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The map label for this gene is rnc [H]

Identifier: 146341377

GI number: 146341377

Start: 4663665

End: 4664738

Strand: Reverse

Name: rnc [H]

Synonym: BRADO4463

Alternate gene names: 146341377

Gene position: 4664738-4663665 (Counterclockwise)

Preceding gene: 146341378

Following gene: 146341376

Centisome position: 62.56

GC content: 67.6

Gene sequence:

>1074_bases
ATGATCGACGACTCACCCGAGATCCAGACGACGCAGGCTGCTGCAACGAGCCCGCAAGCCGGCGCGGGCGCGCTCGAGGC
TGCGCCCAAGACGTCGACGCGACCCAAGCCGGACGCGAAGCCTGAGGTGAAGTCTGAGGCAAAGGTCGAGCTTAAGGTCG
AGCCGAAGATCGAAGCGAAGTCTGACGCGAAGACCGAAGCGAAGTCTGCCAATCCTGCCGAGCCGGCCTCCGAGGTCGAT
GGCCAGGGACCGAACGGCGTTGCGCCTCCGGTCGATGCGGAATCCGATGCCAAGCCGTCCGGCAAGGCCAAGGGCAGCCG
CCGGACCAAGACCGCCGGAACCGGAGTCACGAAGAGCGTGAAGGCCGCCGAGAAGGCGGCCAATGCCGCGATCGAGGCGC
GGATCGGCCATCGCTTCGCCGATCCGTCACTGCTCAGCACGGCCTTCACCCATGTCTCAGCGCTGAAATCCTCCAAGAAG
CGCGGCGACAGCTATCAGCGCCTCGAATTCCTCGGTGACCACGTCCTGGGCCTGATCGTGTCGGACATGCTGTACCGCGC
GTTCCCGAGCGCCGACGAAGGCGAACTGTCGAAGCGGCTGGCCGATCTCGTGCGCAAGGAGAGCTGCGCCGATGTCGCCA
AGTCGCTTGGCCTGCTGGATGACATCAAGCTCGGCGCCGTTGGCGCCGGCGCCGGCGCGCGGCTGCGCAAATCGGTGCTC
GGCGATGTCTGCGAGGCGGTGATCGGCGCGATCTTCCTGGATGGCGGCTACACGGCTGCGGCCGGCTTCGTCGAGCGCAA
CTGGACCGAGCGCATGCGCAAGCCGCGGCGGCCGCTGCGCGATCCGAAGACCGTGTTGCAGGAGTGGGCGCAGGGCAAGG
GCTTGCCGACGCCGGTCTATCGCGAGGTCGAGCGCACCGGCCCGCATCACGATCCGCAATTCCGCGTTGCTGTCGATCTG
CCCGGTCTGGAGCCGGCCGAAGGGGTGGGCGGATCCAAGCGGGCAGCCGAGAAGGTGGCGGCATCCGTGATGATCGAGCG
CGAGGGCGTGAGCGGCGGCAGCAATGACGGCTGA

Upstream 100 bases:

>100_bases
CCCAGATGATCTTCTTCTCCATTCGGGAGAACGAGCATGCCTGGGCGTTCTGGCGCTGGCCGATGTCCATCCGTTGGGAA
CGTCTGTTCAAGATCGTACG

Downstream 100 bases:

>100_bases
GCAACAGGCCGGGCAGGGCGCGACCCGCTGCGGTTTCGTCGCGCTGATCGGCGCTCCGAATGTCGGCAAGTCGACCCTCG
TCAATGCGCTGGTCGGCTCC

Product: ribonuclease III (modular protein)

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MIDDSPEIQTTQAAATSPQAGAGALEAAPKTSTRPKPDAKPEVKSEAKVELKVEPKIEAKSDAKTEAKSANPAEPASEVD
GQGPNGVAPPVDAESDAKPSGKAKGSRRTKTAGTGVTKSVKAAEKAANAAIEARIGHRFADPSLLSTAFTHVSALKSSKK
RGDSYQRLEFLGDHVLGLIVSDMLYRAFPSADEGELSKRLADLVRKESCADVAKSLGLLDDIKLGAVGAGAGARLRKSVL
GDVCEAVIGAIFLDGGYTAAAGFVERNWTERMRKPRRPLRDPKTVLQEWAQGKGLPTPVYREVERTGPHHDPQFRVAVDL
PGLEPAEGVGGSKRAAEKVAASVMIEREGVSGGSNDG

Sequences:

>Translated_357_residues
MIDDSPEIQTTQAAATSPQAGAGALEAAPKTSTRPKPDAKPEVKSEAKVELKVEPKIEAKSDAKTEAKSANPAEPASEVD
GQGPNGVAPPVDAESDAKPSGKAKGSRRTKTAGTGVTKSVKAAEKAANAAIEARIGHRFADPSLLSTAFTHVSALKSSKK
RGDSYQRLEFLGDHVLGLIVSDMLYRAFPSADEGELSKRLADLVRKESCADVAKSLGLLDDIKLGAVGAGAGARLRKSVL
GDVCEAVIGAIFLDGGYTAAAGFVERNWTERMRKPRRPLRDPKTVLQEWAQGKGLPTPVYREVERTGPHHDPQFRVAVDL
PGLEPAEGVGGSKRAAEKVAASVMIEREGVSGGSNDG
>Mature_357_residues
MIDDSPEIQTTQAAATSPQAGAGALEAAPKTSTRPKPDAKPEVKSEAKVELKVEPKIEAKSDAKTEAKSANPAEPASEVD
GQGPNGVAPPVDAESDAKPSGKAKGSRRTKTAGTGVTKSVKAAEKAANAAIEARIGHRFADPSLLSTAFTHVSALKSSKK
RGDSYQRLEFLGDHVLGLIVSDMLYRAFPSADEGELSKRLADLVRKESCADVAKSLGLLDDIKLGAVGAGAGARLRKSVL
GDVCEAVIGAIFLDGGYTAAAGFVERNWTERMRKPRRPLRDPKTVLQEWAQGKGLPTPVYREVERTGPHHDPQFRVAVDL
PGLEPAEGVGGSKRAAEKVAASVMIEREGVSGGSNDG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=223, Percent_Identity=29.1479820627803, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI155030234, Length=223, Percent_Identity=29.1479820627803, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788920, Length=207, Percent_Identity=37.1980676328502, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=31.6017316017316, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=31.6017316017316, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137682, Length=223, Percent_Identity=34.5291479820628, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 37401; Mature: 37401

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDDSPEIQTTQAAATSPQAGAGALEAAPKTSTRPKPDAKPEVKSEAKVELKVEPKIEAK
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
SDAKTEAKSANPAEPASEVDGQGPNGVAPPVDAESDAKPSGKAKGSRRTKTAGTGVTKSV
CCCHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
KAAEKAANAAIEARIGHRFADPSLLSTAFTHVSALKSSKKRGDSYQRLEFLGDHVLGLIV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SDMLYRAFPSADEGELSKRLADLVRKESCADVAKSLGLLDDIKLGAVGAGAGARLRKSVL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHH
GDVCEAVIGAIFLDGGYTAAAGFVERNWTERMRKPRRPLRDPKTVLQEWAQGKGLPTPVY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHH
REVERTGPHHDPQFRVAVDLPGLEPAEGVGGSKRAAEKVAASVMIEREGVSGGSNDG
HHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIDDSPEIQTTQAAATSPQAGAGALEAAPKTSTRPKPDAKPEVKSEAKVELKVEPKIEAK
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
SDAKTEAKSANPAEPASEVDGQGPNGVAPPVDAESDAKPSGKAKGSRRTKTAGTGVTKSV
CCCHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
KAAEKAANAAIEARIGHRFADPSLLSTAFTHVSALKSSKKRGDSYQRLEFLGDHVLGLIV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SDMLYRAFPSADEGELSKRLADLVRKESCADVAKSLGLLDDIKLGAVGAGAGARLRKSVL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHH
GDVCEAVIGAIFLDGGYTAAAGFVERNWTERMRKPRRPLRDPKTVLQEWAQGKGLPTPVY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHH
REVERTGPHHDPQFRVAVDLPGLEPAEGVGGSKRAAEKVAASVMIEREGVSGGSNDG
HHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]