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The map label for this gene is hisD [H]

Identifier: 147673851

GI number: 147673851

Start: 726782

End: 728077

Strand: Direct

Name: hisD [H]

Synonym: VC0395_A0703

Alternate gene names: 147673851

Gene position: 726782-728077 (Clockwise)

Preceding gene: 147674443

Following gene: 147673356

Centisome position: 24.03

GC content: 51.62

Gene sequence:

>1296_bases
ATGAGAACCGTGGTTTGGCAATCGTTGAGTGAAGCTCAGCAAGAATCGATTTTAGAACGTCCTGCGATTACCGAAGGAGC
AAACATCACTGCCGCAGTTGCGCAGGTGATTGCGAAAGTGCGCAGTGAGGGTGATGCCGCACTGTTTGAATTAACTGAAA
AATTTGATCGTGTAAAACCCGCTTCACTGCGCGTATCTCGCGAAGAGATGGATGCCGCGGCCGCGAGTTTGTCGGAAACA
ATGAAACAGGCGTTGGAGCAGGCATACAACAACATCAGCAAATTCCACAAGGCGCAAAAAGCGCAACCAATCAAAGTGGA
AACCATGCCCGGAGTGGTGTGTGAGCAAGTCACTCGTCCGATCAACAAAGTGGGTCTGTATATTCCGGGTGGCAGCGCAC
CGCTACCATCAACCGTACTAATGCTCGGTGTGCCTGCGCAAATCGCTGGTTGTCGTAAAGTGGTGCTCTGCTCACCTCCG
CCAATTGCTGATGAAATTCTCTACGTCGCTAAGCTGTGTAACATCGATGAGGTGTACAACCTAGGCGGCGGTCAGGCAAT
CGCCGCAATGGCTTACGGTACGGAAACGGTGACTAAAGTTGACAAAATCTTTGGCCCCGGTAACGCCTATGTGACGGAAG
CAAAACGCCAAGTGAGTAACGATTTCCGTGGCGCAGCGATTGATATGCCTGCAGGACCTTCAGAAGTATTGGTGATTGCT
GATGAAACGGCGGATGCCAATTTTATCGCCGCCGATCTACTCAGTCAGGCAGAGCACGGCCCAGATTCACAGGTGGTTCT
GGTCACACCATCACCAGTGTTGGCCGATCAAGTGACGGACGCAGTGCAAAAGCAGCTTAAAGTGCTTTCGCGCGCCAGCA
TTGCTGAAAAAGCCTTGGCTTCCAGTCTGATCATTATTGCTGAATCACTCACCCAAGCAGTGTCGATTTCTAACTACTAC
GGCCCTGAGCACTTGATTGTGCAGACGCGCAACCCGCGTGAGTTGGTTCCACTGCTCGATAACGCAGGCTCCATTTTCCT
TGGCGATTGGTCGCCAGAATCGGTAGGCGATTACGCTTCTGGTACCAACCATGTGCTACCCACTTACGGTTACACCCGCA
CCTATTCCAGCTTAGGTTTGGCCGATTTCAGTAAACGCATGACAGTGCAAGAGCTGACCGCTGATGGCTTGCAATTGCTT
GCGCCCACCGTAGTAACGATGGCGGAAGCGGAAGGGTTAGACGCGCACAAACGTGCGGTTACGATTCGAGTAGAAAAATT
ACAGAAGGCTCAATAA

Upstream 100 bases:

>100_bases
AGTTCGGAAAATCTATTCTGGGAAACCATGGAGCAGCTGAAAGCCCTCGGTGCTAGCTCAATTTTGGTGTTACCGATTGA
AAAAATGATGGAGTAAGGCG

Downstream 100 bases:

>100_bases
ATTATGGAAAAACTGGCTCGTCAACAAATTCAGGCGTTAACCCCATACCTTTCTGCGCGTCGTATTGGTGGTAGTGGTGA
TGTTTGGCTCAATGCTAACG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKPASLRVSREEMDAAAASLSET
MKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRPINKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNLGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALASSLIIIAESLTQAVSISNYY
GPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLL
APTVVTMAEAEGLDAHKRAVTIRVEKLQKAQ

Sequences:

>Translated_431_residues
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKPASLRVSREEMDAAAASLSET
MKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRPINKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNLGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALASSLIIIAESLTQAVSISNYY
GPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLL
APTVVTMAEAEGLDAHKRAVTIRVEKLQKAQ
>Mature_431_residues
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKPASLRVSREEMDAAAASLSET
MKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRPINKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNLGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALASSLIIIAESLTQAVSISNYY
GPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLL
APTVVTMAEAEGLDAHKRAVTIRVEKLQKAQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=424, Percent_Identity=63.2075471698113, Blast_Score=553, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=50.5966587112172, Blast_Score=404, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46058; Mature: 46058

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKP
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ASLRVSREEMDAAAASLSETMKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRP
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCC
INKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVAKLCNIDEVYN
HHHCEEEECCCCCCCCCHHEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHC
LGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCCCEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALA
ECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIIIAESLTQAVSISNYYGPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYAS
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEE
TIRVEKLQKAQ
EEEEHHHHCCC
>Mature Secondary Structure
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKP
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ASLRVSREEMDAAAASLSETMKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRP
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCC
INKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVAKLCNIDEVYN
HHHCEEEECCCCCCCCCHHEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHC
LGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCCCEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALA
ECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIIIAESLTQAVSISNYYGPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYAS
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEE
TIRVEKLQKAQ
EEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]