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The map label for this gene is lpxB

Identifier: 147673997

GI number: 147673997

Start: 1955238

End: 1956377

Strand: Reverse

Name: lpxB

Synonym: VC0395_A1838

Alternate gene names: 147673997

Gene position: 1956377-1955238 (Counterclockwise)

Preceding gene: 147674688

Following gene: 147673627

Centisome position: 64.69

GC content: 51.84

Gene sequence:

>1140_bases
GTGAATAGACCATTACGGATTGGCATAGTTGTTGGGGAGCTCTCTGGCGACACCTTAGGCGAAGGCTTTATCAAAGCGAT
ACGTGCTCGTTACCCAGATGCTGAGTTTGTCGGCATCGGTGGGCCGAAAATGAACGCACTTGGCTGTCAATCTCTGTTTG
ATATGGAAGAGTTGGCCGTGATGGGTTTAGTGGAAGTGCTTGGCCGCTTGCCGCGCCTGCTGAAAGTCAAAGCCGAGCTG
GTTAAGTATTTCACTGCCAATCCGCCGGATGTTTTCGTGGGTATCGATGCGCCGGATTTTAATTTACGCCTTGAGCTGAG
CCTTAAACAAGCGGGGATCAAAACCGTACATTACGTCAGTCCATCAGTGTGGGCGTGGCGACAAAACCGCATTCATGGCA
TTGCCGCGGCGACGCATTTAGTGTTGGCCTTCCTTCCATTTGAGAAAGCGTTTTACGACAAATTCAATGTGCCTTGTGAG
TTTATCGGTCATACCTTGGCGGATTCGATCCCGTTAGCGTCCGATAAGTTAGCCGCTCGCCAACTGCTTGGTCTGGATGA
GCAGCGCCGCTGGTTAGCCGTTTTGCCGGGCAGCCGTGGCAGTGAAATGAAGATGCTCGCGGAGCCCTTTATCGCCACCT
GTCAAAAACTGCAGGCGCGCTATCCAGATCTTGGCTTTGTGGTGGCCTTGGTGAATGCTAAACGTCGTGCGCAGTTTGAA
CAGGCTTGGCAACAAGTCGCTCCTGAGCTGAATTTTGTGCTGGTGGATGATACCGCGCGCAATGTGATTACTGCAGCCGA
TGCGGTGATGCTTGCCTCCGGCACGGTGGCCTTGGAGTGCATGCTGCTTAAACGCCCTATGGTGGTCGGTTATCGCGTGA
ATGCCTTTACGGCCTTTTTGGCCAAACGTCTGCTGAAAACGCCGTATGTCTCTTTGCCGAATATCTTGGCGGGAGAGGAA
CTGGTGAAAGAGCTGCTGCAAGATCATTGCACCGTCGACAACCTTTACCATGAAGTGAGCCGTTTACTCGAAAGCGACAA
CCAAGCCTTGATGGACAAATTTACCGAAATGCATCAATGGATCCGTAAAGATGCGGATCAGCAAGCGGCGCAAGCTGTGC
TGCATTTGATTCAGAAATAA

Upstream 100 bases:

>100_bases
TGCATTTCTGTACTCTGGCGAGTGTCAAAACAGGGGAGATACCACCCAAGTGGCGAAGGCTTGAGTATCCATCAGCGCAT
GATGAACTGCGGAGGAAACC

Downstream 100 bases:

>100_bases
CATTAACCAGATTGAGAAGATACCATGGCGAAGAAACCAAGCATTGAGCTGCCTCCCTTTGAGATTCCTGCAGGTTATGC
CTTGATTGCTGGAGTGGATG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNRPLRIGIVVGELSGDTLGEGFIKAIRARYPDAEFVGIGGPKMNALGCQSLFDMEELAVMGLVEVLGRLPRLLKVKAEL
VKYFTANPPDVFVGIDAPDFNLRLELSLKQAGIKTVHYVSPSVWAWRQNRIHGIAAATHLVLAFLPFEKAFYDKFNVPCE
FIGHTLADSIPLASDKLAARQLLGLDEQRRWLAVLPGSRGSEMKMLAEPFIATCQKLQARYPDLGFVVALVNAKRRAQFE
QAWQQVAPELNFVLVDDTARNVITAADAVMLASGTVALECMLLKRPMVVGYRVNAFTAFLAKRLLKTPYVSLPNILAGEE
LVKELLQDHCTVDNLYHEVSRLLESDNQALMDKFTEMHQWIRKDADQQAAQAVLHLIQK

Sequences:

>Translated_379_residues
MNRPLRIGIVVGELSGDTLGEGFIKAIRARYPDAEFVGIGGPKMNALGCQSLFDMEELAVMGLVEVLGRLPRLLKVKAEL
VKYFTANPPDVFVGIDAPDFNLRLELSLKQAGIKTVHYVSPSVWAWRQNRIHGIAAATHLVLAFLPFEKAFYDKFNVPCE
FIGHTLADSIPLASDKLAARQLLGLDEQRRWLAVLPGSRGSEMKMLAEPFIATCQKLQARYPDLGFVVALVNAKRRAQFE
QAWQQVAPELNFVLVDDTARNVITAADAVMLASGTVALECMLLKRPMVVGYRVNAFTAFLAKRLLKTPYVSLPNILAGEE
LVKELLQDHCTVDNLYHEVSRLLESDNQALMDKFTEMHQWIRKDADQQAAQAVLHLIQK
>Mature_379_residues
MNRPLRIGIVVGELSGDTLGEGFIKAIRARYPDAEFVGIGGPKMNALGCQSLFDMEELAVMGLVEVLGRLPRLLKVKAEL
VKYFTANPPDVFVGIDAPDFNLRLELSLKQAGIKTVHYVSPSVWAWRQNRIHGIAAATHLVLAFLPFEKAFYDKFNVPCE
FIGHTLADSIPLASDKLAARQLLGLDEQRRWLAVLPGSRGSEMKMLAEPFIATCQKLQARYPDLGFVVALVNAKRRAQFE
QAWQQVAPELNFVLVDDTARNVITAADAVMLASGTVALECMLLKRPMVVGYRVNAFTAFLAKRLLKTPYVSLPNILAGEE
LVKELLQDHCTVDNLYHEVSRLLESDNQALMDKFTEMHQWIRKDADQQAAQAVLHLIQK

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=379, Percent_Identity=60.4221635883905, Blast_Score=452, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_VIBC3 (A5F627)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F627
- STRING:   A5F627
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1838
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- BioCyc:   VCHO345073:VC0395_A1838-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42251; Mature: 42251

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRPLRIGIVVGELSGDTLGEGFIKAIRARYPDAEFVGIGGPKMNALGCQSLFDMEELAV
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
MGLVEVLGRLPRLLKVKAELVKYFTANPPDVFVGIDAPDFNLRLELSLKQAGIKTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEEHHCCCCEEEECC
PSVWAWRQNRIHGIAAATHLVLAFLPFEKAFYDKFNVPCEFIGHTLADSIPLASDKLAAR
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHH
QLLGLDEQRRWLAVLPGSRGSEMKMLAEPFIATCQKLQARYPDLGFVVALVNAKRRAQFE
HHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QAWQQVAPELNFVLVDDTARNVITAADAVMLASGTVALECMLLKRPMVVGYRVNAFTAFL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEHHHHHHHH
AKRLLKTPYVSLPNILAGEELVKELLQDHCTVDNLYHEVSRLLESDNQALMDKFTEMHQW
HHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IRKDADQQAAQAVLHLIQK
HHHCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRPLRIGIVVGELSGDTLGEGFIKAIRARYPDAEFVGIGGPKMNALGCQSLFDMEELAV
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
MGLVEVLGRLPRLLKVKAELVKYFTANPPDVFVGIDAPDFNLRLELSLKQAGIKTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEEHHCCCCEEEECC
PSVWAWRQNRIHGIAAATHLVLAFLPFEKAFYDKFNVPCEFIGHTLADSIPLASDKLAAR
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHH
QLLGLDEQRRWLAVLPGSRGSEMKMLAEPFIATCQKLQARYPDLGFVVALVNAKRRAQFE
HHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QAWQQVAPELNFVLVDDTARNVITAADAVMLASGTVALECMLLKRPMVVGYRVNAFTAFL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEHHHHHHHH
AKRLLKTPYVSLPNILAGEELVKELLQDHCTVDNLYHEVSRLLESDNQALMDKFTEMHQW
HHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IRKDADQQAAQAVLHLIQK
HHHCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA