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The map label for this gene is cadA [H]

Identifier: 146343094

GI number: 146343094

Start: 6529640

End: 6531934

Strand: Reverse

Name: cadA [H]

Synonym: BRADO6289

Alternate gene names: 146343094

Gene position: 6531934-6529640 (Counterclockwise)

Preceding gene: 146343095

Following gene: 146343093

Centisome position: 87.6

GC content: 70.28

Gene sequence:

>2295_bases
ATGTTCGAACGCATCCTGCGATGGACCCTCGTCGCAATCGCCGTCGCGGGCCTCGCCGCGGGCGGCCTTGCGTATGCGGT
CGGCCGATCCGAGCTTGCCGGGATCGCCTTCACCGCCTCCACCGTTCCGGTCATCGCCGGCCTGATCGTCTCGATCGTCC
GCGATGTCCTGGCCGGCCGTGTCGGCGTCGACGCGATCGCGCTGGTGTCGATGAGCGCGGCCATCGTGCTCGGCGAGCCG
CTGGCGGGCGCCGTGGTGGCGCTGATGTATTCCGGCGGGAACGTGCTCGAGGACATCGCGGTCGCGCGTGCCGAGCACGA
TCTGCGCGCACTGGTCGACCGGGCGCCACGCCTGGCGCACCGCTGGCGGGATGATCGCATCGAGGATGTCGAGGTCGCCG
ACGTCGCCGTTGGCGACCGGCTGATGGTCCGGGCCGGCGAGATCGTACCGGTGGACGGCGTGGTCGAGACGGTCCTGGCG
GTGATCGATGAATCGGCGCTGACGGGCGAGCCGATCCCAGTGTCGAAGACGCGGGGCATGGCGATCCTGTCGGGCTCGCT
GAACACCGGTGAGACGTTCGAGCTGTCGGTTACCGCGACCGCGGGGGAGAGCACCTATGCCGGCATCGTCAAGCTGGTGA
CCGCGGCGCAGACCGCGAAGGCGCCGTTCGTGCGACTCGCCGATCGCTATGCGCTGATCTTCCTGCCGGTGAGCCTGGCG
ATCGCAGCCGCGGCCTGGTTTGCCTCCGGCGATTTGATCCGGGCCCTTGCGGTGATGGTCGCTGCGACGCCGTGTCCGCT
GATCCTGGCGGCGCCGGTTGCCTTTATCGCCGGGGTGGCGCAGGCCGCGCGCAGCGGCATCCTGGTGAAGGGCGGCGGCA
AGCTGGAAGCGCTCGCGCGGGCGCATACCGTGCTGTTCGACAAGACCGGCACGTTGACCGTCGGCGGTGCGCGGTTGCTC
TCTGTGGAGGCGGCGCCCGGCGAGGATGCTGACAGCGTGCTGCTGCTCGGCGCCTCGCTGGAGCAGGCCTCCCACCATGT
CCTGGCGCATGCCATTGTCGAGGCCGGCCAGGCCCGAGGGCTCAAGCTCAAGGTCCCGGAGCGTGTCAGGGAGGCGATGG
GCTCGGGCCTCGAGGGCGTCATCGACGGCCGCCGCATCAGCGCCGGTTCGCCTGACCTGATCCTCGGCAATCACGCCCCG
CCGCCGTGGGCCGGACGCGCCATCCGCCGCGCGTCCTGGCGCTCGGCGCTGATCGTGCTCGTCGCCGTCGATGGCAAACC
GATCGGCGCGCTGTTGCTGGCAGATGAATTGCGCGCCGACACGCCGCGCGCGATCCGCTGGCTGCGCGAGGCCGGTATCG
CCCGCATGGTCATGGTGACCGGCGACCGCGCCGCTGCAGCGCAGGCGATCGGCGCGGCGCTCGATCTCGATGCGGTTCTG
GCCGATCGCGTGCCATCGGATAAGGTCGATGCCGTCAGGAGCGAGCAGCGGCTTCACCCGACCATCATGGTTGGCGACGG
CATCAACGATGCGCCGGCGCTCGCCTCGGCCGATGTCGGCATCGCGCTCGGCGCCCGCGGCGCCAGCGCCTCGTCGGAGG
CGGCTGATGTGGTCATTCTCGCCGACCGGCTCGATCGCGTCGGTGAGGCGATCGTGATCGCGCAGCGTGCGCGGAGGATC
GCGCTGGAGAGCATCATCGCCGGCATGGCGCTGTCATTCATCGCGATGGGCGCCGCGGCATTCGGCTTGCTGCAGCCGGT
GCCTGCTGCGCTGGTGCAGGAGGCGATCGATGTCGCCGTGATCCTCAACGCGCTGCGGGCGCTGCTGCCGGCCGGCCGGG
CGCGGACGGGCCGGATCACGGTGGAGGACGGTCAGGGCCTGCGGCACGATCATCAGGCGCTGCTGCGCGGACTGGATCGG
CTGCGCGCGATCGTCGATACGCTCGATGAGGCCCCGCCGGAGCGAGCGGTGTCGCTGATCGTCGAAGCCAATGCCGTTGT
GCAAGACCAGGTCGTCGCACATGAGCGCGATGACGAAGGCTCGGTCTATCCGCGGCTGGCTCGGCTGCTGCAGGACAGCC
ACGGCCTGTCCGCGATGAGCCGGGCGCATCGCGAGATCCTGCATCTGGCGCGCCTGCTTGGGCGGGTGGTCGAGGACCTG
CCGTCCGAGAAGGTCGACCGCTATCTGATCCGCGATGCCCAGCGGGTGATCGAGGCAATCGAGACGCTGGTGCGCATGCA
TACCGCGCAGGAGGACGACATCTACGAGGCCGTGGCGGCGCGCTCGGCCGCTTGA

