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The map label for this gene is hutU [H]

Identifier: 146338673

GI number: 146338673

Start: 1717351

End: 1719021

Strand: Direct

Name: hutU [H]

Synonym: BRADO1605

Alternate gene names: 146338673

Gene position: 1717351-1719021 (Clockwise)

Preceding gene: 146338672

Following gene: 146338674

Centisome position: 23.03

GC content: 65.59

Gene sequence:

>1671_bases
ATGAACCGACGCCTCGACAATCAACGCGTGATCCGCGCCCCTCATGGCAGCGACATCAGCGCCAAGAGCTGGCTCACCGA
AGCGCCGCTGCGGATGCTGATGAACAACCTCGACCCCGATGTCGCGGAGAAGCCGAGCGAGCTGATCGTCTATGGCGGCA
TCGGCCGCGCCGCGCGCGACTGGGACAGCTTTGATCGCATCGTTGCGTCCTTGCGCAAACTCGAAGCTGATCAAACTCTC
GTGGTGCAGTCCGGCAAACCCGTCGGCATCTTCCGCACCCATCCCGATGCGCCGCGCGTGCTGATCGCCAACTCCAACAT
CGTGCCGCATTGGGCGACGCTCGACCATTTCAACGCGCTCGATAAAATGGGCCTGATGATGTACGGCCAGATGACGGCCG
GCTCTTGGATTTACATTGGCAGCCAGGGCATCGTGCAGGGCACTTACGAGACCTTCGTCGAAGTCGGCCGCCGCCACTAC
AATGGTGATCTCTCAGGAAAGTGGATTCTCACCGCGGGCCTCGGCGGCATGGGCGGCGCGCAGCCGCTGGCGGCCACCAT
GGCCGGCGCGTCGATGCTCGCCGTCGAGTGCCAGCCGAGCCGCATCGAGATGCGGCTGCGCACCGGCTATCTCGATCGCC
AAGCGGCCTCGCTCGACGAGGCGCTGGCGTTGATGGAAGAGGCAGCGAGGACCAAGACGGCGGTGTCGGTCGGCCTGCTC
GGCAATGCCGCCGAGATCTTTCCTGAGCTGGTGCGCCGCGGCGTGCGTCCCGATATCGTGACAGATCAGACCAGCGCGCA
TGATCCGATCAACGGCTATCTGCCGAAGGGCTGGACGCTCGCCGAATGGGAGGCCAAGCGGGCGTCGGAGCCGAAGGCGG
TGGAGCAGGCGTCGAAGACCTCGATGGTCGGCCACGTCCAGGCGATGCTCGATTTTCACGCCATGGGCATTCCAACGCTC
GACTACGGCAACAACATCCGCCAGATGGCCAAGGACATGGGCCTCGCCAACGCTTTCGATTTTCCGGGCTTTGTGCCGGC
TTACATCCGTCCGCTGTTCTGCCGCGGCATCGGCCCGTTCCGCTGGGCGGCGCTGTCGGGCGACCCTGAGGACATCTACA
AGACCGACGCCAAGGTCAAGGAGCTGCTGCCGGACAACAAGCACCTGCATAACTGGCTCGACATGGCCAGGCAGCGCATC
AAGTTCCAGGGCCTGCCGGCGCGGATCTGCTGGGTCGGGCTCGGCGACCGGCATCGCCTCGGGCTCGCCTTCAACGAGAT
GGTGGCGCGCGGCGAGCTGAAGGCGCCGATCGTGATCGGTCGCGACCATCTCGACTCCGGCTCGGTCGCAAGCCCGAACC
GCGAGACCGAGGCGATGAAGGACGGCTCGGATGCGGTGTCGGATTGGCCGCTGCTGAACGCGCTGTTGAATTGCGCCAGT
GGCGCGACCTGGGTGTCGCTGCATCATGGCGGTGGCGTCGGCATCGGCTATTCGCAGCATGCCGGCATGGTCATCGTCGC
CGACGGCACTGACGATGCTGCGCGCCGGCTGGAGCGCGTGCTGTGGAATGATCCCGCGACCGGCGTGATGCGCCATGCCG
ACGCCGGGTACGACGACGCCATCGGTTGCGCCGAGGCCAACGGGCTCGATCTGCCGAGCCTCGCTCGCTGA

Upstream 100 bases:

>100_bases
CGCCAAGGCCGCCGCGCTCGTGGCCGGCGGCGCGTTGGCCCGCGCGGCGAACGTTGCACTCGGACGCGATTCGTTTCCCA
GGCTTGGATGAGAGGGACCC

Downstream 100 bases:

>100_bases
TCCCTGAGTGGGTTGAAGAGCGGCCCCTGATTGTGGTCTCATGCCGCCAACGCGGCGGAGACCTGCCGCGAACAGGGGAC
GCTCATGGGAATTGCCTTTC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MNRRLDNQRVIRAPHGSDISAKSWLTEAPLRMLMNNLDPDVAEKPSELIVYGGIGRAARDWDSFDRIVASLRKLEADQTL
VVQSGKPVGIFRTHPDAPRVLIANSNIVPHWATLDHFNALDKMGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEVGRRHY
NGDLSGKWILTAGLGGMGGAQPLAATMAGASMLAVECQPSRIEMRLRTGYLDRQAASLDEALALMEEAARTKTAVSVGLL
GNAAEIFPELVRRGVRPDIVTDQTSAHDPINGYLPKGWTLAEWEAKRASEPKAVEQASKTSMVGHVQAMLDFHAMGIPTL
DYGNNIRQMAKDMGLANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMARQRI
KFQGLPARICWVGLGDRHRLGLAFNEMVARGELKAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNCAS
GATWVSLHHGGGVGIGYSQHAGMVIVADGTDDAARRLERVLWNDPATGVMRHADAGYDDAIGCAEANGLDLPSLAR

Sequences:

>Translated_556_residues
MNRRLDNQRVIRAPHGSDISAKSWLTEAPLRMLMNNLDPDVAEKPSELIVYGGIGRAARDWDSFDRIVASLRKLEADQTL
VVQSGKPVGIFRTHPDAPRVLIANSNIVPHWATLDHFNALDKMGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEVGRRHY
NGDLSGKWILTAGLGGMGGAQPLAATMAGASMLAVECQPSRIEMRLRTGYLDRQAASLDEALALMEEAARTKTAVSVGLL
GNAAEIFPELVRRGVRPDIVTDQTSAHDPINGYLPKGWTLAEWEAKRASEPKAVEQASKTSMVGHVQAMLDFHAMGIPTL
DYGNNIRQMAKDMGLANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMARQRI
KFQGLPARICWVGLGDRHRLGLAFNEMVARGELKAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNCAS
GATWVSLHHGGGVGIGYSQHAGMVIVADGTDDAARRLERVLWNDPATGVMRHADAGYDDAIGCAEANGLDLPSLAR
>Mature_556_residues
MNRRLDNQRVIRAPHGSDISAKSWLTEAPLRMLMNNLDPDVAEKPSELIVYGGIGRAARDWDSFDRIVASLRKLEADQTL
VVQSGKPVGIFRTHPDAPRVLIANSNIVPHWATLDHFNALDKMGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEVGRRHY
NGDLSGKWILTAGLGGMGGAQPLAATMAGASMLAVECQPSRIEMRLRTGYLDRQAASLDEALALMEEAARTKTAVSVGLL
GNAAEIFPELVRRGVRPDIVTDQTSAHDPINGYLPKGWTLAEWEAKRASEPKAVEQASKTSMVGHVQAMLDFHAMGIPTL
DYGNNIRQMAKDMGLANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMARQRI
KFQGLPARICWVGLGDRHRLGLAFNEMVARGELKAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNCAS
GATWVSLHHGGGVGIGYSQHAGMVIVADGTDDAARRLERVLWNDPATGVMRHADAGYDDAIGCAEANGLDLPSLAR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=559, Percent_Identity=34.8837209302326, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI260306182, Length=619, Percent_Identity=32.4717285945073, Blast_Score=281, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71997891, Length=551, Percent_Identity=36.4791288566243, Blast_Score=329, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60546; Mature: 60546

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRLDNQRVIRAPHGSDISAKSWLTEAPLRMLMNNLDPDVAEKPSELIVYGGIGRAARD
CCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCHHHH
WDSFDRIVASLRKLEADQTLVVQSGKPVGIFRTHPDAPRVLIANSNIVPHWATLDHFNAL
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHH
DKMGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEVGRRHYNGDLSGKWILTAGLGGMGGA
HHHHHHEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
QPLAATMAGASMLAVECQPSRIEMRLRTGYLDRQAASLDEALALMEEAARTKTAVSVGLL
CHHHHHHCCCEEEEEECCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEC
GNAAEIFPELVRRGVRPDIVTDQTSAHDPINGYLPKGWTLAEWEAKRASEPKAVEQASKT
CCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCEEECCHHHCCCCCHHHHHHHHH
SMVGHVQAMLDFHAMGIPTLDYGNNIRQMAKDMGLANAFDFPGFVPAYIRPLFCRGIGPF
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
RWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMARQRIKFQGLPARICWVGLGDRHRL
EEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEE
GLAFNEMVARGELKAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNCAS
CHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCHHHCCHHHHHHHHHCC
GATWVSLHHGGGVGIGYSQHAGMVIVADGTDDAARRLERVLWNDPATGVMRHADAGYDDA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
IGCAEANGLDLPSLAR
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNRRLDNQRVIRAPHGSDISAKSWLTEAPLRMLMNNLDPDVAEKPSELIVYGGIGRAARD
CCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCHHHH
WDSFDRIVASLRKLEADQTLVVQSGKPVGIFRTHPDAPRVLIANSNIVPHWATLDHFNAL
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHH
DKMGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEVGRRHYNGDLSGKWILTAGLGGMGGA
HHHHHHEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
QPLAATMAGASMLAVECQPSRIEMRLRTGYLDRQAASLDEALALMEEAARTKTAVSVGLL
CHHHHHHCCCEEEEEECCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEC
GNAAEIFPELVRRGVRPDIVTDQTSAHDPINGYLPKGWTLAEWEAKRASEPKAVEQASKT
CCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCEEECCHHHCCCCCHHHHHHHHH
SMVGHVQAMLDFHAMGIPTLDYGNNIRQMAKDMGLANAFDFPGFVPAYIRPLFCRGIGPF
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
RWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMARQRIKFQGLPARICWVGLGDRHRL
EEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEE
GLAFNEMVARGELKAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNCAS
CHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCHHHCCHHHHHHHHHCC
GATWVSLHHGGGVGIGYSQHAGMVIVADGTDDAARRLERVLWNDPATGVMRHADAGYDDA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
IGCAEANGLDLPSLAR
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]