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The map label for this gene is hisC

Identifier: 147673356

GI number: 147673356

Start: 728081

End: 729121

Strand: Direct

Name: hisC

Synonym: VC0395_A0704

Alternate gene names: 147673356

Gene position: 728081-729121 (Clockwise)

Preceding gene: 147673851

Following gene: 147673310

Centisome position: 24.08

GC content: 49.47

Gene sequence:

>1041_bases
ATGGAAAAACTGGCTCGTCAACAAATTCAGGCGTTAACCCCATACCTTTCTGCGCGTCGTATTGGTGGTAGTGGTGATGT
TTGGCTCAATGCTAACGAATCGCCTTTCAATAACGAATACAAAACCGATTTTGCGCGCCTTAATCGTTACAGTGATTGCC
AACCTAAGGCGATGATCCAAGCTTACGCTAATTACGCTGGAGTACAGCCGGAGCAAGTGCTGACTTCGCGCGGCGCGGAT
GAAGGGATTGAGCTTTTGATCCGTGCGTTTTGCGAACCCAATCAGGATGCGATTCTGTTCTGCCCTCCAACCTATGGCAT
GTACGCGATCAGTGCAGAAACCTTTGGTGTTGAGCGTAAAAAAGTGCCGTTGACTACTGATTGGCAACTCGATTTACCGA
GCATTGAGGCCAATCTGGATCGCGTTAAATTGGTGTTTGTGTGTAGCCCGAATAACCCGACTGGCAACTTGGTCAAACGT
GCTGACATCATCAAACTGCTGGAGATGACCCAAGATCGCGCGATTGTGGTGATGGATGAAGCCTACATCGATTTCTGCCC
AGAGGCATCGACGGTTGATTTGCTCGCCCAATATCCGAACTTGGCGATTCTACGCACACTCTCTAAAGCTTTTGCTTTGG
CGGGACTACGCTGTGGCTTCACGCTTGCCAATGCTGAACTCATCAATGTGTTACTCAAAGTGATCGCGCCTTATCCGGTG
CCAGTGCCGGTTGCCGAAATCGCGGTGCAAGCCTTATCACCTGCAGGTCTCGCGCGCGCCAAATACCAAGTATTGGATCT
CGGCGCGAATCGAGCTTACCTACAAGTGGGGCTCTCTATGGTTCCGGGTGTGCAGGTTTTTGAAGGTTGGGGTAACTATC
TATTAGTGAAATTCCCTGATGGTGATGCACTGTTTAAAGCGGCGTGGGAGCACGGCATTATTTTGCGTAATTCACCGATT
GAAAACTGTGTGCGTATCAGTGTTGGCAATCGCGAAGAGTGTGAAAAAACCGTCGCGTTTATTCGCAACTACTACCAGTA
A

Upstream 100 bases:

>100_bases
TGCGCCCACCGTAGTAACGATGGCGGAAGCGGAAGGGTTAGACGCGCACAAACGTGCGGTTACGATTCGAGTAGAAAAAT
TACAGAAGGCTCAATAAATT

Downstream 100 bases:

>100_bases
TTTTGTTTACAGCAGCTCGCTGCGCGGGCTGCTGATGAAAAGGACATTCTTGTGAGCAAACAACAAAAAATTCTTTTTAT
CGACCGCGACGGCACCTTAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEKLARQQIQALTPYLSARRIGGSGDVWLNANESPFNNEYKTDFARLNRYSDCQPKAMIQAYANYAGVQPEQVLTSRGAD
EGIELLIRAFCEPNQDAILFCPPTYGMYAISAETFGVERKKVPLTTDWQLDLPSIEANLDRVKLVFVCSPNNPTGNLVKR
ADIIKLLEMTQDRAIVVMDEAYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANAELINVLLKVIAPYPV
PVPVAEIAVQALSPAGLARAKYQVLDLGANRAYLQVGLSMVPGVQVFEGWGNYLLVKFPDGDALFKAAWEHGIILRNSPI
ENCVRISVGNREECEKTVAFIRNYYQ

Sequences:

>Translated_346_residues
MEKLARQQIQALTPYLSARRIGGSGDVWLNANESPFNNEYKTDFARLNRYSDCQPKAMIQAYANYAGVQPEQVLTSRGAD
EGIELLIRAFCEPNQDAILFCPPTYGMYAISAETFGVERKKVPLTTDWQLDLPSIEANLDRVKLVFVCSPNNPTGNLVKR
ADIIKLLEMTQDRAIVVMDEAYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANAELINVLLKVIAPYPV
PVPVAEIAVQALSPAGLARAKYQVLDLGANRAYLQVGLSMVPGVQVFEGWGNYLLVKFPDGDALFKAAWEHGIILRNSPI
ENCVRISVGNREECEKTVAFIRNYYQ
>Mature_346_residues
MEKLARQQIQALTPYLSARRIGGSGDVWLNANESPFNNEYKTDFARLNRYSDCQPKAMIQAYANYAGVQPEQVLTSRGAD
EGIELLIRAFCEPNQDAILFCPPTYGMYAISAETFGVERKKVPLTTDWQLDLPSIEANLDRVKLVFVCSPNNPTGNLVKR
ADIIKLLEMTQDRAIVVMDEAYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANAELINVLLKVIAPYPV
PVPVAEIAVQALSPAGLARAKYQVLDLGANRAYLQVGLSMVPGVQVFEGWGNYLLVKFPDGDALFKAAWEHGIILRNSPI
ENCVRISVGNREECEKTVAFIRNYYQ

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=344, Percent_Identity=60.1744186046512, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322075, Length=375, Percent_Identity=32.8, Blast_Score=170, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_VIBC3 (A5F2A2)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F2A2
- SMR:   A5F2A2
- STRING:   A5F2A2
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0704
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   IMRVIAP
- ProtClustDB:   PRK04635
- BioCyc:   VCHO345073:VC0395_A0704-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38360; Mature: 38360

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLARQQIQALTPYLSARRIGGSGDVWLNANESPFNNEYKTDFARLNRYSDCQPKAMIQ
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
AYANYAGVQPEQVLTSRGADEGIELLIRAFCEPNQDAILFCPPTYGMYAISAETFGVERK
HHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEHHHHCCCCC
KVPLTTDWQLDLPSIEANLDRVKLVFVCSPNNPTGNLVKRADIIKLLEMTQDRAIVVMDE
CCCCCCCCEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
AYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANAELINVLLKVIAPYPV
HHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCC
PVPVAEIAVQALSPAGLARAKYQVLDLGANRAYLQVGLSMVPGVQVFEGWGNYLLVKFPD
CCCHHHHHHHHCCCCHHHHHEEEEEECCCCCEEEEECHHHCCCHHEEECCCCEEEEEECC
GDALFKAAWEHGIILRNSPIENCVRISVGNREECEKTVAFIRNYYQ
CCHHHHHHHHCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKLARQQIQALTPYLSARRIGGSGDVWLNANESPFNNEYKTDFARLNRYSDCQPKAMIQ
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
AYANYAGVQPEQVLTSRGADEGIELLIRAFCEPNQDAILFCPPTYGMYAISAETFGVERK
HHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEHHHHCCCCC
KVPLTTDWQLDLPSIEANLDRVKLVFVCSPNNPTGNLVKRADIIKLLEMTQDRAIVVMDE
CCCCCCCCEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
AYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANAELINVLLKVIAPYPV
HHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCC
PVPVAEIAVQALSPAGLARAKYQVLDLGANRAYLQVGLSMVPGVQVFEGWGNYLLVKFPD
CCCHHHHHHHHCCCCHHHHHEEEEEECCCCCEEEEECHHHCCCHHEEECCCCEEEEEECC
GDALFKAAWEHGIILRNSPIENCVRISVGNREECEKTVAFIRNYYQ
CCHHHHHHHHCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA