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The map label for this gene is lpxD

Identifier: 147675586

GI number: 147675586

Start: 1957865

End: 1958920

Strand: Reverse

Name: lpxD

Synonym: VC0395_A1841

Alternate gene names: 147675586

Gene position: 1958920-1957865 (Counterclockwise)

Preceding gene: 147674756

Following gene: 147674767

Centisome position: 64.78

GC content: 49.24

Gene sequence:

>1056_bases
ATGACCACACTCACTTTAGCCGAATTGGCTACTATCACCGGGGGGGAGTTGTTCGGTGATCCAACAGCACTGGTCAGTGC
CGTTGCGCCTATGGATAAGGCACAGCTTGGACATGTGACATTCTTGTCTAATCCTAAATACAGTAAGCACTTAGGTGATT
GTAAAGCCACGGTGATCATGGTGAAAACCAGTGAGCGAGAACTCTGTCCGAGTAACGCTCTGGTGGTTGCCGATCCGTAT
GTTGCATTTGCTAAAGTGGCTCAGGCGCTGGATTCAACTCCTTCTCCTGCACACGGTATTGCACCGAGTGCTGTGATTGC
TGAAGATGCAAAGTTAGGTCACAACGTTTCGATTGGGGCAAATGCGGTCATTGAGTCAGGTGTTCAGCTTGGCGATAACG
TAGTGATTGGTGCTGGCTGTTTTATCGGTAAACAAGCGCGTTTGGGCGATAACACTAAGCTTTGGGCCAATGTAACGATT
TACCACAAAGTGGAAATCGGCTCAGATTGTTTGATTCAATCTGGAACCGTGATTGGTGCTGATGGCTTTGGCTATGCGAA
TGAGCGTGGCGAGTGGATTAAAATTCCTCAGCTTGGCTCTGTGCGTATTGGTGATCGCGTTGAGATTGGTGCTTGCACCA
CCATCGACCGCGGCGCGCTGGATGATACGGTGATTGAAGATAACGTGATCATCGATAATCAGCTGCAAATCGCTCACAAC
GTGCACATCGGATATGGTAGTGCGCTGGCGGGTGGTACAGTAATCGCCGGCAGTACACGCATTGGCAAGTACTGTATTAT
TGGTGGCGCTAGCGTGATTAACGGACATATCGAAATTGCCGATGGGGTGACCATCACTGGCATGGGTATGGTGATGCGCA
GTATTGAGGAGAAGGGGATGTACTCTTCGGGTATTCCTCTGCAAACCAATAAAGAGTGGCGTAAAACGGCCGCTCGCGTA
CACCGTATTGACGATATGCATAAGCGACTGAAAGCTTTAGAAAAGTTGCTTGAGCAATCCGACACGGTACAGCCCGATAA
CTCTCAAGCTGAATAA

Upstream 100 bases:

>100_bases
AGGCTACGATATCGTGCTAGACACGAGCTCAATGCAATACGGTAAGCCAGAACACAATCTGTCTGAGAAAGTTATTAAAG
CCATTAAATAATCGAAAATT

Downstream 100 bases:

>100_bases
GCTGGTTTCAAAGGCTCGCACATTGCGAGTCTTTTCGCTGTTGGGTATTCCCTTATTTTTCTATTTACAAACAGGATGAT
GACTTTGACTACTGATAAGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTTLTLAELATITGGELFGDPTALVSAVAPMDKAQLGHVTFLSNPKYSKHLGDCKATVIMVKTSERELCPSNALVVADPY
VAFAKVAQALDSTPSPAHGIAPSAVIAEDAKLGHNVSIGANAVIESGVQLGDNVVIGAGCFIGKQARLGDNTKLWANVTI
YHKVEIGSDCLIQSGTVIGADGFGYANERGEWIKIPQLGSVRIGDRVEIGACTTIDRGALDDTVIEDNVIIDNQLQIAHN
VHIGYGSALAGGTVIAGSTRIGKYCIIGGASVINGHIEIADGVTITGMGMVMRSIEEKGMYSSGIPLQTNKEWRKTAARV
HRIDDMHKRLKALEKLLEQSDTVQPDNSQAE

Sequences:

