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The map label for this gene is garR [H]

Identifier: 146342680

GI number: 146342680

Start: 6064331

End: 6065248

Strand: Reverse

Name: garR [H]

Synonym: BRADO5847

Alternate gene names: 146342680

Gene position: 6065248-6064331 (Counterclockwise)

Preceding gene: 146342681

Following gene: 146342677

Centisome position: 81.34

GC content: 69.5

Gene sequence:

>918_bases
ATGAGCGCGCCGCGAAGCGTCCTGTTCGTGGGCATCGGCAACATGGGCTGGCCGATGTCGGCGCGGCTGCTCGAGGCCGG
CTGGGCCGTGGCGGTCAATGACGCGGTCGCCGGCCGCGCCGCGGATTTCGTCCGCCAGGTTGGCGGCACCGAGGCTTCCG
ATCTCGCCGCGGCTGCGGCGCAGGCGGATGTCGTCATCACGATGCTGCCGACCAGCAAGCACGTCGCCGATGCCGTGAGC
GCGTTGCGCCCCGGCCTGAAGCAAGGTCACATCCTCGTCGACATGAGCTCCGGCGCGCCGGCGGCGACCCAGGCGATCGC
GGCCGATCTCGCCCCGCTCGGCGTGGTGATGCTCGATGCGCCCGTCAGCGGTGGCGTGCCGCGGGCGAAAACCGGTGAGC
TCGCGATCATGGCCGGCGGCGACGCCGCGGCGCTCGACCGTGTCGAGCCGATGCTGCGCGCGATGGGCACCACGATCCAT
CGCATCGGCGGCCTCGGCTCGGGACAGGCGATGAAGGCGCTCAACAACCTCGTCTCGGCCGGCGGCTTCCTGATCGGCAT
CGAGGCGTTGCTGATCGGCCAGCAGTTCGGCATCGATCCCGGCCTGATGACCGACGTGCTGAATGCCTCCACCGGCATGA
ACAATTCGACGCAGAAGAAGTTCAAGCAGTTCGTGCTGTCACGCCGGTTCAACAGCGGCTTCGGTCTCGACCTGATGCTC
AAGGACCTGTCGATCGCGCTCGATGTCGCCCGCGCGGCCGGCGTCGCCGCCCCCTTTTCGAATCTCTGCCGCGAGCTCAG
CGCCAGCGCGCAAGGACTGCTCGGTCCGGGTCAGGATCACACCGCGCTCGCGAAGCTGAGCGAGGCCCTGGCCGGCGTTG
AACTCGGCGGTGAACAAGGCCCGCGCCCGCCAGGCTGA

Upstream 100 bases:

>100_bases
ATGCGACCGTGTATTGCGGCATTCCCGCAGGTCTCGAAGCGTTCAAGGCGGCGCATGAGGTGCTGGTCGCGGAGGGCGCG
ATTGCCAAGAAGGGCGGCGC

Downstream 100 bases:

>100_bases
GCTCGTCGCCCCCGCAGCCTGACGATGAAGGATCGGTAGCGCTTTGGCCATCAAATCGCTGGTGGGCCCGGCAGGACTCG
AACCTGCAACCAGACCGTTA

Product: putative hydroxyacid dehydrogenase/reductase 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSAPRSVLFVGIGNMGWPMSARLLEAGWAVAVNDAVAGRAADFVRQVGGTEASDLAAAAAQADVVITMLPTSKHVADAVS
ALRPGLKQGHILVDMSSGAPAATQAIAADLAPLGVVMLDAPVSGGVPRAKTGELAIMAGGDAAALDRVEPMLRAMGTTIH
RIGGLGSGQAMKALNNLVSAGGFLIGIEALLIGQQFGIDPGLMTDVLNASTGMNNSTQKKFKQFVLSRRFNSGFGLDLML
KDLSIALDVARAAGVAAPFSNLCRELSASAQGLLGPGQDHTALAKLSEALAGVELGGEQGPRPPG

Sequences:

>Translated_305_residues
MSAPRSVLFVGIGNMGWPMSARLLEAGWAVAVNDAVAGRAADFVRQVGGTEASDLAAAAAQADVVITMLPTSKHVADAVS
ALRPGLKQGHILVDMSSGAPAATQAIAADLAPLGVVMLDAPVSGGVPRAKTGELAIMAGGDAAALDRVEPMLRAMGTTIH
RIGGLGSGQAMKALNNLVSAGGFLIGIEALLIGQQFGIDPGLMTDVLNASTGMNNSTQKKFKQFVLSRRFNSGFGLDLML
KDLSIALDVARAAGVAAPFSNLCRELSASAQGLLGPGQDHTALAKLSEALAGVELGGEQGPRPPG
>Mature_304_residues
SAPRSVLFVGIGNMGWPMSARLLEAGWAVAVNDAVAGRAADFVRQVGGTEASDLAAAAAQADVVITMLPTSKHVADAVSA
LRPGLKQGHILVDMSSGAPAATQAIAADLAPLGVVMLDAPVSGGVPRAKTGELAIMAGGDAAALDRVEPMLRAMGTTIHR
IGGLGSGQAMKALNNLVSAGGFLIGIEALLIGQQFGIDPGLMTDVLNASTGMNNSTQKKFKQFVLSRRFNSGFGLDLMLK
DLSIALDVARAAGVAAPFSNLCRELSASAQGLLGPGQDHTALAKLSEALAGVELGGEQGPRPPG

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=251, Percent_Identity=34.2629482071713, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI40556376, Length=289, Percent_Identity=26.643598615917, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=38.0952380952381, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786719, Length=293, Percent_Identity=33.4470989761092, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=31.2714776632302, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789092, Length=299, Percent_Identity=27.4247491638796, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17557316, Length=268, Percent_Identity=28.7313432835821, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655230, Length=273, Percent_Identity=31.5018315018315, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19922568, Length=273, Percent_Identity=31.5018315018315, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30853; Mature: 30722

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPRSVLFVGIGNMGWPMSARLLEAGWAVAVNDAVAGRAADFVRQVGGTEASDLAAAAA
CCCCCEEEEEEECCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHH
QADVVITMLPTSKHVADAVSALRPGLKQGHILVDMSSGAPAATQAIAADLAPLGVVMLDA
CCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCEEEECC
PVSGGVPRAKTGELAIMAGGDAAALDRVEPMLRAMGTTIHRIGGLGSGQAMKALNNLVSA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GGFLIGIEALLIGQQFGIDPGLMTDVLNASTGMNNSTQKKFKQFVLSRRFNSGFGLDLML
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
KDLSIALDVARAAGVAAPFSNLCRELSASAQGLLGPGQDHTALAKLSEALAGVELGGEQG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
PRPPG
CCCCC
>Mature Secondary Structure 
SAPRSVLFVGIGNMGWPMSARLLEAGWAVAVNDAVAGRAADFVRQVGGTEASDLAAAAA
CCCCEEEEEEECCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHH
QADVVITMLPTSKHVADAVSALRPGLKQGHILVDMSSGAPAATQAIAADLAPLGVVMLDA
CCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCEEEECC
PVSGGVPRAKTGELAIMAGGDAAALDRVEPMLRAMGTTIHRIGGLGSGQAMKALNNLVSA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GGFLIGIEALLIGQQFGIDPGLMTDVLNASTGMNNSTQKKFKQFVLSRRFNSGFGLDLML
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
KDLSIALDVARAAGVAAPFSNLCRELSASAQGLLGPGQDHTALAKLSEALAGVELGGEQG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
PRPPG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]