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The map label for this gene is hemH [H]

Identifier: 147674210

GI number: 147674210

Start: 541978

End: 542952

Strand: Direct

Name: hemH [H]

Synonym: VC0395_A0508

Alternate gene names: 147674210

Gene position: 541978-542952 (Clockwise)

Preceding gene: 147673458

Following gene: 147674992

Centisome position: 17.92

GC content: 47.59

Gene sequence:

>975_bases
TTGAAGGAAGCCATGAATAATCATAAAAAACTTGGCATTTTGCTTGCCAACTTAGGTACTCCGCAAGCGCCAACCTCTCA
AGCGGTAAAAGCGTTTTTGAGCCAATTTCTGCATGATCAGCGAGTGGTAGACATGAGTCGTTGGTTATGGTGCCCCCTTT
TACATGGCATTATCTTGCCAACGCGATCGCCTAAGGTGGCTAAGCTGTATCAATCAATCTGGATGGATGAGGGATCGCCT
TTGATGGTCTACTCTCGACGTCAACGCGATAAATTGGCAGAGCTTAGCCAACGGCCTGTTGAGCTAGGGATGACCTACGG
AGAGCCGAGTTTATTGGAGGGTGTACGCAAGTTGCAGCAACAAGGTGTTGAACAGATAGTGGTGCTGCCGCTTTATCCGC
AATATTCCGCGACGACAACGGCGGCGGTGTTTGATGGTCTCGCCAAAGCGTTGCGTCAGTTACCTGTAGTCCCTGAATTG
CACTTTATTCGTGATTATCATGACCATCCACTCTATATCCAAGCCCTCGCGAAAAGCGTTCGTGCTTCATGGCAACAACA
TGGACAAGGTGATCTGTTACTCTGCTCTTACCATGGTATTCCCAAACGTTATGCGCAAAATGGCGATATCTACCCAGAGC
ATTGCCTAAAAACCACAGAGTTATTGGCTCAAGCATTAGGATTGCCTCAAGATAAAGTCATGATGACTTACCAATCTCAG
TTTGGTAAGGAAGAGTGGCTGCAGCCATACACGGACAAGACGATGGAAGCGCTTCCTCGCCAAGGCATTAAAAAGCTTGA
TGTTATTTGCCCTGCCTTTTCAGTGGACTGCTTAGAAACGCTGGAAGAAATTGCTGAGCAGAACCAAGAAATCTTTTTGC
ACAGTGGTGGCGAAGCGTTCCACTATGTCCCCTGTTTGAATGACAGTCAGAGCCACATTGAGCTGATGGCCGCGCTGGTT
AAAGCCCATTGTTAA

Upstream 100 bases:

>100_bases
TGCTGATTGCATTGATAGGTGAAATAAAGCGGCAGTAAAGCCGCTTTTTTTATAAACTTTTTACCAGAAAGAGACGTAAT
AACGTATTCAACAGTGCATT

Downstream 100 bases:

>100_bases
GCTTCAACGTGAGCGAGTCATGCATAAAGCAGCCATACAAAAACAGCGCCTCATTCGGCGCTGTTTTCAGTTCCACGGCG
TATTTATGATTCCATCTTTA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILPTRSPKVAKLYQSIWMDEGSP
LMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQQGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPEL
HFIRDYHDHPLYIQALAKSVRASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAFHYVPCLNDSQSHIELMAALV
KAHC

Sequences:

>Translated_324_residues
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILPTRSPKVAKLYQSIWMDEGSP
LMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQQGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPEL
HFIRDYHDHPLYIQALAKSVRASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAFHYVPCLNDSQSHIELMAALV
KAHC
>Mature_324_residues
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILPTRSPKVAKLYQSIWMDEGSP
LMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQQGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPEL
HFIRDYHDHPLYIQALAKSVRASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAFHYVPCLNDSQSHIELMAALV
KAHC

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=329, Percent_Identity=24.0121580547112, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI60499021, Length=329, Percent_Identity=24.0121580547112, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=59.3650793650794, Blast_Score=377, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324750, Length=342, Percent_Identity=26.6081871345029, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17864156, Length=332, Percent_Identity=25.6024096385542, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24651774, Length=265, Percent_Identity=25.2830188679245, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36702; Mature: 36702

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILP
CCCHHHCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TRSPKVAKLYQSIWMDEGSPLMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQ
CCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
QGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPELHFIRDYHDHPLYIQALAKSV
CCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHH
RASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
HHHHHHCCCCCEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAF
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCEE
HYVPCLNDSQSHIELMAALVKAHC
EEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILP
CCCHHHCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TRSPKVAKLYQSIWMDEGSPLMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQ
CCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
QGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPELHFIRDYHDHPLYIQALAKSV
CCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHH
RASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
HHHHHHCCCCCEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAF
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCEE
HYVPCLNDSQSHIELMAALVKAHC
EEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]