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The map label for this gene is relA [H]

Identifier: 146341381

GI number: 146341381

Start: 4667052

End: 4669343

Strand: Reverse

Name: relA [H]

Synonym: BRADO4468

Alternate gene names: 146341381

Gene position: 4669343-4667052 (Counterclockwise)

Preceding gene: 146341382

Following gene: 146341380

Centisome position: 62.62

GC content: 66.62

Gene sequence:

>2292_bases
ATGGTGGTTCCGGGCCACACTCCTCAGCAGATGCAGGCGGCGGCCGAATCAGCCGCGGTGGCGCCGCCGGCTGAGCGGCC
GCGGCCGCCGAAGCCGCGCTCGCGCATGATGCGGCAGTACGACCTCGTCGAGCGGGTCCGTTCCTACAATCCGGATACGA
ACGAGGATCTGCTCAATCGCGCCTATGTGTACGCGATGAAGGCGCACGGCTCGCAGACGCGGGCCTCGGGCGACCCGTAT
TTTACCCATCCCCTCGAGGTCGCGGCCATTTTGACCGACCTCAAGCTGGACGACGCCACGATCGTCGCGGCGCTGCTGCA
CGACACGATCGAGGATACCGAGGCGACCCGCGCCGAGATCGACCGCTTCTTCGGGCCGGAGATCGGCGCGCTGGTCGAGG
GTTTGACCAAGCTGAAGCGGCTCGAGCTGGTGTCGCGGGAGGCCAAGCAGGCCGAGAACCTGCGCAAGCTGTTGCTGGCG
ATCGCCGACGATGTCCGCGTGCTGCTCGTCAAGCTCGCCGACCGCCTGCACAACATGCGCACGCTCGACTTCGTGCCGGA
GGCCTCGCGCCGCCGCATCGCCGAGGAGACGCTCGACATCTATGCGCCGCTGGCCGGCCGCATGGGCATGCAGGAGATGC
GCGAGGAGCTGGAGGATCTCTCCTTCCGCACGCTCGATCCGCAGGCCTATGGCGTCGTGATGCAGCGGCTGGACGCGCTG
GCCGACCGCAACCGCAATCTGATCGGCGAGATCGAGAGCCAGCTGGCGCGCAAGTTCCGCGACCATGGGCTGACCGCCCG
GGTGTTCGGCCGGCGCAAGCGGCCATTCTCGATCTGGACCAAGATGGAGCGCAAATCCATCGGCTTCGAGCAGCTGTCCG
ACATCTTCGGCTTCCGCGTCATCATGCCGGACCTCGAATCCTGCTACCGCGCGCTCGGCATCGTGCACACGACCTGGCCG
GTCGTGCCGGGGCGCTTCAAGGATTACATCTCGACGCCGAAGCAGAACGACTATCGCTCCATCCACACCACCGTGATCGG
GCCGGGCAAGCAGCGCGTCGAGCTGCAGATCCGCACCGAGGACATGGACCAGATCGCCGAGCTCGGCATCGCCGCGCACG
CCTTCTACAAGGACGACATCGGCTCGCCGACCGAGCTCCTGAAGCGCGAATCGAATGCGTTCGCCTGGCTGCGCCACACC
ATCGGCATCCTCTCGGAGAGCGCCAATCCGGAGGAGTTCCTCGAGCACACCAAGCTCGAGCTGTTTCACGATCAGGTGTT
CTGCTTTACGCCGAAGGGCAAGCTGATCGCGCTGCCGCGCCACGCCAATGTGATCGACTTCGCCTATGCCGTGCATACCG
ATGTCGGCAACAGCGCCGTCGGCTGCAAGATCAACGGCAAGTTCGCCGCGCTCTCGTCGGAGCTGCAGAACGGCGACGAG
GTCGAGGTGCTCACCTCGGATGCGCAGTCGGCGCCGCCCTCGGCCTGGGAGACGCTCGCCATCACCGGCAAGGCGCGGGC
GGCGATCCGGCGCGCCACGCGCACCGCGGTGCGCGATCAATATGCCGGGCTCGGCCGACGCATCGTCGAACGCCTGTTCG
AGCGCACCAAGCTCGAATATGCCGACGACAAGCTCAAGGGCGCGCTGCCGCGGCTGGCGCGGGCGTCGATCGAGGACGTG
ATGGCGGCGGTCGGGCGCGGCGAGATCAAGGCGTCCGACGTCGCCCGCGCGATGTATCCCGACTACAAGGAAGAGCGCGT
CGTGCGCTATGGCGCCAAGAAGACGGCAACGCCGGCTGCAAAAACCGCGGCACCGGCAACCGAGCCGGCGCGCGGCGCAT
TCGCGATTCCGATCAGCGGCCTCAACTCCGGCCTGCCGGTGAAGTTCGCGCCCAATGGCGGCGCCGTGCCGGGCGACCGC
ATCGTCGGCATCGTCACGCCGGGCGAGGGCATCACGATCTATCCGATCCAGTCGCCGGCGCTGAAGGATTTCGAGGACGA
GCCGGAGCGCTGGCTCGACGTGCGCTGGGACGTCGATGAAACCACGCCCCAGCGCTTTCCGGCGCGCATCAAGGTCGAGA
ACGTCAACGAGCCCGGCAGCCTCGCGCAGGTGGCGACCGTCATTGCCGAGCACGACGGCAACATCGACAATATCAGCATG
AGCCGCCGCTCGCCGGACTTCACCGAGCTGACGATCGATCTCGAAGTCTACGACCTCAAGCATCTCTCGGCGATCATCAA
CCAGCTGCGCGCCAAGACGATCGTGGCGAAGGTCGACCGTGTGAATGGCTAA

