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The map label for this gene is blh [H]

Identifier: 146282863

GI number: 146282863

Start: 2753281

End: 2754144

Strand: Direct

Name: blh [H]

Synonym: PST_2522

Alternate gene names: 146282863

Gene position: 2753281-2754144 (Clockwise)

Preceding gene: 146282862

Following gene: 146282864

Centisome position: 60.28

GC content: 65.28

Gene sequence:

>864_bases
ATGAATGTCCACGTCGAAGCCTTCTTCGATCCCGCGACCATTACCTACAGCTACGTGGTCAGCGACCTGGAAACGCGCCA
GTGTGCGGTGATCGACTCGGTGCTGGACTACGACCCGGCATCCGGCCGCACCTCCCATGCAAGCGCGCAGCGCCTGGTCG
ACTACGTGCGCAACCAGGACCTGCGGGTGCAGTGGCTGCTGGAAACCCATGTGCACGCCGACCATCTGAGCGCGGCGCCC
TATCTCAAGCAGCACCTGGGCGGCAAACTGGCGATCGGTGATCGCATCACCGTGGTGCAGGACACCTTCGGCAAGCTGTT
CAACGCAGGCAGCGGGTTCGCCACCGATGGCCGTCAGTTCGATCACCTGTTCCACGACGGCGACCGCTTCCAGGTCGGCA
ACGTGCAGGCCCGCGCCCTCCACACCCCGGGCCACACCCCGGCCTGCATGACCTACGTCATCGGTGACGCCGCCTTCGTC
GGTGACACCCTGTTCATGCCCGACTACGGCACCGCCCGCTGCGATTTTCCCGGCGGCGACGCGCGCACCCTGTACCAGTC
GATCCAGAAGCTGTTCGCCCTGCCAGGCGAGACCCGGGTGTTCATGTGCCATGACTACAAGGCGCCCGGGCGCGAGGAGT
TTCTCTACGAGACCACCATCGCCGCCGAGCGCGAGCACAACGTGCATATCCACAGCGGTATCAGCGAGGAGCAGTTCGTC
GCCATGCGCACCGCACGCGATGCCACGCTGGGCATGCCCACCCTGATCCTGCCGTCGGTGCAGATCAACATGCGCGGCGG
CGAACTGCCCGAGCCCGAAAGCAACGGGACGCGCTACCTGAAGATCCCCCTGGACGTGCTGTAA

Upstream 100 bases:

>100_bases
ACTAATAACCAATAAATCTAAGCATATAACCTAATTCAGGGCTAAGATCTCTCCGGACAGATACCCCCACCGGTATTAAT
CTGAAGAGGAGCCCCGCGCC

Downstream 100 bases:

>100_bases
CCCCCGAATGCGGAGGACGTCGACATGCAAACAATAAAACGACTGACCCCTTTTCTCTCCGTCGCGGCCCAGCTGCAACC
GGCCGACATGGCACTGCTGG

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNVHVEAFFDPATITYSYVVSDLETRQCAVIDSVLDYDPASGRTSHASAQRLVDYVRNQDLRVQWLLETHVHADHLSAAP
YLKQHLGGKLAIGDRITVVQDTFGKLFNAGSGFATDGRQFDHLFHDGDRFQVGNVQARALHTPGHTPACMTYVIGDAAFV
GDTLFMPDYGTARCDFPGGDARTLYQSIQKLFALPGETRVFMCHDYKAPGREEFLYETTIAAEREHNVHIHSGISEEQFV
AMRTARDATLGMPTLILPSVQINMRGGELPEPESNGTRYLKIPLDVL

Sequences:

>Translated_287_residues
MNVHVEAFFDPATITYSYVVSDLETRQCAVIDSVLDYDPASGRTSHASAQRLVDYVRNQDLRVQWLLETHVHADHLSAAP
YLKQHLGGKLAIGDRITVVQDTFGKLFNAGSGFATDGRQFDHLFHDGDRFQVGNVQARALHTPGHTPACMTYVIGDAAFV
GDTLFMPDYGTARCDFPGGDARTLYQSIQKLFALPGETRVFMCHDYKAPGREEFLYETTIAAEREHNVHIHSGISEEQFV
AMRTARDATLGMPTLILPSVQINMRGGELPEPESNGTRYLKIPLDVL
>Mature_287_residues
MNVHVEAFFDPATITYSYVVSDLETRQCAVIDSVLDYDPASGRTSHASAQRLVDYVRNQDLRVQWLLETHVHADHLSAAP
YLKQHLGGKLAIGDRITVVQDTFGKLFNAGSGFATDGRQFDHLFHDGDRFQVGNVQARALHTPGHTPACMTYVIGDAAFV
GDTLFMPDYGTARCDFPGGDARTLYQSIQKLFALPGETRVFMCHDYKAPGREEFLYETTIAAEREHNVHIHSGISEEQFV
AMRTARDATLGMPTLILPSVQINMRGGELPEPESNGTRYLKIPLDVL

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=268, Percent_Identity=29.8507462686567, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1787158, Length=193, Percent_Identity=29.0155440414508, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538952, Length=257, Percent_Identity=28.0155642023346, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221330176, Length=263, Percent_Identity=30.7984790874525, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 31886; Mature: 31886

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVHVEAFFDPATITYSYVVSDLETRQCAVIDSVLDYDPASGRTSHASAQRLVDYVRNQD
CCEEEEEEECCCCEEEEHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
LRVQWLLETHVHADHLSAAPYLKQHLGGKLAIGDRITVVQDTFGKLFNAGSGFATDGRQF
CEEEEEEECCCCHHHHCCCHHHHHHCCCEEEECCEEEEEHHHHHHHHCCCCCCCCCCHHH
DHLFHDGDRFQVGNVQARALHTPGHTPACMTYVIGDAAFVGDTLFMPDYGTARCDFPGGD
HHHHCCCCEEEECCEEEEEEECCCCCCCEEEEECCCHHHHCCEEECCCCCCEECCCCCCC
ARTLYQSIQKLFALPGETRVFMCHDYKAPGREEFLYETTIAAEREHNVHIHSGISEEQFV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEHHHHCCCCCCEEEECCCCHHHEE
AMRTARDATLGMPTLILPSVQINMRGGELPEPESNGTRYLKIPLDVL
EHHHCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MNVHVEAFFDPATITYSYVVSDLETRQCAVIDSVLDYDPASGRTSHASAQRLVDYVRNQD
CCEEEEEEECCCCEEEEHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
LRVQWLLETHVHADHLSAAPYLKQHLGGKLAIGDRITVVQDTFGKLFNAGSGFATDGRQF
CEEEEEEECCCCHHHHCCCHHHHHHCCCEEEECCEEEEEHHHHHHHHCCCCCCCCCCHHH
DHLFHDGDRFQVGNVQARALHTPGHTPACMTYVIGDAAFVGDTLFMPDYGTARCDFPGGD
HHHHCCCCEEEECCEEEEEEECCCCCCCEEEEECCCHHHHCCEEECCCCCCEECCCCCCC
ARTLYQSIQKLFALPGETRVFMCHDYKAPGREEFLYETTIAAEREHNVHIHSGISEEQFV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEHHHHCCCCCCEEEECCCCHHHEE
AMRTARDATLGMPTLILPSVQINMRGGELPEPESNGTRYLKIPLDVL
EHHHCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]