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The map label for this gene is hisB [H]

Identifier: 146300624

GI number: 146300624

Start: 3411292

End: 3412428

Strand: Reverse

Name: hisB [H]

Synonym: Fjoh_2875

Alternate gene names: 146300624

Gene position: 3412428-3411292 (Counterclockwise)

Preceding gene: 146300625

Following gene: 146300623

Centisome position: 55.97

GC content: 36.76

Gene sequence:

>1137_bases
ATGAAAAAAGTACTTTTTATCGATCGTGACGGAACGATTGTTTTAGAACCTGAAAACTACCAATTAGACAGTTTAGCTAA
ACTGGAATTTTATCCAAAAGCTTTTCAATATCTGGCTAAAATTGCCGCTGAACTAGATTACGAACTGGCAATGGTAACCA
ATCAGGACGGATTAGGAACGGATAGTTTTCCAGAAGATACGTTTTGGCCAACTCAGAATTTTATCCTTAAAGCCTTTGAA
AACGAAGGTGTTGTTTTTGATGAAATTTTTGTAGACAGAACTTTTCCGGAAGAAAATGCGCCAACACGCAAACCAAGAAC
GGGAATGCTGACAAAATATATGAATAATCCAGCATATGATTTAGAAAATTCTTTTGTTTTAGGTGATCGTTTAACTGATG
TTGAATTGGCTAAAAATCTAGGCGCAAAAGCCATTTTCATGAATATGACTGATGGAATTGGAAGCAATGAAATTTCATCA
AAACGAGAAGAATTAAACGATACGATTGCTTTGCAGACGATAGATTGGAAAAGAATTTACGAGTTCCTGAAATTAGAGGC
ACGTTCAGCTTCGATTACTCGTAAAACCAATGAAACCGATATTTATATCAACTTAAACCTTGACGGAACTGGAAAAAGCA
AAATCGACACCGGAATTGCGTTTTTTGACCACATGTTGGATCAAATCTCACGTCACGGACAAATGGACTTAGAAATTACT
GTAAAAGGCGATTTAGAAGTCGATGAACACCATACAATTGAAGACACGGCAATTGCTTTAGGAGAAGTTTTCGCGAAAGC
GTTAGGAAATAAACTAGGAATCGAACGTTACGGTTTCTGTCTTCCAATGGACGATTGTTTAGCACAGGCAGCAATTGACT
TCGGCGGAAGAAACTGGCTGATTTGGGAAACTGAATTTAAACGCGAAATGGTTGGTAAAATGCCGACAGAAATGTTCTAT
CACTTCTTTAAATCATTTACAGACGGCGCAAAAGCGAATTTAAATATCAAAGCAGAAGGAATAAACGAACATCACAAAAT
TGAAGCGATCTTTAAAGCTTTCGCAAAAGCGATAAAAGTAGCCGTAAAAAGAGATACCGAAAAAATGATTTTGCCTTCTA
CGAAAGGAATGCTTTAA

Upstream 100 bases:

>100_bases
TTGCACGAATTAGCACAAATTAAATTAGTGAAAATTAGTGCAATTCGTGGCAAAGAAAAAATCATTTTAATCTGTGAAAT
CTGTGGCAAAACAAAAAAAT

Downstream 100 bases:

>100_bases
ATAAGTCGAAAGTTGAAAGTCATAAAGTCAAAAGATTCCTAAATTATGGATTTCAGAAAGCGACTTTAAGACTTTGGACT
TTAGACTTTAAGACTAAAAT

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKKVLFIDRDGTIVLEPENYQLDSLAKLEFYPKAFQYLAKIAAELDYELAMVTNQDGLGTDSFPEDTFWPTQNFILKAFE
NEGVVFDEIFVDRTFPEENAPTRKPRTGMLTKYMNNPAYDLENSFVLGDRLTDVELAKNLGAKAIFMNMTDGIGSNEISS
KREELNDTIALQTIDWKRIYEFLKLEARSASITRKTNETDIYINLNLDGTGKSKIDTGIAFFDHMLDQISRHGQMDLEIT
VKGDLEVDEHHTIEDTAIALGEVFAKALGNKLGIERYGFCLPMDDCLAQAAIDFGGRNWLIWETEFKREMVGKMPTEMFY
HFFKSFTDGAKANLNIKAEGINEHHKIEAIFKAFAKAIKVAVKRDTEKMILPSTKGML

Sequences:

>Translated_378_residues
MKKVLFIDRDGTIVLEPENYQLDSLAKLEFYPKAFQYLAKIAAELDYELAMVTNQDGLGTDSFPEDTFWPTQNFILKAFE
NEGVVFDEIFVDRTFPEENAPTRKPRTGMLTKYMNNPAYDLENSFVLGDRLTDVELAKNLGAKAIFMNMTDGIGSNEISS
KREELNDTIALQTIDWKRIYEFLKLEARSASITRKTNETDIYINLNLDGTGKSKIDTGIAFFDHMLDQISRHGQMDLEIT
VKGDLEVDEHHTIEDTAIALGEVFAKALGNKLGIERYGFCLPMDDCLAQAAIDFGGRNWLIWETEFKREMVGKMPTEMFY
HFFKSFTDGAKANLNIKAEGINEHHKIEAIFKAFAKAIKVAVKRDTEKMILPSTKGML
>Mature_378_residues
MKKVLFIDRDGTIVLEPENYQLDSLAKLEFYPKAFQYLAKIAAELDYELAMVTNQDGLGTDSFPEDTFWPTQNFILKAFE
NEGVVFDEIFVDRTFPEENAPTRKPRTGMLTKYMNNPAYDLENSFVLGDRLTDVELAKNLGAKAIFMNMTDGIGSNEISS
KREELNDTIALQTIDWKRIYEFLKLEARSASITRKTNETDIYINLNLDGTGKSKIDTGIAFFDHMLDQISRHGQMDLEIT
VKGDLEVDEHHTIEDTAIALGEVFAKALGNKLGIERYGFCLPMDDCLAQAAIDFGGRNWLIWETEFKREMVGKMPTEMFY
HFFKSFTDGAKANLNIKAEGINEHHKIEAIFKAFAKAIKVAVKRDTEKMILPSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=378, Percent_Identity=43.1216931216931, Blast_Score=318, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=34.5622119815668, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 42975; Mature: 42975

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLFIDRDGTIVLEPENYQLDSLAKLEFYPKAFQYLAKIAAELDYELAMVTNQDGLGT
CCEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
DSFPEDTFWPTQNFILKAFENEGVVFDEIFVDRTFPEENAPTRKPRTGMLTKYMNNPAYD
CCCCCCCCCCCHHHHHEEECCCCEEEEHEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCC
LENSFVLGDRLTDVELAKNLGAKAIFMNMTDGIGSNEISSKREELNDTIALQTIDWKRIY
CCCCEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCHHHHH
EFLKLEARSASITRKTNETDIYINLNLDGTGKSKIDTGIAFFDHMLDQISRHGQMDLEIT
HHHHHHHCCCEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
VKGDLEVDEHHTIEDTAIALGEVFAKALGNKLGIERYGFCLPMDDCLAQAAIDFGGRNWL
EECCCEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCCCEEE
IWETEFKREMVGKMPTEMFYHFFKSFTDGAKANLNIKAEGINEHHKIEAIFKAFAKAIKV
EECHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
AVKRDTEKMILPSTKGML
HHHCCCCCEECCCCCCCC
>Mature Secondary Structure
MKKVLFIDRDGTIVLEPENYQLDSLAKLEFYPKAFQYLAKIAAELDYELAMVTNQDGLGT
CCEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
DSFPEDTFWPTQNFILKAFENEGVVFDEIFVDRTFPEENAPTRKPRTGMLTKYMNNPAYD
CCCCCCCCCCCHHHHHEEECCCCEEEEHEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCC
LENSFVLGDRLTDVELAKNLGAKAIFMNMTDGIGSNEISSKREELNDTIALQTIDWKRIY
CCCCEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCHHHHH
EFLKLEARSASITRKTNETDIYINLNLDGTGKSKIDTGIAFFDHMLDQISRHGQMDLEIT
HHHHHHHCCCEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
VKGDLEVDEHHTIEDTAIALGEVFAKALGNKLGIERYGFCLPMDDCLAQAAIDFGGRNWL
EECCCEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCCCEEE
IWETEFKREMVGKMPTEMFYHFFKSFTDGAKANLNIKAEGINEHHKIEAIFKAFAKAIKV
EECHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
AVKRDTEKMILPSTKGML
HHHCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA