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The map label for this gene is adk

Identifier: 147673458

GI number: 147673458

Start: 541219

End: 541863

Strand: Direct

Name: adk

Synonym: VC0395_A0507

Alternate gene names: 147673458

Gene position: 541219-541863 (Clockwise)

Preceding gene: 147674825

Following gene: 147674210

Centisome position: 17.9

GC content: 46.98

Gene sequence:

>645_bases
ATGCGCATCATTCTTCTCGGTGCTCCGGGTGCAGGTAAAGGCACACAAGCTCAATTCATCATGGAAAAATTTGGTATTCC
ACAAATTTCTACTGGTGACATGCTGCGTGCAGCCATTAAGGCGGGCACTGAGCTCGGTAAGCAAGCGAAAGCGGTAATCG
ATGCAGGACAATTGGTATCGGATGACATCATTTTAGGCCTTATCAAAGAGCGTATTGCTCAGGCTGACTGTGAGAAAGGT
TTCCTGCTAGATGGTTTCCCTCGCACGATTCCACAAGCCGATGGCCTAAAAGAGATGGGTATCAATGTTGACTATGTGAT
TGAATTTGACGTAGCGGATGATGTGATTGTTGAGCGTATGGCGGGTCGTCGTGCTCATCTACCTTCAGGCCGTACGTACC
ACGTAGTGTACAATCCACCTAAAGTTGAAGGTAAAGATGACGTAACGGGTGAAGACCTTGTGATCCGTGAAGATGACAAA
GAAGAAACCGTACGTGCGCGTCTGAATGTTTACCACACCCAAACTGCGCCACTTATTGAATACTACGGTAAAGAAGCAGC
TGCAGGTAAAACTCAATACCTGAAGTTTGACGGCACTAAGCAAGTGAGCGAAGTGAGTGCTGACATTGCTAAAGCGTTGG
CTTAA

Upstream 100 bases:

>100_bases
CGCTGTGCGGGCTGTTCTGTCTGTTATACCGAAACTTACCGTGAGTATTTGCAAGCGCTGTGAGCTTCGGTATAAAAATC
AATTAGTATGAGGATAAAAC

Downstream 100 bases:

>100_bases
TCATTATTGTGATGTGCTGATTGCATTGATAGGTGAAATAAAGCGGCAGTAAAGCCGCTTTTTTTATAAACTTTTTACCA
GAAAGAGACGTAATAACGTA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMEKFGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDDIILGLIKERIAQADCEKG
FLLDGFPRTIPQADGLKEMGINVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVIREDDK
EETVRARLNVYHTQTAPLIEYYGKEAAAGKTQYLKFDGTKQVSEVSADIAKALA

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMEKFGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDDIILGLIKERIAQADCEKG
FLLDGFPRTIPQADGLKEMGINVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVIREDDK
EETVRARLNVYHTQTAPLIEYYGKEAAAGKTQYLKFDGTKQVSEVSADIAKALA
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMEKFGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDDIILGLIKERIAQADCEKG
FLLDGFPRTIPQADGLKEMGINVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVIREDDK
EETVRARLNVYHTQTAPLIEYYGKEAAAGKTQYLKFDGTKQVSEVSADIAKALA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=51.063829787234, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=51.063829787234, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=45.4054054054054, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=44.5652173913043, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=44.5652173913043, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=44.5652173913043, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=44.5652173913043, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=29.5698924731183, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=30.0546448087432, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI28144899, Length=213, Percent_Identity=28.6384976525822, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI28144897, Length=213, Percent_Identity=28.6384976525822, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=29.4930875576037, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=24.4604316546763, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=73.7089201877934, Blast_Score=333, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=44.954128440367, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=34.2723004694836, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=32.967032967033, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=216, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=29.3023255813954, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=218, Percent_Identity=45.8715596330275, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=193, Percent_Identity=44.0414507772021, Blast_Score=154, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6322828, Length=215, Percent_Identity=29.7674418604651, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=47.6190476190476, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17737899, Length=185, Percent_Identity=45.4054054054054, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24645822, Length=185, Percent_Identity=45.4054054054054, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=34.2541436464088, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=34.2541436464088, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=29.5774647887324, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=29.5774647887324, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_VIBC3 (A5F2U0)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F2U0
- SMR:   A5F2U0
- STRING:   A5F2U0
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0507
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   VCHO345073:VC0395_A0507-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23277; Mature: 23277

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMEKFGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
DDIILGLIKERIAQADCEKGFLLDGFPRTIPQADGLKEMGINVDYVIEFDVADDVIVERM
HHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHCCCEEEEEEECCHHHHHHHHH
AGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVIREDDKEETVRARLNVYHTQTAPLIE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHEECCCCHHHH
YYGKEAAAGKTQYLKFDGTKQVSEVSADIAKALA
HHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMEKFGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
DDIILGLIKERIAQADCEKGFLLDGFPRTIPQADGLKEMGINVDYVIEFDVADDVIVERM
HHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHCCCEEEEEEECCHHHHHHHHH
AGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVIREDDKEETVRARLNVYHTQTAPLIE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHEECCCCHHHH
YYGKEAAAGKTQYLKFDGTKQVSEVSADIAKALA
HHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA