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The map label for this gene is adh [H]

Identifier: 146284115

GI number: 146284115

Start: 4112023

End: 4113096

Strand: Direct

Name: adh [H]

Synonym: PST_3803

Alternate gene names: 146284115

Gene position: 4112023-4113096 (Clockwise)

Preceding gene: 146284114

Following gene: 146284117

Centisome position: 90.03

GC content: 65.92

Gene sequence:

>1074_bases
ATGGCCATGATGAAAGCCGCCGTGTTCGTCGAGCCGGGCCGCATCGAACTGCAGGACAAGCCCATCCCCGAGATTGGTCC
CAACGATGCGCTGCTGCGCATCACCACGACCACCATCTGCGGCACCGACGTCCACATTCTCAAGGGTGAATACCCGGTCG
CTCCCGGCCTGACCATCGGTCACGAACCGGTGGGCATCATCGAAAAGCTGGGCTGCAACGTGAAGGGCTACCAGGAAGGC
CAGCGGGTGATCGCCGGCGCCATCTGCCCCAGCTTCACCTCCTACGCCTGCCAGGACGGCCTGCCCGCTCAGGATGGCGG
CTGCTCCTGCCATGGCTACAAGCCCATGGGCGGCTGGCGATTCGGCAATACCATCGACGGCACTCAGGCCGAATACGTGC
TGGTGCCCGACGCCCAAGCCAACCTGGCGCCGGTGCCGGACGCGCTGACCGACGAGCAGGTGCTGATGTGTCCGGACATC
ATGTCCACCGGTTTCGCTGGCGCCGAGGCGGCCAATATCAAGATCGGCGATATCGTGGTGATCTTCGCCCAGGGCCCGAT
CGGGCTGTGCGCCACCGCCGGCGCCCGGCTGCGCGGCGCCGGCACCATCATCGCGGTGGACGGCGTGGATGCGCGGCTGG
ATATCGCGCGCAAGATGGGTGCGGATGTGACGCTCAACTTCCGCAATGTGGATGTGGTGGAGGAAGTGCTGAAACTGACC
GGTGGCCGCGGCGTCGACGCCTCGATCGAGGCGCTGGGCCTGCAATCGACCTTCGAAAGTGCGCTGCGGGTGCTCAAGCC
GGGCGGAACCCTGTCCAGTCTGGGCGTCTACTCCAGCGACCTGAGCATTCCGCTGGGCGCCTTCCATGCCGGCCTGGGCG
ACAACAAGATCGTCACCTCGCTCTGCCCCGGCGGCAAGGAACGCATGCGCCGACTGCTCAATGTGGTGGCGTCCGGCCGC
GTCGATCTCGCCCCGCTGGTCACCCATCACTACGCGCTGGACGACATCGGTGCCGCCTATGACCTGTTCGCCAATCAGCG
CGACGGTGTGCTGAAGGTGGCGATCAAGCCCTGA

Upstream 100 bases:

>100_bases
CCTTCTGCGCCAACTCGCCCTGACTTGATCGCGGTCATCCGCCGGCTTCCACGCTGGGCTAGAGTGTCCGGACGTCTTCA
CTTCCAAGAGGAGTCGCACC

Downstream 100 bases:

>100_bases
CGACCTTGTGCTGGCCGGGCGCGCCGTTCGCCGCCCGACCGGTGCGCATCACTCCGAACCCTCGCGGTCGCGGAAGCCCA
GCAGATAGAGGATGCCGTCC

Product: alcohol dehydrogenase (Zn-dependent)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MAMMKAAVFVEPGRIELQDKPIPEIGPNDALLRITTTTICGTDVHILKGEYPVAPGLTIGHEPVGIIEKLGCNVKGYQEG
QRVIAGAICPSFTSYACQDGLPAQDGGCSCHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPVPDALTDEQVLMCPDI
MSTGFAGAEAANIKIGDIVVIFAQGPIGLCATAGARLRGAGTIIAVDGVDARLDIARKMGADVTLNFRNVDVVEEVLKLT
GGRGVDASIEALGLQSTFESALRVLKPGGTLSSLGVYSSDLSIPLGAFHAGLGDNKIVTSLCPGGKERMRRLLNVVASGR
VDLAPLVTHHYALDDIGAAYDLFANQRDGVLKVAIKP

Sequences:

>Translated_357_residues
MAMMKAAVFVEPGRIELQDKPIPEIGPNDALLRITTTTICGTDVHILKGEYPVAPGLTIGHEPVGIIEKLGCNVKGYQEG
QRVIAGAICPSFTSYACQDGLPAQDGGCSCHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPVPDALTDEQVLMCPDI
MSTGFAGAEAANIKIGDIVVIFAQGPIGLCATAGARLRGAGTIIAVDGVDARLDIARKMGADVTLNFRNVDVVEEVLKLT
GGRGVDASIEALGLQSTFESALRVLKPGGTLSSLGVYSSDLSIPLGAFHAGLGDNKIVTSLCPGGKERMRRLLNVVASGR
VDLAPLVTHHYALDDIGAAYDLFANQRDGVLKVAIKP
>Mature_356_residues
AMMKAAVFVEPGRIELQDKPIPEIGPNDALLRITTTTICGTDVHILKGEYPVAPGLTIGHEPVGIIEKLGCNVKGYQEGQ
RVIAGAICPSFTSYACQDGLPAQDGGCSCHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPVPDALTDEQVLMCPDIM
STGFAGAEAANIKIGDIVVIFAQGPIGLCATAGARLRGAGTIIAVDGVDARLDIARKMGADVTLNFRNVDVVEEVLKLTG
GRGVDASIEALGLQSTFESALRVLKPGGTLSSLGVYSSDLSIPLGAFHAGLGDNKIVTSLCPGGKERMRRLLNVVASGRV
DLAPLVTHHYALDDIGAAYDLFANQRDGVLKVAIKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=358, Percent_Identity=29.0502793296089, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI71565152, Length=381, Percent_Identity=27.0341207349081, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501939, Length=372, Percent_Identity=25.8064516129032, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=25.8064516129032, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=26.9541778975741, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI34577061, Length=376, Percent_Identity=27.1276595744681, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=27.3712737127371, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI22538446, Length=371, Percent_Identity=24.2587601078167, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI22538444, Length=371, Percent_Identity=24.2587601078167, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=30.1020408163265, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790045, Length=345, Percent_Identity=28.1159420289855, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=28.1578947368421, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788075, Length=353, Percent_Identity=26.3456090651558, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788073, Length=361, Percent_Identity=25.207756232687, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=23.0985915492958, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786552, Length=364, Percent_Identity=28.2967032967033, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI226510992, Length=342, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788407, Length=347, Percent_Identity=26.8011527377522, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790718, Length=336, Percent_Identity=25.297619047619, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081918, Length=286, Percent_Identity=25.8741258741259, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787572, Length=119, Percent_Identity=41.1764705882353, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=352, Percent_Identity=28.6931818181818, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17562878, Length=371, Percent_Identity=28.0323450134771, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=348, Percent_Identity=25.5747126436782, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=344, Percent_Identity=25.8720930232558, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=344, Percent_Identity=26.7441860465116, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=278, Percent_Identity=25.8992805755396, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=358, Percent_Identity=29.0502793296089, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322619, Length=358, Percent_Identity=29.0502793296089, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323099, Length=366, Percent_Identity=26.775956284153, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=356, Percent_Identity=27.5280898876405, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=328, Percent_Identity=26.5243902439024, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319520, Length=266, Percent_Identity=26.6917293233083, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=26.605504587156, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=394, Percent_Identity=24.6192893401015, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=343, Percent_Identity=27.1137026239067, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=280, Percent_Identity=25.7142857142857, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137530, Length=352, Percent_Identity=30.9659090909091, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17737897, Length=351, Percent_Identity=30.1994301994302, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=26.5927977839335, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37306; Mature: 37175

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMMKAAVFVEPGRIELQDKPIPEIGPNDALLRITTTTICGTDVHILKGEYPVAPGLTIG
CCCEEEEEEECCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCEEC
HEPVGIIEKLGCNVKGYQEGQRVIAGAICPSFTSYACQDGLPAQDGGCSCHGYKPMGGWR
CCCHHHHHHHCCCCCCCCCCCEEEEHHHCCCHHHHHHCCCCCCCCCCCEECCCCCCCCCC
FGNTIDGTQAEYVLVPDAQANLAPVPDALTDEQVLMCPDIMSTGFAGAEAANIKIGDIVV
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCCCEEEECCEEE
IFAQGPIGLCATAGARLRGAGTIIAVDGVDARLDIARKMGADVTLNFRNVDVVEEVLKLT
EEECCCCCEEECCCCEEECCEEEEEECCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHC
GGRGVDASIEALGLQSTFESALRVLKPGGTLSSLGVYSSDLSIPLGAFHAGLGDNKIVTS
CCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCHHCCEECCCCCCCHHHHHCCCCCCCEEEE
LCPGGKERMRRLLNVVASGRVDLAPLVTHHYALDDIGAAYDLFANQRDGVLKVAIKP
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
AMMKAAVFVEPGRIELQDKPIPEIGPNDALLRITTTTICGTDVHILKGEYPVAPGLTIG
CCEEEEEEECCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCEEC
HEPVGIIEKLGCNVKGYQEGQRVIAGAICPSFTSYACQDGLPAQDGGCSCHGYKPMGGWR
CCCHHHHHHHCCCCCCCCCCCEEEEHHHCCCHHHHHHCCCCCCCCCCCEECCCCCCCCCC
FGNTIDGTQAEYVLVPDAQANLAPVPDALTDEQVLMCPDIMSTGFAGAEAANIKIGDIVV
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCCCEEEECCEEE
IFAQGPIGLCATAGARLRGAGTIIAVDGVDARLDIARKMGADVTLNFRNVDVVEEVLKLT
EEECCCCCEEECCCCEEECCEEEEEECCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHC
GGRGVDASIEALGLQSTFESALRVLKPGGTLSSLGVYSSDLSIPLGAFHAGLGDNKIVTS
CCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCHHCCEECCCCCCCHHHHHCCCCCCCEEEE
LCPGGKERMRRLLNVVASGRVDLAPLVTHHYALDDIGAAYDLFANQRDGVLKVAIKP
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]