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The map label for this gene is hmgA [H]

Identifier: 146343719

GI number: 146343719

Start: 7251677

End: 7253026

Strand: Reverse

Name: hmgA [H]

Synonym: BRADO6966

Alternate gene names: 146343719

Gene position: 7253026-7251677 (Counterclockwise)

Preceding gene: 146343720

Following gene: 146343718

Centisome position: 97.27

GC content: 66.15

Gene sequence:

>1350_bases
ATGATGAACATCAACACATCGCCTGACCGGCTAAGCCGTGCGACTGGGCAGGTCACGCCCGGCTACATGTCCGGCTTCGG
CAATTCGTTCGAGACCGAGGCGCTGCCCGGCGCCTTGCCGATCGGCCGCAACTCGCCGCAGCGCTGCGCCTATGGGCTCT
ATGCCGAGCAGCTCTCCGGCTCGCCGTTCACCGCCCCGCGCGGCTCCAACGAGCGCTCCTGGCTGTACCGCATCCGGCCC
TCGGTGAAGCACTCTGGCCGCTTCGCCAAGGTCGACGCCGGGCTGTGGCGCACCGCGCCGTGCCACGAGCAGGAGATCAC
GGTGCAGCAGCTGCGCTGGGATCCGACGCCGATGCCGGCGGGCGAGGTCACGTTCCTGCAGGGCGTGCAAACGATGACGA
CGGCGGGCGATGCGGCGACGCAGGCCGGCATGGCCGCGCATGTCTACGTCATCACCAAGTCGATGGTCGACCAGCACTTC
TACAATGCCGATGGCGAGCTGATGTTCGTGCTGCAGCAGGGGCGCCTGCTGTTCGTCACCGAGTTCGGCCGCATCGATGC
CGAGCCCGGCGAGATCGTCGTGATTCCGCGCGGCGTGAAGTTCCGGGTTGAGATCCCCGCCGGCCCGGCGCGCGGTTATC
TCTGCGAGAACTATGGCGGCGCCTTCACCCTGCCGGAGCGCGGCCCGATCGGCGCCAACTGCCTCGCCAATGCCCGCGAC
TTCCTGACGCCGGTCGCGTCCTACGAGGACAAGGACACGCCGACCGAGCTCTACGTGAAGTGGGGCGGCGCGCTGTTCAA
GACCGAGCTGAAGCATTCGCCGATCGACGTCGTCGCCTGGCACGGCAACTACGCGCCCTACAAATACGACCTCCGCACCT
TTTCGCCGGTCGGCGCCATCGGCTTCGATCATCCCGATCCGTCCATCTTCACGGTGCTGACCTCGCCGTCGGAAACCGCC
GGCACGGCCAACATCGATTTCGTGATCTTCCCCGAGCGCTGGATGGTGGCCGACAACACCTTCCGTCCGCCTTGGTATCA
CATGAACATCATGTCGGAGTTCATGGGCCTGATCTACGGCGTCTACGACGCCAAGCCGCAAGGCTTCGTGCCCGGCGGCA
TGAGCCTGCACAATTGCATGCTGCCGCACGGCCCGGACCGCGAGGCGTTCGACCACGCCAGCAACAGCGAGCTGAAGCCG
GTGAAGCTGACGGGCACCATGGCCTTCATGTTCGAGACCCGCTTCCCGCAGCGGATCACCAGGCATGCCGCCGAGTCCGG
CACCCTGCAGCCGGACTACGCCGATTGCTGGAACGGATTGGAAAAGCGCTTCGATCCGAACAGGCCGTAG

Upstream 100 bases:

>100_bases
ACGTGTCCCGCGCCTATGACGAAGCCAGCGGCATCGACGATCCCGTGATCTGGACCGCCGAGCGCGACCGCGAGATGTGG
GCCCGCCTGCAGGGAGAAGG

Downstream 100 bases:

>100_bases
GCTGAGCCATGTCACCGCCGTCATGGCCGGGCTTGACCCGGCCATCCACGTCTATCAGCCCGCCGGGTGGATATGGATGC
CCGGGTCAAGCCCGGGCATG

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MMNINTSPDRLSRATGQVTPGYMSGFGNSFETEALPGALPIGRNSPQRCAYGLYAEQLSGSPFTAPRGSNERSWLYRIRP
SVKHSGRFAKVDAGLWRTAPCHEQEITVQQLRWDPTPMPAGEVTFLQGVQTMTTAGDAATQAGMAAHVYVITKSMVDQHF
YNADGELMFVLQQGRLLFVTEFGRIDAEPGEIVVIPRGVKFRVEIPAGPARGYLCENYGGAFTLPERGPIGANCLANARD
FLTPVASYEDKDTPTELYVKWGGALFKTELKHSPIDVVAWHGNYAPYKYDLRTFSPVGAIGFDHPDPSIFTVLTSPSETA
GTANIDFVIFPERWMVADNTFRPPWYHMNIMSEFMGLIYGVYDAKPQGFVPGGMSLHNCMLPHGPDREAFDHASNSELKP
VKLTGTMAFMFETRFPQRITRHAAESGTLQPDYADCWNGLEKRFDPNRP

Sequences:

>Translated_449_residues
MMNINTSPDRLSRATGQVTPGYMSGFGNSFETEALPGALPIGRNSPQRCAYGLYAEQLSGSPFTAPRGSNERSWLYRIRP
SVKHSGRFAKVDAGLWRTAPCHEQEITVQQLRWDPTPMPAGEVTFLQGVQTMTTAGDAATQAGMAAHVYVITKSMVDQHF
YNADGELMFVLQQGRLLFVTEFGRIDAEPGEIVVIPRGVKFRVEIPAGPARGYLCENYGGAFTLPERGPIGANCLANARD
FLTPVASYEDKDTPTELYVKWGGALFKTELKHSPIDVVAWHGNYAPYKYDLRTFSPVGAIGFDHPDPSIFTVLTSPSETA
GTANIDFVIFPERWMVADNTFRPPWYHMNIMSEFMGLIYGVYDAKPQGFVPGGMSLHNCMLPHGPDREAFDHASNSELKP
VKLTGTMAFMFETRFPQRITRHAAESGTLQPDYADCWNGLEKRFDPNRP
>Mature_449_residues
MMNINTSPDRLSRATGQVTPGYMSGFGNSFETEALPGALPIGRNSPQRCAYGLYAEQLSGSPFTAPRGSNERSWLYRIRP
SVKHSGRFAKVDAGLWRTAPCHEQEITVQQLRWDPTPMPAGEVTFLQGVQTMTTAGDAATQAGMAAHVYVITKSMVDQHF
YNADGELMFVLQQGRLLFVTEFGRIDAEPGEIVVIPRGVKFRVEIPAGPARGYLCENYGGAFTLPERGPIGANCLANARD
FLTPVASYEDKDTPTELYVKWGGALFKTELKHSPIDVVAWHGNYAPYKYDLRTFSPVGAIGFDHPDPSIFTVLTSPSETA
GTANIDFVIFPERWMVADNTFRPPWYHMNIMSEFMGLIYGVYDAKPQGFVPGGMSLHNCMLPHGPDREAFDHASNSELKP
VKLTGTMAFMFETRFPQRITRHAAESGTLQPDYADCWNGLEKRFDPNRP

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=435, Percent_Identity=50.3448275862069, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17507969, Length=427, Percent_Identity=51.5222482435597, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24583650, Length=431, Percent_Identity=49.6519721577726, Blast_Score=411, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 49812; Mature: 49812

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNINTSPDRLSRATGQVTPGYMSGFGNSFETEALPGALPIGRNSPQRCAYGLYAEQLSG
CCCCCCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
SPFTAPRGSNERSWLYRIRPSVKHSGRFAKVDAGLWRTAPCHEQEITVQQLRWDPTPMPA
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCC
GEVTFLQGVQTMTTAGDAATQAGMAAHVYVITKSMVDQHFYNADGELMFVLQQGRLLFVT
CCCHHHHCCHHHHCCCCHHHHCCCEEEEEEEEHHHHHHHHCCCCCCEEEEEECCCEEEEE
EFGRIDAEPGEIVVIPRGVKFRVEIPAGPARGYLCENYGGAFTLPERGPIGANCLANARD
ECCCCCCCCCCEEEEECCEEEEEECCCCCCCCCEEECCCCEEECCCCCCCCCHHHHCHHH
FLTPVASYEDKDTPTELYVKWGGALFKTELKHSPIDVVAWHGNYAPYKYDLRTFSPVGAI
HHHHHHCCCCCCCCEEEEEEECCEEEEHHCCCCCEEEEEECCCCCCEEEECEECCCCCCC
GFDHPDPSIFTVLTSPSETAGTANIDFVIFPERWMVADNTFRPPWYHMNIMSEFMGLIYG
CCCCCCCCEEEEEECCCCCCCCCEEEEEEECCEEEECCCCCCCCEEEHHHHHHHHHHHHH
VYDAKPQGFVPGGMSLHNCMLPHGPDREAFDHASNSELKPVKLTGTMAFMFETRFPQRIT
HCCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCEEEEECEEEEEEECCCHHHHH
RHAAESGTLQPDYADCWNGLEKRFDPNRP
HHHHHCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMNINTSPDRLSRATGQVTPGYMSGFGNSFETEALPGALPIGRNSPQRCAYGLYAEQLSG
CCCCCCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
SPFTAPRGSNERSWLYRIRPSVKHSGRFAKVDAGLWRTAPCHEQEITVQQLRWDPTPMPA
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCC
GEVTFLQGVQTMTTAGDAATQAGMAAHVYVITKSMVDQHFYNADGELMFVLQQGRLLFVT
CCCHHHHCCHHHHCCCCHHHHCCCEEEEEEEEHHHHHHHHCCCCCCEEEEEECCCEEEEE
EFGRIDAEPGEIVVIPRGVKFRVEIPAGPARGYLCENYGGAFTLPERGPIGANCLANARD
ECCCCCCCCCCEEEEECCEEEEEECCCCCCCCCEEECCCCEEECCCCCCCCCHHHHCHHH
FLTPVASYEDKDTPTELYVKWGGALFKTELKHSPIDVVAWHGNYAPYKYDLRTFSPVGAI
HHHHHHCCCCCCCCEEEEEEECCEEEEHHCCCCCEEEEEECCCCCCEEEECEECCCCCCC
GFDHPDPSIFTVLTSPSETAGTANIDFVIFPERWMVADNTFRPPWYHMNIMSEFMGLIYG
CCCCCCCCEEEEEECCCCCCCCCEEEEEEECCEEEECCCCCCCCEEEHHHHHHHHHHHHH
VYDAKPQGFVPGGMSLHNCMLPHGPDREAFDHASNSELKPVKLTGTMAFMFETRFPQRIT
HCCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCEEEEECEEEEEEECCCHHHHH
RHAAESGTLQPDYADCWNGLEKRFDPNRP
HHHHHCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]