>Translated_351_residues
MTTLTLAELATITGGELFGDPTALVSAVAPMDKAQLGHVTFLSNPKYSKHLGDCKATVIMVKTSERELCPSNALVVADPY
VAFAKVAQALDSTPSPAHGIAPSAVIAEDAKLGHNVSIGANAVIESGVQLGDNVVIGAGCFIGKQARLGDNTKLWANVTI
YHKVEIGSDCLIQSGTVIGADGFGYANERGEWIKIPQLGSVRIGDRVEIGACTTIDRGALDDTVIEDNVIIDNQLQIAHN
VHIGYGSALAGGTVIAGSTRIGKYCIIGGASVINGHIEIADGVTITGMGMVMRSIEEKGMYSSGIPLQTNKEWRKTAARV
HRIDDMHKRLKALEKLLEQSDTVQPDNSQAE
>Mature_350_residues
TTLTLAELATITGGELFGDPTALVSAVAPMDKAQLGHVTFLSNPKYSKHLGDCKATVIMVKTSERELCPSNALVVADPYV
AFAKVAQALDSTPSPAHGIAPSAVIAEDAKLGHNVSIGANAVIESGVQLGDNVVIGAGCFIGKQARLGDNTKLWANVTIY
HKVEIGSDCLIQSGTVIGADGFGYANERGEWIKIPQLGSVRIGDRVEIGACTTIDRGALDDTVIEDNVIIDNQLQIAHNV
HIGYGSALAGGTVIAGSTRIGKYCIIGGASVINGHIEIADGVTITGMGMVMRSIEEKGMYSSGIPLQTNKEWRKTAARVH
RIDDMHKRLKALEKLLEQSDTVQPDNSQAE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=341, Percent_Identity=64.8093841642229, Blast_Score=465, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_VIBCH (Q9KPW2)

Other databases:

- EMBL:   AE003852
- PIR:   H82098
- RefSeq:   NP_231881.1
- ProteinModelPortal:   Q9KPW2
- GeneID:   2613172
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC2250
- TIGR:   VC_2250
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37011; Mature: 36879

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLTLAELATITGGELFGDPTALVSAVAPMDKAQLGHVTFLSNPKYSKHLGDCKATVIM
CCEEEHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHCCEEEEECCCCHHHHCCCCEEEEEE
VKTSERELCPSNALVVADPYVAFAKVAQALDSTPSPAHGIAPSAVIAEDAKLGHNVSIGA
EECCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHCCCCEECCC
NAVIESGVQLGDNVVIGAGCFIGKQARLGDNTKLWANVTIYHKVEIGSDCLIQSGTVIGA
HHHHHCCHHCCCCEEEECCEEECCCCCCCCCCEEEEEEEEEEEEECCCCEEEECCCEEEC
DGFGYANERGEWIKIPQLGSVRIGDRVEIGACTTIDRGALDDTVIEDNVIIDNQLQIAHN
CCCCCCCCCCCEEECCCCCCEEECCEEEECEECCCCCCCCCCCEECCCEEECCCEEEEEE
VHIGYGSALAGGTVIAGSTRIGKYCIIGGASVINGHIEIADGVTITGMGMVMRSIEEKGM
EEECCCCCCCCCEEEECCCCCCCEEEEECHHHEECEEEEECCEEEEHHHHHHHHHHHCCC
YSSGIPLQTNKEWRKTAARVHRIDDMHKRLKALEKLLEQSDTVQPDNSQAE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTLTLAELATITGGELFGDPTALVSAVAPMDKAQLGHVTFLSNPKYSKHLGDCKATVIM
CEEEHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHCCEEEEECCCCHHHHCCCCEEEEEE
VKTSERELCPSNALVVADPYVAFAKVAQALDSTPSPAHGIAPSAVIAEDAKLGHNVSIGA
EECCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHCCCCEECCC
NAVIESGVQLGDNVVIGAGCFIGKQARLGDNTKLWANVTIYHKVEIGSDCLIQSGTVIGA
HHHHHCCHHCCCCEEEECCEEECCCCCCCCCCEEEEEEEEEEEEECCCCEEEECCCEEEC
DGFGYANERGEWIKIPQLGSVRIGDRVEIGACTTIDRGALDDTVIEDNVIIDNQLQIAHN
CCCCCCCCCCCEEECCCCCCEEECCEEEECEECCCCCCCCCCCEECCCEEECCCEEEEEE
VHIGYGSALAGGTVIAGSTRIGKYCIIGGASVINGHIEIADGVTITGMGMVMRSIEEKGM
EEECCCCCCCCCEEEECCCCCCCEEEEECHHHEECEEEEECCEEEEHHHHHHHHHHHCCC
YSSGIPLQTNKEWRKTAARVHRIDDMHKRLKALEKLLEQSDTVQPDNSQAE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301