATTTGGTGGGCTTTTTTATCTGGGTGATTTGCGCGTATACTGACGCCATG
TTGATCGTACTCTCATTATC

Downstream 100 bases:

>100_bases
TTTGCACTCTGTCATTGCAATGACTCAATCACTCTATATACTCGTTGGAAGACTTTCGCTAAGAGAACAAAGCTATGGAA
TACAATACTTCTGCGCTGTG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNNSVQIWLDAARPKTLPLALISILTGSALAFSAGNFHWLIAVLALLTATLLQILSNLANDYGDAVKGTDNHARLGPMRA
IQSGAVSLSDMKRAMAINVILTMVSGLALVLYAFDNLQNILIFIGLGVLAILAAIAYTVGNKPYGYVGLGDLSVFLFFGL
LGVSGSFFLHTGYIEWSLLLPSLGCGLLAVAVLNVNNMRDIENDAQCGKRTVAVRLGQVRAKQYHFALLFGAVAAFAGYL
VLQDKPLWISLPFLLCLSVVTRHGRAVWFTEQPAQIAPMMPVVVKTSVITNLLFVGVIIAQTLTS

Sequences:

>Translated_305_residues
MNNSVQIWLDAARPKTLPLALISILTGSALAFSAGNFHWLIAVLALLTATLLQILSNLANDYGDAVKGTDNHARLGPMRA
IQSGAVSLSDMKRAMAINVILTMVSGLALVLYAFDNLQNILIFIGLGVLAILAAIAYTVGNKPYGYVGLGDLSVFLFFGL
LGVSGSFFLHTGYIEWSLLLPSLGCGLLAVAVLNVNNMRDIENDAQCGKRTVAVRLGQVRAKQYHFALLFGAVAAFAGYL
VLQDKPLWISLPFLLCLSVVTRHGRAVWFTEQPAQIAPMMPVVVKTSVITNLLFVGVIIAQTLTS
>Mature_305_residues
MNNSVQIWLDAARPKTLPLALISILTGSALAFSAGNFHWLIAVLALLTATLLQILSNLANDYGDAVKGTDNHARLGPMRA
IQSGAVSLSDMKRAMAINVILTMVSGLALVLYAFDNLQNILIFIGLGVLAILAAIAYTVGNKPYGYVGLGDLSVFLFFGL
LGVSGSFFLHTGYIEWSLLLPSLGCGLLAVAVLNVNNMRDIENDAQCGKRTVAVRLGQVRAKQYHFALLFGAVAAFAGYL
VLQDKPLWISLPFLLCLSVVTRHGRAVWFTEQPAQIAPMMPVVVKTSVITNLLFVGVIIAQTLTS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=300, Percent_Identity=50, Blast_Score=283, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17737429, Length=256, Percent_Identity=26.953125, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32703; Mature: 32703

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSVQIWLDAARPKTLPLALISILTGSALAFSAGNFHWLIAVLALLTATLLQILSNLAN
CCCCEEEEEECCCCCHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
DYGDAVKGTDNHARLGPMRAIQSGAVSLSDMKRAMAINVILTMVSGLALVLYAFDNLQNI
HHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIFIGLGVLAILAAIAYTVGNKPYGYVGLGDLSVFLFFGLLGVSGSFFLHTGYIEWSLLL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCEEEEHHH
PSLGCGLLAVAVLNVNNMRDIENDAQCGKRTVAVRLGQVRAKQYHFALLFGAVAAFAGYL
HHHHHHHHHHHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEE
VLQDKPLWISLPFLLCLSVVTRHGRAVWFTEQPAQIAPMMPVVVKTSVITNLLFVGVIIA
EEECCCCEEEHHHHHHHHHHHHCCCEEEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHHH
QTLTS
HHHCC
>Mature Secondary Structure
MNNSVQIWLDAARPKTLPLALISILTGSALAFSAGNFHWLIAVLALLTATLLQILSNLAN
CCCCEEEEEECCCCCHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
DYGDAVKGTDNHARLGPMRAIQSGAVSLSDMKRAMAINVILTMVSGLALVLYAFDNLQNI
HHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIFIGLGVLAILAAIAYTVGNKPYGYVGLGDLSVFLFFGLLGVSGSFFLHTGYIEWSLLL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCEEEEHHH
PSLGCGLLAVAVLNVNNMRDIENDAQCGKRTVAVRLGQVRAKQYHFALLFGAVAAFAGYL
HHHHHHHHHHHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEE
VLQDKPLWISLPFLLCLSVVTRHGRAVWFTEQPAQIAPMMPVVVKTSVITNLLFVGVIIA
EEECCCCEEEHHHHHHHHHHHHCCCEEEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHHH
QTLTS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]