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The map label for this gene is degP [H]

Identifier: 146341537

GI number: 146341537

Start: 4826172

End: 4827566

Strand: Reverse

Name: degP [H]

Synonym: BRADO4635

Alternate gene names: 146341537

Gene position: 4827566-4826172 (Counterclockwise)

Preceding gene: 146341538

Following gene: 146341536

Centisome position: 64.74

GC content: 67.24

Gene sequence:

>1395_bases
ATGACGCTGATTCGCTCCTCCATGGTCCTGCTGCTTGCGCTGCTGGCCGCCACTCCGCTCGCGGCGCAGGAGCGGCGGGT
GCCGCAATCCCAGGCCGAGCTGCGGCTGTCCTATGCGCCGATCGTGCAGCGCGTGCAGCCGGCGGTCGTCAACGTCTATG
CCGCCAAGGTGGTGCAGAACCGCAATCCGTTCCTCGATGATCCGATCTTCCGCCGCTTCTTCGGTCTGCAGGGCGGTCCG
CAGGAGCAAATGCAGCGCTCGCTCGGCTCGGGCGTGATGATCGATTCCTCCGGTCTGGTTGTCACCAATGTGCACGTCAT
CGAGGGCGCCGACGAGGTGAAGGTGTCGCTCGCCGACAAGCGCGAGTACGAGGCCGAGATCGTGCTCAAGGACAGCCGCA
CCGACCTTGCGGTGCTCAGGCTGAAGGGCACCAAGGAGCAGTTTCCGACCCTCGACCTCGCCAATTCCGACGATCTGCAA
GTCGGCGACGTCGTGCTCGCGATCGGCAATCCGTTCGGCGTCGGCCAGACCGTGACCCACGGCATCGTTTCGGCGCTGGC
GCGCACCCAGGTCGGCATCACCGACTATCAGTTCTTCATCCAGACCGATGCGGCCATCAATCCCGGCAACTCGGGCGGCG
CGCTGGTCGACATGACCGGGAAGCTCGCCGGCATCAACACCGCGATCTATTCGAAGTCAGGCGGCTCACAGGGCATCGGC
TTCGCGATCCCGGCGAACATGGTGCGCGTCGTGGTCGCCTCGGCCAAGAGCGGCGGCAAGGCGGTCAAGCGTCCCTGGCT
GGGCGCGCGCTTGCAGGCGGTGACGCCTGACATCGCCGAGAGCCTCGGCCTGCGCTCGCCGACCGGCGCGCTGGTCGCGA
GCGTCACGCCGAACAGCCCGGCGGCGCGTGCCGGCATCAAATCGTCCGACCTGATCGTGTCGATCGACGGGCAGACCGTC
GATGATCCCAACGCCTTCGACTATCGCTTCGCGACCCGCCCGCTCGGTGGCAGCGCACAGATCGAGGTGCAGCGCGGCGG
CAAGCCGGTGAAGGTCGCGGTCGCGCTGGAGACCGCGCCAGACACCGGGCGCAACGAGATCGTCATCAGCGGCCGCTCGC
CGTTCCAGGGAGCCAAGGTCGCCAACATCTCGCCGGCGGTGGCCGACGAGCTGCATCTCGACGCCGACACCGAGGGCGTC
GTCGTGCTCGAGCCCGGCGACGGCACAACGGCCGCCAATGTCGGCTTCCAGAAGGGCGACGTGATCATGGCCGTCAACAA
CCAGAAGATCGCCAAGACCACCGATCTCGACAAGGCCTCGCGCGAGTCCGCTCGCCTCTGGCGTATTACCGTGCTGCGCG
GCGGCCAGCAGATCAACGTCACGCTCGGCGGATGA

Upstream 100 bases:

>100_bases
CGTTGCAGAGACCATCAAAACGCCGCATCAGACCGCCTGAGCTTGGCCGCACCGGCCGTACCGCCTATATCGAAGCCGTC
ATTTTCCCAGGATTGCTCGC

Downstream 100 bases:

>100_bases
GCCCGAAGCGCCCCCAGCAAGGCGGGCCGAGCCTCTTCGCCGCGGCGGGGCTGGAGCATGATGCGCCGCGGCCGCTGCCG
GAGCGGCTGCGTCCACACAA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTLIRSSMVLLLALLAATPLAAQERRVPQSQAELRLSYAPIVQRVQPAVVNVYAAKVVQNRNPFLDDPIFRRFFGLQGGP
QEQMQRSLGSGVMIDSSGLVVTNVHVIEGADEVKVSLADKREYEAEIVLKDSRTDLAVLRLKGTKEQFPTLDLANSDDLQ
VGDVVLAIGNPFGVGQTVTHGIVSALARTQVGITDYQFFIQTDAAINPGNSGGALVDMTGKLAGINTAIYSKSGGSQGIG
FAIPANMVRVVVASAKSGGKAVKRPWLGARLQAVTPDIAESLGLRSPTGALVASVTPNSPAARAGIKSSDLIVSIDGQTV
DDPNAFDYRFATRPLGGSAQIEVQRGGKPVKVAVALETAPDTGRNEIVISGRSPFQGAKVANISPAVADELHLDADTEGV
VVLEPGDGTTAANVGFQKGDVIMAVNNQKIAKTTDLDKASRESARLWRITVLRGGQQINVTLGG

Sequences:

>Translated_464_residues
MTLIRSSMVLLLALLAATPLAAQERRVPQSQAELRLSYAPIVQRVQPAVVNVYAAKVVQNRNPFLDDPIFRRFFGLQGGP
QEQMQRSLGSGVMIDSSGLVVTNVHVIEGADEVKVSLADKREYEAEIVLKDSRTDLAVLRLKGTKEQFPTLDLANSDDLQ
VGDVVLAIGNPFGVGQTVTHGIVSALARTQVGITDYQFFIQTDAAINPGNSGGALVDMTGKLAGINTAIYSKSGGSQGIG
FAIPANMVRVVVASAKSGGKAVKRPWLGARLQAVTPDIAESLGLRSPTGALVASVTPNSPAARAGIKSSDLIVSIDGQTV
DDPNAFDYRFATRPLGGSAQIEVQRGGKPVKVAVALETAPDTGRNEIVISGRSPFQGAKVANISPAVADELHLDADTEGV
VVLEPGDGTTAANVGFQKGDVIMAVNNQKIAKTTDLDKASRESARLWRITVLRGGQQINVTLGG
>Mature_463_residues
TLIRSSMVLLLALLAATPLAAQERRVPQSQAELRLSYAPIVQRVQPAVVNVYAAKVVQNRNPFLDDPIFRRFFGLQGGPQ
EQMQRSLGSGVMIDSSGLVVTNVHVIEGADEVKVSLADKREYEAEIVLKDSRTDLAVLRLKGTKEQFPTLDLANSDDLQV
GDVVLAIGNPFGVGQTVTHGIVSALARTQVGITDYQFFIQTDAAINPGNSGGALVDMTGKLAGINTAIYSKSGGSQGIGF
AIPANMVRVVVASAKSGGKAVKRPWLGARLQAVTPDIAESLGLRSPTGALVASVTPNSPAARAGIKSSDLIVSIDGQTVD
DPNAFDYRFATRPLGGSAQIEVQRGGKPVKVAVALETAPDTGRNEIVISGRSPFQGAKVANISPAVADELHLDADTEGVV
VLEPGDGTTAANVGFQKGDVIMAVNNQKIAKTTDLDKASRESARLWRITVLRGGQQINVTLGG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=358, Percent_Identity=33.2402234636872, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI4506141, Length=304, Percent_Identity=34.2105263157895, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI7019477, Length=333, Percent_Identity=34.2342342342342, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI24308541, Length=308, Percent_Identity=31.1688311688312, Blast_Score=134, Evalue=3e-31,
Organism=Escherichia coli, GI1786356, Length=472, Percent_Identity=36.6525423728814, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI1789629, Length=429, Percent_Identity=36.1305361305361, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI1789630, Length=362, Percent_Identity=38.3977900552486, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24646839, Length=308, Percent_Identity=32.4675324675325, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48760; Mature: 48629

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIRSSMVLLLALLAATPLAAQERRVPQSQAELRLSYAPIVQRVQPAVVNVYAAKVVQN
CCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHEEEEHHHHHHHCCHHHHHHHHHHHHHC
RNPFLDDPIFRRFFGLQGGPQEQMQRSLGSGVMIDSSGLVVTNVHVIEGADEVKVSLADK
CCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCEEEEEEEEEECCCCEEEEECCC
REYEAEIVLKDSRTDLAVLRLKGTKEQFPTLDLANSDDLQVGDVVLAIGNPFGVGQTVTH
CCCEEEEEEECCCCCEEEEEEECCHHHCCEEECCCCCCCEECEEEEEECCCCCCCHHHHH
GIVSALARTQVGITDYQFFIQTDAAINPGNSGGALVDMTGKLAGINTAIYSKSGGSQGIG
HHHHHHHHHCCCCEEEEEEEEECCEECCCCCCCEEEEECCCEECCEEEEEECCCCCCCCE
FAIPANMVRVVVASAKSGGKAVKRPWLGARLQAVTPDIAESLGLRSPTGALVASVTPNSP
EECCHHEEEEEEECCCCCCHHHCCCCCCCEEEECCHHHHHHCCCCCCCCCEEEEECCCCC
AARAGIKSSDLIVSIDGQTVDDPNAFDYRFATRPLGGSAQIEVQRGGKPVKVAVALETAP
HHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEEEEECCC
DTGRNEIVISGRSPFQGAKVANISPAVADELHLDADTEGVVVLEPGDGTTAANVGFQKGD
CCCCCEEEEECCCCCCCCEECCCCCHHHHHEEECCCCCCEEEEECCCCCEEECCCCCCCC
VIMAVNNQKIAKTTDLDKASRESARLWRITVLRGGQQINVTLGG
EEEEECCCCEEEECCCCHHCCCCCEEEEEEEEECCCEEEEEECC
>Mature Secondary Structure 
TLIRSSMVLLLALLAATPLAAQERRVPQSQAELRLSYAPIVQRVQPAVVNVYAAKVVQN
CCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHEEEEHHHHHHHCCHHHHHHHHHHHHHC
RNPFLDDPIFRRFFGLQGGPQEQMQRSLGSGVMIDSSGLVVTNVHVIEGADEVKVSLADK
CCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCEEEEEEEEEECCCCEEEEECCC
REYEAEIVLKDSRTDLAVLRLKGTKEQFPTLDLANSDDLQVGDVVLAIGNPFGVGQTVTH
CCCEEEEEEECCCCCEEEEEEECCHHHCCEEECCCCCCCEECEEEEEECCCCCCCHHHHH
GIVSALARTQVGITDYQFFIQTDAAINPGNSGGALVDMTGKLAGINTAIYSKSGGSQGIG
HHHHHHHHHCCCCEEEEEEEEECCEECCCCCCCEEEEECCCEECCEEEEEECCCCCCCCE
FAIPANMVRVVVASAKSGGKAVKRPWLGARLQAVTPDIAESLGLRSPTGALVASVTPNSP
EECCHHEEEEEEECCCCCCHHHCCCCCCCEEEECCHHHHHHCCCCCCCCCEEEEECCCCC
AARAGIKSSDLIVSIDGQTVDDPNAFDYRFATRPLGGSAQIEVQRGGKPVKVAVALETAP
HHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEEEEECCC
DTGRNEIVISGRSPFQGAKVANISPAVADELHLDADTEGVVVLEPGDGTTAANVGFQKGD
CCCCCEEEEECCCCCCCCEECCCCCHHHHHEEECCCCCCEEEEECCCCCEEECCCCCCCC
VIMAVNNQKIAKTTDLDKASRESARLWRITVLRGGQQINVTLGG
EEEEECCCCEEEECCCCHHCCCCCEEEEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9688822; 12089438 [H]