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The map label for this gene is ribBA [H]

Identifier: 146339174

GI number: 146339174

Start: 2268010

End: 2269086

Strand: Direct

Name: ribBA [H]

Synonym: BRADO2133

Alternate gene names: 146339174

Gene position: 2268010-2269086 (Clockwise)

Preceding gene: 146339172

Following gene: 146339175

Centisome position: 30.42

GC content: 65.65

Gene sequence:

>1077_bases
ATGGCCGACTCGATCCAGGAAGTTCTGCACGCCTTCGCCAAGGGCGAGATGGTCGTCGTGACCGACGATGACGATCGCGA
GGGCGAGGGCGATCTGATCGTTGCGGCCTCGCTGTGCACGCCCGATAAGATGGCGTTCATCATCCGCCACACCTCCGGCA
TCGTCTGCGCGCCGATCACGGCCGACGACGCGCGGCGGCTGCGGCTCGATCCGATGGTCGCGCACAACGACTCCAACCAC
ACCACGGCGTTCACGGTCTCGATCGACTACAAGCCGGACGGCGGCACCGGCATCTCGGCCGAGGAGCGCGCGTCCTGCTG
CCGTGCGCTCGCCAATCCCAACGCCGGCGCCAATGATTTCGCGCGCCCCGGCCATATCTTCCCGCTCATCGCGCGTGACG
GCGGCGTGCTGCTGCGTTCGGGTCATACCGAGGCGGCCGTGGATCTTTGCAAGCTTTCGGGGTTGCCGCCGGTCGGCGTC
ATCTCCGAGTTGATGAACGACGACGGCACCGTCATGAAGGGCGAGCAGGTCGTCCGCTTCGCCGCGGCGCATAACCTCAA
GCACGTGACGATCGCCGACCTGATCTCCTACCGGCAGGCGCGCGAGAAGCTGATCGAGCGCGTGTCGACCTTCACGACCG
AGAGCCCGATCGGCCCGCTGCAGGGCTATGCTTACCGCTCGCCGTTCGATCCGATCACCCACGCCGCTTTTGTCTACAAC
GGCATCGGCGACGGCAAGAACGTGCTGACGCGGCTGCACAAGCCCAACATCGTGAAGGATCTGATCGCGGGTCCGCAGCG
TATTCAAGCCGTGCTGCAGCACTTCAAGAAGAACGGTCGCGGCGTTCTGATCTATCTGCGCGACGGCGCCGCCGGTGTTC
CGGTCGAGCCCGTCGCGGAGCCGCATACGGCGGAGGCCGACCGCCATCGCCAATGGCGCGAGGTCGGCGTCGGCGCGCAG
ATTCTGCGTGATCTCGGCGTGACGTCGATCCGGAACCTGACCTCGTCGGTCCATGACTACAAGGGCCTGTCTGGCTTCGG
CATCGAGATCGTCGCCAATGAGCGGCTTGAAGGCTGA

Upstream 100 bases:

>100_bases
TTTCCCGGGGAAGGCGACCTTCGAGCGGCGGTTCCGCTGCTCTGGCGTGCGCCTGCGATCCCGGCTAAAGCAGCCCCGGA
AAAAGCAGCGAGACTTTGCA

Downstream 100 bases:

>100_bases
ACTGCCAGGATTTAACCTCCAGACGGCTGCGACCCGTGCGCAGCGAGACGCGAAAGGACCATTCATGAGCGCGCGCCCTC
AGGCAAAGGACAAGCCGGCC

Product: putative GTP cyclohydrolase II, riboflavin biosynthesis

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MADSIQEVLHAFAKGEMVVVTDDDDREGEGDLIVAASLCTPDKMAFIIRHTSGIVCAPITADDARRLRLDPMVAHNDSNH
TTAFTVSIDYKPDGGTGISAEERASCCRALANPNAGANDFARPGHIFPLIARDGGVLLRSGHTEAAVDLCKLSGLPPVGV
ISELMNDDGTVMKGEQVVRFAAAHNLKHVTIADLISYRQAREKLIERVSTFTTESPIGPLQGYAYRSPFDPITHAAFVYN
GIGDGKNVLTRLHKPNIVKDLIAGPQRIQAVLQHFKKNGRGVLIYLRDGAAGVPVEPVAEPHTAEADRHRQWREVGVGAQ
ILRDLGVTSIRNLTSSVHDYKGLSGFGIEIVANERLEG

Sequences:

>Translated_358_residues
MADSIQEVLHAFAKGEMVVVTDDDDREGEGDLIVAASLCTPDKMAFIIRHTSGIVCAPITADDARRLRLDPMVAHNDSNH
TTAFTVSIDYKPDGGTGISAEERASCCRALANPNAGANDFARPGHIFPLIARDGGVLLRSGHTEAAVDLCKLSGLPPVGV
ISELMNDDGTVMKGEQVVRFAAAHNLKHVTIADLISYRQAREKLIERVSTFTTESPIGPLQGYAYRSPFDPITHAAFVYN
GIGDGKNVLTRLHKPNIVKDLIAGPQRIQAVLQHFKKNGRGVLIYLRDGAAGVPVEPVAEPHTAEADRHRQWREVGVGAQ
ILRDLGVTSIRNLTSSVHDYKGLSGFGIEIVANERLEG
>Mature_357_residues
ADSIQEVLHAFAKGEMVVVTDDDDREGEGDLIVAASLCTPDKMAFIIRHTSGIVCAPITADDARRLRLDPMVAHNDSNHT
TAFTVSIDYKPDGGTGISAEERASCCRALANPNAGANDFARPGHIFPLIARDGGVLLRSGHTEAAVDLCKLSGLPPVGVI
SELMNDDGTVMKGEQVVRFAAAHNLKHVTIADLISYRQAREKLIERVSTFTTESPIGPLQGYAYRSPFDPITHAAFVYNG
IGDGKNVLTRLHKPNIVKDLIAGPQRIQAVLQHFKKNGRGVLIYLRDGAAGVPVEPVAEPHTAEADRHRQWREVGVGAQI
LRDLGVTSIRNLTSSVHDYKGLSGFGIEIVANERLEG

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=201, Percent_Identity=47.2636815920398, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=45.6310679611651, Blast_Score=175, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 38633; Mature: 38502

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSIQEVLHAFAKGEMVVVTDDDDREGEGDLIVAASLCTPDKMAFIIRHTSGIVCAPIT
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEECCCEEEEECC
ADDARRLRLDPMVAHNDSNHTTAFTVSIDYKPDGGTGISAEERASCCRALANPNAGANDF
CCCCCCEEECCEEEECCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
ARPGHIFPLIARDGGVLLRSGHTEAAVDLCKLSGLPPVGVISELMNDDGTVMKGEQVVRF
CCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEHHHHHHH
AAAHNLKHVTIADLISYRQAREKLIERVSTFTTESPIGPLQGYAYRSPFDPITHAAFVYN
HHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
GIGDGKNVLTRLHKPNIVKDLIAGPQRIQAVLQHFKKNGRGVLIYLRDGAAGVPVEPVAE
CCCCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
PHTAEADRHRQWREVGVGAQILRDLGVTSIRNLTSSVHDYKGLSGFGIEIVANERLEG
CCCCCHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
ADSIQEVLHAFAKGEMVVVTDDDDREGEGDLIVAASLCTPDKMAFIIRHTSGIVCAPIT
CHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEECCCEEEEECC
ADDARRLRLDPMVAHNDSNHTTAFTVSIDYKPDGGTGISAEERASCCRALANPNAGANDF
CCCCCCEEECCEEEECCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
ARPGHIFPLIARDGGVLLRSGHTEAAVDLCKLSGLPPVGVISELMNDDGTVMKGEQVVRF
CCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEHHHHHHH
AAAHNLKHVTIADLISYRQAREKLIERVSTFTTESPIGPLQGYAYRSPFDPITHAAFVYN
HHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
GIGDGKNVLTRLHKPNIVKDLIAGPQRIQAVLQHFKKNGRGVLIYLRDGAAGVPVEPVAE
CCCCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
PHTAEADRHRQWREVGVGAQILRDLGVTSIRNLTSSVHDYKGLSGFGIEIVANERLEG
CCCCCHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA