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The map label for this gene is arcB-2 [H]

Identifier: 146284291

GI number: 146284291

Start: 4315131

End: 4316141

Strand: Direct

Name: arcB-2 [H]

Synonym: PST_3979

Alternate gene names: 146284291

Gene position: 4315131-4316141 (Clockwise)

Preceding gene: 146284290

Following gene: 146284292

Centisome position: 94.48

GC content: 63.11

Gene sequence:

>1011_bases
ATGGCCTTCAACATTCACAACCGCAGCCTGCTCAGCCTGATGCACCACAGCGAGCGCGAACTGCAGTACCTGCTCGATCT
CTCCCGCGACCTCAAGCGCGCCAAGTACAGCGGTACCGAGCGCCAGCATCTCAAGGGCAAGAACATCGCGCTGATCTTCG
AGAAGACCTCCACGCGAACCCGCTGCGCCTTCGAGGTCGCCGCCTACGATCAGGGCGCCAACGTCACCTACATCGACCCC
AACTCATCGCAGATCGGCCACAAGGAAAGCATGAAGGACACCGCGCGGGTGCTCGGACGGCTGTACGACGCCATCGAATA
CCGTGGCTTCAAGCAGGAGATCGTCGAGGAGCTGGCGCGCTACGCCGGCGTGCCGGTCTACAATGGCCTGACCGACGAAT
ATCATCCGACGCAGATGATCGCCGACGTCATGACCATGCGCGAGCACAGCGACAAGCCGCTGCACCAGATCAGCTACGCC
TATCTGGGCGATGCGCGCAACAACATGGGCAATTCCCTGCTGCTGATCGGTGCCAAGCTGGGCATGGATGTACGCATCGC
CGCGCCACGTGCCCTTTGGCCCAGCGAGCAACACGTCAAGGCCTGCGAGGAATTCGCCGCGCAGAGCGGTGCGCGCCTGC
TGCTCACCGAGGATACGCAGGCGGCGGTGCAAGGCGTCGACTTCATCCACACCGACGTCTGGGTCTCGATGGGCGAGCCG
ATGGACGCCTGGGCCGAGCGCATCCAGCAGCTGCTGCCCTACCAGGTGAACGCGGCGCTGATGCAGGCGAGCAACAATCC
GCGGGTGAAGTTCATGCATTGCCTGCCGGCGTTCCACAACAGCGAGACCAAGGTCGGCAAGGAGATCGCCACGCGCTATC
CGCACCTGGCCAACGGTATCGAGGTCACCGAGGAGGTGTTCGAATCCCCGGCCTGCATTGCCTTCGAGCAGGCGGAGAAC
CGCATGCACACCATCAAGGCGATCCTGGTCTCCACCCTCGCCGACATCTGA

Upstream 100 bases:

>100_bases
CGGCCACTGCATGACCTGCCCGATCGCGCGCGACGCGCTCGACTCCTGATCACCGCGCCGGGCCCACCCCGGCAAACCGA
CATTGCGGAGGACTCACCCC

Downstream 100 bases:

>100_bases
CGTGACCGGCGCCCGTGATGGGCGCCCTGGAGAAACCGACATGCGCATCGTCATCGCGCTGGGCGGCAATGCCCTGCTTC
GCCGAGGGGAGCCGCTGAGC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAFNIHNRSLLSLMHHSERELQYLLDLSRDLKRAKYSGTERQHLKGKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDP
NSSQIGHKESMKDTARVLGRLYDAIEYRGFKQEIVEELARYAGVPVYNGLTDEYHPTQMIADVMTMREHSDKPLHQISYA
YLGDARNNMGNSLLLIGAKLGMDVRIAAPRALWPSEQHVKACEEFAAQSGARLLLTEDTQAAVQGVDFIHTDVWVSMGEP
MDAWAERIQQLLPYQVNAALMQASNNPRVKFMHCLPAFHNSETKVGKEIATRYPHLANGIEVTEEVFESPACIAFEQAEN
RMHTIKAILVSTLADI

Sequences:

>Translated_336_residues
MAFNIHNRSLLSLMHHSERELQYLLDLSRDLKRAKYSGTERQHLKGKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDP
NSSQIGHKESMKDTARVLGRLYDAIEYRGFKQEIVEELARYAGVPVYNGLTDEYHPTQMIADVMTMREHSDKPLHQISYA
YLGDARNNMGNSLLLIGAKLGMDVRIAAPRALWPSEQHVKACEEFAAQSGARLLLTEDTQAAVQGVDFIHTDVWVSMGEP
MDAWAERIQQLLPYQVNAALMQASNNPRVKFMHCLPAFHNSETKVGKEIATRYPHLANGIEVTEEVFESPACIAFEQAEN
RMHTIKAILVSTLADI
>Mature_335_residues
AFNIHNRSLLSLMHHSERELQYLLDLSRDLKRAKYSGTERQHLKGKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPN
SSQIGHKESMKDTARVLGRLYDAIEYRGFKQEIVEELARYAGVPVYNGLTDEYHPTQMIADVMTMREHSDKPLHQISYAY
LGDARNNMGNSLLLIGAKLGMDVRIAAPRALWPSEQHVKACEEFAAQSGARLLLTEDTQAAVQGVDFIHTDVWVSMGEPM
DAWAERIQQLLPYQVNAALMQASNNPRVKFMHCLPAFHNSETKVGKEIATRYPHLANGIEVTEEVFESPACIAFEQAENR
MHTIKAILVSTLADI

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=332, Percent_Identity=36.4457831325301, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1786469, Length=333, Percent_Identity=57.6576576576577, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1790703, Length=332, Percent_Identity=58.433734939759, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI48994908, Length=381, Percent_Identity=22.8346456692913, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI2367364, Length=170, Percent_Identity=30.5882352941176, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322373, Length=330, Percent_Identity=31.5151515151515, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322331, Length=160, Percent_Identity=29.375, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24642586, Length=233, Percent_Identity=24.4635193133047, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 37895; Mature: 37763

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNIHNRSLLSLMHHSERELQYLLDLSRDLKRAKYSGTERQHLKGKNIALIFEKTSTRT
CEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCC
RCAFEVAAYDQGANVTYIDPNSSQIGHKESMKDTARVLGRLYDAIEYRGFKQEIVEELAR
CEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
YAGVPVYNGLTDEYHPTQMIADVMTMREHSDKPLHQISYAYLGDARNNMGNSLLLIGAKL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHCCCCCEEEEEEECC
GMDVRIAAPRALWPSEQHVKACEEFAAQSGARLLLTEDTQAAVQGVDFIHTDVWVSMGEP
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCC
MDAWAERIQQLLPYQVNAALMQASNNPRVKFMHCLPAFHNSETKVGKEIATRYPHLANGI
HHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHCCHH
EVTEEVFESPACIAFEQAENRMHTIKAILVSTLADI
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFNIHNRSLLSLMHHSERELQYLLDLSRDLKRAKYSGTERQHLKGKNIALIFEKTSTRT
EECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCC
RCAFEVAAYDQGANVTYIDPNSSQIGHKESMKDTARVLGRLYDAIEYRGFKQEIVEELAR
CEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
YAGVPVYNGLTDEYHPTQMIADVMTMREHSDKPLHQISYAYLGDARNNMGNSLLLIGAKL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHCCCCCEEEEEEECC
GMDVRIAAPRALWPSEQHVKACEEFAAQSGARLLLTEDTQAAVQGVDFIHTDVWVSMGEP
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCC
MDAWAERIQQLLPYQVNAALMQASNNPRVKFMHCLPAFHNSETKVGKEIATRYPHLANGI
HHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHCCHH
EVTEEVFESPACIAFEQAENRMHTIKAILVSTLADI
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3109911; 10984043; 2118516; 7479879 [H]