Upstream 100 bases:

>100_bases
ACCGCCTGACGCGATGATCCGCCGCATCAGCGTTGATTTCGCTCAAGCGTCCGAGGCGCGGTCGCGGCGATAGTGCCGGC
GCAATCCGGATCTGATCGCC

Downstream 100 bases:

>100_bases
TTTGGCGCAAGTCGGACCACAATGATCGGTATCATAATCATTCTAAAGAATGAAGCCTGATGGTGTGGGACGGGGGCTGC
TGGACCAAGCGGCGATTGCG

Product: putative cation-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 764; Mature: 764

Protein sequence:

>764_residues
MFERILRWTLVAIAVAGLAAGGLAYAVGRSELAGIAFTASTVPVIAGLIVSIVRDVLAGRVGVDAIALVSMSAAIVLGEP
LAGAVVALMYSGGNVLEDIAVARAEHDLRALVDRAPRLAHRWRDDRIEDVEVADVAVGDRLMVRAGEIVPVDGVVETVLA
VIDESALTGEPIPVSKTRGMAILSGSLNTGETFELSVTATAGESTYAGIVKLVTAAQTAKAPFVRLADRYALIFLPVSLA
IAAAAWFASGDLIRALAVMVAATPCPLILAAPVAFIAGVAQAARSGILVKGGGKLEALARAHTVLFDKTGTLTVGGARLL
SVEAAPGEDADSVLLLGASLEQASHHVLAHAIVEAGQARGLKLKVPERVREAMGSGLEGVIDGRRISAGSPDLILGNHAP
PPWAGRAIRRASWRSALIVLVAVDGKPIGALLLADELRADTPRAIRWLREAGIARMVMVTGDRAAAAQAIGAALDLDAVL
ADRVPSDKVDAVRSEQRLHPTIMVGDGINDAPALASADVGIALGARGASASSEAADVVILADRLDRVGEAIVIAQRARRI
ALESIIAGMALSFIAMGAAAFGLLQPVPAALVQEAIDVAVILNALRALLPAGRARTGRITVEDGQGLRHDHQALLRGLDR
LRAIVDTLDEAPPERAVSLIVEANAVVQDQVVAHERDDEGSVYPRLARLLQDSHGLSAMSRAHREILHLARLLGRVVEDL
PSEKVDRYLIRDAQRVIEAIETLVRMHTAQEDDIYEAVAARSAA

Sequences:

>Translated_764_residues
MFERILRWTLVAIAVAGLAAGGLAYAVGRSELAGIAFTASTVPVIAGLIVSIVRDVLAGRVGVDAIALVSMSAAIVLGEP
LAGAVVALMYSGGNVLEDIAVARAEHDLRALVDRAPRLAHRWRDDRIEDVEVADVAVGDRLMVRAGEIVPVDGVVETVLA
VIDESALTGEPIPVSKTRGMAILSGSLNTGETFELSVTATAGESTYAGIVKLVTAAQTAKAPFVRLADRYALIFLPVSLA
IAAAAWFASGDLIRALAVMVAATPCPLILAAPVAFIAGVAQAARSGILVKGGGKLEALARAHTVLFDKTGTLTVGGARLL
SVEAAPGEDADSVLLLGASLEQASHHVLAHAIVEAGQARGLKLKVPERVREAMGSGLEGVIDGRRISAGSPDLILGNHAP
PPWAGRAIRRASWRSALIVLVAVDGKPIGALLLADELRADTPRAIRWLREAGIARMVMVTGDRAAAAQAIGAALDLDAVL
ADRVPSDKVDAVRSEQRLHPTIMVGDGINDAPALASADVGIALGARGASASSEAADVVILADRLDRVGEAIVIAQRARRI
ALESIIAGMALSFIAMGAAAFGLLQPVPAALVQEAIDVAVILNALRALLPAGRARTGRITVEDGQGLRHDHQALLRGLDR
LRAIVDTLDEAPPERAVSLIVEANAVVQDQVVAHERDDEGSVYPRLARLLQDSHGLSAMSRAHREILHLARLLGRVVEDL
PSEKVDRYLIRDAQRVIEAIETLVRMHTAQEDDIYEAVAARSAA
>Mature_764_residues
MFERILRWTLVAIAVAGLAAGGLAYAVGRSELAGIAFTASTVPVIAGLIVSIVRDVLAGRVGVDAIALVSMSAAIVLGEP
LAGAVVALMYSGGNVLEDIAVARAEHDLRALVDRAPRLAHRWRDDRIEDVEVADVAVGDRLMVRAGEIVPVDGVVETVLA
VIDESALTGEPIPVSKTRGMAILSGSLNTGETFELSVTATAGESTYAGIVKLVTAAQTAKAPFVRLADRYALIFLPVSLA
IAAAAWFASGDLIRALAVMVAATPCPLILAAPVAFIAGVAQAARSGILVKGGGKLEALARAHTVLFDKTGTLTVGGARLL
SVEAAPGEDADSVLLLGASLEQASHHVLAHAIVEAGQARGLKLKVPERVREAMGSGLEGVIDGRRISAGSPDLILGNHAP
PPWAGRAIRRASWRSALIVLVAVDGKPIGALLLADELRADTPRAIRWLREAGIARMVMVTGDRAAAAQAIGAALDLDAVL
ADRVPSDKVDAVRSEQRLHPTIMVGDGINDAPALASADVGIALGARGASASSEAADVVILADRLDRVGEAIVIAQRARRI
ALESIIAGMALSFIAMGAAAFGLLQPVPAALVQEAIDVAVILNALRALLPAGRARTGRITVEDGQGLRHDHQALLRGLDR
LRAIVDTLDEAPPERAVSLIVEANAVVQDQVVAHERDDEGSVYPRLARLLQDSHGLSAMSRAHREILHLARLLGRVVEDL
PSEKVDRYLIRDAQRVIEAIETLVRMHTAQEDDIYEAVAARSAA

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=549, Percent_Identity=30.2367941712204, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI55743073, Length=519, Percent_Identity=30.4431599229287, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI115529486, Length=263, Percent_Identity=32.6996197718631, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI1789879, Length=588, Percent_Identity=33.5034013605442, Blast_Score=233, Evalue=4e-62,
Organism=Escherichia coli, GI1786691, Length=620, Percent_Identity=31.6129032258064, Blast_Score=208, Evalue=9e-55,
Organism=Escherichia coli, GI1786914, Length=456, Percent_Identity=30.0438596491228, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17556548, Length=491, Percent_Identity=27.2912423625255, Blast_Score=154, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320475, Length=544, Percent_Identity=28.8602941176471, Blast_Score=193, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6319772, Length=487, Percent_Identity=26.4887063655031, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6325221, Length=521, Percent_Identity=26.679462571977, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321430, Length=521, Percent_Identity=25.9117082533589, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221329854, Length=258, Percent_Identity=36.8217054263566, Blast_Score=119, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 79762; Mature: 79762

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFERILRWTLVAIAVAGLAAGGLAYAVGRSELAGIAFTASTVPVIAGLIVSIVRDVLAGR
CHHHHHHHHHHHHHHHHHHHCHHHHHHCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCC
VGVDAIALVSMSAAIVLGEPLAGAVVALMYSGGNVLEDIAVARAEHDLRALVDRAPRLAH
CCHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHH
RWRDDRIEDVEVADVAVGDRLMVRAGEIVPVDGVVETVLAVIDESALTGEPIPVSKTRGM
HHCCCCCCCCEEHHHCCCCEEEEECCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
AILSGSLNTGETFELSVTATAGESTYAGIVKLVTAAQTAKAPFVRLADRYALIFLPVSLA
EEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEHHHHHH
IAAAAWFASGDLIRALAVMVAATPCPLILAAPVAFIAGVAQAARSGILVKGGGKLEALAR
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHH
AHTVLFDKTGTLTVGGARLLSVEAAPGEDADSVLLLGASLEQASHHVLAHAIVEAGQARG
HHHHEEECCCCEEECCEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
LKLKVPERVREAMGSGLEGVIDGRRISAGSPDLILGNHAPPPWAGRAIRRASWRSALIVL
CEEECCHHHHHHHCCCCCCCCCCCEECCCCCCEEECCCCCCCCHHHHHHHHHCCCEEEEE
VAVDGKPIGALLLADELRADTPRAIRWLREAGIARMVMVTGDRAAAAQAIGAALDLDAVL
EEECCCCCCHHEEHHHHCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHH
ADRVPSDKVDAVRSEQRLHPTIMVGDGINDAPALASADVGIALGARGASASSEAADVVIL
HCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEE
ADRLDRVGEAIVIAQRARRIALESIIAGMALSFIAMGAAAFGLLQPVPAALVQEAIDVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ILNALRALLPAGRARTGRITVEDGQGLRHDHQALLRGLDRLRAIVDTLDEAPPERAVSLI
HHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VEANAVVQDQVVAHERDDEGSVYPRLARLLQDSHGLSAMSRAHREILHLARLLGRVVEDL
HHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PSEKVDRYLIRDAQRVIEAIETLVRMHTAQEDDIYEAVAARSAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MFERILRWTLVAIAVAGLAAGGLAYAVGRSELAGIAFTASTVPVIAGLIVSIVRDVLAGR
CHHHHHHHHHHHHHHHHHHHCHHHHHHCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCC
VGVDAIALVSMSAAIVLGEPLAGAVVALMYSGGNVLEDIAVARAEHDLRALVDRAPRLAH
CCHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHH
RWRDDRIEDVEVADVAVGDRLMVRAGEIVPVDGVVETVLAVIDESALTGEPIPVSKTRGM
HHCCCCCCCCEEHHHCCCCEEEEECCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
AILSGSLNTGETFELSVTATAGESTYAGIVKLVTAAQTAKAPFVRLADRYALIFLPVSLA
EEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEHHHHHH
IAAAAWFASGDLIRALAVMVAATPCPLILAAPVAFIAGVAQAARSGILVKGGGKLEALAR
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHH
AHTVLFDKTGTLTVGGARLLSVEAAPGEDADSVLLLGASLEQASHHVLAHAIVEAGQARG
HHHHEEECCCCEEECCEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
LKLKVPERVREAMGSGLEGVIDGRRISAGSPDLILGNHAPPPWAGRAIRRASWRSALIVL
CEEECCHHHHHHHCCCCCCCCCCCEECCCCCCEEECCCCCCCCHHHHHHHHHCCCEEEEE
VAVDGKPIGALLLADELRADTPRAIRWLREAGIARMVMVTGDRAAAAQAIGAALDLDAVL
EEECCCCCCHHEEHHHHCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHH
ADRVPSDKVDAVRSEQRLHPTIMVGDGINDAPALASADVGIALGARGASASSEAADVVIL
HCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEE
ADRLDRVGEAIVIAQRARRIALESIIAGMALSFIAMGAAAFGLLQPVPAALVQEAIDVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ILNALRALLPAGRARTGRITVEDGQGLRHDHQALLRGLDRLRAIVDTLDEAPPERAVSLI
HHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VEANAVVQDQVVAHERDDEGSVYPRLARLLQDSHGLSAMSRAHREILHLARLLGRVVEDL
HHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PSEKVDRYLIRDAQRVIEAIETLVRMHTAQEDDIYEAVAARSAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]