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The map label for this gene is arlS [H]

Identifier: 146300628

GI number: 146300628

Start: 3416307

End: 3417707

Strand: Reverse

Name: arlS [H]

Synonym: Fjoh_2879

Alternate gene names: 146300628

Gene position: 3417707-3416307 (Counterclockwise)

Preceding gene: 146300629

Following gene: 146300627

Centisome position: 56.06

GC content: 29.76

Gene sequence:

>1401_bases
ATGAAATTATTATCTTTTAAAAATAGAATTGCATTAAACTATATCGTAGGAACAGGACTTTTGGTTCTGGCAGTTTTTTC
GGCTATTTATTTTATTGTAAAACTTACCGTTTACAATCATATAGATGAAAATCTTAATATCGAGGTTCAGGACCACTTAA
AAGAAGTTAAAGTCGAGAACGGTGTTGTTATTATGATGGATGCAGAAGAATGGGAAGAAAGAGAACACAATTCTGTCGAT
GTAAATCCTGTATTTGTTCAGTTTTTAGATTTAAATAAAAAAATCATTGAAAAATCTCCTAATTTAAAAAATGAAAAACT
CGTTTTTCATAATAACAAAGATCACTTTCAGCTTTTTGATACTAAATTATTAGGAAACAAAATTCGTCAGATACAAGTAC
CGCTTCATTTACATTCAAAAAAAATCGGTTATTTGATTATTGCGATGTCTTTGTCAGATTCTTCAAAGGTATTAGATAAT
CTAATGGATACCTTATTGGTTACATTTCCCATTATTTTATTGATTTTATTTTTTCTTGCCAGATTCTTTGCCGGAAGAAG
TATAAAACCCATAAATGATATTATTCAGACTTCCAATATTATTACAAAAGATAATCTCAAAACAAGAATTCCGCTGCCTA
AAACCAGAGACGAATTATACACACTTTCTAAAACAATAAATAATTTATTAAATAGAATTGAAGACGCTATTGAGCGCGAA
AAACAATTTACATCTGACGCCTCGCACGAGTTAAGAACGCCACTAACAGTAATTAAAGGAACACTTGAAGTGCTTATTCG
TAAACCCAGAGACAGCAGGGAATACGAAGATAAAATTAATTATTGCATAAACGAAGTCGACCATTTAAATATGCTTGTTG
ACCAGCTCTTAACAATGGCTCGTTTTGAAAATCAAAAGCATCAGATAAATGCAGAAAACGTTTATTTAAACGCTGTAATT
TTAGATGTTTTAACTTTGAATTCAGAGAAAATAAACAGCAAAAAACTCAAAGTAAAATTTGATGCCGGCCAGGATTATTA
CACCTATTCAGATAATTTTCTGATCATAACAATTTTAAGAAATATAATTTCAAACTCACTTAAATACACGAAAGATGGAG
GAGAAGTTTCTGTTTTTCTTTCTAAAGAAGGAGACAGAACAATCTGCAGAATTTCAGATAACGGAATAGGAATTGCAAAA
GGTGATCTCGAAATGATTTTTAATCCTTTTTTTAGATCAAATTATACAGATCATCCTGAAATAAAAGGAGTTGGTTTAGG
TTTGTCTATCGTAAAAAGAATTACAGAACAGCTTGATATTCAATTTAAAATAGAAAGTAAAATAGGAGTTGGCACAACTG
TAATTTTAGGTTTTAAAGAAGAAATGAAAACGATATCGTAA

Upstream 100 bases:

>100_bases
TTTTTATGAATGCTATTCGTAAAAAACTGAACCTTAAAATTGAAGAAGATTACATTAAAACTATTCGGGGCATTGGTTAT
ATCGCCAATGATTAAGCAAA

Downstream 100 bases:

>100_bases
ATTGAAAATTTATAATAGAAACTGTACTTCAGCTTTTTTTTTAACAATAAACTATAGTTAAGTTATATTAAAAATTGCTT
TTTTATGAAATTAACTAGTA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKLLSFKNRIALNYIVGTGLLVLAVFSAIYFIVKLTVYNHIDENLNIEVQDHLKEVKVENGVVIMMDAEEWEEREHNSVD
VNPVFVQFLDLNKKIIEKSPNLKNEKLVFHNNKDHFQLFDTKLLGNKIRQIQVPLHLHSKKIGYLIIAMSLSDSSKVLDN
LMDTLLVTFPIILLILFFLARFFAGRSIKPINDIIQTSNIITKDNLKTRIPLPKTRDELYTLSKTINNLLNRIEDAIERE
KQFTSDASHELRTPLTVIKGTLEVLIRKPRDSREYEDKINYCINEVDHLNMLVDQLLTMARFENQKHQINAENVYLNAVI
LDVLTLNSEKINSKKLKVKFDAGQDYYTYSDNFLIITILRNIISNSLKYTKDGGEVSVFLSKEGDRTICRISDNGIGIAK
GDLEMIFNPFFRSNYTDHPEIKGVGLGLSIVKRITEQLDIQFKIESKIGVGTTVILGFKEEMKTIS

Sequences:

>Translated_466_residues
MKLLSFKNRIALNYIVGTGLLVLAVFSAIYFIVKLTVYNHIDENLNIEVQDHLKEVKVENGVVIMMDAEEWEEREHNSVD
VNPVFVQFLDLNKKIIEKSPNLKNEKLVFHNNKDHFQLFDTKLLGNKIRQIQVPLHLHSKKIGYLIIAMSLSDSSKVLDN
LMDTLLVTFPIILLILFFLARFFAGRSIKPINDIIQTSNIITKDNLKTRIPLPKTRDELYTLSKTINNLLNRIEDAIERE
KQFTSDASHELRTPLTVIKGTLEVLIRKPRDSREYEDKINYCINEVDHLNMLVDQLLTMARFENQKHQINAENVYLNAVI
LDVLTLNSEKINSKKLKVKFDAGQDYYTYSDNFLIITILRNIISNSLKYTKDGGEVSVFLSKEGDRTICRISDNGIGIAK
GDLEMIFNPFFRSNYTDHPEIKGVGLGLSIVKRITEQLDIQFKIESKIGVGTTVILGFKEEMKTIS
>Mature_466_residues
MKLLSFKNRIALNYIVGTGLLVLAVFSAIYFIVKLTVYNHIDENLNIEVQDHLKEVKVENGVVIMMDAEEWEEREHNSVD
VNPVFVQFLDLNKKIIEKSPNLKNEKLVFHNNKDHFQLFDTKLLGNKIRQIQVPLHLHSKKIGYLIIAMSLSDSSKVLDN
LMDTLLVTFPIILLILFFLARFFAGRSIKPINDIIQTSNIITKDNLKTRIPLPKTRDELYTLSKTINNLLNRIEDAIERE
KQFTSDASHELRTPLTVIKGTLEVLIRKPRDSREYEDKINYCINEVDHLNMLVDQLLTMARFENQKHQINAENVYLNAVI
LDVLTLNSEKINSKKLKVKFDAGQDYYTYSDNFLIITILRNIISNSLKYTKDGGEVSVFLSKEGDRTICRISDNGIGIAK
GDLEMIFNPFFRSNYTDHPEIKGVGLGLSIVKRITEQLDIQFKIESKIGVGTTVILGFKEEMKTIS

Specific function: Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=28.6792452830189, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786783, Length=311, Percent_Identity=27.0096463022508, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786600, Length=264, Percent_Identity=25.3787878787879, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=26, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=26.3888888888889, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789403, Length=279, Percent_Identity=31.1827956989247, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=26.8398268398268, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=219, Percent_Identity=28.7671232876712, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=25.0847457627119, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=26.6094420600858, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788279, Length=227, Percent_Identity=27.7533039647577, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=23.5537190082645, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=26.4840182648402, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=25.8964143426295, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=227, Percent_Identity=23.7885462555066, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=23.0452674897119, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=23.1441048034935, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=24.0549828178694, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53521; Mature: 53521

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLSFKNRIALNYIVGTGLLVLAVFSAIYFIVKLTVYNHIDENLNIEVQDHLKEVKVEN
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCC
GVVIMMDAEEWEEREHNSVDVNPVFVQFLDLNKKIIEKSPNLKNEKLVFHNNKDHFQLFD
CEEEEEECHHHHHHCCCCCCCCHHHHEEHHCCHHHHHCCCCCCCCEEEEECCCCCEEEEH
TKLLGNKIRQIQVPLHLHSKKIGYLIIAMSLSDSSKVLDNLMDTLLVTFPIILLILFFLA
HHHHCCHHHEEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFFAGRSIKPINDIIQTSNIITKDNLKTRIPLPKTRDELYTLSKTINNLLNRIEDAIERE
HHHCCCCCCHHHHHHHHCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KQFTSDASHELRTPLTVIKGTLEVLIRKPRDSREYEDKINYCINEVDHLNMLVDQLLTMA
HHHCCCCCHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFENQKHQINAENVYLNAVILDVLTLNSEKINSKKLKVKFDAGQDYYTYSDNFLIITILR
HHCCCCCEECCCCEEEHHEEEHHHHCCCCCCCCCEEEEEEECCCCEEEECCCEEEHHHHH
NIISNSLKYTKDGGEVSVFLSKEGDRTICRISDNGIGIAKGDLEMIFNPFFRSNYTDHPE
HHHHCCCEECCCCCEEEEEEECCCCCEEEEECCCCCEEECCCHHHHHCHHHHCCCCCCCC
IKGVGLGLSIVKRITEQLDIQFKIESKIGVGTTVILGFKEEMKTIS
CEEECCHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEEHHHHHCCC
>Mature Secondary Structure
MKLLSFKNRIALNYIVGTGLLVLAVFSAIYFIVKLTVYNHIDENLNIEVQDHLKEVKVEN
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCC
GVVIMMDAEEWEEREHNSVDVNPVFVQFLDLNKKIIEKSPNLKNEKLVFHNNKDHFQLFD
CEEEEEECHHHHHHCCCCCCCCHHHHEEHHCCHHHHHCCCCCCCCEEEEECCCCCEEEEH
TKLLGNKIRQIQVPLHLHSKKIGYLIIAMSLSDSSKVLDNLMDTLLVTFPIILLILFFLA
HHHHCCHHHEEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFFAGRSIKPINDIIQTSNIITKDNLKTRIPLPKTRDELYTLSKTINNLLNRIEDAIERE
HHHCCCCCCHHHHHHHHCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KQFTSDASHELRTPLTVIKGTLEVLIRKPRDSREYEDKINYCINEVDHLNMLVDQLLTMA
HHHCCCCCHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFENQKHQINAENVYLNAVILDVLTLNSEKINSKKLKVKFDAGQDYYTYSDNFLIITILR
HHCCCCCEECCCCEEEHHEEEHHHHCCCCCCCCCEEEEEEECCCCEEEECCCEEEHHHHH
NIISNSLKYTKDGGEVSVFLSKEGDRTICRISDNGIGIAKGDLEMIFNPFFRSNYTDHPE
HHHHCCCEECCCCCEEEEEEECCCCCEEEEECCCCCEEECCCHHHHHCHHHHCCCCCCCC
IKGVGLGLSIVKRITEQLDIQFKIESKIGVGTTVILGFKEEMKTIS
CEEECCHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA