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The map label for this gene is trpC [H]

Identifier: 146302621

GI number: 146302621

Start: 5915998

End: 5916777

Strand: Direct

Name: trpC [H]

Synonym: Fjoh_4894

Alternate gene names: 146302621

Gene position: 5915998-5916777 (Clockwise)

Preceding gene: 146302620

Following gene: 146302622

Centisome position: 97.03

GC content: 34.49

Gene sequence:

>780_bases
ATGAATATTTTAGATAAAATAATAATAGATAAAAAACGAGAAGTTATTCTAAAGAAATCCATTATTCCGGTTTCTCAGCT
GGAAGCTTCGGTCTTTTTTAATAAACAAACTATTTCTTTAAGTCAGAAATTAAAACAAAGCAATTCAGGAATTATAGCCG
AACACAAACGTCGTTCACCTTCAAAATCAATCATCAACAACAATTTTACAGTTGAAGAAGTCGTAAAAGGCTACGAAAAT
GCTGGCGCCTGCGGAATTTCGGTTTTAACAGACGGGAAATATTTTGGCGGATCTTTAGACGATTTACTTTTAGCCAGAGC
AAGCGTAAACATTCCGCTTTTGCGAAAAGAATTTATTGTAGACGAATATCAGATTTTAGAAGCAAAAGCACATGGAGCCG
ATTTAATTCTATTAATCGCAGCGGTTTTAACCCGTGAAGAAATCAAATCTTTATCTGAATTTGCCAAAAAACTAGGTTTA
GAAGTTTTACTGGAAGTTCACAATCAGGAAGAATTAGAAAAATCGATTATGCCAACTTTAGACATGATTGGCGTTAACAA
CAGAAACCTAAAAACTTTTGAAGTAAGTCTTGATTTCAGTAAAGATTTAGCATCGCAAATTCCGGACGATTTTGTAAAAG
TATCCGAAAGCGGCATTTCATCAATAGAAGCCATTCAGGAACTAAAACCATACGGTTACAAAGGTTTCTTAATAGGAGAA
AACTTCATGAAAACCGAAAACGCCGGTCAAGCAGCTGTTGACTTTATAAGTCAGCTGTAA

Upstream 100 bases:

>100_bases
GTTCTCAGGAAAAGGGTTAAAAGCTTTACAAAAATTACAGGAATTATCACTTTAAAAAAAGCTTTGTATCAGTATCTTAG
AATCTTAGCACCTTAAAAAA

Downstream 100 bases:

>100_bases
GCCGTAAGCTATAAGCAAAAAGTAAATAAAAAAATCAGCACAAAGCAAAAAGCCTATTGCCTATTGCCTAAAGCTTAAAG
CAGTATAAAAAAAATGAAAC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNILDKIIIDKKREVILKKSIIPVSQLEASVFFNKQTISLSQKLKQSNSGIIAEHKRRSPSKSIINNNFTVEEVVKGYEN
AGACGISVLTDGKYFGGSLDDLLLARASVNIPLLRKEFIVDEYQILEAKAHGADLILLIAAVLTREEIKSLSEFAKKLGL
EVLLEVHNQEELEKSIMPTLDMIGVNNRNLKTFEVSLDFSKDLASQIPDDFVKVSESGISSIEAIQELKPYGYKGFLIGE
NFMKTENAGQAAVDFISQL

Sequences:

>Translated_259_residues
MNILDKIIIDKKREVILKKSIIPVSQLEASVFFNKQTISLSQKLKQSNSGIIAEHKRRSPSKSIINNNFTVEEVVKGYEN
AGACGISVLTDGKYFGGSLDDLLLARASVNIPLLRKEFIVDEYQILEAKAHGADLILLIAAVLTREEIKSLSEFAKKLGL
EVLLEVHNQEELEKSIMPTLDMIGVNNRNLKTFEVSLDFSKDLASQIPDDFVKVSESGISSIEAIQELKPYGYKGFLIGE
NFMKTENAGQAAVDFISQL
>Mature_259_residues
MNILDKIIIDKKREVILKKSIIPVSQLEASVFFNKQTISLSQKLKQSNSGIIAEHKRRSPSKSIINNNFTVEEVVKGYEN
AGACGISVLTDGKYFGGSLDDLLLARASVNIPLLRKEFIVDEYQILEAKAHGADLILLIAAVLTREEIKSLSEFAKKLGL
EVLLEVHNQEELEKSIMPTLDMIGVNNRNLKTFEVSLDFSKDLASQIPDDFVKVSESGISSIEAIQELKPYGYKGFLIGE
NFMKTENAGQAAVDFISQL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=246, Percent_Identity=33.739837398374, Blast_Score=137, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322638, Length=205, Percent_Identity=39.5121951219512, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28734; Mature: 28734

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILDKIIIDKKREVILKKSIIPVSQLEASVFFNKQTISLSQKLKQSNSGIIAEHKRRSP
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEHHHCCCC
SKSIINNNFTVEEVVKGYENAGACGISVLTDGKYFGGSLDDLLLARASVNIPLLRKEFIV
CHHHHCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
DEYQILEAKAHGADLILLIAAVLTREEIKSLSEFAKKLGLEVLLEVHNQEELEKSIMPTL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHH
DMIGVNNRNLKTFEVSLDFSKDLASQIPDDFVKVSESGISSIEAIQELKPYGYKGFLIGE
HHHCCCCCCEEEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
NFMKTENAGQAAVDFISQL
CHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MNILDKIIIDKKREVILKKSIIPVSQLEASVFFNKQTISLSQKLKQSNSGIIAEHKRRSP
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEHHHCCCC
SKSIINNNFTVEEVVKGYENAGACGISVLTDGKYFGGSLDDLLLARASVNIPLLRKEFIV
CHHHHCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
DEYQILEAKAHGADLILLIAAVLTREEIKSLSEFAKKLGLEVLLEVHNQEELEKSIMPTL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHH
DMIGVNNRNLKTFEVSLDFSKDLASQIPDDFVKVSESGISSIEAIQELKPYGYKGFLIGE
HHHCCCCCCEEEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
NFMKTENAGQAAVDFISQL
CHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]