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The map label for this gene is 146298491

Identifier: 146298491

GI number: 146298491

Start: 804687

End: 805844

Strand: Direct

Name: 146298491

Synonym: Fjoh_0728

Alternate gene names: NA

Gene position: 804687-805844 (Clockwise)

Preceding gene: 146298490

Following gene: 146298492

Centisome position: 13.2

GC content: 38.43

Gene sequence:

>1158_bases
ATGCCACTATATCATAAACTTGGGGATTTTCCTCAAAAGCGACACACCCAATTCGAAAAACCAAACGGCGGATTTTACTA
CGAACAGTTATTCGGAACCGAAGGTTTTCACGGACATTCGTCTCTGTCTTATCACGTACACAGACCAACGCAGGTTAAGG
AAATTTTAAACTCATATTCGGTTGAACCTAAAATTGCAATCGGAAAAAATATAAAATCACTTCTTTTTAAAGGTTTTGAA
TTAAAACCTGAAAATGATTTTCTGGACAGCCGAAAAGCAATGTTAGTCAACAAAGACTGTATTATTGGTTTAGCCGCACC
GAAAGAATCGCTTCGAAATTATTTCTACAAAAATGCCGATGCCGATGAAATGCTTTTTATCCATAGAGGAAAAGGAAAAT
TAAGAACCATGTTAGGAAATATTCCGTTTGAATATGGTGATTACTTAATTATTCCGCGCGGTATTATTTATCAAATCGAT
TTCGAAACAGAAGATAACCGACTATTTTACGTAGAATCATATTCTCCTTTTTATACTCCAAAACGTTATAAAAACCAATC
TGGCCAGCATTTAGAACATTCTCCATTTTGCGAGCGTGATTTTATTCTGCCAAATGAATTGGAAACGTATGACGAAAAAG
GTGATTTTCTAATCAAAATCAAAAAAGAAGGAATGATCCACGAAGTGGTTTATGCCACACATCCGTTTGACGTTGTAGGC
TGGGACGGCTACAATTTCCCATACGGATTTTCAATTCACAATTTCGAACCTATAACGGGGCGTGTTCACCAACCGCCTCC
GGTACACCAGACTTTTGAAACAGCAGCTTTTGTTGTTTGTTCATTCTGCCCGAGACTTTACGATTATCATCCTAAAGCCA
TTCCGGCACCATACAATCACAGCAATATAGATTCTGACGAAGTACTATATTATGTTGATGGTGATTTTATGAGCCGTAAT
AATATTGAGCAAGGGCATATCACTTTACACCCAAAAGGAATTCCACACGGACCAGCGCCTGGCGCAATGGAACGCAGTAT
TGGTCACAAAGAAACTCAGGAATTAGCCGTTATGGTGGACACTTTCCGTCCACTTATGGTTACTGAAGAAGCTATGGGAT
TGGATGATGGTCAGTATTACAAATCTTGGGTTGAATAA

Upstream 100 bases:

>100_bases
AATTGAAATAATCAGTTAATTGAAAAATTAAACTGGTTATTTATCTCTGCAATTCAAATTTTCGAATTATCTAATTTACT
AATTATCTAATTGAAAAGCC

Downstream 100 bases:

>100_bases
ATTCACTTTCGATCTAACCGCAAAGTTCGCAAGGATTTTACGCAAAGATCGCCATGAATAACTTAGCTCCCGATAACTAT
CGGGATTGCGATTTGCCTTT

Product: homogentisate 1,2-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MPLYHKLGDFPQKRHTQFEKPNGGFYYEQLFGTEGFHGHSSLSYHVHRPTQVKEILNSYSVEPKIAIGKNIKSLLFKGFE
LKPENDFLDSRKAMLVNKDCIIGLAAPKESLRNYFYKNADADEMLFIHRGKGKLRTMLGNIPFEYGDYLIIPRGIIYQID
FETEDNRLFYVESYSPFYTPKRYKNQSGQHLEHSPFCERDFILPNELETYDEKGDFLIKIKKEGMIHEVVYATHPFDVVG
WDGYNFPYGFSIHNFEPITGRVHQPPPVHQTFETAAFVVCSFCPRLYDYHPKAIPAPYNHSNIDSDEVLYYVDGDFMSRN
NIEQGHITLHPKGIPHGPAPGAMERSIGHKETQELAVMVDTFRPLMVTEEAMGLDDGQYYKSWVE

Sequences:

>Translated_385_residues
MPLYHKLGDFPQKRHTQFEKPNGGFYYEQLFGTEGFHGHSSLSYHVHRPTQVKEILNSYSVEPKIAIGKNIKSLLFKGFE
LKPENDFLDSRKAMLVNKDCIIGLAAPKESLRNYFYKNADADEMLFIHRGKGKLRTMLGNIPFEYGDYLIIPRGIIYQID
FETEDNRLFYVESYSPFYTPKRYKNQSGQHLEHSPFCERDFILPNELETYDEKGDFLIKIKKEGMIHEVVYATHPFDVVG
WDGYNFPYGFSIHNFEPITGRVHQPPPVHQTFETAAFVVCSFCPRLYDYHPKAIPAPYNHSNIDSDEVLYYVDGDFMSRN
NIEQGHITLHPKGIPHGPAPGAMERSIGHKETQELAVMVDTFRPLMVTEEAMGLDDGQYYKSWVE
>Mature_384_residues
PLYHKLGDFPQKRHTQFEKPNGGFYYEQLFGTEGFHGHSSLSYHVHRPTQVKEILNSYSVEPKIAIGKNIKSLLFKGFEL
KPENDFLDSRKAMLVNKDCIIGLAAPKESLRNYFYKNADADEMLFIHRGKGKLRTMLGNIPFEYGDYLIIPRGIIYQIDF
ETEDNRLFYVESYSPFYTPKRYKNQSGQHLEHSPFCERDFILPNELETYDEKGDFLIKIKKEGMIHEVVYATHPFDVVGW
DGYNFPYGFSIHNFEPITGRVHQPPPVHQTFETAAFVVCSFCPRLYDYHPKAIPAPYNHSNIDSDEVLYYVDGDFMSRNN
IEQGHITLHPKGIPHGPAPGAMERSIGHKETQELAVMVDTFRPLMVTEEAMGLDDGQYYKSWVE

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=298, Percent_Identity=24.496644295302, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 44573; Mature: 44442

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLYHKLGDFPQKRHTQFEKPNGGFYYEQLFGTEGFHGHSSLSYHVHRPTQVKEILNSYS
CCCHHHHCCCCHHHCCCCCCCCCCEEHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHCC
VEPKIAIGKNIKSLLFKGFELKPENDFLDSRKAMLVNKDCIIGLAAPKESLRNYFYKNAD
CCCEEEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCEEEEECCCHHHHHHHHCCCCC
ADEMLFIHRGKGKLRTMLGNIPFEYGDYLIIPRGIIYQIDFETEDNRLFYVESYSPFYTP
CCCEEEEECCCCHHHHHHCCCCCCCCCEEEECCCEEEEEEEECCCCEEEEEECCCCCCCC
KRYKNQSGQHLEHSPFCERDFILPNELETYDEKGDFLIKIKKEGMIHEVVYATHPFDVVG
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCEEEEEEECCCCEEEE
WDGYNFPYGFSIHNFEPITGRVHQPPPVHQTFETAAFVVCSFCPRLYDYHPKAIPAPYNH
CCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SNIDSDEVLYYVDGDFMSRNNIEQGHITLHPKGIPHGPAPGAMERSIGHKETQELAVMVD
CCCCCCCEEEEECCCEECCCCCCCCEEEECCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
TFRPLMVTEEAMGLDDGQYYKSWVE
CCCCEEEEHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
PLYHKLGDFPQKRHTQFEKPNGGFYYEQLFGTEGFHGHSSLSYHVHRPTQVKEILNSYS
CCHHHHCCCCHHHCCCCCCCCCCEEHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHCC
VEPKIAIGKNIKSLLFKGFELKPENDFLDSRKAMLVNKDCIIGLAAPKESLRNYFYKNAD
CCCEEEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCEEEEECCCHHHHHHHHCCCCC
ADEMLFIHRGKGKLRTMLGNIPFEYGDYLIIPRGIIYQIDFETEDNRLFYVESYSPFYTP
CCCEEEEECCCCHHHHHHCCCCCCCCCEEEECCCEEEEEEEECCCCEEEEEECCCCCCCC
KRYKNQSGQHLEHSPFCERDFILPNELETYDEKGDFLIKIKKEGMIHEVVYATHPFDVVG
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCEEEEEEECCCCEEEE
WDGYNFPYGFSIHNFEPITGRVHQPPPVHQTFETAAFVVCSFCPRLYDYHPKAIPAPYNH
CCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SNIDSDEVLYYVDGDFMSRNNIEQGHITLHPKGIPHGPAPGAMERSIGHKETQELAVMVD
CCCCCCCEEEEECCCEECCCCCCCCEEEECCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
TFRPLMVTEEAMGLDDGQYYKSWVE
CCCCEEEEHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]