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The map label for this gene is dxr

Identifier: 147674244

GI number: 147674244

Start: 1963269

End: 1964477

Strand: Reverse

Name: dxr

Synonym: VC0395_A1845

Alternate gene names: 147674244

Gene position: 1964477-1963269 (Counterclockwise)

Preceding gene: 147674661

Following gene: 147673634

Centisome position: 64.96

GC content: 50.79

Gene sequence:

>1209_bases
ATGCGTAAACTAACCATTTTAGGTGCCACAGGTTCGATAGGAGCCAGCACCCTTAAGGTGATAGCCCAAAATCCACAGCA
GTTTTCCATTGTTGCGTTAGTGGCTGGGGTCAACGTAGCCAAAATGTACCAGCTGTGCCAACAGTGGCGGCCGAAATATG
CCGTTATGGCAACGGCGTCAGCAGCATCTGAGTTGCAAGGCTTGCTCAAAAACCAAGCGATGGCGACCGAAGTGCTGTAC
GGCGAAGAGGCGATGTGCCAAGTCGCGGCGCTGGATGATGTGGATACCGTGATGGCGGCCATTGTTGGGGCCGCAGGTTT
GTTACCCACCATGGCGGCGGTGAAAGCGGGTAAGCGTGTGTTACTTGCCAATAAAGAAGCATTGGTCATGTCGGGACAGC
TATTTATTGATGCTGTCGCACAATCTGGCGCTGAATTAATGCCCGTAGATAGTGAACACAACGCGATTTTCCAATGTCTG
CCGACTGAAATCCAAACTCAGTTGGGGCGCTGTGATTTATCTCAACACGGTATCGACCATATTTTGCTCACGGGCTCTGG
CGGCCCTTTCCGCTATAGCGACCTTGCGACCTTAGATAGCGTGACTCCTGAGCAGGCGATTGCTCATCCAAACTGGTCAA
TGGGACCGAAAATTTCGGTAGATTCCGCGACCATGATGAACAAAGGCCTTGAATACATTGAAGCTAAATGGCTATTTAAC
ACGTCACGTGAACAGCTCAAAGTGCTCATCCATCCTCAGTCGGTGATCCACTCTATGGTGCAATACCAAGATGGTTCAGT
GATTGCTCAGTTGGGCGAGCCGGATATGGCAACGCCAATCTCCTATGCCATGGCTTATCCTGAGCGAGTGACCGCGGGAG
TGCCAGCACTGGATTTTACGCGTTTGCAGCAACTGACCTTTATGGAGGTCGATTTTGCGCGCTACCCGTGCTTGCAATTA
GCGATGGATGCGTGTTTCCTCGGCCAACATGCGACAACCTCGCTCAATGCAGCCAATGAAGTAGCCGTTGACGCGTTTTT
AAAGCGGAAAATACGGTTTACTGACATTGCACTCATCAATGATCAAGTATTGTCCAAGGTCTGTGCGACCAACACCCAGT
TACATTGCCGTGACTTGGAAAGCCTGCTTGAGCTAGATACAATGGCTCGGCATTTTGCCCATCAAGTACTCAAAGAGCGC
CAAGCATGA

Upstream 100 bases:

>100_bases
TAGCCTAACGGCCGCTTTCCCTGTGTTCGCTCTTCTCTATTTCTTGTTCTAGTACTCAGGCTGCTTAGGCAGCCTGATGT
GAATAACAGCGATCTTCACT

Downstream 100 bases:

>100_bases
CCGACATATTGTGGAACTTTATCGCCTTCATCATTGCGCTGGGCATTCTCGTCGCAGTGCATGAGTTCGGACACTTCTGG
GTTGCCAGACGTTGCGGTGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MRKLTILGATGSIGASTLKVIAQNPQQFSIVALVAGVNVAKMYQLCQQWRPKYAVMATASAASELQGLLKNQAMATEVLY
GEEAMCQVAALDDVDTVMAAIVGAAGLLPTMAAVKAGKRVLLANKEALVMSGQLFIDAVAQSGAELMPVDSEHNAIFQCL
PTEIQTQLGRCDLSQHGIDHILLTGSGGPFRYSDLATLDSVTPEQAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFN
TSREQLKVLIHPQSVIHSMVQYQDGSVIAQLGEPDMATPISYAMAYPERVTAGVPALDFTRLQQLTFMEVDFARYPCLQL
AMDACFLGQHATTSLNAANEVAVDAFLKRKIRFTDIALINDQVLSKVCATNTQLHCRDLESLLELDTMARHFAHQVLKER
QA

Sequences:

>Translated_402_residues
MRKLTILGATGSIGASTLKVIAQNPQQFSIVALVAGVNVAKMYQLCQQWRPKYAVMATASAASELQGLLKNQAMATEVLY
GEEAMCQVAALDDVDTVMAAIVGAAGLLPTMAAVKAGKRVLLANKEALVMSGQLFIDAVAQSGAELMPVDSEHNAIFQCL
PTEIQTQLGRCDLSQHGIDHILLTGSGGPFRYSDLATLDSVTPEQAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFN
TSREQLKVLIHPQSVIHSMVQYQDGSVIAQLGEPDMATPISYAMAYPERVTAGVPALDFTRLQQLTFMEVDFARYPCLQL
AMDACFLGQHATTSLNAANEVAVDAFLKRKIRFTDIALINDQVLSKVCATNTQLHCRDLESLLELDTMARHFAHQVLKER
QA
>Mature_402_residues
MRKLTILGATGSIGASTLKVIAQNPQQFSIVALVAGVNVAKMYQLCQQWRPKYAVMATASAASELQGLLKNQAMATEVLY
GEEAMCQVAALDDVDTVMAAIVGAAGLLPTMAAVKAGKRVLLANKEALVMSGQLFIDAVAQSGAELMPVDSEHNAIFQCL
PTEIQTQLGRCDLSQHGIDHILLTGSGGPFRYSDLATLDSVTPEQAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFN
TSREQLKVLIHPQSVIHSMVQYQDGSVIAQLGEPDMATPISYAMAYPERVTAGVPALDFTRLQQLTFMEVDFARYPCLQL
AMDACFLGQHATTSLNAANEVAVDAFLKRKIRFTDIALINDQVLSKVCATNTQLHCRDLESLLELDTMARHFAHQVLKER
QA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=62.0253164556962, Blast_Score=474, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_VIBC3 (A5F615)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F615
- SMR:   A5F615
- STRING:   A5F615
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1845
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   VCHO345073:VC0395_A1845-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43685; Mature: 43685

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLTILGATGSIGASTLKVIAQNPQQFSIVALVAGVNVAKMYQLCQQWRPKYAVMATAS
CCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHCCCEEEEEEHH
AASELQGLLKNQAMATEVLYGEEAMCQVAALDDVDTVMAAIVGAAGLLPTMAAVKAGKRV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKEALVMSGQLFIDAVAQSGAELMPVDSEHNAIFQCLPTEIQTQLGRCDLSQHGIDH
EEECCCEEEEECHHHHHHHHHCCCCEECCCCCCCHHEEECCHHHHHHHCCCCCCCCCCCE
ILLTGSGGPFRYSDLATLDSVTPEQAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFN
EEEECCCCCEECCCHHHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHHCC
TSREQLKVLIHPQSVIHSMVQYQDGSVIAQLGEPDMATPISYAMAYPERVTAGVPALDFT
CCHHHEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHHH
RLQQLTFMEVDFARYPCLQLAMDACFLGQHATTSLNAANEVAVDAFLKRKIRFTDIALIN
HHHHHHHEEHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHEEEHH
DQVLSKVCATNTQLHCRDLESLLELDTMARHFAHQVLKERQA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKLTILGATGSIGASTLKVIAQNPQQFSIVALVAGVNVAKMYQLCQQWRPKYAVMATAS
CCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHCCCEEEEEEHH
AASELQGLLKNQAMATEVLYGEEAMCQVAALDDVDTVMAAIVGAAGLLPTMAAVKAGKRV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKEALVMSGQLFIDAVAQSGAELMPVDSEHNAIFQCLPTEIQTQLGRCDLSQHGIDH
EEECCCEEEEECHHHHHHHHHCCCCEECCCCCCCHHEEECCHHHHHHHCCCCCCCCCCCE
ILLTGSGGPFRYSDLATLDSVTPEQAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFN
EEEECCCCCEECCCHHHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHHCC
TSREQLKVLIHPQSVIHSMVQYQDGSVIAQLGEPDMATPISYAMAYPERVTAGVPALDFT
CCHHHEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHHH
RLQQLTFMEVDFARYPCLQLAMDACFLGQHATTSLNAANEVAVDAFLKRKIRFTDIALIN
HHHHHHHEEHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHEEEHH
DQVLSKVCATNTQLHCRDLESLLELDTMARHFAHQVLKERQA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA