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The map label for this gene is hutH [H]

Identifier: 146338672

GI number: 146338672

Start: 1715794

End: 1717341

Strand: Direct

Name: hutH [H]

Synonym: BRADO1604

Alternate gene names: 146338672

Gene position: 1715794-1717341 (Clockwise)

Preceding gene: 146338671

Following gene: 146338673

Centisome position: 23.01

GC content: 68.09

Gene sequence:

>1548_bases
ATGAACGCGATCATTGCCGAGCCCGGCCACGTCAGCTTCGATGATCTTGCGCGCGTTTACGCGGGCGCGGCGATTGCCCT
TGGTCCGGCGTATTGGCCGCGGGTCGAGGCTGCGGCGGCGATCGTCGCCAAGGCGGCGCAGGGCGCCGAGCCTGTCTATG
GCATCAACACCGGCTTCGGCAAGCTGGCTTCAAAGCGCATTCCGCCGGACCAGACCGCGCTGCTCCAGCGCAATCTGATT
CTGTCGCATTGCTGCGGTGTGGGTCCCGCCACGCCGGAGCCAATCGTGCGTCTGATGATCGCGCTGAAGATCATTTCGCT
CGGCCGCGGTGCTTCCGGCGTGCGCCGACAGATCGTCGATCAACTGCAGGCCATGCTGGCGCAGGGCGTCTGTCCCTTCG
TGCCGCAGCAAGGCTCGGTCGGTGCCTCCGGCGATCTCGCGCCGCTCGCGCACATGACGGCGGTGATGATCGGCGAGGGC
CAAGCGTTCGTCGAGGGGCGTCTGGTGCCGGGCCGCGAGGCGCTGGCGCACGTCGGTCTTGATCCGGTGACGCTCGGGCC
GAAGGAAGGGCTCGCGTTGATCAACGGCACGCAGTTCTCGACGGCCTATGCGCTCGCCGGTCTGTTCCGTGCGCGAGATC
TGCTCAACGCTGCGCTGGTCACCGGCGCGTTGTCGGTCGACGCCGCGATGGCCTCCACCGCGCCATTCCGTCCCGAGATC
CAGGCGCTCCGTGGTCATCCCGGCCAGATCGCGGCCGGTCGCGTGCTGACAGAGTTGGTCGACGGAAGCGCCATTCGCCT
GTCGCATCTCGAAGGTGACGAGCGCGTGCAGGATCCGTATTGCCTGCGCTGCCAGCCCCAGGTCGCTGGTGCCGCGCTCG
ATCTGCTGACGCAGGCGGCGCGTACGCTCGTCAACGAAGCCAATGCCGTCACCGACAATCCGCTGGTGCTGGTCGAGACC
GGAGAGATCATCTCCGGCGGCAACTTCCACGCCGAGCCGGTGGCGTTCGCCGCCGACCAGATCGCGCTGGCACTCTCTGA
ACTCGGCGCGATCAGCGAGCGGCGCATCGCGACGCTGGTCGATCCCGCGCTGAATTTCGGCCTGCCGCCGTTCCTCACGC
CGCAGCCGGGTTTGAACTCCGGCTTCATGATCGCTGAGGTCACGGCGGCGGCGCTGTTCGCCGAGAACAAGCAGCGCGCG
CTGCCATGCTCGATCGACTCCACGCCGACCAGCGCCAATCAGGAAGATCACGTCTCGATGGCCGCGCATGCGGCGCGGCG
GCTGCACGACATGGCCGACAATCTCGCGCATATCATCGGCATCGAGCTGCTGGTCGCAGCGCAGGGCATCGAGCTGCGCG
TGCCGCATGGCACCAGCGCCGCGCTCTCCGCTGTCATCGGCGCGCTGCGCTCGCATGTGCCGGCGCTGGAGAGCGACCGC
TACATGGCCGACGATCTCGCCAAGGCCGCCGCGCTCGTGGCCGGCGGCGCGTTGGCCCGCGCGGCGAACGTTGCACTCGG
ACGCGATTCGTTTCCCAGGCTTGGATGA

Upstream 100 bases:

>100_bases
GCAAGTGGTGCAATCTTGCGATCTGGGATATCGGGCGCCCGGCGGAGCTGGTGTACCGCCTGGGCTTCAATCCCTTGCAT
CAGCGCGTGTGGAGAGGCCG

Downstream 100 bases:

>100_bases
GAGGGACCCATGAACCGACGCCTCGACAATCAACGCGTGATCCGCGCCCCTCATGGCAGCGACATCAGCGCCAAGAGCTG
GCTCACCGAAGCGCCGCTGC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MNAIIAEPGHVSFDDLARVYAGAAIALGPAYWPRVEAAAAIVAKAAQGAEPVYGINTGFGKLASKRIPPDQTALLQRNLI
LSHCCGVGPATPEPIVRLMIALKIISLGRGASGVRRQIVDQLQAMLAQGVCPFVPQQGSVGASGDLAPLAHMTAVMIGEG
QAFVEGRLVPGREALAHVGLDPVTLGPKEGLALINGTQFSTAYALAGLFRARDLLNAALVTGALSVDAAMASTAPFRPEI
QALRGHPGQIAAGRVLTELVDGSAIRLSHLEGDERVQDPYCLRCQPQVAGAALDLLTQAARTLVNEANAVTDNPLVLVET
GEIISGGNFHAEPVAFAADQIALALSELGAISERRIATLVDPALNFGLPPFLTPQPGLNSGFMIAEVTAAALFAENKQRA
LPCSIDSTPTSANQEDHVSMAAHAARRLHDMADNLAHIIGIELLVAAQGIELRVPHGTSAALSAVIGALRSHVPALESDR
YMADDLAKAAALVAGGALARAANVALGRDSFPRLG

Sequences:

>Translated_515_residues
MNAIIAEPGHVSFDDLARVYAGAAIALGPAYWPRVEAAAAIVAKAAQGAEPVYGINTGFGKLASKRIPPDQTALLQRNLI
LSHCCGVGPATPEPIVRLMIALKIISLGRGASGVRRQIVDQLQAMLAQGVCPFVPQQGSVGASGDLAPLAHMTAVMIGEG
QAFVEGRLVPGREALAHVGLDPVTLGPKEGLALINGTQFSTAYALAGLFRARDLLNAALVTGALSVDAAMASTAPFRPEI
QALRGHPGQIAAGRVLTELVDGSAIRLSHLEGDERVQDPYCLRCQPQVAGAALDLLTQAARTLVNEANAVTDNPLVLVET
GEIISGGNFHAEPVAFAADQIALALSELGAISERRIATLVDPALNFGLPPFLTPQPGLNSGFMIAEVTAAALFAENKQRA
LPCSIDSTPTSANQEDHVSMAAHAARRLHDMADNLAHIIGIELLVAAQGIELRVPHGTSAALSAVIGALRSHVPALESDR
YMADDLAKAAALVAGGALARAANVALGRDSFPRLG
>Mature_515_residues
MNAIIAEPGHVSFDDLARVYAGAAIALGPAYWPRVEAAAAIVAKAAQGAEPVYGINTGFGKLASKRIPPDQTALLQRNLI
LSHCCGVGPATPEPIVRLMIALKIISLGRGASGVRRQIVDQLQAMLAQGVCPFVPQQGSVGASGDLAPLAHMTAVMIGEG
QAFVEGRLVPGREALAHVGLDPVTLGPKEGLALINGTQFSTAYALAGLFRARDLLNAALVTGALSVDAAMASTAPFRPEI
QALRGHPGQIAAGRVLTELVDGSAIRLSHLEGDERVQDPYCLRCQPQVAGAALDLLTQAARTLVNEANAVTDNPLVLVET
GEIISGGNFHAEPVAFAADQIALALSELGAISERRIATLVDPALNFGLPPFLTPQPGLNSGFMIAEVTAAALFAENKQRA
LPCSIDSTPTSANQEDHVSMAAHAARRLHDMADNLAHIIGIELLVAAQGIELRVPHGTSAALSAVIGALRSHVPALESDR
YMADDLAKAAALVAGGALARAANVALGRDSFPRLG

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=490, Percent_Identity=42.0408163265306, Blast_Score=339, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17567831, Length=494, Percent_Identity=40.6882591093117, Blast_Score=320, Evalue=8e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53268; Mature: 53268

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIIAEPGHVSFDDLARVYAGAAIALGPAYWPRVEAAAAIVAKAAQGAEPVYGINTGFG
CCCEECCCCCCCHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHH
KLASKRIPPDQTALLQRNLILSHCCGVGPATPEPIVRLMIALKIISLGRGASGVRRQIVD
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QLQAMLAQGVCPFVPQQGSVGASGDLAPLAHMTAVMIGEGQAFVEGRLVPGREALAHVGL
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCEEEECCCCCCHHHHHHCCC
DPVTLGPKEGLALINGTQFSTAYALAGLFRARDLLNAALVTGALSVDAAMASTAPFRPEI
CCEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
QALRGHPGQIAAGRVLTELVDGSAIRLSHLEGDERVQDPYCLRCQPQVAGAALDLLTQAA
HHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHCCCCEEEECCCHHHHHHHHHHHHHH
RTLVNEANAVTDNPLVLVETGEIISGGNFHAEPVAFAADQIALALSELGAISERRIATLV
HHHHHHCCCCCCCCEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
DPALNFGLPPFLTPQPGLNSGFMIAEVTAAALFAENKQRALPCSIDSTPTSANQEDHVSM
HHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
AAHAARRLHDMADNLAHIIGIELLVAAQGIELRVPHGTSAALSAVIGALRSHVPALESDR
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
YMADDLAKAAALVAGGALARAANVALGRDSFPRLG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNAIIAEPGHVSFDDLARVYAGAAIALGPAYWPRVEAAAAIVAKAAQGAEPVYGINTGFG
CCCEECCCCCCCHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHH
KLASKRIPPDQTALLQRNLILSHCCGVGPATPEPIVRLMIALKIISLGRGASGVRRQIVD
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QLQAMLAQGVCPFVPQQGSVGASGDLAPLAHMTAVMIGEGQAFVEGRLVPGREALAHVGL
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCEEEECCCCCCHHHHHHCCC
DPVTLGPKEGLALINGTQFSTAYALAGLFRARDLLNAALVTGALSVDAAMASTAPFRPEI
CCEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
QALRGHPGQIAAGRVLTELVDGSAIRLSHLEGDERVQDPYCLRCQPQVAGAALDLLTQAA
HHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHCCCCEEEECCCHHHHHHHHHHHHHH
RTLVNEANAVTDNPLVLVETGEIISGGNFHAEPVAFAADQIALALSELGAISERRIATLV
HHHHHHCCCCCCCCEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
DPALNFGLPPFLTPQPGLNSGFMIAEVTAAALFAENKQRALPCSIDSTPTSANQEDHVSM
HHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
AAHAARRLHDMADNLAHIIGIELLVAAQGIELRVPHGTSAALSAVIGALRSHVPALESDR
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
YMADDLAKAAALVAGGALARAANVALGRDSFPRLG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA