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The map label for this gene is fhuD [H]

Identifier: 145301188

GI number: 145301188

Start: 4672368

End: 4673237

Strand: Direct

Name: fhuD [H]

Synonym: ASA_4366

Alternate gene names: 145301188

Gene position: 4672368-4673237 (Clockwise)

Preceding gene: 145301187

Following gene: 145301189

Centisome position: 99.36

GC content: 65.63

Gene sequence:

>870_bases
TTGCAGGCCAGTCCGGCGAGCCAGAGTGCCATCACCGATACCGCTCGGCCGAGTGAGCACACACAGGTACTACGGATTGC
CACCGTCGACTGGACCATAGCCGAAACCCTGCTGGCGCTCGGGGTGACCCCGCTGGCGGTGGGGGATGTCAGCGCCTACC
GCGCCTGGGTCGGCGAGCCGTTGCTGCCGGCCGATGTGGTTGATATAGGCCTGCGGGCTCAACCCAATCGCGAGCTGCTG
GCCGAGTTGAAACCCGATCGCATCCTCATCTCCCCGCTGGCGGCGCCGCTGGCACCGACCCTGTCCCGCATCGCCCCCGT
GCAGTCCATCGCCCTCTATGATCCACAAACGGATCTGTGGCAGCGGCTCCATGAGGCGACCCTGACCATAGCGGCGCTGG
TGAACAAAACGGCCGAGGCGAACGTGCTGCTGACAGATTTGAATCGGGAGCTCGAGCAGATGAAACAGACCCTGCCGGCG
GAGCTGCCGCCCCTGCTGGTGGTGCAGTTCATCGATGAGCGCCATGTGCGGGTGTTCGGTCGCCACAGCCTGTTCGAGGC
CGTGATGCAGCGACTCGGCCTGCGCAATGCCTGGCAGGGGGAGACAAATGCCTGGGGTTTCTCGGTGGCCAGCATAGAGC
AGTTCATGGCGCTGCCAGCCGCGCGGCTGGTGGTGGTGAATCCCATCCCGGTCGGGGTGAGCGAGCGGCTGCAGGAGCCC
GGCCTGTGGCAGCATCTGCCGCTGGTGCAACAGGCTCCGGTATTGCATCTGCCCGCAGTCTGGAGCTTCGGTGGCGTGCT
CGCCGCCCGTCGCTTCGCCACCTTGCTCAGCGAGGCATTGCAGAAGGATGCCAGGGGAGATCGCCAATGA

Upstream 100 bases:

>100_bases
CCCATGCCCATGCCATCGCCATCATCTAGGCGGGACAGCTATCTTGATATCTTCATTGAAAAGGGCCGGCTGGCTGCTCT
GCCTGCTGGCTCCATTGGGA

Downstream 100 bases:

>100_bases
AACATATATTTCCATCCCCGTTGCTGCGACCGACCTTGATCCTGCTGGGGCTGACCCTTTCGCTCGCTTGCTGGGAGCTG
GCCCGCCAGTTGCCGGGCGC

Product: ABC-type hydroxamate-type ferric siderophore transporter, periplasmic binding protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MQASPASQSAITDTARPSEHTQVLRIATVDWTIAETLLALGVTPLAVGDVSAYRAWVGEPLLPADVVDIGLRAQPNRELL
AELKPDRILISPLAAPLAPTLSRIAPVQSIALYDPQTDLWQRLHEATLTIAALVNKTAEANVLLTDLNRELEQMKQTLPA
ELPPLLVVQFIDERHVRVFGRHSLFEAVMQRLGLRNAWQGETNAWGFSVASIEQFMALPAARLVVVNPIPVGVSERLQEP
GLWQHLPLVQQAPVLHLPAVWSFGGVLAARRFATLLSEALQKDARGDRQ

Sequences:

>Translated_289_residues
MQASPASQSAITDTARPSEHTQVLRIATVDWTIAETLLALGVTPLAVGDVSAYRAWVGEPLLPADVVDIGLRAQPNRELL
AELKPDRILISPLAAPLAPTLSRIAPVQSIALYDPQTDLWQRLHEATLTIAALVNKTAEANVLLTDLNRELEQMKQTLPA
ELPPLLVVQFIDERHVRVFGRHSLFEAVMQRLGLRNAWQGETNAWGFSVASIEQFMALPAARLVVVNPIPVGVSERLQEP
GLWQHLPLVQQAPVLHLPAVWSFGGVLAARRFATLLSEALQKDARGDRQ
>Mature_289_residues
MQASPASQSAITDTARPSEHTQVLRIATVDWTIAETLLALGVTPLAVGDVSAYRAWVGEPLLPADVVDIGLRAQPNRELL
AELKPDRILISPLAAPLAPTLSRIAPVQSIALYDPQTDLWQRLHEATLTIAALVNKTAEANVLLTDLNRELEQMKQTLPA
ELPPLLVVQFIDERHVRVFGRHSLFEAVMQRLGLRNAWQGETNAWGFSVASIEQFMALPAARLVVVNPIPVGVSERLQEP
GLWQHLPLVQQAPVLHLPAVWSFGGVLAARRFATLLSEALQKDARGDRQ

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=262, Percent_Identity=36.2595419847328, Blast_Score=158, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 31689; Mature: 31689

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQASPASQSAITDTARPSEHTQVLRIATVDWTIAETLLALGVTPLAVGDVSAYRAWVGEP
CCCCCCCCHHHCCCCCCCCCCEEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
LLPADVVDIGLRAQPNRELLAELKPDRILISPLAAPLAPTLSRIAPVQSIALYDPQTDLW
CCCHHHHHCCCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHHCCHHHHEEECCCHHHH
QRLHEATLTIAALVNKTAEANVLLTDLNRELEQMKQTLPAELPPLLVVQFIDERHVRVFG
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHH
RHSLFEAVMQRLGLRNAWQGETNAWGFSVASIEQFMALPAARLVVVNPIPVGVSERLQEP
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCC
GLWQHLPLVQQAPVLHLPAVWSFGGVLAARRFATLLSEALQKDARGDRQ
CCHHHCCHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQASPASQSAITDTARPSEHTQVLRIATVDWTIAETLLALGVTPLAVGDVSAYRAWVGEP
CCCCCCCCHHHCCCCCCCCCCEEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
LLPADVVDIGLRAQPNRELLAELKPDRILISPLAAPLAPTLSRIAPVQSIALYDPQTDLW
CCCHHHHHCCCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHHCCHHHHEEECCCHHHH
QRLHEATLTIAALVNKTAEANVLLTDLNRELEQMKQTLPAELPPLLVVQFIDERHVRVFG
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHH
RHSLFEAVMQRLGLRNAWQGETNAWGFSVASIEQFMALPAARLVVVNPIPVGVSERLQEP
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCC
GLWQHLPLVQQAPVLHLPAVWSFGGVLAARRFATLLSEALQKDARGDRQ
CCHHHCCHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]