Upstream 100 bases:

>100_bases
CTTTGCATTTGAACGTCATTTCGTGATTACCATAGGTCGCGCTGCGACCGCCTGCCGTCGGGTGGATTCGGTCCCAAAGA
TAAAGGTTTAGTCATTTTCC

Downstream 100 bases:

>100_bases
TCTGCGGGTTTGGCCGCAGCGTTTCCTCCGGCGATGAGCTAAACCAGCAATTCCGTTTTGAGAGAACACCGCGAGCCTGC
CGATGTCCCATCCCCCGAAG

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MVVPGHTPQQMQAAAESAAVAPPAERPRPPKPRSRMMRQYDLVERVRSYNPDTNEDLLNRAYVYAMKAHGSQTRASGDPY
FTHPLEVAAILTDLKLDDATIVAALLHDTIEDTEATRAEIDRFFGPEIGALVEGLTKLKRLELVSREAKQAENLRKLLLA
IADDVRVLLVKLADRLHNMRTLDFVPEASRRRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPQAYGVVMQRLDAL
ADRNRNLIGEIESQLARKFRDHGLTARVFGRRKRPFSIWTKMERKSIGFEQLSDIFGFRVIMPDLESCYRALGIVHTTWP
VVPGRFKDYISTPKQNDYRSIHTTVIGPGKQRVELQIRTEDMDQIAELGIAAHAFYKDDIGSPTELLKRESNAFAWLRHT
IGILSESANPEEFLEHTKLELFHDQVFCFTPKGKLIALPRHANVIDFAYAVHTDVGNSAVGCKINGKFAALSSELQNGDE
VEVLTSDAQSAPPSAWETLAITGKARAAIRRATRTAVRDQYAGLGRRIVERLFERTKLEYADDKLKGALPRLARASIEDV
MAAVGRGEIKASDVARAMYPDYKEERVVRYGAKKTATPAAKTAAPATEPARGAFAIPISGLNSGLPVKFAPNGGAVPGDR
IVGIVTPGEGITIYPIQSPALKDFEDEPERWLDVRWDVDETTPQRFPARIKVENVNEPGSLAQVATVIAEHDGNIDNISM
SRRSPDFTELTIDLEVYDLKHLSAIINQLRAKTIVAKVDRVNG

Sequences:

>Translated_763_residues
MVVPGHTPQQMQAAAESAAVAPPAERPRPPKPRSRMMRQYDLVERVRSYNPDTNEDLLNRAYVYAMKAHGSQTRASGDPY
FTHPLEVAAILTDLKLDDATIVAALLHDTIEDTEATRAEIDRFFGPEIGALVEGLTKLKRLELVSREAKQAENLRKLLLA
IADDVRVLLVKLADRLHNMRTLDFVPEASRRRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPQAYGVVMQRLDAL
ADRNRNLIGEIESQLARKFRDHGLTARVFGRRKRPFSIWTKMERKSIGFEQLSDIFGFRVIMPDLESCYRALGIVHTTWP
VVPGRFKDYISTPKQNDYRSIHTTVIGPGKQRVELQIRTEDMDQIAELGIAAHAFYKDDIGSPTELLKRESNAFAWLRHT
IGILSESANPEEFLEHTKLELFHDQVFCFTPKGKLIALPRHANVIDFAYAVHTDVGNSAVGCKINGKFAALSSELQNGDE
VEVLTSDAQSAPPSAWETLAITGKARAAIRRATRTAVRDQYAGLGRRIVERLFERTKLEYADDKLKGALPRLARASIEDV
MAAVGRGEIKASDVARAMYPDYKEERVVRYGAKKTATPAAKTAAPATEPARGAFAIPISGLNSGLPVKFAPNGGAVPGDR
IVGIVTPGEGITIYPIQSPALKDFEDEPERWLDVRWDVDETTPQRFPARIKVENVNEPGSLAQVATVIAEHDGNIDNISM
SRRSPDFTELTIDLEVYDLKHLSAIINQLRAKTIVAKVDRVNG
>Mature_763_residues
MVVPGHTPQQMQAAAESAAVAPPAERPRPPKPRSRMMRQYDLVERVRSYNPDTNEDLLNRAYVYAMKAHGSQTRASGDPY
FTHPLEVAAILTDLKLDDATIVAALLHDTIEDTEATRAEIDRFFGPEIGALVEGLTKLKRLELVSREAKQAENLRKLLLA
IADDVRVLLVKLADRLHNMRTLDFVPEASRRRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPQAYGVVMQRLDAL
ADRNRNLIGEIESQLARKFRDHGLTARVFGRRKRPFSIWTKMERKSIGFEQLSDIFGFRVIMPDLESCYRALGIVHTTWP
VVPGRFKDYISTPKQNDYRSIHTTVIGPGKQRVELQIRTEDMDQIAELGIAAHAFYKDDIGSPTELLKRESNAFAWLRHT
IGILSESANPEEFLEHTKLELFHDQVFCFTPKGKLIALPRHANVIDFAYAVHTDVGNSAVGCKINGKFAALSSELQNGDE
VEVLTSDAQSAPPSAWETLAITGKARAAIRRATRTAVRDQYAGLGRRIVERLFERTKLEYADDKLKGALPRLARASIEDV
MAAVGRGEIKASDVARAMYPDYKEERVVRYGAKKTATPAAKTAAPATEPARGAFAIPISGLNSGLPVKFAPNGGAVPGDR
IVGIVTPGEGITIYPIQSPALKDFEDEPERWLDVRWDVDETTPQRFPARIKVENVNEPGSLAQVATVIAEHDGNIDNISM
SRRSPDFTELTIDLEVYDLKHLSAIINQLRAKTIVAKVDRVNG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=124, Percent_Identity=39.5161290322581, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1790082, Length=721, Percent_Identity=38.002773925104, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1789147, Length=722, Percent_Identity=30.4709141274238, Blast_Score=348, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI25143118, Length=131, Percent_Identity=36.6412213740458, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24650996, Length=123, Percent_Identity=37.3983739837398, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 85036; Mature: 85036

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVPGHTPQQMQAAAESAAVAPPAERPRPPKPRSRMMRQYDLVERVRSYNPDTNEDLLNR
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AYVYAMKAHGSQTRASGDPYFTHPLEVAAILTDLKLDDATIVAALLHDTIEDTEATRAEI
HHEEEEECCCCCCCCCCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
DRFFGPEIGALVEGLTKLKRLELVSREAKQAENLRKLLLAIADDVRVLLVKLADRLHNMR
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
TLDFVPEASRRRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPQAYGVVMQRLDAL
EECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEECCHHHHHHHHHHHHHH
ADRNRNLIGEIESQLARKFRDHGLTARVFGRRKRPFSIWTKMERKSIGFEQLSDIFGFRV
HHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEE
IMPDLESCYRALGIVHTTWPVVPGRFKDYISTPKQNDYRSIHTTVIGPGKQRVELQIRTE
EHHHHHHHHHHHCCHHHCCCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEEECC
DMDQIAELGIAAHAFYKDDIGSPTELLKRESNAFAWLRHTIGILSESANPEEFLEHTKLE
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFHDQVFCFTPKGKLIALPRHANVIDFAYAVHTDVGNSAVGCKINGKFAALSSELQNGDE
HHHCEEEEECCCCCEEEECCCCCHHHHHHHEECCCCCCEEEEEECCCHHHHHHHHCCCCC
VEVLTSDAQSAPPSAWETLAITGKARAAIRRATRTAVRDQYAGLGRRIVERLFERTKLEY
EEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADDKLKGALPRLARASIEDVMAAVGRGEIKASDVARAMYPDYKEERVVRYGAKKTATPAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCH
KTAAPATEPARGAFAIPISGLNSGLPVKFAPNGGAVPGDRIVGIVTPGEGITIYPIQSPA
HCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCEEEEEECCCCEEEEECCCCC
LKDFEDEPERWLDVRWDVDETTPQRFPARIKVENVNEPGSLAQVATVIAEHDGNIDNISM
CCCCCCCCHHHEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEC
SRRSPDFTELTIDLEVYDLKHLSAIINQLRAKTIVAKVDRVNG
CCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVVPGHTPQQMQAAAESAAVAPPAERPRPPKPRSRMMRQYDLVERVRSYNPDTNEDLLNR
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AYVYAMKAHGSQTRASGDPYFTHPLEVAAILTDLKLDDATIVAALLHDTIEDTEATRAEI
HHEEEEECCCCCCCCCCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
DRFFGPEIGALVEGLTKLKRLELVSREAKQAENLRKLLLAIADDVRVLLVKLADRLHNMR
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
TLDFVPEASRRRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPQAYGVVMQRLDAL
EECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEECCHHHHHHHHHHHHHH
ADRNRNLIGEIESQLARKFRDHGLTARVFGRRKRPFSIWTKMERKSIGFEQLSDIFGFRV
HHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEE
IMPDLESCYRALGIVHTTWPVVPGRFKDYISTPKQNDYRSIHTTVIGPGKQRVELQIRTE
EHHHHHHHHHHHCCHHHCCCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEEECC
DMDQIAELGIAAHAFYKDDIGSPTELLKRESNAFAWLRHTIGILSESANPEEFLEHTKLE
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFHDQVFCFTPKGKLIALPRHANVIDFAYAVHTDVGNSAVGCKINGKFAALSSELQNGDE
HHHCEEEEECCCCCEEEECCCCCHHHHHHHEECCCCCCEEEEEECCCHHHHHHHHCCCCC
VEVLTSDAQSAPPSAWETLAITGKARAAIRRATRTAVRDQYAGLGRRIVERLFERTKLEY
EEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADDKLKGALPRLARASIEDVMAAVGRGEIKASDVARAMYPDYKEERVVRYGAKKTATPAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCH
KTAAPATEPARGAFAIPISGLNSGLPVKFAPNGGAVPGDRIVGIVTPGEGITIYPIQSPA
HCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCEEEEEECCCCEEEEECCCCC
LKDFEDEPERWLDVRWDVDETTPQRFPARIKVENVNEPGSLAQVATVIAEHDGNIDNISM
CCCCCCCCHHHEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEC
SRRSPDFTELTIDLEVYDLKHLSAIINQLRAKTIVAKVDRVNG
CCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA