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The map label for this gene is idnD [H]

Identifier: 146338865

GI number: 146338865

Start: 1928564

End: 1929595

Strand: Direct

Name: idnD [H]

Synonym: BRADO1804

Alternate gene names: 146338865

Gene position: 1928564-1929595 (Clockwise)

Preceding gene: 146338864

Following gene: 146338866

Centisome position: 25.86

GC content: 69.28

Gene sequence:

>1032_bases
ATGCGTGCCGTCGTGATTCACGCGCCCAAGGATCTGCGCATCGACAGCTTCCCCGACCCGGCGCCGGAGGCGGGCCAGGT
CCGGGTCAAGATCGAGGCCGGCGGCATCTGCGGGTCGGACCTGCATTATTACCATCATGGCGGCTTCGGCACGGTGCGCA
TCAAGCAGCCGATGGCGCTCGGCCATGAAATCGCGGGCGTCGTCGCCGCGGTCGGCGCCGGCGTGACCGGCCTCGCCGAG
GGCACGCGTGTCGCCGTCAATCCAAGCCTGCCGTGCGGCCACTGCGCCTATTGCCGCGAGGGCCTGCGCAACCAGTGCCT
GGACATGCGCTTCATGGGCAGCGCGATGCGCGACCCGCACGTGCAGGGCGGCTTTCGCGAGTTCGTCACCGTCGATGCCT
CGCAGGCGGTGCCGATCGCGCCGTCACTGTCGCTGGGTGAGGCCGCGATGGCCGAGCCGCTGTCGGTGTGCTTGCATGCC
GCGCATCAGGCCGGCTCGCTGCTCGGCAAGCGCGTGCTGGTGACCGGCTGCGGCCCGATCGGCGCGCTGTCGATCCTGGT
CGCGCGCTATGGCGGCGCGGCCGAAATCGTGGCCACCGACGTCGCCGAGGCGCCGCTTGCCGTGGCGCGCAAGCTCGGCG
CCAGCCACGCTGTCAACGTCGCCGCGGAGCCATCCGCGCTCGATCCCTGGCGCGTGGGGAAGGGCACCTTCGACGTGCTG
TTCGAGGCGTCCGGCAACCAGGCCGCGCTGCGCGCAGCGCTCGACGTGATGAGGCCGGGCGGGGTCATCGTCCAGCTCGG
GCTCGGCGGCGAAATGACATTGCCGCTCAACACGCTGGTCACGAAGGAGCTGCAATTGCGCGGCACCTTCCGGTTCGACC
GCGAATTCGATCTGGCGGTGCGGCTGATGGGCGAGGGGCTGCTCGACGTGAAGCCGCTGATCTCAGCCACGCTGCCGTTC
CAGGAGGCAATTTCCGCCTTCGAGCTCGCCAGCGATCGAAGCCGCGCGATGAAGGTTCATTTGACGTTTTAA

Upstream 100 bases:

>100_bases
CGAGGCGTAATGACGGCGGTGGCGGCCATCAACCGCTTGCCGGTCTGATCGCGTCGTGATCTAGGATCGACGGAGAAGAC
CAGACAGGGAGACCCGGCCC

Downstream 100 bases:

>100_bases
CGAGCGGATTGATGCCGATGAGAGTCGCCTGCATCGGAGAGTGCATGGTGGAGTTCGCGCAGGAGGACGGAAGTCTGTTC
CGGCGCGGTTTTGGCGGCGA

Product: L-idonate 5-dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRAVVIHAPKDLRIDSFPDPAPEAGQVRVKIEAGGICGSDLHYYHHGGFGTVRIKQPMALGHEIAGVVAAVGAGVTGLAE
GTRVAVNPSLPCGHCAYCREGLRNQCLDMRFMGSAMRDPHVQGGFREFVTVDASQAVPIAPSLSLGEAAMAEPLSVCLHA
AHQAGSLLGKRVLVTGCGPIGALSILVARYGGAAEIVATDVAEAPLAVARKLGASHAVNVAAEPSALDPWRVGKGTFDVL
FEASGNQAALRAALDVMRPGGVIVQLGLGGEMTLPLNTLVTKELQLRGTFRFDREFDLAVRLMGEGLLDVKPLISATLPF
QEAISAFELASDRSRAMKVHLTF

Sequences:

>Translated_343_residues
MRAVVIHAPKDLRIDSFPDPAPEAGQVRVKIEAGGICGSDLHYYHHGGFGTVRIKQPMALGHEIAGVVAAVGAGVTGLAE
GTRVAVNPSLPCGHCAYCREGLRNQCLDMRFMGSAMRDPHVQGGFREFVTVDASQAVPIAPSLSLGEAAMAEPLSVCLHA
AHQAGSLLGKRVLVTGCGPIGALSILVARYGGAAEIVATDVAEAPLAVARKLGASHAVNVAAEPSALDPWRVGKGTFDVL
FEASGNQAALRAALDVMRPGGVIVQLGLGGEMTLPLNTLVTKELQLRGTFRFDREFDLAVRLMGEGLLDVKPLISATLPF
QEAISAFELASDRSRAMKVHLTF
>Mature_343_residues
MRAVVIHAPKDLRIDSFPDPAPEAGQVRVKIEAGGICGSDLHYYHHGGFGTVRIKQPMALGHEIAGVVAAVGAGVTGLAE
GTRVAVNPSLPCGHCAYCREGLRNQCLDMRFMGSAMRDPHVQGGFREFVTVDASQAVPIAPSLSLGEAAMAEPLSVCLHA
AHQAGSLLGKRVLVTGCGPIGALSILVARYGGAAEIVATDVAEAPLAVARKLGASHAVNVAAEPSALDPWRVGKGTFDVL
FEASGNQAALRAALDVMRPGGVIVQLGLGGEMTLPLNTLVTKELQLRGTFRFDREFDLAVRLMGEGLLDVKPLISATLPF
QEAISAFELASDRSRAMKVHLTF

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=331, Percent_Identity=34.7432024169184, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=26.2734584450402, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4501929, Length=354, Percent_Identity=26.5536723163842, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=26.2032085561497, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71565154, Length=358, Percent_Identity=26.536312849162, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI262073058, Length=385, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71743840, Length=385, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=25.5555555555556, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=25.5555555555556, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1790718, Length=316, Percent_Identity=48.1012658227848, Blast_Score=297, Evalue=6e-82,
Organism=Escherichia coli, GI1788073, Length=338, Percent_Identity=31.0650887573964, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=33.9031339031339, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790045, Length=317, Percent_Identity=34.0694006309148, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1788407, Length=319, Percent_Identity=32.6018808777429, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI226510992, Length=344, Percent_Identity=28.7790697674419, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788075, Length=345, Percent_Identity=28.1159420289855, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87082125, Length=283, Percent_Identity=28.9752650176678, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786825, Length=386, Percent_Identity=25.6476683937824, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=331, Percent_Identity=29.607250755287, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786552, Length=365, Percent_Identity=27.9452054794521, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=346, Percent_Identity=36.7052023121387, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17562878, Length=331, Percent_Identity=38.6706948640483, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI25146526, Length=298, Percent_Identity=28.8590604026846, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=300, Percent_Identity=28.3333333333333, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=243, Percent_Identity=29.2181069958848, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=26.3636363636364, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=305, Percent_Identity=27.5409836065574, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=307, Percent_Identity=23.7785016286645, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=338, Percent_Identity=34.6153846153846, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322619, Length=337, Percent_Identity=35.0148367952522, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319955, Length=337, Percent_Identity=35.0148367952522, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319258, Length=388, Percent_Identity=27.0618556701031, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319257, Length=381, Percent_Identity=27.2965879265092, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320033, Length=363, Percent_Identity=28.6501377410468, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=300, Percent_Identity=25.6666666666667, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=253, Percent_Identity=28.4584980237154, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=317, Percent_Identity=24.6056782334385, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=301, Percent_Identity=23.9202657807309, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=267, Percent_Identity=29.9625468164794, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=277, Percent_Identity=28.158844765343, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17737897, Length=329, Percent_Identity=36.7781155015198, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17137530, Length=329, Percent_Identity=34.3465045592705, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI45550770, Length=341, Percent_Identity=25.5131964809384, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551930, Length=341, Percent_Identity=25.5131964809384, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221457811, Length=341, Percent_Identity=25.5131964809384, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737895, Length=362, Percent_Identity=27.6243093922652, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 35954; Mature: 35954

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVIHAPKDLRIDSFPDPAPEAGQVRVKIEAGGICGSDLHYYHHGGFGTVRIKQPMAL
CCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECCEEEEEECCCHHH
GHEIAGVVAAVGAGVTGLAEGTRVAVNPSLPCGHCAYCREGLRNQCLDMRFMGSAMRDPH
HHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VQGGFREFVTVDASQAVPIAPSLSLGEAAMAEPLSVCLHAAHQAGSLLGKRVLVTGCGPI
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
GALSILVARYGGAAEIVATDVAEAPLAVARKLGASHAVNVAAEPSALDPWRVGKGTFDVL
HHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEE
FEASGNQAALRAALDVMRPGGVIVQLGLGGEMTLPLNTLVTKELQLRGTFRFDREFDLAV
EECCCCHHHHHHHHHHCCCCCEEEEEECCCCEEECHHHHHHHEEEEEEEEEECCCHHHHH
RLMGEGLLDVKPLISATLPFQEAISAFELASDRSRAMKVHLTF
HHHCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure
MRAVVIHAPKDLRIDSFPDPAPEAGQVRVKIEAGGICGSDLHYYHHGGFGTVRIKQPMAL
CCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECCEEEEEECCCHHH
GHEIAGVVAAVGAGVTGLAEGTRVAVNPSLPCGHCAYCREGLRNQCLDMRFMGSAMRDPH
HHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VQGGFREFVTVDASQAVPIAPSLSLGEAAMAEPLSVCLHAAHQAGSLLGKRVLVTGCGPI
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
GALSILVARYGGAAEIVATDVAEAPLAVARKLGASHAVNVAAEPSALDPWRVGKGTFDVL
HHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEE
FEASGNQAALRAALDVMRPGGVIVQLGLGGEMTLPLNTLVTKELQLRGTFRFDREFDLAV
EECCCCHHHHHHHHHHCCCCCEEEEEECCCCEEECHHHHHHHEEEEEEEEEECCCHHHHH
RLMGEGLLDVKPLISATLPFQEAISAFELASDRSRAMKVHLTF
HHHCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]