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The map label for this gene is fhuE [H]

Identifier: 145301189

GI number: 145301189

Start: 4673234

End: 4675216

Strand: Direct

Name: fhuE [H]

Synonym: ASA_4367

Alternate gene names: 145301189

Gene position: 4673234-4675216 (Clockwise)

Preceding gene: 145301188

Following gene: 145301198

Centisome position: 99.38

GC content: 65.15

Gene sequence:

>1983_bases
ATGAAACATATATTTCCATCCCCGTTGCTGCGACCGACCTTGATCCTGCTGGGGCTGACCCTTTCGCTCGCTTGCTGGGA
GCTGGCCCGCCAGTTGCCGGGCGCGCTCTGGTGGCAGACCCTCTTTGCGCCCAATCTGGATGATGCCCGTCAAGCCGTGG
TCCATTTCAGCTGGTTGCCCCGCTTGACGGTGACCCTGCTGGCCGGGGCCGCCCTCGGTCTGGCTGGCACCCTGATGCAG
CAGGTGCTGCGCAACCCGCTCGCCTCGCCGACCACCTTGGGGGTGGCCTCCGGCGCCCAGCTGGCGCTGATGATGGTGAC
TCTGTTTGCTCCCTCCTGGTTGCTGCTGGGGCGTGAGTGGATCGCCATGGCCGGTGGCAGCCTCGCCATGGCGCTGGTGT
TTGCCCTGGCTTGGCGTCGTCAGCTCAATCCCGTCGTCATCGTCTTCGCGGGGCTGGTGATCAACCTCTATCTGGCGGCC
ATCAGCATGGGGCTGCTGCTGTTTTTTCAGGAGGAGTTGAAAGGCTTGCTGGTGTGGGGCAGTGGTTCTCTGGCCCAGAA
CAGCTGGAGTGGCGTGCACTACCTGTTGCCCAGGTTGCTGGTGGCGGGGGGGCTGGCGGCTGCGCTGGTGCGCCCGCTGG
CTGTGCTTGAACTGGATGATGCCAGCGCCCGCAGTCTGGGGGGCTCGCTCCAACACTTGCGACTGGCGGGGCTTGGCTTG
GCGGTATTTGTCACCGCCTGCGTGGTGAGCGTGGTGGGGCTGATCGGTTTTATCGGGTTGGCCGCACCGGCCATGGTGCG
GCTGCTGGGGATCCGCCAGCTCGGTCAGCGGCTGCTGTGGGCGCCTGTTCTGGGGGCTCTGCTGTTGGCGGCCACCGATC
TGTTGCTGCAATCCGTCAGTCGATTCTGGCCCATGCTGATCCCGACCGGTGCCATGACGGCTCTGTTGGGGGCGCCGCTT
TTGCTCTGGCTGATCCCGCGACTTTCCTTGAAGTCGGGCACACCCAAAGCGAGTACCGGTTTGCTGGTAGCACGACATCC
GGCCCCGACTCGCCTGATCACCTTGCTGCTGCTCGGTTTGGGGCTCGCCATCATAGGCTCTCTGCTGTTCGGTCAGGGAA
TGCACGGCTGGAGCTGGCCGAGCTGGCTCAGGTGGCAGGCCCAGCTGGAGTGGCGGCTGCCGCGCACTCTGGCGGCGGGA
GCTGCCGGGATCTTGCTGGCGCTGGCGGGCACCCTGCTGCAGCGGGTCAGCAACAATCCCATGGCGAGTCCGGAACTGCT
GGGAGTGAGTGGCGGCACCTTCATGGGAGTGATAGCAACGGCACTGCTGCTGCCTGCCTTGCCATTGCCCATGATGCTGC
TTGGGGGCTTGATCGGGGCTTTCGGTTGCCTCTTGCTGCTGGTGCTGGTCAACCGCAAGCATGGCTTCCAGCCGGAGCGG
ATCCTGCTGTCCGGCATCGCCATCACGGCGCTGTTCGAACCATTACAGGCGATAGCGCTGGCCAACGGCGATATGCGGGT
GCAGCAACTGCTCTCCTGGATGTCCGGCTCTACCTATTACGTCACCCTGCCGGTGGCTTATGGACTGGTGGCACTGGCGG
TATTGATGCTGGCTGCCTGCCTGCTCATCAGCCGCTGGCTCGATCTGTTGCCCATGGGACCGGCACTGGCAACCGCATTG
GGAATTCGCCTCAACCGTGCCCAGCTCGCGATACTGCTGCTGGTGGCCGTGCTCACCGCCAGCGCCACCCTGGTGGTGGG
GCCGCTATCCTTCGTTGGTCTGCTGGCCCCGCACATGGCCAAGCTGATGGGATTGGTGCGGGCGCGCTGGCACCTGCTCG
GTGCCGCCGCTTCCGGTGCCCTGCTGATGGTGTCGGCGGACTGGATCGGCCAGCAGATCCTGTTCCCGCAGGACGTGCCG
GTCGGGCTGGTCTCCACCCTGTTAGGGGGCGCTTACTTCATGTGGTGCCTGCGCCGCCTCTAG

Upstream 100 bases:

>100_bases
ATCTGCCCGCAGTCTGGAGCTTCGGTGGCGTGCTCGCCGCCCGTCGCTTCGCCACCTTGCTCAGCGAGGCATTGCAGAAG
GATGCCAGGGGAGATCGCCA

Downstream 100 bases:

>100_bases
GTGTGTGGATGACAAATGCACAAAAAAGAGCCCGGGATAATCCCGGGCTCTTTGTTTCAAGGCTGGCGCCGACTCATGTG
CCGAGGCAGACAGCCAACTC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MKHIFPSPLLRPTLILLGLTLSLACWELARQLPGALWWQTLFAPNLDDARQAVVHFSWLPRLTVTLLAGAALGLAGTLMQ
QVLRNPLASPTTLGVASGAQLALMMVTLFAPSWLLLGREWIAMAGGSLAMALVFALAWRRQLNPVVIVFAGLVINLYLAA
ISMGLLLFFQEELKGLLVWGSGSLAQNSWSGVHYLLPRLLVAGGLAAALVRPLAVLELDDASARSLGGSLQHLRLAGLGL
AVFVTACVVSVVGLIGFIGLAAPAMVRLLGIRQLGQRLLWAPVLGALLLAATDLLLQSVSRFWPMLIPTGAMTALLGAPL
LLWLIPRLSLKSGTPKASTGLLVARHPAPTRLITLLLLGLGLAIIGSLLFGQGMHGWSWPSWLRWQAQLEWRLPRTLAAG
AAGILLALAGTLLQRVSNNPMASPELLGVSGGTFMGVIATALLLPALPLPMMLLGGLIGAFGCLLLLVLVNRKHGFQPER
ILLSGIAITALFEPLQAIALANGDMRVQQLLSWMSGSTYYVTLPVAYGLVALAVLMLAACLLISRWLDLLPMGPALATAL
GIRLNRAQLAILLLVAVLTASATLVVGPLSFVGLLAPHMAKLMGLVRARWHLLGAAASGALLMVSADWIGQQILFPQDVP
VGLVSTLLGGAYFMWCLRRL

Sequences:

>Translated_660_residues
MKHIFPSPLLRPTLILLGLTLSLACWELARQLPGALWWQTLFAPNLDDARQAVVHFSWLPRLTVTLLAGAALGLAGTLMQ
QVLRNPLASPTTLGVASGAQLALMMVTLFAPSWLLLGREWIAMAGGSLAMALVFALAWRRQLNPVVIVFAGLVINLYLAA
ISMGLLLFFQEELKGLLVWGSGSLAQNSWSGVHYLLPRLLVAGGLAAALVRPLAVLELDDASARSLGGSLQHLRLAGLGL
AVFVTACVVSVVGLIGFIGLAAPAMVRLLGIRQLGQRLLWAPVLGALLLAATDLLLQSVSRFWPMLIPTGAMTALLGAPL
LLWLIPRLSLKSGTPKASTGLLVARHPAPTRLITLLLLGLGLAIIGSLLFGQGMHGWSWPSWLRWQAQLEWRLPRTLAAG
AAGILLALAGTLLQRVSNNPMASPELLGVSGGTFMGVIATALLLPALPLPMMLLGGLIGAFGCLLLLVLVNRKHGFQPER
ILLSGIAITALFEPLQAIALANGDMRVQQLLSWMSGSTYYVTLPVAYGLVALAVLMLAACLLISRWLDLLPMGPALATAL
GIRLNRAQLAILLLVAVLTASATLVVGPLSFVGLLAPHMAKLMGLVRARWHLLGAAASGALLMVSADWIGQQILFPQDVP
VGLVSTLLGGAYFMWCLRRL
>Mature_660_residues
MKHIFPSPLLRPTLILLGLTLSLACWELARQLPGALWWQTLFAPNLDDARQAVVHFSWLPRLTVTLLAGAALGLAGTLMQ
QVLRNPLASPTTLGVASGAQLALMMVTLFAPSWLLLGREWIAMAGGSLAMALVFALAWRRQLNPVVIVFAGLVINLYLAA
ISMGLLLFFQEELKGLLVWGSGSLAQNSWSGVHYLLPRLLVAGGLAAALVRPLAVLELDDASARSLGGSLQHLRLAGLGL
AVFVTACVVSVVGLIGFIGLAAPAMVRLLGIRQLGQRLLWAPVLGALLLAATDLLLQSVSRFWPMLIPTGAMTALLGAPL
LLWLIPRLSLKSGTPKASTGLLVARHPAPTRLITLLLLGLGLAIIGSLLFGQGMHGWSWPSWLRWQAQLEWRLPRTLAAG
AAGILLALAGTLLQRVSNNPMASPELLGVSGGTFMGVIATALLLPALPLPMMLLGGLIGAFGCLLLLVLVNRKHGFQPER
ILLSGIAITALFEPLQAIALANGDMRVQQLLSWMSGSTYYVTLPVAYGLVALAVLMLAACLLISRWLDLLPMGPALATAL
GIRLNRAQLAILLLVAVLTASATLVVGPLSFVGLLAPHMAKLMGLVRARWHLLGAAASGALLMVSADWIGQQILFPQDVP
VGLVSTLLGGAYFMWCLRRL

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=638, Percent_Identity=43.1034482758621, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=33.9350180505415, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1786805, Length=274, Percent_Identity=36.8613138686131, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1790741, Length=272, Percent_Identity=33.4558823529412, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1786804, Length=266, Percent_Identity=34.9624060150376, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788004, Length=271, Percent_Identity=32.8413284132841, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70002; Mature: 70002

Theoretical pI: Translated: 11.63; Mature: 11.63

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIFPSPLLRPTLILLGLTLSLACWELARQLPGALWWQTLFAPNLDDARQAVVHFSWLP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
RLTVTLLAGAALGLAGTLMQQVLRNPLASPTTLGVASGAQLALMMVTLFAPSWLLLGREW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
IAMAGGSLAMALVFALAWRRQLNPVVIVFAGLVINLYLAAISMGLLLFFQEELKGLLVWG
HHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
SGSLAQNSWSGVHYLLPRLLVAGGLAAALVRPLAVLELDDASARSLGGSLQHLRLAGLGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHCCHHHHHHHHHHHH
AVFVTACVVSVVGLIGFIGLAAPAMVRLLGIRQLGQRLLWAPVLGALLLAATDLLLQSVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFWPMLIPTGAMTALLGAPLLLWLIPRLSLKSGTPKASTGLLVARHPAPTRLITLLLLGL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
GLAIIGSLLFGQGMHGWSWPSWLRWQAQLEWRLPRTLAAGAAGILLALAGTLLQRVSNNP
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
MASPELLGVSGGTFMGVIATALLLPALPLPMMLLGGLIGAFGCLLLLVLVNRKHGFQPER
CCCCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ILLSGIAITALFEPLQAIALANGDMRVQQLLSWMSGSTYYVTLPVAYGLVALAVLMLAAC
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHH
LLISRWLDLLPMGPALATALGIRLNRAQLAILLLVAVLTASATLVVGPLSFVGLLAPHMA
HHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHH
KLMGLVRARWHLLGAAASGALLMVSADWIGQQILFPQDVPVGLVSTLLGGAYFMWCLRRL
HHHHHHHHHHHHHHHHCCCCEEEEECHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKHIFPSPLLRPTLILLGLTLSLACWELARQLPGALWWQTLFAPNLDDARQAVVHFSWLP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
RLTVTLLAGAALGLAGTLMQQVLRNPLASPTTLGVASGAQLALMMVTLFAPSWLLLGREW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
IAMAGGSLAMALVFALAWRRQLNPVVIVFAGLVINLYLAAISMGLLLFFQEELKGLLVWG
HHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
SGSLAQNSWSGVHYLLPRLLVAGGLAAALVRPLAVLELDDASARSLGGSLQHLRLAGLGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHCCHHHHHHHHHHHH
AVFVTACVVSVVGLIGFIGLAAPAMVRLLGIRQLGQRLLWAPVLGALLLAATDLLLQSVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFWPMLIPTGAMTALLGAPLLLWLIPRLSLKSGTPKASTGLLVARHPAPTRLITLLLLGL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
GLAIIGSLLFGQGMHGWSWPSWLRWQAQLEWRLPRTLAAGAAGILLALAGTLLQRVSNNP
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
MASPELLGVSGGTFMGVIATALLLPALPLPMMLLGGLIGAFGCLLLLVLVNRKHGFQPER
CCCCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ILLSGIAITALFEPLQAIALANGDMRVQQLLSWMSGSTYYVTLPVAYGLVALAVLMLAAC
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHH
LLISRWLDLLPMGPALATALGIRLNRAQLAILLLVAVLTASATLVVGPLSFVGLLAPHMA
HHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHH
KLMGLVRARWHLLGAAASGALLMVSADWIGQQILFPQDVPVGLVSTLLGGAYFMWCLRRL
HHHHHHHHHHHHHHHHCCCCEEEEECHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]