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The map label for this gene is hpd [H]

Identifier: 146298492

GI number: 146298492

Start: 806034

End: 807194

Strand: Direct

Name: hpd [H]

Synonym: Fjoh_0729

Alternate gene names: 146298492

Gene position: 806034-807194 (Clockwise)

Preceding gene: 146298491

Following gene: 146298493

Centisome position: 13.22

GC content: 36.61

Gene sequence:

>1161_bases
ATGTCAAAAGAAGTTAAATCAGTAGAATACGGATTAGAAAAAATATTTGAAGGAGCGCAAGACTTCCTTCCATTATTAGG
AACAGATTATGTAGAATTTTATGTAGGTAATGCCAAACAAGCCGCTCATTACTATAAATCTGCATTTGGATATCAATCTT
TGGCTTATGCCGGATTAGAAACCGGAGTAAAAGACAGAGCGTCTTATGTTTTAAAACAAGATAAAATCAGAATTGTTTTA
ACTACGCCACTAACAGCTGATTCTCCAATCAACGAACATTTAAAAAAACACGGTGACGGAGTAAAAGTTGCAGCACTTTG
GGTTGAAGATGCTACAAAATCTTACGAAGAAACTATGAAACGCGGCGCGCGTTCTTTTATGGAACCAACTATTGAGGAAG
ATGAATTTGGTCAGGTAGTTCGTTCTGGAATTTATACTTACGGAGAAACCGTTCATATTTTTGTAGAAAGAAAAAACTAC
AATGGTGTTTTCTTACCAGGTTACAGAGAATGGAAATCTGACTTTAACCCAGAATCAACTGGATTAAAATACATCGACCA
CATGGTTGGAAACGTAGGATGGAACGAAATGAATACCTGGGTAAAATTTTACGAAGAAGTTATGGGATTCGTAAACTTCC
TATCTTTTGATGACAAACAAATCACTACAGAGTATTCTGCTTTGATGAGTAAAGTAATGTCTAACGGAAACGGAAGAATT
AAATTCCCAATCAACGAACCGGCTGAAGGAAAGAAAAAATCGCAGATTGAAGAATATTTAGATTTTTATGGCGGACCTGG
AATTCAGCACATCGCCATTGCTACAGATGATATTATTAAAACCGTATCGCAGCTAAGAGCCCGCGGTGTTGAATTTTTAT
CTGCTCCTCCTCATACCTATTATCAGGCAATCCCTGAGAGATTAGGTGTTCATATGGATATGATGAAAGAAGATTTAAAC
GAAATTGAAAAGCTGGCTATCATGGTCGATGCAGACGAAGATGGTTATCTTTTACAAATATTTACAAAACCAGTTCAGGA
CAGACCAACTTTATTCTTCGAAATTATTCAAAGAATGGGTGCAAAAGGATTTGGTGCAGGGAACTTTAAGGCTCTGTTTG
AATCAATTGAGAGAGAACAGGAATTGAGAGGAACTTTGTAA

Upstream 100 bases:

>100_bases
GATTTGCCTTTGCGTACTTTGCGGTTAAAAAAAATCAAATCTTAAAACAACACTTCGGCCAAATCAATTAAACGATTAAC
CGATTAAACAAATAAACATC

Downstream 100 bases:

>100_bases
AAATGCATTATTTTTACATTATGCAAAAAAAATCCCTATAAAATGATGATTTTTATGCAAATGTTATGTTAAACTTACTA
TTTGCTATTTTTTTTATCGA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSKEVKSVEYGLEKIFEGAQDFLPLLGTDYVEFYVGNAKQAAHYYKSAFGYQSLAYAGLETGVKDRASYVLKQDKIRIVL
TTPLTADSPINEHLKKHGDGVKVAALWVEDATKSYEETMKRGARSFMEPTIEEDEFGQVVRSGIYTYGETVHIFVERKNY
NGVFLPGYREWKSDFNPESTGLKYIDHMVGNVGWNEMNTWVKFYEEVMGFVNFLSFDDKQITTEYSALMSKVMSNGNGRI
KFPINEPAEGKKKSQIEEYLDFYGGPGIQHIAIATDDIIKTVSQLRARGVEFLSAPPHTYYQAIPERLGVHMDMMKEDLN
EIEKLAIMVDADEDGYLLQIFTKPVQDRPTLFFEIIQRMGAKGFGAGNFKALFESIEREQELRGTL

Sequences:

>Translated_386_residues
MSKEVKSVEYGLEKIFEGAQDFLPLLGTDYVEFYVGNAKQAAHYYKSAFGYQSLAYAGLETGVKDRASYVLKQDKIRIVL
TTPLTADSPINEHLKKHGDGVKVAALWVEDATKSYEETMKRGARSFMEPTIEEDEFGQVVRSGIYTYGETVHIFVERKNY
NGVFLPGYREWKSDFNPESTGLKYIDHMVGNVGWNEMNTWVKFYEEVMGFVNFLSFDDKQITTEYSALMSKVMSNGNGRI
KFPINEPAEGKKKSQIEEYLDFYGGPGIQHIAIATDDIIKTVSQLRARGVEFLSAPPHTYYQAIPERLGVHMDMMKEDLN
EIEKLAIMVDADEDGYLLQIFTKPVQDRPTLFFEIIQRMGAKGFGAGNFKALFESIEREQELRGTL
>Mature_385_residues
SKEVKSVEYGLEKIFEGAQDFLPLLGTDYVEFYVGNAKQAAHYYKSAFGYQSLAYAGLETGVKDRASYVLKQDKIRIVLT
TPLTADSPINEHLKKHGDGVKVAALWVEDATKSYEETMKRGARSFMEPTIEEDEFGQVVRSGIYTYGETVHIFVERKNYN
GVFLPGYREWKSDFNPESTGLKYIDHMVGNVGWNEMNTWVKFYEEVMGFVNFLSFDDKQITTEYSALMSKVMSNGNGRIK
FPINEPAEGKKKSQIEEYLDFYGGPGIQHIAIATDDIIKTVSQLRARGVEFLSAPPHTYYQAIPERLGVHMDMMKEDLNE
IEKLAIMVDADEDGYLLQIFTKPVQDRPTLFFEIIQRMGAKGFGAGNFKALFESIEREQELRGTL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=362, Percent_Identity=50.828729281768, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI285002264, Length=344, Percent_Identity=50, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI14249394, Length=374, Percent_Identity=25.4010695187166, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17555220, Length=377, Percent_Identity=49.867374005305, Blast_Score=344, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17550752, Length=364, Percent_Identity=37.6373626373626, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24667510, Length=366, Percent_Identity=50, Blast_Score=340, Evalue=7e-94,
Organism=Drosophila melanogaster, GI21356105, Length=294, Percent_Identity=51.7006802721088, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 43920; Mature: 43789

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEVKSVEYGLEKIFEGAQDFLPLLGTDYVEFYVGNAKQAAHYYKSAFGYQSLAYAGLE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCHHHHHHHHHHHHCHHHHHHHHHH
TGVKDRASYVLKQDKIRIVLTTPLTADSPINEHLKKHGDGVKVAALWVEDATKSYEETMK
CCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHH
RGARSFMEPTIEEDEFGQVVRSGIYTYGETVHIFVERKNYNGVFLPGYREWKSDFNPEST
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEECCCHHHHHCCCCCCHH
GLKYIDHMVGNVGWNEMNTWVKFYEEVMGFVNFLSFDDKQITTEYSALMSKVMSNGNGRI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
KFPINEPAEGKKKSQIEEYLDFYGGPGIQHIAIATDDIIKTVSQLRARGVEFLSAPPHTY
EECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCHHHCCCCHHH
YQAIPERLGVHMDMMKEDLNEIEKLAIMVDADEDGYLLQIFTKPVQDRPTLFFEIIQRMG
HHHHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHC
AKGFGAGNFKALFESIEREQELRGTL
CCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKEVKSVEYGLEKIFEGAQDFLPLLGTDYVEFYVGNAKQAAHYYKSAFGYQSLAYAGLE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCHHHHHHHHHHHHCHHHHHHHHHH
TGVKDRASYVLKQDKIRIVLTTPLTADSPINEHLKKHGDGVKVAALWVEDATKSYEETMK
CCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHH
RGARSFMEPTIEEDEFGQVVRSGIYTYGETVHIFVERKNYNGVFLPGYREWKSDFNPEST
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEECCCHHHHHCCCCCCHH
GLKYIDHMVGNVGWNEMNTWVKFYEEVMGFVNFLSFDDKQITTEYSALMSKVMSNGNGRI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
KFPINEPAEGKKKSQIEEYLDFYGGPGIQHIAIATDDIIKTVSQLRARGVEFLSAPPHTY
EECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCHHHCCCCHHH
YQAIPERLGVHMDMMKEDLNEIEKLAIMVDADEDGYLLQIFTKPVQDRPTLFFEIIQRMG
HHHHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHC
AKGFGAGNFKALFESIEREQELRGTL
CCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]