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The map label for this gene is gcdH [H]

Identifier: 146339175

GI number: 146339175

Start: 2269151

End: 2270365

Strand: Direct

Name: gcdH [H]

Synonym: BRADO2134

Alternate gene names: 146339175

Gene position: 2269151-2270365 (Clockwise)

Preceding gene: 146339174

Following gene: 146339176

Centisome position: 30.43

GC content: 64.94

Gene sequence:

>1215_bases
ATGAGCGCGCGCCCTCAGGCAAAGGACAAGCCGGCCCAGTCGAGCTTCCAGTGGGACGATCCCTTTCTGCTGGACGAGCA
GTTGACCGAGGACGAGCGCATGGTGCGTGACACCGCGCGCGCCTATGCCCAGGACAAGCTGCTGCCGCGCGTCACCAAGG
CTTACCTCGAAGAGAAAACCGACCGCGAGATCTTCAACGAGATGGGCGAGCTCGGCCTGATCGGCATCACGCTGCCGGAG
GAATATGGCTGCGCCAATGCGAGCTACGTCGCTTATGGCCTCGTGGCGCGCGAGATCGAGCGGGTCGATTCCGGCTACCG
CTCGATGAACTCGGTGCAGTCGTCGCTGGTGATGTATCCGATCTATGCCTATGGCGACGAGAACCAGCGCAAGAAATATC
TGCCGAAGCTCGCCAGCGGCGAATGGGTCGGCTGTTTCGGCCTGACCGAGCCGGATGCCGGCTCCGATCCCGCTGGCATG
AAGACGCGCGCCGAGAAGGTTGCCGACGGCTACCGCCTGACCGGCAGCAAGATGTGGATCTCGAACGCGCCGATCGCCGA
CGTGTTCGTGGTGTGGGCCAAATCGGCCGCGCATGACAACCAGATCCGCGGCTTCATTCTCGAGAAGGGCATGAAGGGCT
TGTCGGCGCCGAAGATCGGCGGCAAGCTCTCGCTGCGCGCCTCGATCACCGGTGAGATCGTGATGGACGGCGTGGTGGTG
CCGGAAGATGCGCTGCTGCCCAACGTGTCCGGCCTCAAGGGCCCGTTCGGCTGCCTCAACCGCGCCCGCTACGGCATCTC
CTGGGGGGTGCTCGGCGCCGCCGAGGACTGCATGCATCGCGCCCGCCAGTACACGCTCGACCGCAAGCAGTTTGGCCGCC
CGCTCGCCGCCACCCAGCTGGTGCAGAAGAAGCTCGCCGACATGGAGACCGAGATCGCGCTCGGCCTGCAGGCGAGCCTG
CGCGTCGGTCGTCTGATGGACGAGGGCAAGATGGCCCCGGAAATGATCTCGATCGTCAAGCGCAACAATTGCGGCAAGGC
GCTGGACATCGCCCGCGTGTCGCGTGACATGCACGGCGGCAACGGCATCCAGATCGAGTACCAGGTAATGCGCCACGTCT
CGAACCTCGAGACGGTCAACACCTACGAGGGCACGCACGACGTCCACGCCCTGATCCTCGGCCGCGCCATCACCGGCATC
CAGGCGTTCTTCTAG

Upstream 100 bases:

>100_bases
ATCGAGATCGTCGCCAATGAGCGGCTTGAAGGCTGAACTGCCAGGATTTAACCTCCAGACGGCTGCGACCCGTGCGCAGC
GAGACGCGAAAGGACCATTC

Downstream 100 bases:

>100_bases
TTCGCCTGGTCGTTCGCGGGGGCGGGTCTTGAGTCCTCAACTGTCATCGTCCGCGAAAGCGGACGATCCACTACGCCGAG
ATGACAGTGATCAGCTGAGA

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSARPQAKDKPAQSSFQWDDPFLLDEQLTEDERMVRDTARAYAQDKLLPRVTKAYLEEKTDREIFNEMGELGLIGITLPE
EYGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDENQRKKYLPKLASGEWVGCFGLTEPDAGSDPAGM
KTRAEKVADGYRLTGSKMWISNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVV
PEDALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCMHRARQYTLDRKQFGRPLAATQLVQKKLADMETEIALGLQASL
RVGRLMDEGKMAPEMISIVKRNNCGKALDIARVSRDMHGGNGIQIEYQVMRHVSNLETVNTYEGTHDVHALILGRAITGI
QAFF

Sequences:

>Translated_404_residues
MSARPQAKDKPAQSSFQWDDPFLLDEQLTEDERMVRDTARAYAQDKLLPRVTKAYLEEKTDREIFNEMGELGLIGITLPE
EYGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDENQRKKYLPKLASGEWVGCFGLTEPDAGSDPAGM
KTRAEKVADGYRLTGSKMWISNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVV
PEDALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCMHRARQYTLDRKQFGRPLAATQLVQKKLADMETEIALGLQASL
RVGRLMDEGKMAPEMISIVKRNNCGKALDIARVSRDMHGGNGIQIEYQVMRHVSNLETVNTYEGTHDVHALILGRAITGI
QAFF
>Mature_403_residues
SARPQAKDKPAQSSFQWDDPFLLDEQLTEDERMVRDTARAYAQDKLLPRVTKAYLEEKTDREIFNEMGELGLIGITLPEE
YGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDENQRKKYLPKLASGEWVGCFGLTEPDAGSDPAGMK
TRAEKVADGYRLTGSKMWISNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVVP
EDALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCMHRARQYTLDRKQFGRPLAATQLVQKKLADMETEIALGLQASLR
VGRLMDEGKMAPEMISIVKRNNCGKALDIARVSRDMHGGNGIQIEYQVMRHVSNLETVNTYEGTHDVHALILGRAITGIQ
AFF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=396, Percent_Identity=66.4141414141414, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI7669494, Length=376, Percent_Identity=64.8936170212766, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=32.5396825396825, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI226958414, Length=348, Percent_Identity=32.7586206896552, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=31.2, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=30.7277628032345, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=29.3333333333333, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=29.3333333333333, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI4557235, Length=411, Percent_Identity=29.683698296837, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=29.9479166666667, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI21361497, Length=378, Percent_Identity=29.3650793650794, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=27.2251308900524, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI7656849, Length=382, Percent_Identity=28.0104712041885, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI1786223, Length=353, Percent_Identity=22.6628895184136, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081958, Length=389, Percent_Identity=23.6503856041131, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17534353, Length=392, Percent_Identity=65.8163265306122, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17538396, Length=391, Percent_Identity=33.2480818414322, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=31.0626702997275, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17506239, Length=383, Percent_Identity=29.7650130548303, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=29.6296296296296, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=252, Percent_Identity=37.6984126984127, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71985184, Length=377, Percent_Identity=28.6472148541114, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=28.3068783068783, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=27.8215223097113, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=30.7142857142857, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=34.6320346320346, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=30.2919708029197, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17533517, Length=386, Percent_Identity=25.3886010362694, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=249, Percent_Identity=26.1044176706827, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17505929, Length=314, Percent_Identity=23.2484076433121, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19920834, Length=398, Percent_Identity=62.0603015075377, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=32.171581769437, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=30.6666666666667, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=31.9261213720317, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=29.9465240641711, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=30.6878306878307, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281363737, Length=393, Percent_Identity=29.5165394402036, Blast_Score=151, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 44580; Mature: 44448

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARPQAKDKPAQSSFQWDDPFLLDEQLTEDERMVRDTARAYAQDKLLPRVTKAYLEEKT
CCCCCCCCCCCCCCCCCCCCCEECCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DREIFNEMGELGLIGITLPEEYGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYP
HHHHHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYAYGDENQRKKYLPKLASGEWVGCFGLTEPDAGSDPAGMKTRAEKVADGYRLTGSKMWI
EEEECCCCHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCEEECCCEEEE
SNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVV
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCEEC
PEDALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCMHRARQYTLDRKQFGRPLAATQL
CCHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHH
VQKKLADMETEIALGLQASLRVGRLMDEGKMAPEMISIVKRNNCGKALDIARVSRDMHGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCC
NGIQIEYQVMRHVSNLETVNTYEGTHDVHALILGRAITGIQAFF
CCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SARPQAKDKPAQSSFQWDDPFLLDEQLTEDERMVRDTARAYAQDKLLPRVTKAYLEEKT
CCCCCCCCCCCCCCCCCCCCEECCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DREIFNEMGELGLIGITLPEEYGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYP
HHHHHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYAYGDENQRKKYLPKLASGEWVGCFGLTEPDAGSDPAGMKTRAEKVADGYRLTGSKMWI
EEEECCCCHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCEEECCCEEEE
SNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVV
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCEEC
PEDALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCMHRARQYTLDRKQFGRPLAATQL
CCHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHH
VQKKLADMETEIALGLQASLRVGRLMDEGKMAPEMISIVKRNNCGKALDIARVSRDMHGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCC
NGIQIEYQVMRHVSNLETVNTYEGTHDVHALILGRAITGIQAFF
CCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]