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The map label for this gene is degP [H]

Identifier: 146339698

GI number: 146339698

Start: 2894809

End: 2895906

Strand: Reverse

Name: degP [H]

Synonym: BRADO2695

Alternate gene names: 146339698

Gene position: 2895906-2894809 (Counterclockwise)

Preceding gene: 146339704

Following gene: 146339697

Centisome position: 38.84

GC content: 67.3

Gene sequence:

>1098_bases
ATGCAGCTTCTGCGTTGTACCCGGCCTTTGGTCCTGCTGCCGGCGATCCTGCTCTCCCTTCTGTATGCCCCTGCCCTCGC
CCAGATCCCGGATCTCAAGCTCGGCCGCGTCCCGACGCTGGCGCCGCTGGTCAAGGAGGTGACGCCCGCCGTCGTCAACA
TCTCGGTCGAGGGCAAGGTCCGGCAGGACAATCCGCTGTATCAGGACCCGCTGTTCCGCGACTTCTTCGACGTGCCGAAG
CAGGTCGAGAAGCAGATCAGCGCGACCGGCTCCGGCGTCATCGTGGATGCGCAGCGCGGCTACGTGATGACGGCCAACCA
TGTCGTCGAGCATGTCACCAGTGCCCAGATCCGAACCAAGGATGGCCGCAAGTTCTCCGCTCGCCTGGTCGGACGCGATC
CCGCCACCGACATCGCACTGCTGCAGATCAAGGACCCGACCGAACTGAAGGCGATCGCGCTCGGCGACAGCGATGCGCTG
GAGGTCGGCGACTTCGTGATCGCGGTCGGCAATCCCTTCGGCCTGGGACAGACCGTCACCTCCGGCCTCGTCAGCGCGCT
CGGACGTACCGGGCTCGGCAAGCAGGGCTATGAAGACTTCATCCAGACCGATGCCGCGATCAATCCCGGCAATTCCGGCG
GCGCGCTGATCAATCTGCGCGGCGAACTGGTCGGCATCAACACGGCGATCATCTCGCCCGGCGGCGGCAATGTCGGCATC
GGCTTCGCTGTGCCGATCAACATGGCCCGTCGCGTGATGGAGCAACTGGTCGCGAACGGCCGCGTCGATCGCGGCCGCAT
CGGCGTCACCCTGCTCGATCTGGATTCGGCGGCGGACGGCCTTGTCGTCGGTGCCCGCGTCGCCGACGTGGCAGCCGGCT
CGCCGGCGGAGCGCGCCGGCCTGCGCAAGGGCGATGTCATCGTGAAGGCGAATGACATGCCGGTGCGCAGCGCGACCCAG
GTTCGCAATCTCATCGGACTCACGCCGGTCGGCCAGCGTGTCCGCCTTGTGTTCGAGCGCGACCGTGCGCTCGGCAACGC
GACGGTCGAGGTCGCGCCGATCGCAGAGGAGCGCGCCCGCGTGCGGACGTCGGGTTGA

Upstream 100 bases:

>100_bases
CTCGGCAGGAACGATTGCCAGGTCGGCTCTTGACCGCGGCAGCCGTCCTGACCAGTTCTACGGGTGCCAAAATCCGCCCC
CTTCCGTCGAGGAAAACACG

Downstream 100 bases:

>100_bases
GGACGGCTCGGTGTTCAGCCTGGACGGCGTAGATTCGAGTTAAATTTTACCGTCCATCAAGCATGCAGCGAGACGCTGAT
ACCTCCCTAAAGACCTGTTA

Product: Serine protease do-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQLLRCTRPLVLLPAILLSLLYAPALAQIPDLKLGRVPTLAPLVKEVTPAVVNISVEGKVRQDNPLYQDPLFRDFFDVPK
QVEKQISATGSGVIVDAQRGYVMTANHVVEHVTSAQIRTKDGRKFSARLVGRDPATDIALLQIKDPTELKAIALGDSDAL
EVGDFVIAVGNPFGLGQTVTSGLVSALGRTGLGKQGYEDFIQTDAAINPGNSGGALINLRGELVGINTAIISPGGGNVGI
GFAVPINMARRVMEQLVANGRVDRGRIGVTLLDLDSAADGLVVGARVADVAAGSPAERAGLRKGDVIVKANDMPVRSATQ
VRNLIGLTPVGQRVRLVFERDRALGNATVEVAPIAEERARVRTSG

Sequences:

>Translated_365_residues
MQLLRCTRPLVLLPAILLSLLYAPALAQIPDLKLGRVPTLAPLVKEVTPAVVNISVEGKVRQDNPLYQDPLFRDFFDVPK
QVEKQISATGSGVIVDAQRGYVMTANHVVEHVTSAQIRTKDGRKFSARLVGRDPATDIALLQIKDPTELKAIALGDSDAL
EVGDFVIAVGNPFGLGQTVTSGLVSALGRTGLGKQGYEDFIQTDAAINPGNSGGALINLRGELVGINTAIISPGGGNVGI
GFAVPINMARRVMEQLVANGRVDRGRIGVTLLDLDSAADGLVVGARVADVAAGSPAERAGLRKGDVIVKANDMPVRSATQ
VRNLIGLTPVGQRVRLVFERDRALGNATVEVAPIAEERARVRTSG
>Mature_365_residues
MQLLRCTRPLVLLPAILLSLLYAPALAQIPDLKLGRVPTLAPLVKEVTPAVVNISVEGKVRQDNPLYQDPLFRDFFDVPK
QVEKQISATGSGVIVDAQRGYVMTANHVVEHVTSAQIRTKDGRKFSARLVGRDPATDIALLQIKDPTELKAIALGDSDAL
EVGDFVIAVGNPFGLGQTVTSGLVSALGRTGLGKQGYEDFIQTDAAINPGNSGGALINLRGELVGINTAIISPGGGNVGI
GFAVPINMARRVMEQLVANGRVDRGRIGVTLLDLDSAADGLVVGARVADVAAGSPAERAGLRKGDVIVKANDMPVRSATQ
VRNLIGLTPVGQRVRLVFERDRALGNATVEVAPIAEERARVRTSG

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=307, Percent_Identity=33.8762214983713, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI22129776, Length=308, Percent_Identity=32.7922077922078, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI24308541, Length=301, Percent_Identity=30.5647840531561, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI7019477, Length=254, Percent_Identity=36.6141732283465, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1786356, Length=352, Percent_Identity=46.0227272727273, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1789629, Length=312, Percent_Identity=50.6410256410256, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1789630, Length=306, Percent_Identity=37.2549019607843, Blast_Score=181, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24646839, Length=261, Percent_Identity=32.9501915708812, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 38474; Mature: 38474

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLLRCTRPLVLLPAILLSLLYAPALAQIPDLKLGRVPTLAPLVKEVTPAVVNISVEGKV
CCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEEEEEECCEE
RQDNPLYQDPLFRDFFDVPKQVEKQISATGSGVIVDAQRGYVMTANHVVEHVTSAQIRTK
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHCEEECC
DGRKFSARLVGRDPATDIALLQIKDPTELKAIALGDSDALEVGDFVIAVGNPFGLGQTVT
CCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCEEECCEEEEECCCCCCHHHHH
SGLVSALGRTGLGKQGYEDFIQTDAAINPGNSGGALINLRGELVGINTAIISPGGGNVGI
HHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEECCCCCCEEE
GFAVPINMARRVMEQLVANGRVDRGRIGVTLLDLDSAADGLVVGARVADVAAGSPAERAG
EEEECHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEEHHHHCCCCCHHHCC
LRKGDVIVKANDMPVRSATQVRNLIGLTPVGQRVRLVFERDRALGNATVEVAPIAEERAR
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHEEHHHHCCCCCEEEEEECHHHHHH
VRTSG
HCCCC
>Mature Secondary Structure
MQLLRCTRPLVLLPAILLSLLYAPALAQIPDLKLGRVPTLAPLVKEVTPAVVNISVEGKV
CCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEEEEEECCEE
RQDNPLYQDPLFRDFFDVPKQVEKQISATGSGVIVDAQRGYVMTANHVVEHVTSAQIRTK
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHCEEECC
DGRKFSARLVGRDPATDIALLQIKDPTELKAIALGDSDALEVGDFVIAVGNPFGLGQTVT
CCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCEEECCEEEEECCCCCCHHHHH
SGLVSALGRTGLGKQGYEDFIQTDAAINPGNSGGALINLRGELVGINTAIISPGGGNVGI
HHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEECCCCCCEEE
GFAVPINMARRVMEQLVANGRVDRGRIGVTLLDLDSAADGLVVGARVADVAAGSPAERAG
EEEECHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEEHHHHCCCCCHHHCC
LRKGDVIVKANDMPVRSATQVRNLIGLTPVGQRVRLVFERDRALGNATVEVAPIAEERAR
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHEEHHHHCCCCCEEEEEECHHHHHH
VRTSG
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]